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Developmental NeuroToxicity Data Integration and Visualization Enabling Resource (DNT-DIVER)

National Toxicology Program. 2018. Data Release: Developmental NeuroToxicity Data Integration and Visualization Enabling Resource (DNT-DIVER). Last Updated: December 3, 2018.
DOI: https://doi.org/10.22427/NTP-DATA-002-00062-0001-0000-1

NOTE: Files in Data Release.zip were replaced on 26 Feb 2020 due to inconsistent data

Benchmark Dose data added on 10 March 2022

A 13-week subchronic toxicity study of hexyl acetate in SD rats

Toyoda T1, Cho YM1, Matsushita K1, Tachibana S2, Senuma M2, Akagi JI1, Ogawa K1.

Author information:
1. Division of Pathology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-9501, Japan.
2. Hatano Research Institute, Food and Drug Safety Center, 729-5 Ochiai, Hadano, Kanagawa 257-8523, Japan

PMID: 31402808 PMCID: PMC6682557

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1Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
2Battelle Memorial Institute, Columbus, OH, USA.
3RTI International, Research Triangle Park, NC, USA.

DOI: https://doi.org/10.22427/NTP-DATA-002-03276-0000-0000-0

Note: The study data are being disseminated prior to external peer review under applicable information quality guidelines and do not represent and should not be construed to represent any final NTP determination or policy.

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Corresponding Author:
Scott Auerbach

1Data and AI Section, Oak Ridge National Laboratory, Oak Ridge, TN
2Carnegie Mellon University, Pittsburgh, PA
3Division of Translational Toxicology, National Institute of Environmental Health Sciences, RTP, NC
4Sciome LLC, RTP, NC

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DTT Data Dictionary 2022-Present

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DOI: https://doi.org/10.22427/NTP-DATA-002-00092-0001-0000-4

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Radiolabel Description:
Carbon-14 uniformly on the rings; 2',2'''-Dithiobisbenzanilide, [phenyl-14C(U)]-

Intravenous, emulphor:ethanol:water (3:5:2) or dimethylacetamide:polyethylene glycol 400:saline (15:55:30); Oral methylcellulose; Dermal, ethanol or acetone

Additional Information:
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Radiolabel Description:
Carbon-14 on the ring carbons adjacent to the nitrogen; 2,2'-Dimorpholinodiethyl ether, [morpholine-2,6-14C]-

Intravenous, saline; Oral, purified water; Dermal, ethanol.

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Radiolabel Description:
Carbon-14 in 2 positions: Ethylene glycol 2-ethylhexyl ether, [2-ethylhexyl-1-14C, ethylene glycol-1-14C]- 

Oral, corn oil; Dermal, ethanol.

DOI: https://doi.org/10.22427/NTP-DATA-002-03310-0005-0000-4

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Radiolabel Description:
carbon-14 uniformly in the ring; N-Butylbenzenesulfonamide, [ring-14C(U)]-

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Toxicology Letters (2020): https://pubmed.ncbi.nlm.nih.gov/31760063/
DOI: https://doi.org/10.22427/NTP-DATA-002-03240-0010-0000-2

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Toxicology and Applied Pharmacology (2018). DOI: https://doi.org/10.1016/j.taap.2017.12.008 PMID: 29248465

Dose-Response Assessment of the Dermal Toxicity of Virginia Cedarwood Oil in F344/N Rats and B6C3F1/N Mice

Catlin NR, Herbert R, Janardhan K, Hejtmancik MR, Fomby LM, Vallant M, Kissling GE, DeVito MJ.
Food Chem Toxicol. (2016) DOI: http:/dx.doi.org/10.1016/j.fct.2016.10.016 PMID: 27769849

Dose–Response Analysis of RNA-Seq Profiles in Archival Formalin-Fixed Paraffin-Embedded Samples

Susan D. Hester, Virunya Bhat, Brian N. Chorley, Gleta Carswell, Wendell Jones, Leah C. Wehmas, Charles E. Wood
Toxicological Sciences (2016) DOI: https://doi.org/10.1093/toxsci/kfw161 PMID: 27562560


This page will be updated with more data as it becomes available.

DOI: https://doi.org/10.22427/NTP-DATA-107-022-001-000-3

Effect of Cell Phone Radiofrequency Radiation on Body Temperature in Rodents: Pilot Studies of the National Toxicology Program's Reverberation Chamber Exposure System

Michael E. Wyde, Thomas L. Horn, Myles H. Capstick, John M. Ladbury, Galen Koepke, Perry F. Wilson, Grace E. Kissling, Matthew D. Stout, Niels Kuster, Ronald L. Melnick, James Gauger, John R. Bucher, and David L. McCormick.
Bioelectromagnetics (2018) DOI: https://doi.org/10.1002/bem.22116 PMID: 29537695

Effects of Continuous Bisphenol A Exposure from Early Gestation on 90 Day Old Rat Testes Function and Sperm Molecular Profiles: A CLARITY-BPA Consortium Study

Edward Dere, Linnea M. Anderson, Susan M. Huse, Daniel J. Spade, Elizabeth McDonnell-Clark, Samantha J. Madnick, Susan J. Hall, Luísa Camacho, Sherry M. Lewis, Michelle M. Vanlandingham, and Kim Boekelheide.
Toxicology and Applied Pharmacology (2018) DOI: https://doi.org/10.1016/j.taap.2018.03.021 PMID: 29596923

Effects of Developmental Exposure to Bisphenol A on Spatial Navigational Learning and Memory in Rats: A CLARITY-BPA Study

Sarah A. Johnson, Angela B. Javurek, Michele S. Painter, Mark R. Ellersieck, Thomas H. Welsh, Jr., Luísa Camacho, Sherry M. Lewis, Michelle M. Vanlandingham, Sherry A. Ferguson, and Cheryl S. Rosenfeld.
Hormones and Behavior (2016) DOI: https://doi.org/10.1016/j.yhbeh.2015.09.005 PMID: 26436835

Effects of Perfluorinated Chemicals on Thyroid Function, Markers of Ovarian Reserve, and Natural Fertility

Natalie M. Crawford, Suzanne E. Fenton, Mark Strynar, Erin P. Hines, David A. Pritchard, and Anne Z. Steiner.
Reproductive Toxicology (2017) DOI: https://doi.org/10.1016/j.reprotox.2017.01.006 PMID: 28111093

Effects of perinatal hydroxyurea treatment and investigation of maternal transfer and age-dependency of toxicokinetics in Sprague Dawley rats

Madelyn Huang, Katie Turner, Molly Vallant, Yi Lu, Catherine Price, Timothy Fennell, Melanie A. Silinski, Suramya Waidyanatha, Kristen Ryan, Sherry R. Black, Reshan Fernando, Barry McIntyre

DOI: https://doi.org/10.22427/NTP-DATA-002-02275-0007-0000-5

Embryo-Fetal Development Studies with The Dietary Supplement Vinpocetine in The Rat and Rabbit

Natasha Catlin, Suramya Waidyanatha, Eve Mylchreest, Lutfiya Miller-Pinsler, Helen Cunny, Paul Foster, Vicki Sutherland, Barry McIntyre
Birth Defects Research (2018) DOI: https://doi.org/10.1002/bdr2.1207 PMID: 29460393

Embryonic Vascular Disruption Adverse Outcomes: Linking High Throughput Signaling Signatures with Functional Consequences

Ellis-Hutchings RG, Settivari RS, McCoy AT, Kleinstreuer N, Franzosa J, Knudsen TB, Carney EW.
Reproductive Toxicology (2017) DOI: https://doi.org/10.1016/j.reprotox.2017.05.005 PMID: 28527947

Evaluation of 4-methylcyclohexanemethanol (MCHM) in a Combined Irritancy and Local Lymph Node Assay (LLNA) in Mice

Johnson VJ, Auerbach SS, Luster MI, Waidyanatha S, Masten SA, Wolfe MS, Burleson FG, Burleson GR, Germolec DR.
Food and Chemical Toxicology (2017) DOI: https://doi.org/10.1016/j.fct.2017.03.034 PMID: 28343035

Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes

William M. Gwinn, Scott S. Auerbach, Fred Parham, Matthew D. Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, B. Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R. Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R. Shah, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Georgia Roberts, Michael J. DeVito

CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005

Evaluation of Immunotoxicity of Sodium Metavanadate Following Drinking Water Exposure in Female B6C3F1/N Mice in a 28-day Study

Rachel Frawley, Victor J. Johnson, Gary R. Burleson, Keith R Shockley, Mark F. Cesta, Greg Travlos, Michelle Cora, Georgia Roberts, Dori Germolec

TOX-106 Vanadium Compounds (Sodium Metavanadate and Vanadyl Sulfate): Abstract for TOX-106
DOI: https://doi.org/10.22427/NTP-DATA-500-001-001-000-7

Evaluation of Maternal, Embryo, and Placental Effects in CD-1 Mice following Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide Dimer Acid (HFPO-DA or GenX)

Bevin E. Blake, Harlie A. Cope, Samantha M. Hall, Robert D. Keys, Beth W. Mahler, James McCord, Brittany Scott, Heather M. Stapleton, Mark J. Strynar, Susan A. Elmore, Suzanne E. Fenton
Environmental Health Perspectives(2020) DOI: https://doi.org/10.1289/EHP6233 PMID: 32074459 PMCID: PMC7064328
DOI: https://doi.org/10.22427/NTP-DATA-021-00006-0001-0000-0

Evaluation of Skin Sensitization Induced by Four Ionic Liquids

Rachel Frawley, Dori Germolec, Victor Johnson, Travis Gulledge, Wimolnut Manheng, Kimber White Jr, Keith R Shockley, Shawn F Harris, Michelle Hooth, Kristen Ryan

Note: Data from this study are available upon request

DOI: https://doi.org/10.22427/NTP-DATA-002-03253-0003-0000-8

Evaluation of the Respiratory Tract Toxicity of ortho-Phthalaldehyde, a Proposed Alternative for the Chemical Disinfectant Glutaraldehyde

Natasha R. Catlin, Cynthia J. Willson, Matthew Stout, Grace E. Kissling, Suramya Waidyanatha, Gregory L. Baker, Barry K. Hayden, Michael Wyde.
Inhalation Toxicology (2017). DOI: https://doi.org/10.1080/08958378.2017.1390015 PMID: 29039228

Evaluation of the herbicide glyphosate, (aminomethyl)phosphonic acid, and glyphosate-based formulations for genotoxic activity using in vitro assays

Stephanie L. Smith-Roe, Carol D. Swartz, Asma Rashid, Nicholas C. Christy, Jamie E. Sly, Xiaoqing Chang, Nisha S. Sipes, Keith R. Shockley, Shawn F. Harris, Sandra J. McBride, Gary J. Larson, Bradley J. Collins, Esra Mutlu, Kristine L. Witt

Environmental and Molecular Mutagenesis: https://onlinelibrary.wiley.com/doi/10.1002/em.22534
DOI: https://doi.org/10.22427/NTP-DATA-002-02220-0014-0000-3

Two data values for one concentration in the 4 h +S9 experimental condition were corrected after a quality assurance audit. This finding did not impact the interpretation of the study.

Evaluation of the immunomodulatory effects of the disinfection by-product, sodium chlorite, in female B6C3F1 mice: a drinking water study

Karrow NA, Guo TL, McCay JA, Johnson GW, Brown RD, Musgrove DL, Germolec DR, Luebke RW, White KL Jr.
Journal of Immunotoxicology (2018) DOI: https://doi.org/10.1081/DCT-100103722 PMID: 11452397

Evidence for an Aneugenic Mechanism of Action for Micronucleus Induction by Black Cohosh Extract

Derek T. Bernacki, Steven M. Bryce, Jeffrey C. Bemis, Stephen D. Dertinger, Kristine L. Witt, Stephanie L. Smith-Roe
Environmental and Molecular Mutagenesis, (in press): First Published: 30 September 2019 DOI: https://doi.org/10.1002/em.22334

Experimental studies of the hematologic and immune system toxicity of nucleoside derivatives used against HIV infection

Luster MI, Rosenthal GJ, Cao W, Thompson MB, Munson AE, Prejean JD, Shopp G, Fuchs BA, Germolec DR, Tomaszewski JE.
Toxicol Appl Pharmacol (1989) DOI: https://doi.org/ PMID: 1668555

Exploring Drug Space with ChemMaps.com

Alexandre Borrel, Nicole Kleinstreuer, and Denis Fourches.
Bioinformatics (2018) DOI: https://doi.org/10.1093/bioinformatics/bty412 PMID: 29790904

Exposure to Select PFAS and PFAS Mixtures Alters Response to Platinum-Based Chemotherapy in Endometrial Cancer Cell Lines

Brittany P. Rickard, Marta Overchuk, Justin Tulino, Xianming Tan, Frances S. Ligler, Victoria L. Bae-Jump, Suzanne E. Fenton, and Imran Rizvi

DOI: https://doi.org/10.22427/NTP-DATA-500-009-001-000-5

Gene Expression Alterations in Immune System Pathways in the Thymus Following Exposure to Immunosuppressive Chemicals

Rachel Frawley, Kimber White, Jr., Ronnetta Brown, Deborah Musgrove, Nigel Walker, Dori Germolec
Environmental Health Perspectives (2011) DOI: https://doi.org/10.1289/ehp.1002358 PMID: 21041162
DOI: https://doi.org/10.22427/NTP-DATA-002-00086-0001-0000-6

Gene Ontology Mapping as an Unbiased Method for Identifying Molecular Pathways and Processes Affected by Toxicant Exposure: Application to Acute Effects Caused by the Rodent Non-Genotoxic Carcinogen Diethylhexylphthalate

Richard A. Currie, Vincent Bombail, Jason D. Oliver, David J. Moore, Fei Ling Lim, Victoria Gwilliam, Ian Kimber, Kevin Chipman, Jonathan G. Moggs, George Orphanides
Toxicological Sciences (2005) DOI: https://doi.org/10.1093/toxsci/kfi207 PMID: 15901911

Genetic versus Chemoprotective Activation of Nrf2 Signaling: Overlapping yet Distinct Gene Expression Profiles between Keap1 Knockout and Triterpenoid-treated Mice

Melinda S. Yates, Quynh T. Tran, Patrick M. Dolan, William O. Osburn, Soona Shin, Colin C. McCulloch, Jay B. Silkworth, Keiko Taguchi, Masayuki Yamamoto, Charlotte R. Williams, Karen T. Liby, Michael B. Sporn, Thomas R. Sutter, Thomas W. Kensler
Carcinogenesis (2009). DOI: https://doi.org/10.1093/carcin/bgp100 PMID: 19386581

Genistein modulates immune responses and increases host resistance to B16F10 tumor in adult female B6C3F1 mice

Guo TL, McCay JA, Zhang LX, Brown RD, You L, Karrow NA, Germolec DR, White KL Jr.
Journal of Immunotoxicology (2018) DOI: https://doi.org/10.1093/jn/131.12.3251 PMID: 11739876

Genistein protects female nonobese diabetic mice from developing type 1 diabetes when fed a soy- and alfalfa-free diet

Guo TL, Germolec DR, Zheng JF, Kooistra L, Auttachoat W, Smith MJ, White KL, Elmore SA.
Toxicol Pathol (2015) DOI: https://doi.org/10.1177/0192623314526318 PMID: 24713318

Genome-Wide Binding and Transcriptome Analysis of Human Farnesoid X Receptor in Primary Human Hepatocytes

Le Zhan, Hui-Xin Liu, Yaping Fang, Bo Kong, Yuqi He, Xiao-bo Zhong, Jianwen Fang, Yu-Jui Yvonne Wan, Grace L. Guo
PLoS ONE (2014) DOI: https://doi.org/10.1371/journal.pone.0105930 PMID: 25198545

Gestational Exposure to Perfluorooctanoic Acid (PFOA): Alterations in Motor Related Behaviors

David R. Goulding, Sally S. White, Sandra J. McBride, Suzanne E. Fenton, and G. Jean Harry.
Neurotoxicology (2017) DOI: https://doi.org/10.1016/j.neuro.2016.11.008 PMID: 27888120

Glycidol modulation of the immune responses in female B6C3F1 mice

Guo TL, McCay JA, Brown RD, Musgrove DL, Butterworth L, Munson AE, Germolec DR, White KL Jr.
Drug Chem Toxicol (2000) DOI: https://doi.org/10.1081/DCT-100100127 PMID: 10959546

