TR-598: Perfluorooctanoic acid (335-67-1)
Publications
TR-598
Toxicology and Carcinogenesis Studies of Perfluorooctanoic Acid Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley SD) Rats
Study Data
Toxicity and Carcinogenicity Studies
Evaluation of the Chronic Toxicity and Carcinogenicity (C20614) of Perfluorooctanoic Acid (335-67-1) in Harlan Sprague-Dawley Rats Exposed via Dosed Feed
Interim (16 Week) of Chronic Study One (C20614) – Male and Female Rats
- E01 - Animal Removal Summary By Treatment Group (12 kB)
- E02 - Animals Removed from Experiment (57 kB)
- E05 - Clinical Observations Summary (23 kB)
- E08 - Feed Water and Compound Consumption Table (33 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (34 kB)
- P04 - Neoplasms by Individual Animal (272 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (33 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (306 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Females 0-0, 0-300, 0-1000 (62 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Females 0-0, 150-300, 300-1000 (57 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Females 0-1000, 300-1000 (58 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Females 0-300, 150-300 (29 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-0, 0-150, 0-300 (73 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-0, 150-150, 300-300 (73 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-150, 150-150 (48 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-300, 300-300 (66 kB)
- P14 - Individual Animal Pathology Data (276 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (273 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (36 kB)
- PA06 - Organ Weights Summary (165 kB)
- PA41 - Clinical Chemistry Summary (171 kB)
- PA45 - Liver Special Studies Summary (67 kB)
- PA48 - Tissue Concentration Summary (80 kB)
- R02 - Reproductive Performance Summary (38 kB)
Chronic Study One (C20614) - Male and Female Rats
- E01 - Animal Removal Summary By Treatment Group (12 kB)
- E02 - Animals Removed from Experiment (96 kB)
- E03 - Growth Curves - litter (0-0, 0-150, 0-300) male (31 kB)
- E03 - Growth Curves - litter (0-0, 0-300, 0-1000) female (35 kB)
- E03 - Growth Curves - litter (0-0, 150-150, 300-300) male (32 kB)
- E03 - Growth Curves - litter (0-0, 150-300, 300-1000) female (36 kB)
- E03 - Growth Curves - litter (0-1000, 300-1000) female (31 kB)
- E03 - Growth Curves - litter (0-150, 150-150) male (28 kB)
- E03 - Growth Curves - litter (0-300, 150-300) female (30 kB)
- E03 - Growth Curves - litter (0-300, 300-300) male (28 kB)
- E04 - Mean Body Weights and Survival Table litter (0-0, 0-300, 0-1000) female (11 kB)
- E04 - Mean Body Weights and Survival Table litter (0-0, 150-300, 300-1000) female (11 kB)
- E04 - Mean Body Weights and Survival Table litter (0-0,0-150,0-300) male (8 kB)
- E04 - Mean Body Weights and Survival Table litter (0-0,150-150,300-300) male (8 kB)
- E04 - Mean Body Weights and Survival Table litter (0-1000, 300-1000) female (10 kB)
- E04 - Mean Body Weights and Survival Table litter (0-150,150-150) male (8 kB)
- E04 - Mean Body Weights and Survival Table litter (0-300, 150-300) female (10 kB)
- E04 - Mean Body Weights and Survival Table litter (0-300, 300-300) male (8 kB)
- E05 - Clinical Observations Summary (23 kB)
- E08 - Feed Water and Compound Consumption Table (33 kB)
- F0 Female Harlan Sprague Dawley Rats Post-Cull Pup Body Weights (21 kB)
- F0 Female Harlan Sprague Dawley Rats Gestational Body and Body Weight Gains (19 kB)
- F0 Female Harlan Sprague Dawley Rats Gestational and Lactational Chemical Consumption (19 kB)
- F0 Female Harlan Sprague Dawley Rats Gestational and Lactational Food Consumption (20 kB)
- F0 Female Harlan Sprague Dawley Rats Lactational Body and Body Weight Gains (19 kB)
- F0 Litter Data Analysis in Female Harlan Sprague Dawley Rats: Live Litter Size and Survival (22 kB)
- F0 Litter Data Analysis in Female Harlan Sprague Dawley Rats: PND1 Data (21 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (35 kB)
- P04 - Neoplasms by Individual Animal (414 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (32 kB)
- P08 - Statistical Analysis of Primary Tumors - Uterine 0-0 0-300 0-1000 (74 kB)
- P08 - Statistical Analysis of Primary Tumors - Uterine 0-0 150-300 300-1000 (55 kB)
- P08 - Statistical Analysis of Primary Tumors - Uterine 0-1000 300-1000 (57 kB)
- P08 - Statistical Analysis of Primary Tumors - Uterine 0-300 150-300 (48 kB)
