Publications

14-Day Toxicity Studies of Tetravalent and Pentavalent Vanadium Compounds in Harlan Sprague Dawley Rats and B6C3F1/N Mice via Drinking Water Exposure

Roberts GK, Stout MD, Sayers B, Fallacara DM, Hejtmancik MR, Waidyanatha S, Hooth MJ.
Toxicology Reports (2016) DOI: https://doi.org/10.1016/j.toxrep.2016.05.001 PMID: 28042531

2-Chloro and 2-Bromopalmitic Acids inhibit mitochondrial Function in Airway epithelial cells

Karina Ricart¹, Kyle S. McCommis^2,3, David A. Ford ^2,^3,^* and Rakesh P. Patel^1,*.

¹Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
²Center for Cardiovascular Research, Saint Louis University School of Medicine, St. Louis, MO 63104, USA
³Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA
*Correspondence: David Ford david.ford@health.slu.edu or rakeshpatel@uabmc.edu

DOI: https://doi.org/10.22427/NTP-DATA-501-002-001-000-9

3-Month Toxicity Studies of Tetravalent and Pentavalent Vanadium Compounds in Hsd:Sprague Dawley SD Rats and B6C3F1/N Mice via Drinking Water Exposure

Developmental NeuroToxicity Data Integration and Visualization Enabling Resource (DNT-DIVER)

National Toxicology Program. 2018. Data Release: Developmental NeuroToxicity Data Integration and Visualization Enabling Resource (DNT-DIVER). Last Updated: December 3, 2018.
DOI: https://doi.org/10.22427/NTP-DATA-002-00062-0001-0000-1

NOTE: Files in Data Release.zip were replaced on 26 Feb 2020 due to inconsistent data

Benchmark Dose data added on 10 March 2022

A 13-week subchronic toxicity study of hexyl acetate in SD rats

Toyoda T1, Cho YM1, Matsushita K1, Tachibana S2, Senuma M2, Akagi JI1, Ogawa K1.

Author information:
1. Division of Pathology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-9501, Japan.
2. Hatano Research Institute, Food and Drug Safety Center, 729-5 Ochiai, Hadano, Kanagawa 257-8523, Japan

PMID: 31402808 PMCID: PMC6682557

Similar articles

A Black Cohosh Extract Causes Hematologic and Biochemical Changes Consistent with a Functional Cobalamin Deficiency in Female B6C3F1/N Mice

Michelle C. Cora, William Gwinn, Ralph Wilson, Debra King, Suramya Waidyanatha, Grace E. Kissling, Sukhdev S. Brar, Dorian Olivera, Chad Blystone, and Greg Travlos.
Toxicologic Pathology (2017) DOI: https://doi.org/10.1177/0192623317714343 PMID: 28618975

A Hybrid Gene Selection Approach to Create the S1500+ Targeted Gene Sets for Use in High-Throughput Transcriptomics

Deepak Mav, Ruchir R. Shah, Brian E. Howard, Scott S. Auerbach, Pierre R. Bushel, Jennifer B. Collins, David L. Gerhold, Richard S. Judson, Agnes L. Karmaus, Elizabeth A. Maull, Donna L. Mendrick, B. Alex Merrick, Nisha S. Sipes, Daniel Svoboda, Richard S. Paules.
PLOS One. 2018 DOI: https://doi.org/10.1371/journal.pone.0191105 PMID: 29462216

A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro

Melanie Adler, Susanne Ramm, Marc Hafner, Jeremy L. Muhlich, Esther Maria Gottwald, Elijah Weber, Alenka Jaklic, Amrendra Kumar Ajay, Daniel Svoboda, Scott Auerbach, Edward J. Kelly, Jonathan Himmelfarb and Vishal S. Vaidya
JASN (2015) DOI: https://doi.org/10.1681/ASN.2015010060 PMID: 26260164

A comparison of three nucleoside analogs with anti-retroviral activity on immune and hematopoietic functions in mice: in vitro toxicity to precursor cells and microstromal environment