Health Consequences of Electric Lighting Practices in The Modern World: A Report on The National Toxicology Program's Workshop on Shift Work At Night, Artificial Light At Night, and Circadian Disruption

Lunn RM, Blask DE, Coogan AN, Figueiro MG, Gorman MR, Hall JE, Hansen J, Nelson RJ, Panda S, Smolensky MH, Stevens RG, Turek FW, Vermeulen R, Carreón T, Caruso CC, Lawson CC, Thayer KA, Twery MJ, Ewens AD, Garner SC, Schwingl PJ, Boyd WA.
The Science of the Total Environment (2017) DOI: https://doi.org/10.1016/j.scitotenv.2017.07.056 PMID: 28724246

Histology Atlas of the Developing Prenatal and Postnatal Mouse Central Nervous System, with Emphasis on Prenatal Days E7.5 to E18.5

Vivian S. Chen, James P. Morrison, Myra F. Southwell, Julie F. Foley, Brad Bolon, and Susan A. Elmore.
Toxicologic Pathology (2017) DOI: https://doi.org/10.1177/0192623317728134 PMID: 28891434

House Dust Endotoxin and Peripheral Leukocyte Counts: Results from Two Large Epidemiologic Studies

Michael B. Fessler, Megan U. Carnes, Päivi M. Salo, Jesse Wilkerson, Richard D. Cohn, Debra King, Jane A. Hoppin, Dale P. Sandler, Greg Travlos, Stephanie J. London, Peter S. Thorne, and Darryl C. Zeldin.
Environmental Health Perspectives (2017). DOI: https://doi.org/10.1289/EHP661 PMID: 28599265

Identification of Estrogen-Related Receptor Alpha Agonists in the Tox21 Compound Library

Caitlin Lynch, Jinghua Zhao, Ruili Huang, Noriko Kanaya, Lauren Bernal, Jui-Hua Hsieh, Scott S Auerbach, Kristine L Witt, B Alex Merrick, Shiuan Chen, Christina T Teng, and Menghang Xia.
Endocrinology (2018). DOI: https://doi.org/10.1210/en.2017-00658 PMID: 29216352

Identification of Novel NRF2-regulated Genes by ChIP-Seq: Influence on Retinoid X Receptor alpha

Brian N. Chorley, Michelle R. Campbell, Xuting Wang, Mehmet Karaca, Deepa Sambandan, Fatu Bangura, Peng Xue, Jingbo Pi, Steven R. Kleeberger, Douglas A. Bell
Nucleic Acids Research (2012). DOI: https://doi.org/10.1093/nar/gks409 PMID: 22581777

Identification of Vascular Disruptor Compounds by Analysis in Zebrafish Embryos and Mouse Embryonic Endothelial Cells

McCollum CW, Conde-Vancells J, Hans C, Vazquez-Chantada M, Kleinstreuer N, Tal T, Knudsen T, Shah SS, Merchant FA, Finnell RH, Gustafsson JÅ, Cabrera R, Bondesson M.
Reproductive Toxicology (2017) DOI: https://doi.org/10.1016/j.reprotox.2016.11.005 PMID: 27838387

Identification of p53 Activators in a Human Microarray Compendium

Corton JC, KL Witt and CL Yauk
Chemical Research in Toxicology (2019) v. 32 (9): pp. 1748-1759 DOI: https://doi.org/10.1021/acs.chemrestox.9b00052

Identifying Environmental Chemicals as Agonists of the Androgen Receptor by using a Quantitative High-Throughput Screening Platform

Lynch C, Sakamuru S, Huang R, Stavreva DA, Varticovski L, Hager GL, Judson RS, Houck KA, Kleinstreuer NC, Casey W, Paules RS, Simeonov A, Xia M.
Toxicology (2017) DOI: https://doi.org/10.1016/j.tox.2017.05.001 PMID: 28478275

Immunohistochemistry in Investigative and Toxicologic Pathology

Kyathanahalli S. Janardhan, Heather Jensen, Natasha P. Clayton, and Ronald A. Herbert
Toxicologic Pathology (2018) DOI: http://dx.doi.org/10.1177/0192623318776907 PMID: 29966501

Immunomodulatory activity of orphan drug Elmiron® in female B6C3F1/N mice

Thakur SA, Nyska A, White KL Jr, Smith MJ, Auttachoat W, Germolec DR.
Food Chem Toxicol. (2014) DOI: https://doi.org/10.1016/j.fct.2014.03.015 PMID: 24657363

Immunotoxic Effects of Sodium Tungstate Dihydrate on Female B6C3F1/N Mice When Administered in Drinking Water

Frawley RP, Smith MJ, White KL Jr, Elmore SA, Herbert R, Moore R, Staska LM, Behl M, Hooth MJ, Kissling GE, Germolec DR.
J Immunotoxicol. (2016). DOI: https://doi.org/10.3109/1547691X.2016.1154118 PMID: 27223060

Immunotoxic and Hepatotoxic Effects of Perfluoro-n-decanoic Acid (PFDA) on Female Harlan Sprague–Dawley Rats and B6C3F1/N Mice when Administered by Oral Gavage for 28 Days

Rachel P. Frawley, Matthew Smith, Mark F. Cesta, Schantel Hayes-Bouknight, Chad Blystone, Grace E. Kissling, Shawn Harris & Dori Germolec.
Journal of Immunotoxicology (2018) DOI: https://doi.org/10.1080/1547691X.2018.1445145 PMID: 29514525

Immunotoxicity Studies of Sulfolane Following Developmental Exposure in Hsd:Sprague Dawley SD Rats and Adult Exposure in B6C3F1/N Mice.

K A Shipkowski 1, M C Cora 1, M F Cesta 1, V G Robinson 1, S Waidyanatha 1, K L Witt 1, M K Vallant 1, D M Fallacara 2, M R Hejtmancik 2, S A Masten 1, S D Cooper 3, R A Fernando 3, C R Blystone 1

1Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
2Battelle Memorial Institute, Columbus, OH, USA.
3RTI International, Research Triangle Park, NC, USA.

Note: The PA46 was updated on September 14, 2021 for updates to stats for calculation of % animals with a finding.

Note: M09 was updated for number of spleen cells on September 1, 2021. The new tables contain a correction to a typographical error in the units for the Ig concentrations.

Note: M07 was updated for number of spleen cells on July 22, 2021. The I07 was updated on August 12, 2021 to reflect updated footnotes. The I04G was also updated on August 22, 2021 to reflect updated statistical analysis.

DOI: https://doi.org/10.22427/NTP-DATA-002-03276-0016-0000-7

Immunotoxicity of 180 day exposure to polydimethylsiloxane (silicone) fluid, gel and elastomer and polyurethane disks in female B6C3F1 mice

Bradley SG, White KL Jr, McCay JA, Brown RD, Musgrove DL, Wilson S, Stern M, Luster MI, Munson AE.
Drug Chem Toxicol (1994) DOI: https://doi.org/10.3109/01480549409017861 PMID: 7988384

Immunotoxicity of N-Butylbenzenesulfonamide (NBBS): Impacts on Immune Function in Adult Mice and Developmentally Exposed Rats

Victor J. Johnson1, Cynthia V. Rider2, Michael I. Luster1, Amy Brix3, Gary R. Burleson1, Michelle Cora2, Susan A. Elmore2, Rachel P. Frawley2, Franklin R. Lopez4, Esra Mutlu2, Keith R. Shockley2,5, Jessica Pierfelice6, Brian Burback6, Caroll A. Co7, Dori R. Germolec2

1Burleson Research Technologies, Inc., Morrisville, NC, USA
2Division of Translational Toxicology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
3Experimental Pathology Laboratories, Inc., Morrisville, NC, USA
4Charles River Laboratories, Morrisville, NC USA
5Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
6Battelle, Columbus, OH, USA
7Social and Scientific Systems Inc., a DLH Holdings Corp Company, Durham, NC, USA

DOI: https://doi.org/10.22427/NTP-DATA-500-005-003-000-3

Immunotoxicity of dibromoacetic acid administered via drinking water to female B₆C₃F₁ mice

Smith MJ, Germolec DR, Luebke RW, Sheth CM, Auttachoat W, Guo TL, White KL Jr.
Journal of Immunotoxicology (2010) DOI: https://doi.org/110.3109/1547691X.2010.519744 PMID: 20958156

