TOX-108: Toxicity Report Tables & Curves
Pathology Tables, Survival and Growth Curves from NTP
2-(2H-benzotriazol-2-yl)phenol (P-BZT), 2-(2H-benzotriazol-2-yl)-4-methylphenol (Drometrizole), 2-(2H-benzotriazol-2-yl)-4-tert-butylphenol (tBu-BZT), 2-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol (Octrizole), 2-(2H-benzotriazol-2-yl)-4,6-bis(1,1-dimethylpropyl)phenol (ditPe-BZT), 2-(2H-benzotriazol-2-yl)-4,6-bis(1-methyl-1-phenylethyl)phenol (diMeEtPh-BZT), 3-(2H-benzotriazol-2-yl)-5-(1,1-dimethylethyl)-4-hydroxybenzenepropanoic acid, octyl ester (tBuPrOcEst-BZT), 2-(5-chloro-2H-1,2,3-benzotriazol-2-yl)-6-(1,1-dimethylethyl)-4-methylphenol (Bumetrizole), 2-(5-chloro-2H-benzotriazol-2-yl)-4,6-bis(1,1-dimethylethyl)phenol (ditBuCl-BZT), Additional Materials, Genetic Toxicology Studies
TOX-108: Phenolic Benzotriazoles
2-(2H-benzotriazol-2-yl)phenol (P-BZT)
Two-week Study Tables - Rats
- I01 - Animal Removal Summary (28 KB)
- I02 - Animal Removals (100 KB)
- I03 - Growth Curve (294 KB)
- I03C - Growth Curve (274 KB)
- I04 - Mean Body Weights and Survival (63 KB)
- I04G - Mean Body Weight Gain (58 KB)
- I05 - Clinical Observations Summary (31 KB)
- PA02 - Incidence Rates of Neoplasms by Anatomic Site (73 KB)
- PA03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (69 KB)
- PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (73 KB)
- PA06 - Organ Weights Summary (73 KB)
- PA08X - Statistical Analysis of Primary Tumors (70 KB)
- PA10X - Statistical Analysis of Non-Neoplastic Lesions (70 KB)
- PA14 - Individual Animal Pathology Data (215 KB)
- PA18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (69 KB)
- PA41 - Clinical Chemistry Summary (104 KB)
- PA43 - Hematology Summary (77 KB)
- PA46s - Gross Pathology Summary (211 KB)
- PA48 - Summary of Tissue Concentration (81 KB)
Two-week Individual Animal Data - Rats
- Individual Animal Body Weight Data (7 KB)
- Individual Animal Clinical Chemistry Data (7 KB)
- Individual Animal Clinical Observations Data (13 KB)
- Individual Animal Gross Pathology Data (31 KB)
- Individual Animal Hematology Data (8 KB)
- Individual Animal Organ Weight Data (7 KB)
- Individual Animal Polymerase Chain Reaction Data (10 KB)
- Individual Animal Removal Reasons Data (5 KB)
- Individual Animal Tissue Concentration Data (6 KB)
2-(2H-benzotriazol-2-yl)-4-methylphenol (Drometrizole)
Two-week Study Tables - Rats
- I01 - Animal Removal Summary (67 KB)
- I02 - Animal Removals (139 KB)
- I03 - Growth Curve (348 KB)
- I03C - Growth Curve (334 KB)
- I04 - Mean Body Weight Summary (99 KB)
- I04G - Mean Body Weight Gain (37 KB)
- I05 - Clinical Observations Summary (70 KB)
- PA02 - Neoplastic Lesion Summary with Percent Incidence (157 KB)
- PA03 - Nonneoplastic Lesion Summary with Percent Incidence (138 KB)
- PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (157 KB)
- PA06 - Organ Weights Summary (110 KB)
- PA08X - Statistical Analysis of Neoplastic Lesions (146 KB)
- PA10X - Statistical Analysis of Nonneoplastic Lesions (150 KB)
- PA14 - Individual Animal Pathology Data (714 KB)
- PA18 - Incidence Rates of Nonneoplastic Lesions by Anatomic Site with Average Severity Grade (138 KB)
- PA41 - Clinical Chemistry Summary (49 KB)
- PA43 - Hematology Summary (172 KB)
- PA46s - Summary of Gross Pathology (211 KB)
- PA48 - Summary of Tissue Concentration (80 KB)
Two-week Individual Animal Data - Rats
- Individual Animal Body Weight Data (7 KB)
- Individual Animal Clinical Chemistry Data (7 KB)
- Individual Animal Clinical Observations Data (13 KB)
- Individual Animal Gross Pathology Data (32 KB)
- Individual Animal Hematology Data (8 KB)
- Individual Animal Organ Weight Data (7 KB)
