TR-598: Technical Report Pathology Tables and Curves
Pathology Tables, Survival and Growth Curves from NTP
General Study Information, Long-Term, Genetic Toxicology Studies
DOI:
https://doi.org/10.22427/NTP-DATA-TR598
A number of Individual animal Data Files were produced in an older version of excel. Please note that you may receive an alert regarding excel file extensions upon opening the files. These files are safe to open.
Select tables were updated due to corrections in uterine neoplasm incidence and number of animals evaluated; uterine neoplastic (P08) and nonneoplastic statistics (P10) were updated due to these changes
A number of Individual animal Data Files were produced in an older version of excel. Please note that you may receive an alert regarding excel file extensions upon opening the files. These files are safe to open.
Select tables were updated due to corrections in uterine neoplasm incidence and number of animals evaluated; uterine neoplastic (P08) and nonneoplastic statistics (P10) were updated due to these changes
TR-598: Perfluorooctanoic Acid
General Study Information
Study Information
- PFOA Chronic Readme File (94 KB)
Long-Term
Interim (16 Week) of Chronic Study One (C20614) – Male and Female Rats
- E01 - Animal Removal Summary By Treatment Group (12 KB)
- E02 - Animals Removed from Experiment (56 KB)
- E05 - Clinical Observations Summary (23 KB)
- E08 - Feed Water and Compound Consumption Table (32 KB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (34 KB)
- P04 - Neoplasms by Individual Animal (266 KB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (33 KB)
- P09 - Non-Neoplastic Lesions by Individual Animal (298 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Females 0-0, 0-300, 0-1000 (61 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Females 0-0, 150-300, 300-1000 (55 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Females 0-300, 150-300 (28 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Females 0-1000, 300-1000 (57 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-0, 0-150, 0-300 (71 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-0, 150-150, 300-300 (71 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-150, 150-150 (47 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-300, 300-300 (65 KB)
- P14 - Individual Animal Pathology Data (269 KB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (267 KB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (35 KB)
- PA06 - Organ Weights Summary (161 KB)
- PA41 - Clinical Chemistry Summary (167 KB)
- PA45 - Liver Special Studies Summary (65 KB)
- PA48 - Tissue Concentration Summary (78 KB)
- R02 - Reproductive Performance Summary (37 KB)
Chronic Study One (C20614) – Male and Female Rats
- E01 - Animal Removal Summary By Treatment Group (12 KB)
- E02 - Animals Removed from Experiment (94 KB)
- E03 - Growth Curves - litter (0-0, 0-150, 0-300) male (31 KB)
- E03 - Growth Curves - litter (0-0, 0-300, 0-1000) female (34 KB)
- E03 - Growth Curves - litter (0-0, 150-150, 300-300) male (31 KB)
- E03 - Growth Curves - litter (0-0, 150-300, 300-1000) female (35 KB)
- E03 - Growth Curves - litter (0-150, 150-150) male (28 KB)
- E03 - Growth Curves - litter (0-300, 150-300) female (30 KB)
- E03 - Growth Curves - litter (0-300, 300-300) male (28 KB)
- E03 - Growth Curves - litter (0-1000, 300-1000) female (31 KB)
- E04 - Mean Body Weights and Survival Table litter (0-0,0-150,0-300) male (8 KB)
- E04 - Mean Body Weights and Survival Table litter (0-0, 0-300, 0-1000) female (11 KB)
- E04 - Mean Body Weights and Survival Table litter (0-0,150-150,300-300) male (8 KB)