Luster MI, Germolec DR, White KL Jr, Fuchs BA, Fort MM, Tomaszewski JE, Thompson M, Blair PC, McCay JA, Munson AE, et al.
Toxicol Appl Pharmacol (1989) DOI: https://doi.org/ PMID: 2554533

A high-throughput toxicity screen of 42 per- and polyfluoroalkyl substances (PFAS) and functional assessment of migration and gene expression in human placental trophoblast cells

Bevin E. Blake, Brittany P. Rickard, and Suzanne E. Fenton
DOI: https://doi.org/10.22427/NTP-DATA-025-00001-0001-000-9

Accelerating Adverse Outcome Pathway Development Using Publicly Available Data Sources

Noffisat O. Oki, Mark D. Nelms, Shannon M. Bell, Holly M. Mortensen, Stephen W. Edwards.
Current Environmental Health Reports. 2016 DOI: http://dx.doi.org/10.1007/s40572-016-0079-y PMID: 26809562

Advancing Alternative Analysis: Integration of Decision Science

Malloy TF, Zaunbrecher VM, Batteate CM, Blake A, Carroll WF, Jr., Corbett CJ, Hansen SF, Lempert RJ, Linkov I, McFadden R, Moran KD, Olivetti E, Ostrom NK, Romero M, Schoenung JM, Seager TP, Sinsheimer P, Thayer KA.
Environmental Health Perspectives (2017) DOI: https://doi.org/10.1289/ehp483 PMID: 28669940

Advancing Alternatives Analysis: The Role of Predictive Toxicology in Selecting Safer Chemical Products and Processes

Timothy Malloy, Virginia Zaunbrecher, Elizabeth Beryt, Richard Judson, Raymond Tice, Patrick Allard, Ann Blake, Ila Cote, Hilary Godwin, Lauren Heine, Patrick Kerzic, Jakub Kostal, Gary Marchant, Jennifer McPartland, Kelly Moran, Andre Nel, Oladele Ogunseitan, Mark Rossi, Kristina Thayer, Joel Tickner, Margaret Whittaker, Ken Zarker.
Integrated Environmental Assessment and Management (2017) DOI: https://doi.org/10.1002/ieam.1923 PMID: 28247928

Airway Injury in an in vitro Human Epithelium-Fibroblast Model of Diacetyl Vapor Exposure: Diacetyl-Induced Basal/Suprabasal Spongiosis

William M. Gwinn, Gordon P. Flake, Ronald W. Bousquet, Genie J. Taylor, and Daniel L. Morgan.
Inhalation Toxicology (2017) DOI: https://doi.org/10.1080/08958378.2017.1369604 PMID: 28984536

Alternative Approaches for Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing

Jon Hamm, Kristie Sullivan, Amy J. Clippinger, Judy Strickland, Shannon Bell, Barun Bhhatarai, Bas Blaauboer, Warren Casey, David Dorman, Anna Forsby, Natàlia Garcia-Reyero, Sean Gehen, Rabea Graepel, Jon Hotchkiss, Anna Lowit, Joanna Matheson, Elissa Reaves, Louis Scarano, Catherine Sprankle, Jay Tunkel, Dan Wilson, Menghang Xia, Hao Zhu, David Allen.
Toxicology in Vitro (2017) DOI: https://doi.org/10.1016/j.tiv.2017.01.004 PMID: 28069485

An Evaluation of Neurotoxicity Following Fluoride Exposure from Gestational Through Adult Ages in Long-Evans Hooded Rats

Christopher A. McPherson, Guozhu Zhang, Richard Gilliam, Sukhdev S. Brar, Ralph Wilson, Amy Brix, Catherine Picut, and G. Jean Harry
Neurotoxicity Research (2018) DOI: https://doi.org/10.1007/s12640-018-9870-x PMID: 29404855

An Integrated Chemical Environment to Support 21st-Century Toxicology

Bell SM, Phillips J, Sedykh A, Tandon A, Sprankle C, Morefield SQ, Shapiro A, Allen D, Shah R, Maull EA, Casey WM, Kleinstreuer NC.
Environmental Health Perspectives (2017) DOI: https://doi.org/10.1289/ehp1759 PMID: 28557712