- P08 - Statistical Analysis of Primary Tumors - litter 0-0 0-300 0-1000 (54 kB)
- P08 - Statistical Analysis of Primary Tumors - litter 0-0 150-300 300-1000 (62 kB)
- P08 - Statistical Analysis of Primary Tumors - litter 0-1000 300-1000 (59 kB)
- P08 - Statistical Analysis of Primary Tumors - litter 0-300 150-300 (40 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (490 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Uterine 0-0 0-300 0-1000 (112 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Uterine 0-0 150-300 300-1000 (88 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Uterine 0-1000 300-1000 (80 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Uterine 0-300 150-300 (82 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - litter (0-0, 0-300, 0-1000) (154 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - litter (0-0, 150-300, 300-1000) (156 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - litter (0-1000, 300-1000) (128 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - litter (0-300, 150-300) (118 kB)
- P11 - Statistical Analysis of Survival Data - litter (0-0, 0-300, 0-1000) (12 kB)
- P11 - Statistical Analysis of Survival Data - litter (0-0, 150-300, 300-1000) (12 kB)
- P11 - Statistical Analysis of Survival Data - litter (0-1000, 300-1000) (12 kB)
- P11 - Statistical Analysis of Survival Data - litter (0-300, 150-300) (11 kB)
- P14 - Individual Animal Pathology Data (858 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (372 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (36 kB)
- P18_-_Incidence_Rates_of_Non-Neoplastic_Lesions_by_Anatomic_Site_with_Average_Severity_Grades-Uterine_Hyperplasia_ (2 mB)
- P40 - Survival Curves - 0-0, 0-300, 0-1000 (33 kB)
- P40 - Survival Curves - 0-0, 150-300, 300-1000 (33 kB)
- P40 - Survival Curves - 0-1000, 300-1000 (31 kB)
- P40 - Survival Curves - 0-300, 150-300 (30 kB)
- P40 - Survival Curves - All Treatments (35 kB)
Chronic Individual Animal Data of Study One (C20614) - Male and Female Rats
- Female Individual Animal Body Weight All Animals (610 kB)
- Female Individual Animal Neoplastic Pathology Data (160 kB)
- Female Individual Animal Non Neoplastic Pathology Data (1 mB)
- Female Individual Animal Survival Data (50 kB)
- Female Individual Animal Terminal Body Weight Data (85 kB)
- Female Individual Clinical Observations (238 kB)
- Individual Animal Clinical Chemistry Data (13 kB)
- Individual Animal DamID and PupID Data (26 kB)
- Individual Animal Liver Special Studies Data (7 kB)
- Individual Animal Organ Weight Data (14 kB)
- Individual Animal Reproductive Performance Data (12 kB)
- Individual Animal Tissue Concentration Data (10 kB)
- Male Individual Animal Body Weight All Animals (180 kB)
- Male Individual Animal Neoplastic Pathology Data (2 kB)
- Male Individual Animal Non Neoplastic Pathology Data (109 kB)
- Male Individual Animal Survival Data (47 kB)
- Male Individual Clinical Observations (3 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity (C20614B) of Perfluorooctanoic Acid (335-67-1) in Harlan Sprague-Dawley Rats Exposed via Dosed Feed
Interim (16 Week) of Chronic Study Two (C20614B) – Male Rats
- E01 - Animal Removal Summary By Treatment Group (12 kB)
- E02 - Animals Removed from Experiment (47 kB)
- E05 - Clinical Observations Summary (24 kB)
- E08 - Feed Water and Compound Consumption Table (34 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (26 kB)
- P04 - Neoplasms by Individual Animal (98 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (27 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (101 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-0, 0-20, 0-40, 0-80 (25 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-0, 300-0 (13 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-20, 300-20 (22 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-40, 300-40 (20 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-80, 300-80 (22 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 300-0, 300-20, 300-40, 300-80 (25 kB)
- P14 - Individual Animal Pathology Data (166 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (99 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (27 kB)
- PA48 - Tissue Concentration Summary (75 kB)
- R02 - Reproductive Performance Summary (36 kB)
Chronic Study Two (C20614B) – Male Rats
- E01 - Animal Removal Summary By Treatment Group (12 kB)
- E02 - Animals Removed from Experiment (118 kB)