- Individual Animal Polymerase Chain Reaction Data (10 KB)
- Individual Animal Removal Reasons Data (5 KB)
- Individual Animal Tissue Concentration Data (6 KB)
2-(2H-benzotriazol-2-yl)-4-tert-butylphenol (tBu-BZT)
Two-week Study Tables - Rats
- I01 - Animal Removal Summary (28 KB)
- I02 - Animal Removals (100 KB)
- I03 - Growth Curve (295 KB)
- I03C - Growth Curve (292 KB)
- I04 - Mean Body Weight Summary (143 KB)
- I04G - Mean Body Weight Gain (119 KB)
- I05 - Clinical Observations Summary (31 KB)
- PA02 - Neoplastic Lesion Summary with Percent Incidence (204 KB)
- PA03 - Nonneoplastic Lesion Summary with Percent Incidence (186 KB)
- PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (204 KB)
- PA06 - Organ Weights Summary (154 KB)
- PA08X - Statistical Analysis of Neoplastic Lesions (191 KB)
- PA10X - Statistical Analysis of Nonneoplastic Lesions (199 KB)
- PA14 - Individual Animal Pathology Data (822 KB)
- PA18 - Incidence Rates of Nonneoplastic Lesions by Anatomic Site with Average Severity Grade (187 KB)
- PA41 - Clinical Chemistry Summary (104 KB)
- PA43 - Hematology Summary (222 KB)
- PA46s - Summary of Gross Pathology (191 KB)
- PA48 - Summary of Tissue Concentration (123 KB)
Two-week Individual Animal Data - Rats
- Individual Animal Body Weight Data (7 KB)
- Individual Animal Clinical Chemistry Data (7 KB)
- Individual Animal Clinical Observations Data (13 KB)
- Individual Animal Gross Pathology Data (42 KB)
- Individual Animal Hematology Data (8 KB)
- Individual Animal Organ Weight Data (7 KB)
- Individual Animal Polymerase Chain Reaction Data (10 KB)
- Individual Animal Removal Reasons Data (5 KB)
- Individual Animal Tissue Concentration Data (6 KB)
2-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol (Octrizole)
Two-week Study Tables - Rats
- I01 - Animal Removal Summary (35 KB)
- I02 - Animal Removals (139 KB)
- I03 - Growth Curve (325 KB)
- I03C - Growth Curve (315 KB)
- I04 - Mean Body Weight Summary (99 KB)
- I04G - Mean Body Weight Gain (77 KB)
- I05 - Clinical Observations Summary (79 KB)
- PA02 - Incidence Rates of Neoplasms by Anatomic Site (163 KB)
- PA03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (153 KB)
- PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (163 KB)
- PA06 - Organ Weights Summary (109 KB)
- PA08X - Statistical Analysis of Primary Tumors (146 KB)
- PA10X - Statistical Analysis of Non-Neoplastic Lesions (130 KB)
- PA14 - Individual Animal Pathology Data (743 KB)
- PA18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (154 KB)
- PA41 - Clinical Chemistry Summary (103 KB)
- PA43 - Hematology Summary (135 KB)
- PA46s - Gross Pathology Summary (142 KB)
- PA48 - Summary of Tissue Concentration (81 KB)
Two-week Individual Animal Data - Rats
- Individual Animal Body Weight Data (7 KB)
- Individual Animal Clinical Chemistry Data (7 KB)
- Individual Animal Clinical Observations Data (14 KB)
- Individual Animal Gross Pathology Data (42 KB)
- Individual Animal Hematology Data (8 KB)
- Individual Animal Organ Weight Data (7 KB)
- Individual Animal Polymerase Chain Reaction Data (10 KB)
- Individual Animal Removal Reasons Data (5 KB)
- Individual Animal Tissue Concentration Data (6 KB)
2-(2H-benzotriazol-2-yl)-4,6-bis(1,1-dimethylpropyl)phenol (ditPe-BZT)
Two-week Study Tables - Rats
- I01 - Animal Removal Summary (67 KB)
- I02 - Animal Removals (140 KB)
- I03 - Growth Curve (333 KB)
- I03C - Growth Curve (317 KB)
- I04 - Mean Body Weight Summary (99 KB)
- I04G - Mean Body Weight Gain (78 KB)
- I05 - Clinical Observations Summary (70 KB)
- PA02 - Neoplastic Lesion Summary with Percent Incidence (157 KB)
- PA03 - Nonneoplastic Lesion Summary with Percent Incidence (140 KB)
- PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (157 KB)
- PA06 - Organ Weights Summary (72 KB)
- PA08X - Statistical Analysis of Neoplastic Lesions (146 KB)
- PA10X - Statistical Analysis of Nonneoplastic Lesions (151 KB)
- PA14 - Individual Animal Pathology Data (720 KB)
- PA18 - Incidence Rates of Nonneoplastic Lesions by Anatomic Site with Average Severity Grade (140 KB)
- PA41 - Clinical Chemistry Summary (104 KB)
- PA43 - Hematology Summary (135 KB)
- PA46 - Summary of Gross Pathology (192 KB)
- PA48 - Summary of Tissue Concentration (81 KB)
Two-week Individual Animal Data - Rats
- Individual Animal Body Weight Data (7 KB)
- Individual Animal Clinical Chemistry Data (7 KB)
- Individual Animal Clinical Observations Data (13 KB)
- Individual Animal Gross Pathology Data (30 KB)
- Individual Animal Hematology Data (8 KB)
- Individual Animal Organ Weight Data (7 KB)
- Individual Animal Polymerase Chain Reaction Data (10 KB)
- Individual Animal Removal Reasons Data (5 KB)
- Individual Animal Tissue Concentration Data (6 KB)
2-(2H-benzotriazol-2-yl)-4,6-bis(1-methyl-1-phenylethyl)phenol (diMeEtPh-BZT)
Two-week Study Tables - Rats
- I01 - Animal Removal Summary (28 KB)
- I02 - Animal Removals (101 KB)
- I03 - Growth Curve (297 KB)
- I03C - Growth Curve (281 KB)
- I04 - Mean Body Weights and Survival (84 KB)
- I04G - Mean Body Weight Gain (118 KB)
- I05 - Clinical Observations Summary (31 KB)
- PA02 - Incidence Rates of Neoplasms by Anatomic Site (204 KB)
- PA03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (181 KB)
- PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (210 KB)
- PA06 - Organ Weights Summary (153 KB)
- PA08X - Statistical Analysis of Primary Tumors (191 KB)
- PA10X - Statistical Analysis of Non-Neoplastic Lesions (264 KB)
- PA14 - Individual Animal Pathology Data (803 KB)
- PA18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (182 KB)
- PA41 - Clinical Chemistry Summary (141 KB)
- PA43 - Hematology Summary (173 KB)
- PA48 - Summary of Tissue Concentration (121 KB)
Two-week Individual Animal Data -Rats
- Individual Animal Body Weight Data (7 KB)
- Individual Animal Clinical Chemistry Data (7 KB)
- Individual Animal Clinical Observations Data (14 KB)
- Individual Animal Gross Pathology Data (31 KB)
- Individual Animal Hematology Data (8 KB)
- Individual Animal Organ Weight Data (7 KB)
- Individual Animal Polymerase Chain Reaction Data (10 KB)
- Individual Animal Removal Reasons Data (5 KB)
- Individual Animal Tissue Concentration Data (6 KB)
3-(2H-benzotriazol-2-yl)-5-(1,1-dimethylethyl)-4-hydroxybenzenepropanoic acid, octyl ester (tBuPrOcEst-BZT)
Two-week Study Tables - Rats
- I01 - Animal Removal Summary (28 KB)
- I02 - Animal Removals (101 KB)
- I03 - Growth Curve (273 KB)
- I03C - Growth Curve (258 KB)
- I04 - Mean Body Weight Summary (143 KB)
- I04G - Mean Body Weight Gain (119 KB)
- I05 - Clinical Observations Summary (59 KB)
- PA02 - Neoplastic Lesion Summary with Percent Incidence (209 KB)
- PA03 - Nonneoplastic Lesion Summary with Percent Incidence (207 KB)
- PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (210 KB)
- PA06 - Organ Weights Summary (155 KB)
- PA08X - Statistical Analysis of Neoplastic Lesions (191 KB)
- PA10X - Statistical Analysis of Nonneoplastic Lesions (145 KB)
- PA14 - Individual Animal Pathology Data (930 KB)
- PA18 - Incidence Rates of Nonneoplastic Lesions by Anatomic Site with Average Severity Grade (244 KB)
- PA41 - Clinical Chemistry Summary (104 KB)
- PA43 - Hematology Summary (136 KB)
- PA46s - Summary of Gross Pathology (217 KB)
- PA48 - Summary of Tissue Concentration (125 KB)
Two-week Individual Animal Data - Rats