An Intuitive Approach for Predicting Potential Human Health Risk with the Tox21 10k Library

Sipes NS, Wambaugh JF, Pearce R, Auerbach SS, Wetmore BA, Hsieh JH, Shapiro AJ, Svoboda D, DeVito MJ, Ferguson SS.
Environmental Science & Technology (2017) DOI: https://doi.org/10.1021/acs.est.7b00650 PMID: 27814246

An ethanolic extract of black cohosh causes hematological changes but not estrogenic effects in female rodents

Minerva Mercado-Feliciano, Michelle C. Cora, Kristine L. Witt, Courtney A. Granville, Milton R. Hejtmancik, Laurene Fomby, Katherine A. Knostman, Michael J. Ryan, Retha Newbold, Cynthia Smith, Paul M. Foster, Molly K. Vallant, Matthew D. Stout
Toxicology and Applied Pharmacology (2012) DOI: https://doi.org/10.1016/j.taap.2012.05.022 PMID: 22687605

DOI: https://doi.org/10.22427/NTP-DATA-002-01731-0031-0000-8

An investigation of systemic exposure to bisphenol AF during critical periods of development in the rat

Suramya Waidyanatha, Bradley J. Collins, Helen Cunny, Kristin Aillon, Felicia Riordan, Katie Turner, and Vicki Sutherland

DOI: https://doi.org/10.22427/NTP-DATA-002-03263-0010-0000-7

Annotated Toxicokinetics Data

Files were updated in September 2024 to ensure clarity.

DOI: https://doi.org/10.22427/NTP-DATA-500-012-008-000-6

Application of Adverse Outcome Pathways to U.S. EPA's Endocrine Disruptor Screening Program

Browne P, Noyes PD, Casey WM, Dix DJ
Environmental Health Perspectives (2017) DOI: https://doi.org/10.1289/ehp1304 PMID: 28934726

Application of Sholl Analysis to Quantify Changes in Growth and Development in Rat Mammary Gland Whole Mounts

Stanko JP, Easterling MR, Fenton SE
Reprod Toxicol (2015), DOI: https://doi.org/10.1016/j.reprotox.2014.11.004 PMID: 25463529

Assessment of immunotoxicity in female Fischer 344/N and Sprague Dawley rats and female B(6)C(3)F(1) mice exposed to hexavalent chromium via the drinking water

Shipkowski KA, Sheth CM, Smith MJ, Hooth MJ, White KL Jr, Germolec DR.
Journal of Immunotoxicology (2018) DOI: https://doi.org/10.1080/1547691X.2017.1394932 PMID: 29141474

Assessment of the DNA Damaging Potential of Environmental Chemicals Using a Quantitative High-throughput Screening Approach to Measure p53 Activation

Witt KL, Hsieh JH, Smith-Roe SL, Xia M, Huang R, Zhao J, Auerbach SS, Hur J, Tice RR.
Environmental and Molecular Mutagenesis (2017) DOI: https://doi.org/10.1002/em.22112 PMID: 28714573

Benchmark Concentrations for Untargeted Metabolomics vs. Transcriptomics for Liver Injury Compounds in In Vitro Liver Models

David M Crizer, Sreenivasa C Ramaiahgari, Stephen S Ferguson, Julie R Rice, Paul E Dunlap, Nisha S Sipes, Scott S Auerbach, B Alex Merrick, Michael J DeVito

Toxicological Science (2021) DOI: https://doi.org/10.1093/toxsci/kfab036 PMID: 33749773
DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0003-0000-8

Benchmark Dose Analysis for Neoplastic and Non-neoplastic Lesions

Benchmark Dose (BMD) analysis for all public neoplastic and non-neoplastic lesion incidence data with best fit models.

The data contained herein were collected in 2019 from a source now known to contain omissions. We plan to replace with an up to date dataset in 2023.

