Comparison of sulfolane effects in Sprague Dawley rats, B6C3F1/N mice, and Hartley guinea pigs after 28 days of exposure via oral gavage
K A Shipkowski 1, M C Cora 1, M F Cesta 1, V G Robinson 1, S Waidyanatha 1, K L Witt 1, M K Vallant 1, D M Fallacara 2, M R Hejtmancik 2, S A Masten 1, S D Cooper 3, R A Fernando 3, C R Blystone 1
1Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
2Battelle Memorial Institute, Columbus, OH, USA.
3RTI International, Research Triangle Park, NC, USA.
DOI:
https://doi.org/10.22427/NTP-DATA-002-03276-0000-0000-0
Note: The study data are being disseminated prior to external peer review under applicable information quality guidelines and do not represent and should not be construed to represent any final NTP determination or policy.
Genetox data was added on August 7, 2020
Publication
Program Overview
https://ntp.niehs.nih.gov/results/areas/sulfolane/index.html
Rat Short-Term Toxicity
Study Tables
- I01 - Animal Removal Summary (40 KB)
- I02 - Animal Removals (544 KB)
- I03 - Growth Curve (671 KB)
- I04 - Mean Body Weights and Survival (192 KB)
- I04G - Mean Body Weight Gain (74 KB)
- I05 - Clinical Observations Summary (78 KB)
- PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (421 KB)
- PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (402 KB)
- PA06 - Organ Weights Summary (157 KB)
- PA10 - Statistical Analysis of Non-Neoplastic Lesions (346 KB)
- PA14 - Individual Animal Pathology Data (3 MB)
- PA18 - Non-Neoplastic Lesion Summary with Severity Grade (422 KB)
- PA41 - Clinical Chemistry Summary (232 KB)
- PA43 - Hematology Summary (317 KB)
- PA46 - Summary of Gross Pathology (453 KB)
- PA48 - Summary of Tissue Concentration (50 KB)
- Rectal Temperature Summary (36 KB)
Individual Animal Data
- Individual Animal Body Weight Data (82 KB)
- Individual Animal Clinical Chemistry Data (22 KB)
- Individual Animal Clinical Observations Data (69 KB)
- Individual Animal Gross Pathology Data (322 KB)
- Individual Animal Hematology Data (21 KB)
- Individual Animal Histo Pathology Data (218 KB)
- Individual Animal Organ Weight Data (30 KB)
- Individual Animal Removal Reasons Data (14 KB)
- Individual Animal Temperature Data (16 KB)
- Individual Animal Tissue Concentration Data (17 KB)
Mouse Short-Term Toxicity
Study Tables
- I01 - Animal Removal Summary (51 KB)
- I02 - Animal Removals (676 KB)
- I03 - Growth Curve (674 KB)
- I04 - Mean Body Weights and Survival (182 KB)
- I04G - Mean Body Weight Gain (69 KB)
- I05 - Clinical Observations Summary (44 KB)
- PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (396 KB)
- PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (411 KB)
- PA06 - Organ Weights Summary (145 KB)
- PA10 - Statistical Analysis of Non-Neoplastic Lesions (306 KB)
- PA14 - Individual Animal Pathology Data (3 MB)
- PA18 - Non-Neoplastic Lesion Summary with Severity Grade (397 KB)
- PA43 - Hematology Summary (290 KB)
- PA46 - Summary of Gross Pathology (453 KB)
- PA48 - Summary of Tissue Concentration (56 KB)
- Rectal Temperature Summary (37 KB)
Individual Animal Data
- Individual Animal Body Weight Data (84 KB)
- Individual Animal Clinical Observations Data (71 KB)
- Individual Animal Gross Pathology Data (299 KB)
- Individual Animal Hematology Data (25 KB)
- Individual Animal Histo Pathology Data (181 KB)
- Individual Animal Organ Weight Data (24 KB)
- Individual Animal Removal Reasons (15 KB)
- Individual Animal Temperature Data (19 KB)
- Individual Animal Tissue Concentration Data (13 KB)
Guinea Pig Short-Term Toxicity
Study Tables
- I01 - Animal Removal Summary (53 KB)
- I02 - Animal Removals (609 KB)
- I03 - Growth Curve (639 KB)
- I04 - Mean Body Weights and Survival (199 KB)
- I04G - Mean Body Weight Gain (69 KB)
- I05 - Clinical Observations Summary (50 KB)
- PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (478 KB)
- PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (406 KB)
- PA06 - Organ Weights Summary (145 KB)
- PA10 - Statistical Analysis of Non-Neoplastic Lesions (426 KB)
- PA14 - Individual Animal Pathology Data (3 MB)
- PA18 - Non-Neoplastic Lesion Summary with Severity Grade (479 KB)
- PA41 - Clinical Chemistry Summary (211 KB)
- PA43 - Hematology Summary (290 KB)
- PA46 - Summary of Gross Pathology (489 KB)
- PA48 - Summary of Tissue Concentration (56 KB)
- Rectal Temperature Summary (36 KB)
Individual Animal Data
- Individual Animal Body Weight Data (90 KB)
- Individual Animal Clinical Chemistry Data (22 KB)
- Individual Animal Clinical Observations Data (64 KB)
- Individual Animal Gross Pathology Data (393 KB)
- Individual Animal Hematology Data (280 KB)
- Individual Animal Histo Pathology Data (209 KB)
- Individual Animal Organ Weight Data (28 KB)
- Individual Animal Removal Reasons (14 KB)
- Individual Animal Temperature Data (15 KB)
- Individual Animal Tissue Concentration Data (17 KB)