TOX-99: Toxicity Report Tables & Curves
Pathology Tables, Survival and Growth Curves from NTP
Short-Term, Immunotoxicology, In Vitro Activity (Human), Micronucleus Studies
TOX-99: Gum Guggul Extract
Short-Term
28-Day Interim Study Tables - Rats
- E03 - Growth Curves (360 KB)
- E04 - Mean Body Weights and Survival Table (12 KB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (20 KB)
- P04 - Neoplasms by Individual Animal (142 KB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (22 KB)
- P08 - Statistical Analysis of Primary Tumors (7 KB)
- P09 - Non-Neoplastic Lesions by Individual Animal (135 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (57 KB)
- P14 - Individual Animal Pathology Data (159 KB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (21 KB)
- P40 - Survival Curves (385 KB)
- PA06 - Organ Weights Summary (149 KB)
- PA41 - Clinical Chemistry Summary (496 KB)
- PA43 - Hematology Summary (569 KB)
- PA49 - Cytochrome Activity Summary (76 KB)
- R07 - Hormone Summary (100 KB)
28-Day Individual Animal Data - Rats
- Female Individual Animal BodyWeight (18 KB)
- Female Individual Animal Non Neoplastic Pathology Data (12 KB)
- Female Individual Animal Survival Data (11 KB)
- Female Individual Animal Terminal Body Weight Data (18 KB)
- Individual Animal Clinical Chemistry Data (23 KB)
- Individual Animal Cytochrome Activity Data (14 KB)
- Individual Animal Hematology Data (31 KB)
- Individual Animal Hormone Data (14 KB)
- Individual Animal Organ Weight Data (20 KB)
- Male Individual Animal Body Weight Data (18 KB)
- Male Individual Animal Non Neoplastic Pathology Data (10 KB)
- Male Individual Animal Survival Data (11 KB)
- Male Individual Animal Terminal Body Weight Data (18 KB)
28-Day Interim Study Tables - Mice
- E03 - Growth Curves (397 KB)
- E04 - Mean Body Weights and Survival Table (12 KB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (19 KB)
- P04 - Neoplasms by Individual Animal (134 KB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (22 KB)
- P08 - Statistical Analysis of Primary Tumors (8 KB)
- P09 - Non-Neoplastic Lesions by Individual Animal (72 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (23 KB)
- P14 - Individual Animal Pathology Data (151 KB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (20 KB)
- P40 - Survival Curves (380 KB)
- PA06 - Organ Weights Summary (149 KB)
- PA41 - Clinical Chemistry Summary (170 KB)
- PA49 - Cytochrome Activity Summary (76 KB)
28-Day Individual Animal Data - Mice
- Female Individual Animal Body Weight Data (17 KB)
- Female Individual Animal Neoplastic Pathology Data (2 KB)
- Female Individual Animal Non Neoplastic Pathology Data (2 KB)
- Female Individual Animal Survival Data (11 KB)
- Female Individual Animal Terminal Body Weight Data (18 KB)
- Individual Animal Clinical Chemistry Data (17 KB)
- Individual Animal Cytochrome Activity Data (9 KB)
- Individual Animal Organ Weight Data (15 KB)
- Male Individual Animal Body Weight Data (17 KB)
- Male Individual Animal Non Neoplastic Pathology Data (3 KB)
- Male Individual Animal Survival Data (11 KB)
- Male Individual Animal Terminal Body Weight Data (18 KB)
3-Month Study Tables - Rats
- E03 - Growth Curves (444 KB)
- E04 - Mean Body Weights and Survival Table (17 KB)
- E05 - Clinical Observations Summary (14 KB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (33 KB)
- P04 - Neoplasms by Individual Animal (225 KB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (33 KB)
- P09 - Non-Neoplastic Lesions by Individual Animal (231 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (187 KB)
- P14 - Individual Animal Pathology Data (259 KB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (34 KB)
- P40 - Survival Curves (425 KB)
- PA06 -Organ Weights Summary (149 KB)
- PA41 -Clinical Chemistry Summary (496 KB)
- PA43 -Hematology Summary (569 KB)
- PA49 -Cytochrome Activity Summary (76 KB)
- R06 -Andrology Summary (49 KB)
- R07 -Hormone Summary (100 KB)
3-Month Individual Animal Data - Rats
- Female Individual Animal Body Weight Data (34 KB)
- Female Individual Animal Neoplastic Pathology Data (2 KB)
- Female Individual Animal Non Neoplastic Pathology Data (27 KB)
- Female Individual Animal Survival Data (11 KB)
- Female Individual Animal Terminal Body Weight Data (18 KB)
- Female Individual Clinical Observations (2 KB)