DOI: https://doi.org/10.22427/NTP-DATA-022-00002-0005-000-1

Benchmark Dose Modeling Estimates of the Concentrations of Inorganic Arsenic That Induce Changes to the Neonatal Transcriptome, Proteome, and Epigenome in a Pregnancy Cohort

Julia E. Rager, Scott S. Auerbach, Grace A. Chappell, Elizabeth Martin, Chad M. Thompson, and Rebecca C. Fry
Chemical Research in Toxicology (2017). DOI: https://doi.org/10.1021/acs.chemrestox.7b00221 PMID: 28927277

Beyond the RfD: Broad Application of a Probabilistic Approach to Improve Chemical Dose-Response Assessments for Noncancer Effects

Weihsueh A. Chiu, Daniel A. Axelrad, Chimeddulam Dalaijamts, Chris Dockins, Kan Shao, Andrew J. Shapiro, and Greg Paoli
Environ Health Perspect (2018) DOI: http://dx.doi.org/10.1289/ehp3368 PMID: 29968566

Binding of Bisphenol A, Bisphenol AF, and Bisphenol S on the Androgen Receptor: Coregulator Recruitment and Stimulation of Potential Interaction Sites

Lalith Perera, Yin Li, Laurel A. Coons, Rene Houtman, Rinie van Beuningen, Bonnie Goodwin, Scott S. Auerbach, and Christina T. Teng.
Toxicology in Vitro (2017) DOI: https://doi.org/10.1016/j.tiv.2017.07.020 PMID: 28751236

Bisphenol A Exposure, Ovarian Follicle Numbers, and Female Sex Steroid Hormone Levels: Results From a CLARITY-BPA Study

Shreya Patel, Emily Brehm, Liying Gao, Saniya Rattan, Ayelet Ziv-Gal, and Jodi A. Flaws.
Endocrinology (2017) DOI: https://doi.org/10.1210/en.2016-1887 PMID: 28324068

Black Cohosh Extracts and Powders Induce Micronuclei, A Biomarker of Genetic Damage, in Human Cells

Stephanie L. Smith‐Roe, Carol D. Swartz, Kim G. Shepard, Steven M. Bryce, Stephen D. Dertinger, Suramya Waidyanatha, Grace E. Kissling, Scott S. Auerbach, Kristine L. Witt, and E. Zeiger.
Environmental and Molecular Mutagenesis (2018) DOI: https://doi.org/10.1002/em.22182 PMID: 29668046

DOI: https://doi.org/10.22427/NTP-DATA-002-01731-0030-0000-7

Bone Marrow Related Biomarker Summaries

DOI: https://doi.org/10.22427/NTP-DATA-500-010-003-000-9

Botanical Safety Consortium Publications

Botanical dietary supplement use is widespread and growing, therefore, ensuring the safety of botanical products is a public health priority. The Botanical Safety Consortium (BSC) is a public-private partnership aimed at enhancing the toolkit for conducting the safety evaluation of botanicals. This partnership is the result of a Memorandum of Understanding between the US FDA, the National Institute of Environmental Health Sciences, and the Health and Environmental Sciences Institute. The BSC serves as a global forum for scientists from government, academia, consumer health groups, industry, and non-profit organizations to work collaboratively on adapting and integrating new approach methodologies (NAMs) into routine botanical safety assessments.

DOI: https://doi.org/10.22427/NTP-DATA-500-007-003-000-5

Botanical Safety Consortium – Chemical Analysis

Last updated Oct 2024.

Chemical Analysis - Oleander (Nerium oleander) – Oleandrin Quantification file has been added for Oleander (Nerium oleander)
Chemical Analysis - Aconite (Aconitum napellus) - Aconitine Quantification file has been added for Aconite (Aconitum napellus)
Botanical Constituents and Quantification file has been updated with the results from the two files above

July 2024 updates: the following files have been added for Ephedra (Ephedra sinica)

Analysis Summary - Ephedra (Ephedra sinica)
HPTLC Figure 1 - Ephedra (Ephedra sinica)
HPTLC Figure 2 - Ephedra (Ephedra sinica)
DNA Barcoding - Ephedra (Ephedra sinica)

