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DART-08: Developmental and Reproductive Toxicity

Growth and Clinical Finding Tables (I), Pathology Tables (PA), Developmental and Reproductive Tables (R) from NTP Modified One Generation Dose Range Finding Study, Modified One Generation Main Study Studies


DOI: https://doi.org/10.22427/NTP-DATA-DART-08

Pup Body Weight tables (R19/R19G/R19C) were added on September 4, 2020.

Analysis for Gross Pathology table (PA46R) was updated on 14Aug2020. The following tables were updated on November 4, 2020 for clarity in presentation and statistical updates: I04G, I06, R09, R10, R19, R19C and R19G. Gross Pathology table (PA46R) was replaced on November 9, 2020 with additional analysis included.

The R03 report for the Main Study was replaced on January 7,2021.

The following tables were replaced for the Main study on February 3, 2021 due to reanalysis of data: I03, I03C, I04, I04G, and PA06. The Dose range finding study tables (I06 and I08) were reanalyzed and replaced on February 3, 2021.

Individual Animal Andrology Data file for Modified One Generation study replaced on March 30, 2021 due to the inclusion of a value for testis weight for animal 2101 that should have been excluded as an outlier.

PA06R table for Modified One Generation study replaced on March 30,2021 in order to correct the N value for the F2 male 3750 ppm group for left testis and left epididymis weights.

Note: The study data are being disseminated prior to external peer review under applicable information quality guidelines and do not represent and should not be construed to represent any final NTP determination or policy.

The R06 table for Modified One Generation Main Study was updated on April 21, 2021.

DART-08: Bisphenol AF


Modified One Generation Dose Range Finding Study


Modified One Generation Toxicity Dose Range Finding Study Tables

Modified One Generation Toxicity Dose Range Finding Individual Animal Data


Modified One Generation Main Study


Modified One Generation Toxicity Study Tables

Modified One Generation Toxicity Individual Animal Data

Genetox Data