- Individual Animal Andrology Data (8 KB)
- Individual Animal Clinical Chemistry Data (23 KB)
- Individual Animal Cytochrome Activity Data (14 KB)
- Individual Animal Hematology Data (31 KB)
- Individual Animal Hormone Data (14 KB)
- Individual Animal Organ Weight Data (20 KB)
- Male Individual Animal Body Weight Data (34 KB)
- Male Individual Animal Non Neoplastic Pathology Data (26 KB)
- Male Individual Animal Survival Data (11 KB)
- Male Individual Animal TerminalBody Weight Data (18 KB)
- Male Individual Clinical Observations (2 KB)
3-Month Study Tables - Mice
- E03 - Growth Curves (409 KB)
- E04 - Mean Body Weights and Survival Table (17 KB)
- E05 - Clinical Observations Summary (14 KB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (28 KB)
- P04 - Neoplasms by Individual Animal (189 KB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (33 KB)
- P09 - Non-Neoplastic Lesions by Individual Animal (122 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (47 KB)
- P14 - Individual Animal Pathology Data (356 KB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (29 KB)
- P40 - Survival Curves (423 KB)
- PA06-Organ Weights Summary (149 KB)
- PA41-Clinical Chemistry Summary (170 KB)
- PA49-Cytochrome Activity Summary (76 KB)
- R06 Andrology Summary (49 KB)
3-Month Individual Animal Data - Mice
- Female Individual Animal Body Weight Data (49 KB)
- Female Individual Animal Neoplastic Pathology Data (2 KB)
- Female Individual Animal Non Neoplastic Pathology Data (8 KB)
- Female Individual Animal Survival Data (16 KB)
- Female Individual Animal Terminal Body Weight Data (26 KB)
- Individual Animal Andrology Data (8 KB)
- Individual Animal Clinical Chemistry Data (17 KB)
- Individual Animal Cytochrome Activity Data (9 KB)
- Individual Animal Organ Weight Data (15 KB)
- Male Individual Animal Body Weight Data (49 KB)
- Male Individual Animal Non Neoplastic Pathology Data (5 KB)
- Male Individual Animal Survival Data (16 KB)
- Male Individual Animal TerminalBody Weight Data (26 KB)
- Male Individual Clinical Observations (2 KB)
Immunotoxicology
4-Week Immunotoxicity Study Tables
- E03 - Growth Curves (177 KB)
- E04 - Mean Body Weights and Survival Table (14 KB)
- E05 - Clinical Observations Summary (11 KB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (21 KB)
- P04 - Neoplasms by Individual Animal (118 KB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (21 KB)
- P09 - Non-Neoplastic Lesions by Individual Animal (125 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (85 KB)
- P14 - Individual Animal Pathology Data (118 KB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (22 KB)
- P40 - Survival Curves (205 KB)
4-Week Immunotoxicity Individual Animal Data
- Female Individual Animal Body Weight Data (11 KB)
- Female Individual Animal Non Neoplastic Pathology Data (18 KB)
- Female Individual Animal Survival Data (10 KB)
- Female Individual Animal Terminal Body Weight Data (17 KB)
- Individual Animal ANTI-CD3 Proliferation Data (20 KB)
- Individual Animal Body Weight Data (103 KB)
- Individual Animal Gross Observations Data (59 KB)
- Individual Animal Hematology Data (21 KB)
- Individual Animal Histo Pathology Data (9 KB)
- Individual Animal In Vitro Cytotoxic T Lymphocyte Data (29 KB)
- Individual Animal Leukocyte Cell Differential Data (9 KB)
- Individual Animal Mixed Leukocyte Response Data (23 KB)
- Individual Animal Mononuclear Phagocytic System Data (35 KB)
- Individual Animal Natural Killer Cell Activity Data (22 KB)
- Individual Animal Organ Weight Data (35 KB)
- Individual Animal Periodic Weight Gain Data (90 KB)
- Individual Animal Reticulocytes Data (7 KB)
- Individual Animal Serum Anti-KLH ELISA Data (7 KB)
- Individual Animal Serum IgM Data (18 KB)
- Individual Animal Surface Markers Absolute Data (22 KB)
- Individual Animal Surface Markers Percentage Data (21 KB)
- Individual Animal T-Dependent Antibody Response Data (20 KB)
In Vitro Activity (Human)
In Vitro Assays (Human) -Gum Guggul Extract
- In Vitro Assay Raw Activity Data (15 KB)
- PA49 - Cytochrome Activity (50 KB)
In Vitro Assays (Human) -E-guggulsterone
- In Vitro Assay Raw Activity Data (7 KB)
- PA49 - Cytochrome Activity (45 KB)
In Vitro Assays (Human) -Z-guggulsterone
- In Vitro Assay Raw Activity Data (7 KB)
- PA49 - Cytochrome Activity (46 KB)