DOI: https://doi.org/10.22427/NTP-DATA-500-007-001-000-3

Brain Related Biomarker Summaries

DOI: https://doi.org/10.22427/NTP-DATA-500-010-004-000-0

CATMoS: Collaborative Acute Toxicity Modeling Suite Collaborators contributions

Individual contributions from the different members of the consortium

DOI: https://doi.org/10.22427/NTP-DATA-002-00090-0001-0000-2

CEBS Documentation

DOI: https://doi.org/10.22427/NTP-DATA-002-00094-0002-0000-7

CEBS Release Notes

CEBS update: curated toxicology database with enhanced tools for data integration

Cari Martini, Ying Frances Liu, Hui Gong, Nicole Sayers, German Segura, Jennifer Fostel
Nucleic Acids Research (2021) DOI: https://doi.org/10.1093/nar/gkab981

DOI: https://doi.org/10.22427/NTP-DATA-002-00094-0001-0000-6

CEBS: A Comprehensive Annotated Database of Toxicological Data

Lea IA, Gong H, Paleja A, Rashid A, Fostel J.
Nucleic Acids Res (2017). DOI: https://doi.org/10.1093/nar/gkw1077 PMID: 27899660

CEBSR Data Warehouse API Documentation and Examples

DOI: https://doi.org/10.22427/NTP-DATA-002-00091-0001-0000-3

CLARITY-BPA: Effects of Chronic Bisphenol A Exposure on the Immune System: Part 1 – Quantification of the Relative Number and Proportion of Leukocyte Populations in the Spleen and Thymus

Jinpeng Li, Anthony Bach, Robert B. Crawford, Ashwini S. Phadnis-Moghe, Weimin Chen, Shawna D’Ingillo, Natalia Kovalova, Jose E. Suarez-Martinez, Jiajun Zhou, Barbara L. F. Kaplan, and Norbert E. Kaminski.
Toxicology (2018) DOI: https://doi.org/10.1016/j.tox.2018.01.004 PMID: 29428349

CLARITY-BPA: Effects of Chronic Bisphenol A Exposure on the Immune System: Part 2 – Characterization of Lymphoproliferative and Immune Effector Responses by Splenic Leukocytes

Jinpeng Li, Anthony Bach, Robert B. Crawford, Ashwini S. Phadnis-Moghe, Weimin Chen, Shawna D’Ingillo, Natalia Kovalova, Jose E. Suarez-Martinez, Jiajun Zhou, Barbara L. F. Kaplan, and Norbert E. Kaminski.
Toxicology (2018) DOI: https://doi.org/10.1016/j.tox.2018.02.004 PMID: 29427786

Carbon tetrachloride is immunosuppressive and decreases host resistance to Listeria monocytogenes and Streptococcus pneumoniae in female B6C3F1 mice

Guo TL, McCay JA, Brown RD, Musgrove DL, Germolec DR, Butterworth L, Munson AE, White KL Jr.
Toxicology (2000) DOI: https://doi.org/ PMID: 11118673

Carcinogenic Activity of Pentabrominated Diphenyl Ether Mixture (DE-71) in Rats and Mice

J.K. Dunnick, A.R. Pandiri, B.A. Merrick, G.E. Kissling, H. Cunny, E. Mutlu, S. Waidyanatha, R. Sills, H.L. Hong, TV. Ton, T. Maynor, L. Recio, S.L. Phillips, M.J. Devito, and A. Brix.
Toxicology Reports (2018) DOI: https://doi.org/10.1016/j.toxrep.2018.05.010 PMID: 29868454

Channel Interactions and Robust Inference for Ratiometric β-Lactamase Assay Data: A Tox21 Library Analysis

Fjodor Melnikov, Jui-Hua Hsieh, Nisha S. Sipes, and Paul T. Anastas
ACS Sustainable Chemistry & Engineering (2018). DOI: https://doi.org/10.1021/acssuschemeng.7b03394 PMID: Not Available

Characterization of Estrogenic and Androgenic Activities for Bisphenol A-like Chemicals (BPs): In Vitro Estrogen and Androgen Receptors Transcriptional Activation, Gene Regulation, and Binding Profiles