- Individual Animal Body Weight Data (7 KB)
- Individual Animal Clinical Chemistry Data (7 KB)
- Individual Animal Clinical Observations Data (15 KB)
- Individual Animal Gross Pathology Data (42 KB)
- Individual Animal Hematology Data (8 KB)
- Individual Animal Organ Weight Data (7 KB)
- Individual Animal Polymerase Chain Reaction Data (10 KB)
- Individual Animal Removal Reasons Data (5 KB)
- Individual Animal Tissue Concentration Data (6 KB)
2-(5-chloro-2H-1,2,3-benzotriazol-2-yl)-6-(1,1-dimethylethyl)-4-methylphenol (Bumetrizole)
Two-week Study Tables - Rats
- I01 - Animal Removal Summary (69 KB)
- I02 - Animal Removals (139 KB)
- I03 - Growth Curve (331 KB)
- I03C - Growth Curve (312 KB)
- I04 - Mean Body Weight Summary (99 KB)
- I04G - Mean Body Weight Gain (77 KB)
- I05 - Clinical Observations Summary (79 KB)
- PA02 - Neoplastic Lesion Summary with Percent Incidence (164 KB)
- PA03 - Nonneoplastic Lesion Summary with Percent Incidence (148 KB)
- PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (164 KB)
- PA06 - Organ Weights Summary (116 KB)
- PA08X - Statistical Analysis of Neoplastic Lesions (147 KB)
- PA10X - Statistical Analysis of Nonneoplastic Lesions (125 KB)
- PA14 - Individual Animal Pathology Data (713 KB)
- PA18 - Incidence Rates of Nonneoplastic Lesions by Anatomic Site with Average Severity Grade (149 KB)
- PA41 - Clinical Chemistry Summary (141 KB)
- PA43 - Hematology Summary (172 KB)
- PA46s - Gross_Pathology_Summary.pdf (154 KB)
- PA48 - Summary of Tissue Concentration (80 KB)
Two-week Individual Animal Data - Rats
- Individual Animal Body Weight Data (7 KB)
- Individual Animal Clinical Chemistry Data (7 KB)
- Individual Animal Clinical Observations Data (13 KB)
- Individual Animal Gross Pathology Data (40 KB)
- Individual Animal Hematology Data (8 KB)
- Individual Animal Organ Weight Data (7 KB)
- Individual Animal Polymerase Chain Reaction Data (10 KB)
- Individual Animal Removal Reasons Data (5 KB)
- Individual Animal Tissue Concentration Data (6 KB)
2-(5-chloro-2H-benzotriazol-2-yl)-4,6-bis(1,1-dimethylethyl)phenol (ditBuCl-BZT)
Two-week Study Tables - Rats
- I01 - Animal Removal Summary (28 KB)
- I02 - Animal Removals (101 KB)
- I03 - Growth Curve (294 KB)
- I03C - Growth Curve (267 KB)
- I04 - Mean Body Weight Summary (62 KB)
- I04G - Mean Body Weight Gain (78 KB)
- I05 - Clinical Observations Summary (41 KB)
- PA02 - Neoplastic Lesion Summary with Percent Incidence (73 KB)
- PA03 - Nonneoplastic Lesion Summary with Percent Incidence (71 KB)
- PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (74 KB)
- PA06 - Ogan Weights Summary (44 KB)
- PA08X - Statistical Analysis of Neoplastic Lesions (70 KB)
- PA10X - Statistical Analysis of Nonneoplastic Lesions (129 KB)
- PA14 - Individual Animal Pathology Data (202 KB)
- PA18 - Incidence Rates of Nonneoplastic Lesions by Anatomic Site with Average Severity Grade (71 KB)
- PA41 - Clinical Chemistry Summary (104 KB)
- PA43 - Hematology Summary (135 KB)
- PA46s - Gross Pathology Summary (71 KB)
- PA48 - Summary of Tissue Concentration (42 KB)
Two-week Individual Animal Data - Rats
- Individual Animal Body Weight Data (7 KB)
- Individual Animal Clinical Chemistry Data (7 KB)
- Individual Animal Clinical Observations Data (14 KB)
- Individual Animal Gross Pathology Data (41 KB)
- Individual Animal Hematology Data (8 KB)
- Individual Animal Organ Weight Data (7 KB)
- Individual Animal Polymerase Chain Reaction Data (10 KB)
- Individual Animal Removal Reasons Data (5 KB)
- Individual Animal Tissue Concentration Data (6 KB)
Additional Materials
PCR Data
- PBZT PCR Summary Data Files (1 MB)
- PBZT Total PCR Raw Data CT values (83 KB)