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TOX-98: Toxicity Report Tables & Curves

Pathology Tables, Survival and Growth Curves from NTP
Short-Term, Genetic Toxicology Studies

The PA43 tables were replaced in order to remove unneeded endpoints and allow for greater consistency across studies. The cell count percentage data were removed since it is the absolute cell counts that are evaluated/interpreted. Terms for machine generated and manual hematocrit were updated to be consisted with terms for the same measures. A few additional parameters were also removed.

https://doi.org/10.22427/NTP-DATA-TOX-98

TOX-98: Acetoin & 2,3-Pentanedione

Short-Term

2-Week Acetoin Study Tables - Rats

E03 - Growth Curves (327 KB)
E04 - Mean Body Weights and Survival Table (15 KB)
E05 - Clinical Observations Summary (13 KB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (24 KB)
P04 - Neoplasms by Individual Animal (133 KB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (28 KB)
P08 - Statistical Analysis of Primary Tumors (12 KB)
P09 - Non-Neoplastic Lesions by Individual Animal (56 KB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (25 KB)
P14 - Individual Animal Pathology Data (118 KB)
P17 - Neoplasms by Individual Animal (Systemic Lesions Abridged) (134 KB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (25 KB)
P40 - Survival Curves (374 KB)

2-Week Acetoin Individual Animal Data - Rats

Female Individual Animal Body Weight Data (9 KB)
Female Individual Animal Non-Neoplastic Pathology Data (2 KB)
Female Individual Animal Organ Weight Data (10 KB)
Female Individual Animal Survival Data (6 KB)
Male Individual Animal Body Weight Data (9 KB)
Male Individual Animal Non-Neoplastic Pathology Data (2 KB)
Male Individual Animal Organ Weight Data (10 KB)
Male Individual Animal Survival Data (6 KB)

2-Week Acetoin Study Tables - Mice

E03 - Growth Curves (318 KB)
E04 - Mean Body Weights and Survival Table (15 KB)
E05 - Clinical Observations Summary (11 KB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (22 KB)
P04 - Neoplasms by Individual Animal (133 KB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (28 KB)
P08 - Statistical Analysis of Primary Tumors (12 KB)
P09 - Non-Neoplastic Lesions by Individual Animal (55 KB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (10 KB)
P14 - Individual Animal Pathology Data (118 KB)
P17 - Neoplasms by Individual Animal (Systemic Lesions Abridged) (134 KB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (23 KB)
P40 - Survival Curves (366 KB)

2-Week Acetoin Individual Animal Data - Mice

Female Individual Animal Body Weight Data (9 KB)
Female Individual Animal Organ Weight Data (10 KB)
Female Individual Animal Survival Data (6 KB)
Male Individual Animal Body Weight Data (9 KB)
Male Individual Animal Organ Weight Data (10 KB)
Male Individual Animal Survival Data (6 KB)

3-Month Acetoin Study Tables - Rats

E03 - Growth Curves (437 KB)
E04 - Mean Body Weights and Survival Table (18 KB)
E05 - Clinical Observations Summary (11 KB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (33 KB)
P04 - Neoplasms by Individual Animal (198 KB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (34 KB)
P09 - Non-Neoplastic Lesions by Individual Animal (173 KB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (134 KB)
P14 - Individual Animal Pathology Data (252 KB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (34 KB)
P40 - Survival Curves (429 KB)
PA06 - Organ Weights Summary (94 KB)
PA41 - Clinical Chemistry Summary (691 KB)
PA43 - Hematology Summary (750 KB)

3-Month Acetoin Individual Animal Data - Rats

Female Individual Animal Body Weight Data (34 KB)
Female Individual Animal Non-Neoplastic Pathology Data (8 KB)
Female Individual Animal Organ Weight Data (18 KB)
Female Individual Animal Survival Data (11 KB)
Individual Animal Clinical Chemistry Data (31 KB)
Individual Animal Hematology Data (63 KB)
Individual Animal Organ Weight Data (13 KB)
Male Individual Animal Body Weight Data (34 KB)
Male Individual Animal Non-Neoplastic Pathology Data (11 KB)
Male Individual Animal Organ Weight Data (18 KB)
Male Individual Animal Survival Data (11 KB)

3-Month Acetoin Study Tables - Mice

E03 - Growth Curves (422 KB)
E04 - Mean Body Weights and Survival Table (17 KB)
E05 - Clinical Observations Summary (14 KB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (28 KB)
P04 - Neoplasms by Individual Animal (196 KB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (33 KB)
P09 - Non-Neoplastic Lesions by Individual Animal (137 KB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (29 KB)
P14 - Individual Animal Pathology Data (250 KB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (29 KB)
P40 - Survival Curves (437 KB)
PA06 - Organ Weights Summary (94 KB)
PA43 - Hematology Summary (260 KB)