Katherine E. Pelch, Yin Li, Lalith Perera, Kristina A. Thayer, Kenneth S. Korach
DOI: https://doi.org/10.22427/NTP-DATA-002-00060-0001-0000-9

Characterization of Polybrominated Diphenyl Ether Toxicity in Wistar Han Rats and Use of Liver Microarray Data for Predicting Disease Susceptibilities

Dunnick JK, Brix A, Cunny H, Vallant M, Shockley KR.
Toxicol Pathol (2012), DOI: https://doi.org/10.1177/0192623311429973 PMID: 22267650

Characterization of Zinc Carbonate Basic as a Source of Zinc in a Rodent Study Investigating the Effects of Dietary Deficiency or Excess

Keith E. Levine, Bradley J. Collins, Matthew D. Stout, Michael Wyde, Scott E. Afton, Amal S. Essader, Todd J. Ennis, Kelly E. Amato, Andrea C. McWilliams, Brenda L. Fletcher, Reshan A. Fernando, James M. Harrington, Natasha Catlin, Veronica G. Robinson & Suramya Waidyanatha.
Analytical Letters (2017) DOI: https://doi.org/10.1080/00032719.2017.1293073 PMID: Currently Not Available

Chemical Reactivity and Respiratory Toxicity of the α-Diketone Flavoring Agents 2,3-Butanedione, 2,3-Pentanedione, and 2,3-Hexanedione

Morgan DL, Jokinen MP, Johnson CL, Price HC, Gwinn WM, Bousquet RW, Flake GP.
Toxicol Pathol. 2016 DOI: https://doi.org/10.1177/0192623316638962 PMID: 27025954

Chemistry Lists

DOI: https://doi.org/10.22427/NTP-DATA-500-012-010-000-9

Colon Related Biomarker Summaries

DOI: https://doi.org/10.22427/NTP-DATA-500-010-005-000-1

Combination of Multiple Neural Crest Migration Assays to Identify Environmental Toxicants from a Proof-of-Concept Chemical Library

Nyffeler J, Dolde X, Krebs A, Pinto-Gil K, Pastor M, Behl M, Waldmann T, Leist M.
Archives of Toxicology (2017) DOI: https://doi.org/10.1007/s00204-017-1977-y PMID: 28477266

Combined Analysis of Oligonucleotide Microarray Data from Transgenic and Knockout Mice Identifies Direct SREBP Target Genes

Jay D. Horton, Nila A. Shah, Janet A. Warrington, Norma N. Anderson, Sahng Wook Park, Michael S. Brown and Joseph L. Goldstein
PNAS (2003) DOI: https://doi.org/10.1073/pnas.1534923100 PMID: 14512514

Comparative Inhalation Toxicity of Ethyltoluene Isomers in Rats and Mice

Georgia K. Roberts, Cynthia J. Willson, Dorian S. Olivera, David E. Malarkey, Daniel L. Morgan.
Inhal Toxicol (2017) DOI: https://doi.org/10.1080/08958378.2018.1430190 PMID: 29374990

Comparative Pulmonary Toxicity of Inhaled Metalworking Fluids in Rats and Mice

Ryan KR, Cesta MF, Herbert R, Brix A, Cora M, Witt K, Kissling G, Morgan DL.
Toxicol Ind Health. 2017 DOI: https://doi.org/10.1177/0748233716653912 PMID: 27343050

Comparative Toxicity of Organophosphate Flame Retardants and Polybrominated Diphenyl Ethers to Caenorhabditis elegans

Behl M, Rice JR, Smith MV, Co CA, Bridge M, Hsieh JH, Freedman JH, Boyd WA.
Toxicol Sci (2016) DOI: http:/dx.doi.org/10.1093/toxsci/kfw162 PMID: 27566445

Comparative Toxicokinetics of Bisphenol S in Rats and Mice following Gavage Administration

Suramya Waidyanatha, Sherry R. Black, Melanie Silinski, Vicki Sutherland, Brenda L. Fletcher, Reshan A. Fernando, and Timothy R. Fennell
Toxicology and Applied Pharmacology (2020) DOI: https://doi.org/10.1016/j.taap.2020.115207
DOI: https://doi.org/10.22427/NTP-DATA-002-03311-0007-0000-7

