TOX-98: 2,3-Pentanedione (600-14-6), Acetoin (513-86-0)

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to TOX-98: 2,3-Pentanedione (600-14-6), Acetoin (513-86-0).
Micronucleus - Mice
View Male: Negative Female: Negative
View Male: Negative Female: Negative

An overview of Genetic Toxicology Micronucleus Rats study conclusions related to TOX-98: 2,3-Pentanedione (600-14-6), Acetoin (513-86-0).
Micronucleus - Rats
View Male: Negative Female: Negative
View Male: Negative Female: Negative

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to TOX-98: 2,3-Pentanedione (600-14-6), Acetoin (513-86-0).
Bacterial Mutagenicity
View Negative

Citation Information

NTP. TOX-98: 2,3-Pentanedione (600-14-6), Acetoin (513-86-0). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

TOX-98 Toxicity Studies of Acetoin and 2,3-Pentanedione Administered via Inhalation to Wistar Han Rats and B6C3F1 Mice

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Data

2-Week Evaluation of the Toxicity (C20724) of Acetoin (513-86-0) in Wistar Han Rats Exposed via Whole Body Respiratory Exposure

Study Tables

E03 - Growth Curves (335 kB)
E04 - Mean Body Weights and Survival Table (16 kB)
E05 - Clinical Observations Summary (13 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (25 kB)
P04 - Neoplasms by Individual Animal (136 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (28 kB)
P08 - Statistical Analysis of Primary Tumors (12 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (57 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (25 kB)
P14 - Individual Animal Pathology Data (121 kB)
P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (138 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (25 kB)
P40 - Survival Curves (383 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (9 kB)
Female Individual Animal Non-Neoplastic Pathology Data (3 kB)
Female Individual Animal Organ Weight Data (10 kB)
Female Individual Animal Survival Data (6 kB)
Male Individual Animal Body Weight Data (9 kB)
Male Individual Animal Non-Neoplastic Pathology Data (3 kB)
Male Individual Animal Organ Weight Data (10 kB)
Male Individual Animal Survival Data (6 kB)

Data

2-Week Evaluation of the Toxicity (C20724) of Acetoin (513-86-0) in B6C3F1 Mice Exposed via Whole Body Respiratory Exposure

Study Tables

E03 - Growth Curves (326 kB)
E04 - Mean Body Weights and Survival Table (16 kB)
E05 - Clinical Observations Summary (11 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (22 kB)
P04 - Neoplasms by Individual Animal (136 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (28 kB)
P08 - Statistical Analysis of Primary Tumors (12 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (56 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (10 kB)
P14 - Individual Animal Pathology Data (121 kB)
P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (137 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (23 kB)
P40 - Survival Curves (374 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (9 kB)
Female Individual Animal Organ Weight Data (10 kB)
Female Individual Animal Survival Data (6 kB)
Male Individual Animal Body Weight Data (9 kB)
Male Individual Animal Organ Weight Data (10 kB)
Male Individual Animal Survival Data (6 kB)

Data

3-Month Evaluation of the Toxicity (C08010) of 2,3-Pentanedione (600-14-6) in Wistar Han Rats Exposed via Whole Body Respiratory Exposure

Study Tables

E03 - Growth Curves (68 kB)
E04 - Mean Body Weights and Survival Table (18 kB)
E05 - Clinical Observations Summary (19 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (47 kB)
P04 - Neoplasms by Individual Animal (216 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (34 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (294 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (606 kB)
P14 - Individual Animal Pathology Data (327 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (49 kB)
P40 - Survival Curves (432 kB)
PA06 - Organ Weights Summary (96 kB)
PA41 - Clinical Chemistry Summary (708 kB)
PA43 - Hematology Summary (768 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (35 kB)
Female Individual Animal Non-Neoplastic Pathology Data (154 kB)
Female Individual Animal Organ Weight Data (19 kB)
Female Individual Animal Survival Data (11 kB)
Female Individual Clinical Observations (32 kB)
Individual Animal Clinical Chemistry Data (32 kB)
Individual Animal Hematology Data (64 kB)
Individual Animal Organ Weight Data (13 kB)
Male Individual Animal Body Weight Data (35 kB)
Male Individual Animal Non-Neoplastic Pathology Data (180 kB)
Male Individual Animal Organ Weight Data (19 kB)
Male Individual Animal Survival Data (11 kB)
Male Individual Clinical Observations (38 kB)

Data

3-Month Evaluation of the Toxicity (C20724) of Acetoin (513-86-0) in Wistar Han Rats Exposed via Whole Body Respiratory Exposure

Study Tables

E03 - Growth Curves (447 kB)
E04 - Mean Body Weights and Survival Table (18 kB)
E05 - Clinical Observations Summary (12 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (33 kB)
P04 - Neoplasms by Individual Animal (203 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (34 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (178 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (137 kB)
P14 - Individual Animal Pathology Data (258 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (35 kB)
P40 - Survival Curves (439 kB)
PA06 - Organ Weights Summary (96 kB)
PA41 - Clinical Chemistry Summary (708 kB)
PA43 - Hematology Summary (768 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (35 kB)
Female Individual Animal Non-Neoplastic Pathology Data (8 kB)
Female Individual Animal Organ Weight Data (19 kB)
Female Individual Animal Survival Data (11 kB)
Individual Animal Clinical Chemistry Data (32 kB)
Individual Animal Hematology Data (64 kB)
Individual Animal Organ Weight Data (13 kB)
Male Individual Animal Body Weight Data (35 kB)
Male Individual Animal Non-Neoplastic Pathology Data (12 kB)
Male Individual Animal Organ Weight Data (19 kB)
Male Individual Animal Survival Data (11 kB)