Immunotoxicity of sodium bromate in female B6C3F1 mice: a 28-day drinking water study

Guo TL, McCay JA, Karrow NA, Brown RD, Musgrove DL, Luebke RW, Germolec DR, White KL Jr.
Journal of Immunotoxicology (2018) DOI: https://doi.org/10.1081/DCT-100102606 PMID: 11360431

Immunotoxicity studies of trans-resveratrol in male B6C3F1/N mice

Madelyn C. Huang, Kimber L. White Jr., Susan A. Elmore, Tai L. Guo, Dori Germolec

DOI: https://doi.org/10.22427/NTP-DATA-002-02772-0033-0000-6

Immunotoxicological profile of chloramine in female B6C3F1 mice when administered in the drinking water for 28 days

Guo TL, Germolec DR, Collins BJ, Luebke RW, Auttachoat W, Smith MJ, White KL.
Journal of Immunotoxicology (2011) DOI: https://doi.org/10.3109/1547691X.2011.622317 PMID: 22017662

Immunotoxicology: a Brief History, Current Status and Strategies for Future Immunotoxicity Assessment

Dori Germolec, Robert Luebke, Andrew Rooney, Kelly Shipkowski, Rob Vandebriel, Henk van Loveren.
Current Opinion in Toxicology (2017). DOI: https://doi.org/10.1016/j.cotox.2017.08.002 PMID: 28989989

Impact of Low Dose Oral Exposure to Bisphenol A (BPA) on the Neonatal Rat Hypothalamic and Hippocampal Transcriptome: A CLARITY-BPA Consortium Study

Sheryl E. Arambula, Scott M. Belcher, Antonio Planchart, Stephen D. Turner, and Heather B. Patisaul.
Endocrinology (2016). DOI: https://doi.org/10.1210/en.2016-1339 PMID: 27571134

Impact of Low-Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: A CLARITY-BPA Consortium Study

Meghan E. Rebuli, Luísa Camacho, Maria E. Adonay, David M. Reif, David L. Aylor, and Heather B. Patisaul.
Toxicological Sciences (2015) DOI: https://doi.org/10.1093/toxsci/kfv163 PMID: 26209558

In Silico Prediction of Physicochemical Properties of Environmental Chemicals Using Molecular Fingerprints and Machine Learning

Zang Q, Mansouri K, Williams AJ, Judson RS, Allen DG, Casey WM, Kleinstreuer NC.
Journal of Chemical Information and Modeling (2017) DOI: https://doi.org/10.1021/acs.jcim.6b00625 PMID: 28006899

In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making

Shannon M. Bell, Xiaoqing Chang, John F. Wambaugh, David G. Allen, Mike Bartels, Kim L.R. Brouwer, Warren M. Casey, Neepa Choksi, Stephen S. Ferguson, Grazyna Fraczkiewicz, Annie M. Jarabek, Alice Ke, Annie Lumen, Scott G. Lynn, Alicia Paini, Paul S. Price, Caroline Ring, Ted W. Simon, Nisha S. Sipes, Catherine S. Sprankle, Judy Strickland, John Troutman, Barbara A. Wetmore, Nicole C. Kleinstreuer.
Toxicology in Vitro (2018). DOI: https://doi.org/10.1016/j.tiv.2017.11.016 PMID: 29203341

In utero Exposure to DDT and Incidence of Diarrhea Among Boys from Tropical Mexico

Lea A. Cupul-Uicab, Efraín A. Terrazas-Medina, Mauricio Hernández-Ávila, Matthew P. Longnecker.
Environmental Research (2017). DOI: https://doi.org/10.1016/j.envres.2017.08.027 PMID: 28841520

In vitro Cardiotoxicity Assessment of Environmental Chemicals Using an Organotypic Human Induced Pluripotent Stem Cell-Derived Model

Oksana Sirenko, Fabian A. Grimm, Kristen R. Ryan, Yasuhiro Iwata, Weihsueh A. Chiu, Frederick Parham, Jessica A. Wignall, Blake Anson, Evan F. Cromwell, Mamta Behl, Ivan Rusyn, and Raymond R. Tice.
Toxicology and Applied Pharmacology (2017) DOI: https://doi.org/10.1016/j.taap.2017.02.020 PMID: 28259702

Insecticide Use and Breast Cancer Risk among Farmers’ Wives in the Agricultural Health Study

Lawrence S. Engel, Emily Werder, Jaya Satagopan, Aaron Blair, Jane A. Hoppin, Stella Koutros, Catherine C. Lerro, Dale P. Sandler, Michael C. Alavanja, and Laura E. Beane Freeman
Environmental Health Perspectives (2017) DOI: https://doi.org/10.1289/EHP1295 PMID: 28934092

Integrating Drug's Mode of Action into Quantitative Structure-Activity Relationships for Improved Prediction of Drug-Induced Liver Injury

Leihong Wu, Zhichao Liu, Scott Auerbach, Ruili Huang, Minjun Chen, Kristin McEuen, Joshua Xu, Hong Fang, and Weida Tong.
Journal of Chemical Information and Modeling (2017) DOI: https://doi.org/10.1021/acs.jcim.6b00719 PMID: 28350954

Internal dose of vanadium in rats following repeated exposure to vanadyl sulfate and sodium orthovanadate via drinking water

James M. Harrington, Laura G. Haines, Keith E. Levine, Chamindu Liyanapatirana, Amal S. Essader, Reshan A. Fernando, Veronica G. Robinson, Georgia K. Roberts, Matthew D. Stout, Michelle J. Hooth and Suramya Waidyanatha

Toxicology and Applied Pharmacology (2020)
DOI: https://doi.org/10.1016/j.taap.2021.1153955 PMID: 33421504

Corrigendum to “Internal dose of vanadium in rats following repeated exposure to vanadyl sulfate and sodium orthovanadate via drinking water” Toxicology and Applied Pharmacology 412 (2021) Authors: James M. Harrington, Laura G. Haines, Keith E. Levine, Chamindu Liyanapatirana, Amal S. Essader, Reshan A. Fernando, Veronica G. Robinson, Georgia K. Roberts, Matthew D. Stout, Michelle J. Hooth and Suramya Waidyanatha PMID: 33905758

DOI: https://doi.org/10.22427/NTP-DATA-002-02993-0008-0000-3

Investigating the Generalizability of the MultiFlow® DNA Damage Assay and Several Companion Machine Learning Models with a Set of 103 Diverse Test Chemicals

Steven M Bryce, Derek T Bernacki, Stephanie L Smith-Roe, Kristine L Witt, Jeffrey C Bemis, and Stephen D Dertinger.
Toxicological Sciences (2017). DOI: https://doi.org/10.1093/toxsci/kfx235 PMID: 29106658

Is It Adverse, Nonadverse, Adaptive, or Artifact?

Pandiri AR, Kerlin RL, Mann PC, Everds NE, Sharma AK, Myers LP, Steinbach TJ.
Toxicol Pathol. (2016) DOI: http://dx.doi.org/10.1177/0192623316672352 PMID: 27770107

Latent, sex-specific metabolic health effects in CD-1 mouse offspring exposed to PFOA or HFPO-DA (GenX) during gestation

Harlie A. Cope, Bevin E. Blake, Charlotte Love, James McCord, Susan A. Elmore, Janice B. Harvey, Vesna A. Chappell, Suzanne E. Fenton
Science Direct (2021) https://doi.org/10.1016/j.emcon.2021.10.004 PMID: 35097227
DOI: https://doi.org/10.22427/NTP-DATA-002-02657-0013-0000-6

Low Dose Assessment of the Carcinogenicity of Furan in Male F344/N Nctr Rats in a 2-Year Gavage Study

Von Tungeln LS, Walker NJ, Olson GR, Mendoza MC, Felton RP, Thorn BT, Marques MM, Pogribny IP, Doerge DR, Beland FA.
Food Chem Toxicol. (2016), DOI: http://dx.doi.org/10.1016/j.fct.2016.11.015 PMID: 27871980

Lung Anatomy + Particle Deposition (lapd) Mouse Archive for Modeling and Computational Toxicology

Reinhard R. Beichel1, Robb W. Glenny2, Christian Bauer1, Melissa A. Krueger2, Wayne J. E. Lamm2
1 University of Iowa, Dept. of Electrical and Computer Engineering
2 University of Washington, Dept. of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine

Bauer C, Krueger M, Lamm WJE, Glenny RW, Beichel RR. lapdMouse: associating lung anatomy with local particle deposition in mice. J Appl Physiol(1985). 2020 Feb 01;128(2):309-323. doi:10.1152/japplphysiol.00615.2019. PMID: 31774357.