- E04 - Mean Body Weights and Survival Table litter (0-0, 150-300, 300-1000) female (11 KB)
- E04 - Mean Body Weights and Survival Table litter (0-150,150-150) male (8 KB)
- E04 - Mean Body Weights and Survival Table litter (0-300, 150-300) female (10 KB)
- E04 - Mean Body Weights and Survival Table litter (0-300, 300-300) male (8 KB)
- E04 - Mean Body Weights and Survival Table litter (0-1000, 300-1000) female (10 KB)
- E05 - Clinical Observations Summary (23 KB)
- E08 - Feed Water and Compound Consumption Table (32 KB)
- F0 Female Harlan Sprague Dawley Rats Gestational and Lactational Chemical Consumption (19 KB)
- F0 Female Harlan Sprague Dawley Rats Gestational and Lactational Food Consumption (20 KB)
- F0 Female Harlan Sprague Dawley Rats Gestational Body and Body Weight Gains (19 KB)
- F0 Female Harlan Sprague Dawley Rats Lactational Body and Body Weight Gains (18 KB)
- F0 Female Harlan Sprague Dawley Rats Post-Cull Pup Body Weights (20 KB)
- F0 Litter Data Analysis in Female Harlan Sprague Dawley Rats: Live Litter Size and Survival (22 KB)
- F0 Litter Data Analysis in Female Harlan Sprague Dawley Rats: PND1 Data (21 KB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (34 KB)
- P04 - Neoplasms by Individual Animal (404 KB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (31 KB)
- P08 - Statistical Analysis of Primary Tumors - litter 0-0 0-300 0-1000 (53 KB)
- P08 - Statistical Analysis of Primary Tumors - litter 0-0 150-300 300-1000 (61 KB)
- P08 - Statistical Analysis of Primary Tumors - litter 0-300 150-300 (39 KB)
- P08 - Statistical Analysis of Primary Tumors - litter 0-1000 300-1000 (58 KB)
- P08 - Statistical Analysis of Primary Tumors - Uterine 0-0 0-300 0-1000 (72 KB)
- P08 - Statistical Analysis of Primary Tumors - Uterine 0-0 150-300 300-1000 (54 KB)
- P08 - Statistical Analysis of Primary Tumors - Uterine 0-300 150-300 (47 KB)
- P08 - Statistical Analysis of Primary Tumors - Uterine 0-1000 300-1000 (56 KB)
- P09 - Non-Neoplastic Lesions by Individual Animal (479 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - litter (0-0, 0-300, 0-1000) (150 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - litter (0-0, 150-300, 300-1000) (153 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - litter (0-300, 150-300) (115 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - litter (0-1000, 300-1000) (125 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Uterine 0-0 0-300 0-1000 (109 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Uterine 0-0 150-300 300-1000 (86 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Uterine 0-300 150-300 (80 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Uterine 0-1000 300-1000 (79 KB)
- P11 - Statistical Analysis of Survival Data - litter (0-0, 0-300, 0-1000) (12 KB)
- P11 - Statistical Analysis of Survival Data - litter (0-0, 150-300, 300-1000) (12 KB)
- P11 - Statistical Analysis of Survival Data - litter (0-300, 150-300) (11 KB)
- P11 - Statistical Analysis of Survival Data - litter (0-1000, 300-1000) (11 KB)
- P14 - Individual Animal Pathology Data (838 KB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (364 KB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (35 KB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades-Uterine Hyperplasia (2 MB)
- P40 - Survival Curves - 0-0, 0-300, 0-1000 (32 KB)
- P40 - Survival Curves - 0-0, 150-300, 300-1000 (32 KB)
- P40 - Survival Curves - 0-300, 150-300 (29 KB)
- P40 - Survival Curves - 0-1000, 300-1000 (30 KB)
- P40 - Survival Curves - All Treatments (34 KB)
Chronic Individual Animal Data of Study One (C20614) - Male and Female Rats
- Female Individual Animal Body Weight All Animals (596 KB)