Data

3-Month Evaluation of the Toxicity (C08010) of 2,3-Pentanedione (600-14-6) in B6C3F1 Mice Exposed via Whole Body Respiratory Exposure

Study Tables

E03 - Growth Curves (65 kB)
E04 - Mean Body Weights and Survival Table (18 kB)
E05 - Clinical Observations Summary (18 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (47 kB)
P04 - Neoplasms by Individual Animal (219 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (34 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (280 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (517 kB)
P14 - Individual Animal Pathology Data (335 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (48 kB)
P40 - Survival Curves (434 kB)
PA06 - Organ Weights Summary (96 kB)
PA43 - Hematology Summary (266 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (34 kB)
Female Individual Animal Non-Neoplastic Pathology Data (184 kB)
Female Individual Animal Organ Weight Data (19 kB)
Female Individual Animal Survival Data (11 kB)
Female Individual Clinical Observations (37 kB)
Individual Animal Hematology Data (26 kB)
Individual Animal Organ Weight Data (12 kB)
Male Individual Animal Body Weight Data (34 kB)
Male Individual Animal Non-Neoplastic Pathology Data (171 kB)
Male Individual Animal Organ Weight Data (19 kB)
Male Individual Animal Survival Data (11 kB)
Male Individual Clinical Observations (42 kB)

Data

3-Month Evaluation of the Toxicity (C20724) of Acetoin (513-86-0) in B6C3F1 Mice Exposed via Whole Body Respiratory Exposure

Study Tables

E03 - Growth Curves (433 kB)
E04 - Mean Body Weights and Survival Table (18 kB)
E05 - Clinical Observations Summary (14 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (29 kB)
P04 - Neoplasms by Individual Animal (201 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (34 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (140 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (30 kB)
P14 - Individual Animal Pathology Data (256 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (30 kB)
P40 - Survival Curves (448 kB)
PA06 - Organ Weights Summary (96 kB)
PA43 - Hematology Summary (266 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (34 kB)
Female Individual Animal Non-Neoplastic Pathology Data (3 kB)
Female Individual Animal Organ Weight Data (19 kB)
Female Individual Animal Survival Data (11 kB)
Individual Animal Hematology Data (25 kB)
Individual Animal Organ Weight Data (12 kB)
Male Individual Animal Body Weight Data (34 kB)
Male Individual Animal Non-Neoplastic Pathology Data (3 kB)
Male Individual Animal Organ Weight Data (19 kB)
Male Individual Animal Survival Data (11 kB)

Protocol

Genetic Toxicology Studies

Data

Genetic Toxicity Evaluation of 2,3-Pentanedione (600-14-6) in Micronucleus Study G08010 in Wistar Han Rats

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (79 kB)
Individual Animal In Vivo Micronucleus Data (10 kB)

Data

Genetic Toxicity Evaluation of 2,3-Pentanedione (600-14-6) in Micronucleus Study G08010B in B6C3F1 Mice

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (79 kB)
Individual Animal In Vivo Micronucleus Data (10 kB)

Data

Genetic Toxicity Evaluation of Acetoin (513-86-0) in Micronucleus Study G99018 in Wistar Han Rats

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (79 kB)
Individual Animal In Vivo Micronucleus Data (10 kB)

Data

Genetic Toxicity Evaluation of Acetoin (513-86-0) in Micronucleus Study G99018B in B6C3F1 Mice

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (79 kB)
Individual Animal In Vivo Micronucleus Data (10 kB)

Data

Genetic Toxicity Evaluation of Acetoin in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A17696

Summary Data

G06 - Ames Summary Data (143 kB)

TOX-98: 2,3-Pentanedione (600-14-6), Acetoin (513-86-0)

Study Results

Genetic Toxicology

Citation Information

Related Links

Publications

Study Data

Toxicity and Carcinogenicity Studies

2-Week Evaluation of the Toxicity (C20724) of Acetoin (513-86-0) in Wistar Han Rats Exposed via Whole Body Respiratory Exposure

Study Tables

Individual Animal Data

2-Week Evaluation of the Toxicity (C20724) of Acetoin (513-86-0) in B6C3F1 Mice Exposed via Whole Body Respiratory Exposure

Study Tables

Individual Animal Data

3-Month Evaluation of the Toxicity (C08010) of 2,3-Pentanedione (600-14-6) in Wistar Han Rats Exposed via Whole Body Respiratory Exposure

Study Tables

Individual Animal Data

3-Month Evaluation of the Toxicity (C20724) of Acetoin (513-86-0) in Wistar Han Rats Exposed via Whole Body Respiratory Exposure

Study Tables

Individual Animal Data

3-Month Evaluation of the Toxicity (C08010) of 2,3-Pentanedione (600-14-6) in B6C3F1 Mice Exposed via Whole Body Respiratory Exposure

Study Tables

Individual Animal Data

3-Month Evaluation of the Toxicity (C20724) of Acetoin (513-86-0) in B6C3F1 Mice Exposed via Whole Body Respiratory Exposure

Study Tables

Individual Animal Data

Genetic Toxicology Studies

Genetic Toxicity Evaluation of 2,3-Pentanedione (600-14-6) in Micronucleus Study G08010 in Wistar Han Rats

Summary and Individual Animal Data

Genetic Toxicity Evaluation of 2,3-Pentanedione (600-14-6) in Micronucleus Study G08010B in B6C3F1 Mice

Summary and Individual Animal Data

Genetic Toxicity Evaluation of Acetoin (513-86-0) in Micronucleus Study G99018 in Wistar Han Rats

Summary and Individual Animal Data

Genetic Toxicity Evaluation of Acetoin (513-86-0) in Micronucleus Study G99018B in B6C3F1 Mice

Summary and Individual Animal Data

Genetic Toxicity Evaluation of Acetoin in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A17696

Summary Data