RR Beichel, RW Glenny, C Bauer, MA Krueger, and WJ Lamm: “Lung anatomy + particle deposition (lapd) mouse archive.” University of Iowa. 2019. doi:10.25820/9arg-9w56.

DOI: https://doi.org/10.22427/NTP-DATA-501-001-003-000-0

Lung Deposition and Clearance of Microparticle and Nanoparticle C60 Fullerene Aggregates in B6C3F1 Mice and Wistar Han Rats Following Nose-Only Inhalation for 13 Weeks

Sayers BC, Walker NJ, Roycroft JH, Germolec DR, Baker GL, Clark ML, Hayden BK, DeFord H, Dill JA, Gupta A, Stout MD.
Toxicology (2016). DOI: https://doi.org/10.1016/j.tox.2015.11.003 PMID: 26612504

Mammary Gland Evaluation in Juvenile Toxicity Studies: Temporal Developmental Patterns in the Male and Female Harlan Sprague-Dawley Rat

Filgo AJ, Foley JF, Puvanesarajah S, Borde AR, Midkiff BR, Reed CE, Chappell VA, Alexander LB, Borde PR, Troester MA, Hayes Bouknight SA, Fenton SE.
Toxicol Pathol (2016), DOI: https://doi.org/10.1177/0192623316663864 PMID: 27613106

Metabolic Disruption Early in Life is Associated With Latent Carcinogenic Activity of Dichloroacetic Acid in Mice

Leah C. Wehmas, Anthony B. DeAngelo, Susan D. Hester, Brian N. Chorley, Gleta Carswell, Greg R. Olson, Michael H. George, Julia H. Carter, Sandra R. Eldridge, Anna Fisher, Beena Vallanat, Charles E. Wood
Toxicological Sciences (2017) DOI: https://doi.org/10.1093/toxsci/kfx146 PMID: 28962523

Metabolism and Disposition of 2-ethylhexyl-p-methoxycinnamate following Oral Gavage and Dermal Exposure in Harlan Sprague Dawley Rats and B6C3F1/N Mice and in Hepatocytes in vitro

Timothy R. Fennell, James M. Mathews, Rodney W. Snyder, Yan Hong, Scott L. Watson, Sherry R. Black, Barry S. McIntyre, and Suramya Waidyanatha.
Xenobiotica (2017). DOI: https://doi.org/10.1080/00498254.2017.1400129 PMID: 29111853

Molecular Effects of 1-Naphthyl-Methylcarbamate and Solar Radiation Exposures on Human Melanocytes

Bianca Ferrucio, Manoela Tiago, Richard D. Fannin, Liwen Liu, Kevin Gerrish, Silvya Stuchi Maria-Engler, Richard S. Paules, and Silvia Berlanga de Moraes Barros.
Toxicology in Vitro (2017) DOI: https://doi.org/10.1016/j.tiv.2016.11.005 PMID: 27829164

Multigenerational reproductive assessment of 4-methylimidazole administered in the diet to Hsd:Sprague Dawley SD rats

Mamta Behl, Cynthia J Willson, Helen Cunny, Paul M D Foster, Barry McIntyre, Cynthia Shackelford, Keith R Shockley, Sandra McBride, Katie Turner, Suramya Waidyanatha, Chad R Blystone

Reproductive Toxicology (2020) DOI: https://doi.org/10.1016/j.reprotox.2020.03.005 PMID: 32229253
DOI: https://doi.org/10.22427/NTP-DATA-002-01511-0000-0000-0

Multivariate Models for Prediction of Human Skin Sensitization Hazard

Judy Strickland, Qingda Zang, Michael Paris, David M. Lehmann, David Allen, Neepa Choksi, Joanna Matheson, Abigail Jacobs, Warren Casey, Nicole Kleinstreuer.
Journal of Applied Toxicology (2017) DOI: https://doi.org/10.1002/jat.3366 PMID: 27480324

NIEHS/FDA CLARITY-BPA research program update

Heindel JJ, Newbold RR, Bucher JR, Camacho L, Delclos KB, Lewis SM, Vanlandingham M, Churchwell MI, Twaddle NC, McLellen M, Chidambaram M, Bryant M, Woodling K, Gamboa da Costa G, Ferguson SA, Flaws J, Howard PC, Walker NJ, Zoeller RT, Fostel J, Favaro C, Schug TT.
Reprod Toxicol. (2015) DOI: https://doi.org/10.1016/j.reprotox.2015.07.075 PMID: 26232693

NTP Provantis Glossaries

NOTE:The NTP Fetal Observation Classification Glossary, NTP Clinical Observation Symptom Glossary and NTP Measurements and Endpoints Glossary are now searchable excel files

NTP short-term reproductive and developmental toxicity studies on triphenyl phosphate (TPHP) and isopropylated phenyl phosphate (IPP)

Shannah Witchey, Brad Collins, Georgia Roberts, Keith Shockley, Molly Vallant, Eve Mylchreest, Barney Sparrow, Robert Moyer, Tomas Guilarte, Helen Cunny, Jeffrey Krause, Mamta Behl

DOI: https://doi.org/10.22427/NTP-DATA-002-00600-0003-000-1

SOT Poster: https://ntp.niehs.nih.gov/ntp/results/pubs/posters/witchey_sot20210312.pdf

The I03/I03C, I04/I04G, R19/R19G/R19C were updated on November 8, 2021 due to updates in the statistics.

Non-Animal Methods to Predict Skin Sensitization (I): The Cosmetics Europe Database

Sebastian Hoffmann, Nicole Kleinstreuer, Nathalie Alépée, David Allen, Anne Marie Api, Takao Ashikaga, Elodie Clouet, Magalie Cluzel, Bertrand Desprez, Nichola Gellatly, Carsten Goebel, Petra S. Kern, Martina Klaric, Jochen Kühnl, Jon F. Lalko, Silvia Martinozzi-Teissier, Karsten Mewes, Masaaki Miyazawa, Rahul Parakhia, Erwin van Vliet, Qingda Zang, Dirk Petersohn
Critical Reviews in Toxicology (2018) DOI: https://doi.org/10.1080/10408444.2018.1429385 PMID: 29474128

Non-Animal Methods to Predict Skin Sensitization (II): An Assessment of Defined Approaches

Nicole C. Kleinstreuer, Sebastian Hoffmann, Nathalie Alépée, David Allen, Takao Ashikaga, Warren Casey, Elodie Clouet, Magalie Cluzel, Bertrand Desprez, Nichola Gellatly, Carsten Göbel, Petra S. Kern, Martina Klaric, Jochen Kühnl, Silvia Martinozzi-Teissier, Karsten Mewes, Masaaki Miyazawa, Judy Strickland, Erwin van Vliet, Qingda Zang, Dirk Petersohn.
Critical Reviews in Toxicology (2018) DOI: https://doi.org/10.1080/10408444.2018.1429386 PMID: 29474122

Non-targeted Chemical Analysis of Consumer Botanical Products Labelled as Blue Cohosh (Caulophyllum thalictroides), Goldenseal (Hydrastis canadensis), or Yohimbe Bark (Pausinystalia johimbe) by NMR and MS

Giovanni O. Quiroz-Delfi123, Cynthia V. Rider3, Stephen Ferguson 3, Scott A. Gabel1, Alan K. Jarmusch2, Geoffrey A. Mueller1

1 Genome Integrity and Structural Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
2 Immunity, Inflammation, and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
3 Division of Translational Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA

DOI: https://doi.org/10.22427/NTP-DATA-500-006-001-000-2

ORIO (Online Resource for Integrative Omics): A Web-Based Platform for Rapid Integration of Next Generation Sequencing Data

Lavender CA, Shapiro AJ, Burkholder AB, Bennett BD, Adelman K, Fargo DC.
Nucleic Acids Research (2017) DOI: https://doi.org/10.1093/nar/gkx270 PMID: 27933809

Oral Deoxynivalenol Toxicity in Sprague Dawley Rat dams and their offspring

Madelyn C. Huang, Johnathan R. Furr, Veronica G. Robinson, Laura Betz, Keith Shockley, Helen Cunny ,Kristine Witt, Suramya Waidyanatha, Dori Germolec