- Female Individual Animal Neoplastic Pathology Data (156 KB)
- Female Individual Animal Non Neoplastic Pathology Data (1 MB)
- Female Individual Animal Survival Data (48 KB)
- Female Individual Animal Terminal Body Weight Data (83 KB)
- Female Individual Clinical Observations (232 KB)
- Individual Animal Clinical Chemistry Data (13 KB)
- Individual Animal DamID and PupID Data (25 KB)
- Individual Animal Liver Special Studies Data (7 KB)
- Individual Animal Organ Weight Data (13 KB)
- Individual Animal Reproductive Performance Data (11 KB)
- Individual Animal Tissue Concentration Data (9 KB)
- Male Individual Animal Body Weight All Animals (176 KB)
- Male Individual Animal Neoplastic Pathology Data (2 KB)
- Male Individual Animal Non Neoplastic Pathology Data (106 KB)
- Male Individual Animal Survival Data (45 KB)
- Male Individual Clinical Observations (3 KB)
Interim (16 Week) of Chronic Study Two (C20614B) – Male Rats
- E01 - Animal Removal Summary By Treatment Group (12 KB)
- E02 - Animals Removed from Experiment (46 KB)
- E05 - Clinical Observations Summary (24 KB)
- E08 - Feed Water and Compound Consumption Table (33 KB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (25 KB)
- P04 - Neoplasms by Individual Animal (96 KB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (27 KB)
- P09 - Non-Neoplastic Lesions by Individual Animal (98 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-0, 0-20, 0-40, 0-80 (24 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-0, 300-0 (13 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-20, 300-20 (22 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-40, 300-40 (19 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-80, 300-80 (22 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 300-0, 300-20, 300-40, 300-80 (24 KB)
- P14 - Individual Animal Pathology Data (162 KB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (96 KB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (26 KB)
- PA06 - Organ Weights Summary (101 KB)
- PA41 - Clinical Chemistry Summary (103 KB)
- PA45 - Liver Special Studies Summary (45 KB)
- PA48 - Tissue Concentration Summary (73 KB)
- R02 - Reproductive Performance Summary (35 KB)
Chronic Study Two (C20614B) – Male Rats
- E01 - Animal Removal Summary By Treatment Group (12 KB)
- E02 - Animals Removed from Experiment (116 KB)
- E03 - Growth Curves - litter (0-0, 0-20, 0-40, 0-80) (36 KB)
- E03 - Growth Curves - litter (0-0, 300-0) (30 KB)
- E03 - Growth Curves - litter (0-20, 300-20) (30 KB)
- E03 - Growth Curves - litter (0-40, 300-40) (31 KB)
- E03 - Growth Curves - litter (0-80, 300-80) (29 KB)
- E03 - Growth Curves - litter (300-0, 300-20, 300-40, 300-80) (36 KB)
- E04 - Mean Body Weights and Survival Table litter (0-0, 0-20, 0-40, 0-80) (12 KB)
- E04 - Mean Body Weights and Survival Table litter (0-0, 300-0) (10 KB)
- E04 - Mean Body Weights and Survival Table litter (0-20, 300-20) (10 KB)
- E04 - Mean Body Weights and Survival Table litter (0-40, 300-40) (10 KB)
- E04 - Mean Body Weights and Survival Table litter (0-80, 300-80) (10 KB)
- E04 - Mean Body Weights and Survival Table litter (300-0, 300-20, 300-40, 300-80) (12 KB)
- E05 - Clinical Observations Summary (24 KB)
- E08 - Feed Water and Compound Consumption Table (33 KB)
- F0 Female Harlan Sprague Dawley Rats Gestational and Lactational Chemical Consumption (18 KB)
- F0 Female Harlan Sprague Dawley Rats Gestational and Lactational Food Consumption (18 KB)
- F0 Female Harlan Sprague Dawley Rats Gestational Body and Body Weight Gains (17 KB)
- F0 Female Harlan Sprague Dawley Rats Lactational Body and Body Weight Gains (16 KB)