Comparative toxicity and liver transcriptomics of legacy and emerging brominated flame retardants following 5-day exposure in the rat

Keith R Shockley, Michelle C Cora, David E Malarkey, Daven Jackson-Humbles, Molly Vallant, Brad J Collins, Esra Mutlu, Veronica G Robinson, Surayma Waidyanatha, Amy Zmarowski, Nicholas Machesky, Jamie Richey, Sam Harbo, Emily Cheng, Kristin Patton, Barney Sparrow, June K Dunnick

Toxicology Letters (2020) DOI: https://doi.org/10.1016/j.toxlet.2020.07.016 PMID: 32679240

GEO: GSE153366

Comparison of sulfolane effects in Sprague Dawley rats, B6C3F1/N mice, and Hartley guinea pigs after 28 days of exposure via oral gavage

K A Shipkowski ¹, M C Cora ¹, M F Cesta ¹, V G Robinson ¹, S Waidyanatha ¹, K L Witt ¹, M K Vallant ¹, D M Fallacara ², M R Hejtmancik ², S A Masten ¹, S D Cooper ³, R A Fernando ³, C R Blystone ¹

¹Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
²Battelle Memorial Institute, Columbus, OH, USA.
³RTI International, Research Triangle Park, NC, USA.

DOI: https://doi.org/10.22427/NTP-DATA-002-03276-0000-0000-0

Note: The study data are being disseminated prior to external peer review under applicable information quality guidelines and do not represent and should not be construed to represent any final NTP determination or policy.

Genetox data was added on August 7, 2020

Completion of the DrugMatrix Toxicogenomics Database using ToxCompl

Authors:
Guojing Cong¹, Robert Patton¹, Frank Chao³, Daniel L. Svoboda⁴, Warren M. Casey³, Charles P. Schmitt³, Charles Murphy², Jeremy N. Erickson³, Parker A. Combs³, Scott S. Auerbach³

Corresponding Author:
Scott Auerbach

¹Data and AI Section, Oak Ridge National Laboratory, Oak Ridge, TN
²Carnegie Mellon University, Pittsburgh, PA
³Division of Translational Toxicology, National Institute of Environmental Health Sciences, RTP, NC
⁴Sciome LLC, RTP, NC

DOI: https://doi.org/10.22427/NTP-DATA-500-010-001-000-7

Contact sensitizing potential of annatto extract and its two primary color components, cis-bixin and norbixin, in female BALB/c mice

Auttachoat W, Germolec DR, Smith MJ, White KL Jr, Guo TL.
Food Chem Toxicol (2011) DOI: https://doi.org/10.1016/j.fct.2011.07.009 PMID: 21777644

Contact sensitizing potential of pyrogallol and 5-amino-o-cresol in female BALB/c mice

Guo TL, Germolec DR, Zhang LX, Auttachoat W, Smith MJ, White KL Jr.
Toxicology (2013) DOI: https://doi.org/10.1016/j.tox.2013.10.006 PMID: 24172597

Cumulative Effects of Antiandrogenic Chemical Mixtures and Their Relevance to Human Health Risk Assessment

Kembra L. Howdeshell, Andrew K. Hotchkiss, L. Earl Gray Jr.
International Journal of Hygiene and Environmental Health (2017) DOI: https://doi.org/10.1016/j.ijheh.2016.11.007 PMID: 27923611

Cylindrospermopsin Toxicity in Mice following a 90-d Oral Exposure

N. Chernoff, D.J. Hill, I. Chorus, D.L. Diggs, H. Huang, D. King, J.R. Lang, T.-T. Le, J.E. Schmid, G.S. Travlos, E.M. Whitley, R.E. Wilson & C.R. Wood.
Journal of Toxicology and Environmental Health, Part A (2018) DOI: https://doi.org/10.1080/15287394.2018.1460787 PMID: 29693504

DART – Rabbit Historical Control Data (2015-2018)