DOI: https://doi.org/10.22427/NTP-DATA-002-03342-0004-0000-8

Phenolic benzotriazoles: a class comparison of toxicokinetics of ultraviolet-light absorbers in male rats

Suramya Waidyanatha, Esra Mutlu, Seth Gibbs, Jessica Pierfelice, Jeremy P. Smith, Brian Burback, and Chad T. Blystone

PMID: 33952035

DOI: https://doi.org/10.22427/NTP-DATA-002-03291-0028-0000-7

Pred-Skin: A Fast and Reliable Web Application to Assess Skin Sensitization Effect of Chemicals

Rodolpho C. Braga, Vinicius M. Alves, Eugene N. Muratov, Judy Strickland∥, Nicole Kleinstreuer, Alexander Trospsha, and Carolina Horta Andrade.
Journal of Chemical Information and Modeling (2017) DOI: https://doi.org/10.1021/acs.jcim.7b00194 PMID: 28459556

Prediction of Skin Sensitization Potency Using Machine Learning Approaches

Zang Q, Paris M, Lehmann DM, Bell S, Kleinstreuer N, Allen D, Matheson J, Jacobs A, Casey W, Strickland J.
Journal of Applied Toxicology (2017) DOI: https://doi.org/10.1002/jat.3424 PMID: 28074598

Prenatal Arsenic Exposure and the Epigenome: Altered microRNAs Associated With Innate and Adaptive Immune Signaling in Newborn Cord Blood

Julia E. Rager, Kathryn A. Bailey, Lisa Smeester, Sloane K. Miller, Joel S. Parker, Jessica E. Laine, Zuzana Drobná, Jenna Currier, Christelle Douillet, Andrew F. Olshan, Marisela Rubio-Andrade, Miroslav Stýblo, Gonzalo García-Vargas, Rebecca C. Fry
Environmental and Molecular Mutagenesis (2014) DOI: https://doi.org/10.1002/em.21842 PMID: 24327377

Proteomic Analysis of Primary Human Airway Epithelial Cells Exposed to the Respiratory Toxicant Diacetyl

Foster MW, Gwinn WM, Kelly FL, Brass DM, Valente AM, Moseley MA, Thompson JW, Morgan DL, Palmer SM.
Journal of Proteome Research (2017) DOI: https://doi.org/10.1021/acs.jproteome.6b00672 PMID: 27966365

QSAR Models of Human Data can Enrich or Replace LLNA Testing for Human Skin Sensitization

Vinicius M. Alves, Stephen J. Capuzzi, Eugene N. Muratov, Rodolpho C. Braga, Thomas E. Thornton, Denis Fourches, Judy Strickland, Nicole Kleinstreuer, Carolina H. Andrade and Alexander Tropsha.
Green Chemistry (2016) DOI: https://doi.org/10.1039/c6gc01836j PMID: 28630595

RNA-Seq Profiling Reveals Novel Hepatic Gene Expression Pattern in Aflatoxin B1 Treated Rats

Merrick BA, Phadke DP, Auerbach SS, Mav D, Stiegelmeyer SM, Shah RR, Tice RR.
PLoS One (2013) DOI: https://doi.org/10.1371/journal.pone.0061768 PMID: 23630614

Real-time Cell Toxicity Profiling of Tox21 10K Compounds Reveals Cytotoxicity Dependent Toxicity Pathway Linkage

Hsieh JH, Huang R, Lin JA, Sedykh A, Zhao J, Tice RR, Paules RS, Xia M, Auerbach SS.
PLoS One (2017) DOI: https://doi.org/10.1371/journal.pone.0177902 PMID: 28531190

Reduced Disc Shedding and Phagocytosis of Photoreceptor Outer Segment Contributes to Kava Kava Extract-induced Retinal Degeneration in F344/N Rats

Haruhiro Yamashita, Mark J. Hoenerhoff, Keith R. Shockley, Shyamal D. Peddada, Kevin E. Gerrish, Deloris Sutton, Connie A. Cummings, Yu Wang, Julie F. Foley, Mamta Behl, Suramya Waidyanatha, Robert C. Sills, and Arun R. Pandiri.
Toxicologic Pathology (2018) DOI: https://doi.org/10.1177/0192623318778796 PMID: 29806545

Relative potency for altered humoral immunity induced by polybrominated and polychlorinated dioxins/furans in female B6C3F1/N mice

Frawley R, DeVito M, Walker NJ, Birnbaum L, White K Jr, Smith M, Maynor T, Recio L, Germolec D
Toxicol Sci (2014) DOI: https://doi.org/10.1093/toxsci/kfu041 PMID: 24713691

Repeat 5-day in vivo genomic dose response studies

Fred Parham, Michele R Balik-Meisner, William M Gwinn, Matthew D Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, Bruce Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R Shah, Deepak Mav, Dhiral P Phadke, Georgia Roberts, Michael J DeVito, Scott S Auerbach

DOI: https://doi.org/10.22427/NTP-DATA-002-00099-0001-000-1

BioProject ID: PRJNA926950

Reproductive and Developmental Toxicity Assessment of Butyl Paraben in Hsd: Sprague Dawley SD rats following Feed Exposure


Note: The study data are being disseminated prior to external peer review under applicable information quality guidelines and do not represent and should not be construed to represent any final NTP determination or policy.

Reproductive and Developmental Toxicity Assessment of Diisobutyl Phthalate in Sprague Dawley rats following Feed Exposure


Note: The study data are being disseminated prior to external peer review under applicable information quality guidelines and do not represent and should not be construed to represent any final NTP determination or policy.

Reproductive and developmental toxicity following exposure to organophosphate ester flame retardants and plasticizers, triphenyl phosphate and isopropylated phenyl phosphate, in Sprague Dawley rats

Shannah K. Witchey, Vicki Sutherland, Brad Collins, Georgia Roberts, Keith R. Shockley, Molly Vallant, Jeff Krause, Helen Cunny, Suramya Waidyanatha, Eve Mylchreest, Barney Sparrow, Robert Moyer and Mamta Behl

DOI: https://doi.org/10.22427/NTP-DATA-002-02974-0007-0000-1

Respiratory, Dermal, and Eye Irritation Symptoms Associated with Corexit™ EC9527A/EC9500A following the Deepwater Horizon Oil Spill: Findings from the GuLF STUDY

Craig J. McGowan, Richard K. Kwok, Lawrence S. Engel, Mark R. Stenzel, Patricia A. Stewart, and Dale P. Sandler
Environmental Health Perspectives (2017). DOI: https://doi.org/10.1289/EHP1677 PMID: 28934097

Screening a Mouse Liver Gene Expression Compendium Identifies Modulators of the Aryl hydrocarbon Receptor (AhR)

Keiyu Oshida, Naresh Vasani, Russell S. Thomas, Dawn Applegate, Frank J. Gonzalez, Lauren M. Aleksunes, Curtis D. Klaassen and J. Christopher Corton
Toxicology (2015) DOI: https://doi.org/10.1016/j.tox.2015.07.005 PMID: 26215100

Screening for Angiogenic Inhibitors in Zebrafish to Evaluate A Predictive Model for Developmental Vascular Toxicity

Tamara Tal, Claire Kilty, Andrew Smith, Carlie LaLone, Brendán Kennedy, AlanTennant, Catherine W. McCollum, Maria Bondesson, Thomas Knudsen, Stephanie Padilla, and Nicole Kleinstreuer.
Reproductive Toxicology (2017) DOI: https://doi.org/10.1016/j.reprotox.2016.12.004 PMID: 28007540

Select Per- and Polyfluoroalkyl Substances (PFAS) Induce Resistance to Carboplatin in Ovarian Cancer Cell Lines

Brittany P. Rickard, Xianming Tan, Suzanne E. Fenton, and Imran Rizvi
International Journal of Molecular Sciences (2022), 23(9), 5176; DOI: https://doi.org/10.3390/ijms23095176

DOI: https://doi.org/10.22427/NTP-DATA-025-00001-0002-000-0

Shifts in the Gut Microbiota Composition Due to Depleted Bone Marrow Beta Adrenergic Signaling Are Associated with Suppressed Inflammatory Transcriptional Networks in the Mouse Colon