- E03 - Growth Curves - litter (0-0, 0-20, 0-40, 0-80) (37 kB)
- E03 - Growth Curves - litter (0-0, 300-0) (31 kB)
- E03 - Growth Curves - litter (0-20, 300-20) (31 kB)
- E03 - Growth Curves - litter (0-40, 300-40) (31 kB)
- E03 - Growth Curves - litter (0-80, 300-80) (30 kB)
- E03 - Growth Curves - litter (300-0, 300-20, 300-40, 300-80) (37 kB)
- E04 - Mean Body Weights and Survival Table litter (0-0, 0-20, 0-40, 0-80) (12 kB)
- E04 - Mean Body Weights and Survival Table litter (0-0, 300-0) (10 kB)
- E04 - Mean Body Weights and Survival Table litter (0-20, 300-20) (10 kB)
- E04 - Mean Body Weights and Survival Table litter (0-40, 300-40) (10 kB)
- E04 - Mean Body Weights and Survival Table litter (0-80, 300-80) (10 kB)
- E04 - Mean Body Weights and Survival Table litter (300-0, 300-20, 300-40, 300-80) (12 kB)
- E05 - Clinical Observations Summary (25 kB)
- E08 - Feed Water and Compound Consumption Table (34 kB)
- F0 Female Harlan Sprague Dawley Rats Gestational Body and Body Weight Gains (17 kB)
- F0 Female Harlan Sprague Dawley Rats Gestational and Lactational Chemical Consumption (18 kB)
- F0 Female Harlan Sprague Dawley Rats Gestational and Lactational Food Consumption (18 kB)
- F0 Female Harlan Sprague Dawley Rats Lactational Body and Body Weight Gains (17 kB)
- F0 Litter Data Analysis in Female Harlan Sprague Dawley Rats: Male Pup Body Weights (16 kB)
- F0 Litter Data Analysis in Female Harlan Sprague Dawley Rats: PND1 Data (18 kB)
- F0 Litter Data Analysis in Female Harlan Sprague Dawley Rats: PND4 Data (17 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (64 kB)
- P04 - Neoplasms by Individual Animal (654 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (52 kB)
- P08 - Statistical Analysis of Primary Tumors - litter(0-0, 0-20, 0-40, 0-80) (78 kB)
- P08 - Statistical Analysis of Primary Tumors - litter(0-0, 300-0) (61 kB)
- P08 - Statistical Analysis of Primary Tumors - litter(0-20, 300-20) (68 kB)
- P08 - Statistical Analysis of Primary Tumors - litter(0-40, 300-40) (47 kB)
- P08 - Statistical Analysis of Primary Tumors - litter(0-80, 300-80) (49 kB)
- P08 - Statistical Analysis of Primary Tumors - litter(300-0, 300-40, 300-60, 300-80) (78 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (830 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - litter(0-0, 0-20, 0-40, 0-80) (182 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - litter(0-0, 300-0) (133 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - litter(0-20, 300-20) (135 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - litter(0-40, 300-40) (143 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - litter(0-80, 300-80) (132 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - litter(300-0, 300-20, 300-40, 300-80) (173 kB)
- P11 - Statistical Analysis of Survival Data - litter (0-0, 0-20, 0-40, 0-80) (12 kB)
- P11 - Statistical Analysis of Survival Data - litter (0-0, 300-0) (11 kB)
- P11 - Statistical Analysis of Survival Data - litter (0-20, 300-20) (11 kB)
- P11 - Statistical Analysis of Survival Data - litter (0-40, 300-40) (11 kB)
- P11 - Statistical Analysis of Survival Data - litter (0-80, 300-80) (11 kB)
- P11 - Statistical Analysis of Survival Data - litter (300-0, 300-20, 300-40, 300-80) (12 kB)
- P14 - Individual Animal Pathology Data (1 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (585 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (66 kB)
- P40 - Survival Curves - 0-0, 0-20, 0-40, 0-80 (31 kB)
- P40 - Survival Curves - 0-0, 300-0 (29 kB)
- P40 - Survival Curves - 0-20, 300-20 (29 kB)
- P40 - Survival Curves - 0-40, 300-40 (29 kB)
- P40 - Survival Curves - 0-80, 300-80 (29 kB)
- P40 - Survival Curves - 300-0, 300-20, 300-40, 300-80 (31 kB)
- P40 - Survival Curves - All Treatment Groups (36 kB)
Chronic Individual Animal Data of Study Two (C20614B) - Male Rats
- 002-02657-0004-0000-6 Male IndividualBodyWeightAllAnimals (1 mB)
- Individual Animal Clinical Chemistry Data (12 kB)
- Individual Animal DamID and PupID Data (24 kB)
- Individual Animal Liver Special Studies Data (8 kB)
- Individual Animal Organ Weight Data (11 kB)
- Individual Animal Reproductive Performance Data (16 kB)
- Individual Animal Tissue Concentration Data (12 kB)
- Male Individual Animal Neoplastic Pathology Data (223 kB)
- Male Individual Animal Non Neoplastic Pathology Data (2 mB)
- Male Individual Animal Survival Data (78 kB)
- Male Individual Animal Terminal Body Weight Data (134 kB)
- Male Individual Clinical Observations (226 kB)