- F0 Litter Data Analysis in Female Harlan Sprague Dawley Rats: Male Pup Body Weights (16 KB)
- F0 Litter Data Analysis in Female Harlan Sprague Dawley Rats: PND1 Data (18 KB)
- F0 Litter Data Analysis in Female Harlan Sprague Dawley Rats: PND4 Data (16 KB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (63 KB)
- P04 - Neoplasms by Individual Animal (639 KB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (50 KB)
- P08 - Statistical Analysis of Primary Tumors - litter(0-0, 0-20, 0-40, 0-80) (76 KB)
- P08 - Statistical Analysis of Primary Tumors - litter(0-0, 300-0) (59 KB)
- P08 - Statistical Analysis of Primary Tumors - litter(0-20, 300-20) (66 KB)
- P08 - Statistical Analysis of Primary Tumors - litter(0-40, 300-40) (46 KB)
- P08 - Statistical Analysis of Primary Tumors - litter(0-80, 300-80) (48 KB)
- P08 - Statistical Analysis of Primary Tumors - litter(300-0, 300-40, 300-60, 300-80) (76 KB)
- P09 - Non-Neoplastic Lesions by Individual Animal (811 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - litter(0-0, 0-20, 0-40, 0-80) (178 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - litter(0-0, 300-0) (130 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - litter(0-20, 300-20) (132 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - litter(0-40, 300-40) (139 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - litter(0-80, 300-80) (128 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - litter(300-0, 300-20, 300-40, 300-80) (169 KB)
- P11 - Statistical Analysis of Survival Data - litter (0-0, 0-20, 0-40, 0-80) (11 KB)
- P11 - Statistical Analysis of Survival Data - litter (0-0, 300-0) (11 KB)
- P11 - Statistical Analysis of Survival Data - litter (0-20, 300-20) (11 KB)
- P11 - Statistical Analysis of Survival Data - litter (0-40, 300-40) (11 KB)
- P11 - Statistical Analysis of Survival Data - litter (0-80, 300-80) (11 KB)
- P11 - Statistical Analysis of Survival Data - litter (300-0, 300-20, 300-40, 300-80) (11 KB)
- P14 - Individual Animal Pathology Data (1 MB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (571 KB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (65 KB)
- P40 - Survival Curves 0-0, 0-20, 0-40, 0-80 (30 KB)
- P40 - Survival Curves 0-0, 300-0 (28 KB)
- P40 - Survival Curves 0-20, 300-20 (28 KB)
- P40 - Survival Curves 0-40, 300-40 (29 KB)
- P40 - Survival Curves 0-80, 300-80 (29 KB)
- P40 - Survival Curves 300-0, 300-20, 300-40, 300-80 (30 KB)
- P40 - Survival Curves All Treatment Groups.pdf (35 KB)
Chronic Individual Animal Data of Study Two (C20614B) - Male Rats
- Individual Animal Clinical Chemistry Data (11 KB)
- Individual Animal DamID and PupID Data (23 KB)
- Individual Animal Liver Special Studies Data (8 KB)
- Individual Animal Organ Weight Data (11 KB)
- Individual Animal Reproductive Performance Data (16 KB)
- Individual Animal Tissue Concentration Data (12 KB)
- Male Individual Animal Body Weight All Animals (1 MB)
- Male Individual Animal Neoplastic Pathology Data (218 KB)
- Male Individual Animal Non Neoplastic Pathology Data (2 MB)
- Male Individual Animal Survival Data (76 KB)
- Male Individual Animal Terminal Body Weight Data (131 KB)
- Male Individual Clinical Observations (221 KB)
Genetic Toxicology
Genetic Toxicity Evaluation of Perfluorooctanoic Acid (335-67-1) in Micronucleus Study G91070 in Harlan Sprague-Dawley Rats
- G91070 G04 In Vivo Micronucleus Summary Data (77 KB)
- G91070 Individual Animal In Vivo Micronucleus Data (10 KB)
Genetic Toxicity Evaluation of Perfluorooctanoic Acid in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A98283
- A98283 G06 Ames Summary Data (99 KB)