Tao Yang, Niousha Ahmari, Jordan T. Schmidt, Ty Redler, Rebeca Arocha, Kevin Pacholec, Kacy L. Magee, Wendi Malphurs, Jennifer L. Owen, Gregory A. Krane, Eric Li, Gary P. Wang, Thomas W. Vickroy, Mohan K. Raizada, Christopher J. Martyniuk, and Jasenka Zubcevic.
Frontiers in Physiology (2017) DOI: https://doi.org/10.3389/fphys.2017.00220 PMID: 28446880

Short-term Toxicity Studies of Thallium (I) Sulfate Administered in Drinking Water to Sprague Dawley Rats and B6C3F1/N Mice

Kelly A. Shipkowski, Troy D. Hubbard, Kristen Ryan, Suramya Waidyanatha, Helen Cunny, Keith R. Shockley, Joshua L. Allen, Heather Toy, Keith Levine, James Harrington, Laura Betz, Barney Sparrow, Georgia K. Roberts

DOI: https://doi.org/10.22427/NTP-DATA-500-003-001-000-9

Sodium metasilicate hypersensitivity in BALB/c mice

Karrow NA, Guo TL, Leffel EK, Zhang LX, McCay JA, Germolec DR, White KL Jr.
Am J Contact Dermat (2002) DOI: PMID: 12165932

Splenic cell targets in gallium arsenide-induced suppression of the primary antibody response

Sikorski EE, Burns LA, Stern ML, Luster MI, Munson AE
Toxicol Appl Pharmacol (1991) DOI: https://doi.org/ PMID: 1871769

Standardisation of Defined Approaches for Skin Sensitisation Testing to Support Regulatory Use and International Adoption: Position of the International Cooperation on Alternative Test Methods

Casati S, Aschberger K, Barroso J, Casey W, Delgado I, Kim TS, Kleinstreuer N, Kojima H, Lee JK, Lowit A, Park HK, Régimbald-Krnel MJ, Strickland J, Whelan M, Yang Y, Zuang V.
Archives of Toxicology (2017). DOI: https://doi.org/10.1007/s00204-017-2097-4 PMID: 29127450

Statistical Guidance for Reviewers of Toxicologic Pathology

Keith R. Shockley and Grace E. Kissling
Toxicologic Pathology (2018) DOI: http://dx.doi.org/10.1177/0192623318785097 PMID: 29966505

Subchronic 10 day immunotoxicity of polydimethylsiloxane (silicone) fluid, gel and elastomer and polyurethane disks in female B6C3F1 mice

Bradley SG, Munson AE, McCay JA, Brown RD, Musgrove DL, Wilson S, Stern M, Luster MI, White KL Jr.
Drug Chem Toxicol. (1994) DOI: https://doi.org/10.3109/01480549409017860 PMID: 7988383

Supplemental Material for NTP Research Report on Biological Activity of Bisphenol A (BPA) Structural Analogues and Functional Alternatives.

Pelch KE, Wignall JA, Goldstone AE, Ross PK, Blain RB, Shapiro AJ, Holmgren SD, Hsieh J-H, Svoboda D, Auerbach SS, Parham FM, Masten SA, Thayer KA.
2017 NTP Research Report on Biological Activity of Bisphenol A (BPA) Structural Analogues and Functional Alternatives. NTP RR 4. Research Triangle Park, NC: National Toxicology Program. (4): 1-78. https://doi.org/10.22427/NTP-RR-4

Systematic Review of Community Health Impacts of Mountaintop Removal Mining

Boyles AL, Blain RB, Rochester JR, Avanasi R, Goldhaber SB, McComb S, Holmgren SD, Masten SA, Thayer KA.
Environment International (2017) DOI: https://doi.org/10.1016/j.envint.2017.07.002 PMID: 28738262

Systemic Exposure of Vinpocetine in Pregnant Sprague Dawley Rats Following Repeated Oral Exposure: An Investigation of Fetal Transfer

Suramya Waidyanatha, Heather Toy, Natalie South, Seth Gibbs, Esra Mutlu, Brian Burback, Barry S.McIntyre, and Natasha Catlin.
Toxicology and Applied Pharmacology (2018) DOI: https://doi.org/10.1016/j.taap.2017.11.011 PMID: 29155086

Systemic exposure and urinary excretion of vanadium following perinatal subchronic exposure to vanadyl sulfate and sodium metavanadate via drinking water

Suramya Waidyanatha, Frank X. Weber, James M. Harrington, Dawn M. Fallacara, Keith Levine, Veronica G. Robinson, Barney R. Sparrow, Matthew D. Stout, Reshan Fernando, Michelle J. Hooth, Guanhua Xie, Chamindu Liyanapatirana, Georgia K. Roberts
Toxciology Letters(2022) DOI: https://doi.org/10.1016/j.toxlet.2022.03.004

DOI: https://doi.org/10.22427/NTP-DATA-002-00048-0001-000-5

Systems Biology for Organotypic Cell Cultures

Grego S, Dougherty ER, Alexander FJ, Auerbach SS, Berridge BR, Bittner ML, Casey W, Cooley PC, Dash A, Ferguson SS, Fennell TR, Hawkins BT, Hickey AJ, Kleensang A, Liebman MNJ, Martin F, Maull EA, Paragas J, Qiao GG, Ramaiahgari S, Sumner SJ, Yoon M.
ALTEX (2017) DOI: https://doi.org/10.14573/altex.1608221 PMID: 27846345

Tetrabromobisphenol A Activates the Hepatic Interferon Pathway in Rats

Dunnick JK, Morgan DL, Elmore SA, Gerrish K, Pandiri A, Ton TV, Shockley KR, Merrick BA.
Toxicology Letters (2017) DOI: https://doi.org/10.1016/j.toxlet.2016.11.019 PMID: 27914987

Thalidomide modulation of the immune response in female B6C3F1 mice: a host resistance study

Karrow NA, Guo TL, Zhang LX, McCay JA, Musgrove DL, Peachee VL, Germolec DR, White KL Jr.
Int Immunopharmacol (2003) DOI: https://doi.org/10.1016/S1567-5769(03)00143-7 PMID: 12946441

The Association of Arsenic Exposure and Metabolism With Type 1 and Type 2 Diabetes in Youth: The SEARCH Case-Control Study

Grau-Perez M, Kuo CC, Spratlen M, Thayer KA, Mendez MA, Hamman RF, Dabelea D, Adgate JL, Knowler WC, Bell RA, Miller FW, Liese AD, Zhang C, Douillet C, Drobná Z, Mayer-Davis EJ, Styblo M, Navas-Acien A.
Diabetes Care (2017) DOI: https://doi.org/10.2337/dc16-0810 PMID: 27810988

The B lymphocyte is the immune cell target for 2',3'-dideoxyadenosine

Sikorski EE, Fuchs BA, Stern ML, Luster MI, Munson AE.
Toxicol Appl Pharmacol (1990) DOI: https://doi.org/ PMID: 2237921

The Concordance between RNA-seq and Microarray Data Depends on Chemical Treatment And Transcript Abundance

Charles Wang, Binsheng Gong, Pierre R Bushel, Jean Thierry-Mieg, Danielle Thierry-Mieg, Joshua Xu, Hong Fang, Huixiao Hong, Jie Shen, Zhenqiang Su, Joe Meehan, Xiaojin Li, Lu Yang, Haiqing Li, Paweł P Łabaj, David P Kreil, Dalila Megherbi, Stan Gaj, Florian Caiment, Joost van Delft, Jos Kleinjans, Andreas Scherer, Viswanath Devanarayan, Jian Wang, Yong Yang, Hui-Rong Qian, Lee J Lancashire, Marina Bessarabova, Yuri Nikolsky, Cesare Furlanello, Marco Chierici, Davide Albanese, Giuseppe Jurman, Samantha Riccadonna, Michele Filosi, Roberto Visintainer, Ke K Zhang, Jianying Li, Jui-Hua Hsieh, Daniel L Svoboda, James C Fuscoe, Youping Deng, Leming Shi, Richard S Paules, Scott S Auerbach, and Weida Tong.
Nature Biotechnology (2014) DOI: https://doi.org/10.1038/nbt.3001 PMID: 25150839

The Diacetyl-Exposed Human Airway Epithelial Secretome: New Insights into Flavoring-Induced Airways Disease