3-Month Acetoin Individual Animal Data - Mice

Female Individual Animal Body Weight Data (33 KB)
Female Individual Animal Non-Neoplastic Pathology Data (3 KB)
Female Individual Animal Organ Weight Data (18 KB)
Female Individual Animal Survival Data (11 KB)
Individual Animal Hematology Data (25 KB)
Individual Animal Organ Weight Data (11 KB)
Male Individual Animal Body Weight Data (33 KB)
Male Individual Animal Non-Neoplastic Pathology Data (3 KB)
Male Individual Animal Organ Weight Data (18 KB)
Male Individual Animal Survival Data (11 KB)

3-Month 2,3-Pentanedione Study Tables - Rats

E03 - Growth Curves (66 KB)
E04 - Mean Body Weights and Survival Table (18 KB)
E05 - Clinical Observations Summary (18 KB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (46 KB)
P04 - Neoplasms by Individual Animal (210 KB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (33 KB)
P09 - Non-Neoplastic Lesions by Individual Animal (287 KB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (592 KB)
P14 - Individual Animal Pathology Data (319 KB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (48 KB)
P40 - Survival Curves (422 KB)
PA06 - Organ Weights Summary (94 KB)
PA41 - Clinical Chemistry Summary (692 KB)
PA43 - Hematology Summary (750 KB)

3-Month 2,3-Pentanedione Individual Animal Data - Rats

Female Individual Animal Body Weight Data (34 KB)
Female Individual Animal Non-Neoplastic Pathology Data (150 KB)
Female Individual Animal Organ Weight Data (18 KB)
Female Individual Animal Survival Data (11 KB)
Female Individual Clinical Observations (31 KB)
Individual Animal Clinical Chemistry Data (31 KB)
Individual Animal Hematology Data (63 KB)
Individual Animal Organ Weight Data (13 KB)
Male Individual Animal Body Weight Data (34 KB)
Male Individual Animal Non-Neoplastic Pathology Data (176 KB)
Male Individual Animal Organ Weight Data (18 KB)
Male Individual Animal Survival Data (11 KB)
Male Individual Clinical Observations (37 KB)

3-Month 2,3-Pentanedione Study Tables - Mice

E03 - Growth Curves (63 KB)
E04 - Mean Body Weights and Survival Table (17 KB)
E05 - Clinical Observations Summary (18 KB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (46 KB)
P04 - Neoplasms by Individual Animal (214 KB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (34 KB)
P09 - Non-Neoplastic Lesions by Individual Animal (274 KB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (505 KB)
P14 - Individual Animal Pathology Data (327 KB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (47 KB)
P40 - Survival Curves (424 KB)
PA06 - Organ Weights Summary (94 KB)
PA43 - Hematology Summary (260 KB)

3-Month 2,3-Pentanedione Individual Animal Data - Mice

Female Individual Animal Body Weight Data (33 KB)
Female Individual Animal Non-Neoplastic Pathology Data (180 KB)
Female Individual Animal Organ Weight Data (18 KB)
Female Individual Animal Survival Data (11 KB)
Female Individual Clinical Observations (36 KB)
Individual Animal Hematology Data (25 KB)
Individual Animal Organ Weight Data (11 KB)
Male Individual Animal Body Weight Data (33 KB)
Male Individual Animal Non-Neoplastic Pathology Data (167 KB)
Male Individual Animal Organ Weight Data (18 KB)
Male Individual Animal Survival Data (11 KB)
Male Individual Clinical Observations (41 KB)

Genetic Toxicology

Genetic Toxicity Evaluation of Acetoin (513-86-0) in Micronucleus Study G99018 in Wistar Han Rats

G04 - In Vivo Micronucleus Summary Data (77 KB)
Individual Animal In Vivo Micronucleus Data (10 KB)

Genetic Toxicity Evaluation of Acetoin (513-86-0) in Micronucleus Study G99018B in B6C3F1 Mice

G04 - In Vivo Micronucleus Summary Data (77 KB)
Individual Animal In Vivo Micronucleus Data (10 KB)

Genetic Toxicity Evaluation of Acetoin in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A17696

G06 - Ames Summary Data (140 KB)

Genetic Toxicity Evaluation of 2,3-Pentanedione (600-14-6) in Micronucleus Study G08010 in Wistar Han Rats

G04 - In Vivo Micronucleus Summary Data (77 KB)
Individual Animal In Vivo Micronucleus Data (10 KB)

Genetic Toxicity Evaluation of 2,3-Pentanedione (600-14-6) in Micronucleus Study G08010B in B6C3F1 Mice

G04 - In Vivo Micronucleus Summary Data (77 KB)
Individual Animal In Vivo Micronucleus Data (10 KB)