Brass DM, Gwinn WM, Valente AM, Kelly FL, Brinkley CD, Nagler AE, Moseley MA, Morgan DL, Palmer SM, Foster MW.
American Journal of Respiratory Cell and Molecular Biology (2017) DOI: https://doi.org/10.1165/rcmb.2016-0372OC PMID: 28248570

The Genomic Analysis of the Impact of Steroid Receptor Coactivators Ablation on Hepatic Metabolism

Jae-Wook Jeong, Inseok Kwak, Kevin Y. Lee, Lisa D. White, Xiao-Ping Wang, F. C. Brunicardi, Bert W. O’Malley, Francesco J. DeMayo
Molecular Endocrinology (2006) DOI: https://doi.org/10.1210/me.2005-0407 PMID: 16423883

The Power of Resolution: Contextualized Understanding of Biological Responses to Liver Injury Chemicals using High Throughput Transcriptomics and Benchmark Concentration Modeling

Ramaiahgari SC, Auerbach SS, Saddler TO, Rice JR, Dunlap PE, Sipes NS, DeVito MJ, Shah RR, Bushel PR, Merrick BA, Paules RS, Ferguson SS

Toxicological Sciences (2019) DOI: https://doi.org/10.1093/toxsci/kfz065 PMID: 30850835
CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0001-0000-6
SRA No. SRP166108; BioProject No. PRJNA497448

The common indoor air pollutant α-pinene is metabolized to a genotoxic metabolite α-pinene oxide

Suramya Waidyanatha, Sherry R. Black, Kristine L. Witt, Timothy R. Fennell, Carol Swartz, Leslie Recio, Scott L. Watson, Purvi R. Patel, Reshan A. Fernando, and Cynthia V. Rider

Taylor & Francis Online (2022) DOI: https://doi.org/10.1080/00498254.2022.2070047 PMID: 35473450
DOI: https://doi.org/10.22427/NTP-DATA-002-03031-0019-0000-9

Three-Dimensional (3D) HepaRG Spheroid Model with Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening

Sreenivasa C. Ramaiahgari, Suramya Waidyanatha, Darlene Dixon, Michael J. DeVito, Richard S. Paules, Stephen S. Ferguson.
Toxicological Sciences (2017) DOI: https://doi.org/10.1093/toxsci/kfx122 PMID: 28633424

Tox21 Enricher: Web-based Chemical/Biological Functional Annotation Analysis Tool Based on Tox21 Toxicity Screening Platform

Junguk Hur, Larson Danes, Jui‐Hua Hsieh, Brett McGregor, Dakota Krout, Scott Auerbach.
Molecular Informatics (2017) DOI: https://doi.org/10.1002/minf.201700129 PMID: 29377626

Toxicogenomics of the Flame Retardant tris(2-butoxyethyl)Phosphate in HepG2 Cells using RNA-seq

Boris V. Krivoshiev, Gerrit T.S. Beemster, Katrien Sprangers, Bart Cuypers, Kris Laukens, Ronny Blust and Steven J. Husson.
Toxicology in Vitro (2018) DOI: https://doi.org/10.1016/j.tiv.2017.10.011 PMID: 29024780

Toxicokinetic evaluation of the common indoor air pollutant, α-pinene, and its potential reactive metabolite, α-pinene oxide, following inhalation exposure in rodents

Suramya Waidyanatha, Michael Hackett, Sherry R. Black, Timothy R. Fennell, Mathew D. Stout, Melanie R. Silinski, Scott L. Watson, Joseph Licause, Veronica G. Robinson, Barney Sparrow, Reshan A. Fernando, Stephen Cooper and Cynthia V. Rider

DOI: https://doi.org/10.22427/NTP-DATA-002-03031-0014-0000-4

Toxicokinetics and bioavailability of sulfolane, a ground water contaminant, following oral and intravenous administration in rodents: A dose, species, and sex comparison

Suramya Waidyanatha, Sherry R. Black, Timothy R. Fennell, Scott L. Watson, Purvi R.Patel, Stephen D. Cooper, James Blake, Veronica Godfrey Robinson, Reshan A.Fernando, Chad R. Blystone DOI: https://doi.org/10.1016/j.taap.2019.114690

Transcriptional pathways linked to fetal and maternal hepatic dysfunction caused by gestational exposure to perfluorooctanoic acid (PFOA) or hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) in CD-1 mice

Bevin E. Blake, Colette N. Miller, Helen Nguyen, Vesna A. Chappell, Trina P. Phan, Dhiral P. Phadke, Michele R. Balik-Meisner, Deepak Mav, Ruchir R. Shah, Suzanne E. Fenton

Transcriptomic Profiling of Rat Liver Samples in A Comprehensive Study Design by RNA-Seq

Binsheng Gong, Charles Wang, Zhenqiang Su, Huixiao Hong, Jean Thierry-Mieg, Danielle Thierry-Mieg, Leming Shi, Scott S. Auerbach, Weida Tong, and Joshua Xu
Scientific Data (2014) DOI: https://doi.org/10.1038/sdata.2014.21 PMID: 25977778

Transcriptomic biomarkers of toxicological effect

Oleg Stroganov1, Bing Zhou1, Tyler Myers1, Nicole Kleinstreuer2, Warren Casey2, Kelly Shipkowski2,3, Scott Auerbach4
1: Rancho Biosciences, San Diego, CA 92025
2: National Institute of Environmental Health Sciences, Division of Translational Toxicology, Research Triangle Park, NC 27709
3: Contract Office Representative
4: Project Lead
DOI: https://doi.org/10.22427/NTP-DATA-500-010-002-000-8
Dataset: /datasets/search/biomarker-data-collection

Urinary miRNA biomarkers of drug-induced kidney injury and their site specificity within the nephron

Brian Chorley, Heidrun Ellinger-Ziegelbauer, Michael Tackett, Frank J. Simutis, Alison H. Harrill, James McDuffie, Elnaz Atabakhsh, Rounak Nassirpour, Laurence O. Whiteley, Jean-François Léonard, Ernie Harpur, Connie L. Chen, Jean-Charles Gautier

Toxicological Sciences (2020) DOI: https://doi.org/10.1093/toxsci/kfaa181
DOI: https://doi.org/10.22427/NTP-DATA-002-00085-0001-0000-6

Uterine Paramesonephric Cysts in Sprague-Dawley Rats from National Toxicology Program Studies

Daven N. Jackson-Humbles, John Curtis Seely, Ronald A. Herbert, David E. Malarkey, Barry S. McIntyre, Paul M. Foster, and Darlene Dixon
Toxicologic Pathology (2018). DOI: https://doi.org/10.1177/0192623318772487 PMID: 29706125

Whole-body inhalation exposure to 1-bromopropane suppresses the IgM response to sheep red blood cells in female B6C3F1 mice and Fisher 344/N rats

Anderson SE, Munson AE, Butterworth LF, Germolec D, Morgan DL, Roycroft JA, Dill J, Meade BJ.
Journal of Immunotoxicology (2018) DOI: https://doi.org/10.3109/08958370902953910 PMID: 20041805

Whole-body inhalation exposure to 2-ethyltoluene for two weeks produced nasal lesions in rats and mice

Madelyn C. Huang, Cynthia J. Willson, Sridhar Jaligama, Gregory L. Baker, Alan W. Singer, Yu Cao, Jessica Pierfelice, Esra Mutlu, Brian Burback, Guanhua Xie, David E. Malarkey, Barney Sparrow, Kristen Ryan, Matthew Stout, and Georgia K. Roberts
Inhalation Toxicology (2021) DOI: https://doi.org/10.1080/08958378.2021.2002480
DOI: https://doi.org/10.22427/NTP-DATA-002-03356-0005-0000-4

Zileuton Liver Toxicity Study in DO Mice

Dahea You, Lascelles E. Lyn-Cook Jr., Daniel M. Gatti, Natalie Bell,, Philip R. Mayeux, Laura P. James, William B. Mattes, Alison H. Harrill.
DOI: https://doi.org/10.22427/NTP-DATA-002-00076-0001-0000-6

httk: R Package for High-Throughput Toxicokinetics

Robert G. Pearce, R. Woodrow Setzer, Cory L. Strope, Nisha S. Sipes, John F. Wambaugh.
Journal of Statistical Software (2017) DOI: https://doi.org/10.18637/jss.v079.i04 PMID: Not available