DOI: https://doi.org/10.22427/NTP-DATA-500-008-000-000-3

DNA Product Formation in Female Sprague-Dawley Rats Following Polyhalogenated Aromatic Hydrocarbon (PHAH) Exposure

Gao L, Mutlu E, Collins LB, Walker NJ, Hartwell HJ, Olson JR, Sun W, Gold A, Ball LM, Swenberg JA
Chemical Research in Toxicology (2017) DOI: https://doi.org/10.1021/acs.chemrestox.6b00368 PMID: 28207250

DTT Data Dictionary - Past Versions

DTT Data Dictionary 2022-Present

DTT supports FAIR data principles https://www.go-fair.org/fair-principles/. One component of FAIR is to ensure that data are interoperable with applications and workflows, and in particular, that “(Meta)data use vocabularies that follow FAIR principles”.

In support of this aim, DTT is developing the DTT Data Dictionary (DDD), a list of terms, metadata and endpoints used in DTT studies. The DDD is growing as data are consolidated and will be updated or extended approximately monthly. Older versions and change logs will be available. The DDD contains links to external ontologies or other external IDs where available.

We welcome your comments and suggestions. Please contact dttresearchdatacoordinator@mail.nih.gov

DOI: https://doi.org/10.22427/NTP-DATA-002-00092-0002-0000-5

DTT Pathology Dictionary 2019-2021

The Division of Translational Toxicology (DTT) has been collecting and reporting histopathology and clinical pathology data since 1976. Over the years, pathology terminologies have evolved. This dictionary includes legacy terms and their current equivalent, and mappings to external ontologies. This dictionary is currently in progress and under review (Version: November 2021)
DOI: https://doi.org/10.22427/NTP-DATA-002-00092-0001-0000-4

Development and Validation of a Computational Model for Androgen Receptor Activity

Kleinstreuer NC, Ceger P, Watt ED, Martin M, Houck K, Browne P, Thomas RS, Casey WM, Dix DJ, Allen D, Sakamuru S, Xia M, Huang R, Judson R.
Chemical Research in Toxicology (2017) DOI: https://doi.org/10.1021/acs.chemrestox.6b00347 PMID: 27933809

Development of Novel Cell Lines for High-Throughput Screening to Detect Estrogen-Related Receptor Alpha Modulators

Christina T. Teng, Jui-Hua Hsieh, Jinghua Zhao, Ruili Huang, Menghang Xia, Negin Martin, Xiaohua Gao, Darlene Dixon, Scott S. Auerbach, Kristine L. Witt, B. Alex Merrick.
SLAS Discovery (2017) DOI: https://doi.org/10.1177/2472555216689772 PMID: 28346099

Developmental Effects of the ToxCast™ Phase I and Phase II Chemicals in Caenorhabditis elegans and Corresponding Responses in Zebrafish, Rats, and Rabbits

Boyd WA, Smith MV, Co CA, Pirone JR, Rice JR, Shockley KR, Freedman JH.
Environ Health Perspect. (2016) DOI: http:/dx.doi.org/10.1289/ehp.1409645 PMID: 26496690
DOI: https://doi.org/10.22427/NTP-DATA-002-00901-0003-000-5

Developmental Exposure to Low Concentrations of Organophosphate Flame Retardants Causes Life-Long Behavioral Alterations in Zebrafish

Lilah Glazer, Andrew B Hawkey, Corinne N Wells, Meghan Drastal, Kathryn-Ann Odamah, Mamta Behl, and Edward D Levin.
Toxicological Sciences (2018) DOI: http://dx.doi.org/10.1093/toxsci/kfy173 PMID: 29982741

Developmental Exposure to Low Concentrations of Two Brominated Flame Retardants, BDE-47 and BDE-99, Causes Life-Long Behavioral Alterations in Zebrafish

Lilah Glazer, Corinne N. Wells, Meghan Drastal, Kathryn-Ann Odamah, Richard E. Galat, Mamta Behl, Edward D. Levin.
Neurotoxicology (2017). DOI: https://doi.org/10.1016/j.neuro.2017.09.007 PMID: 28935585

Dietary methoxychlor exposure modulates splenic natural killer cell activity, antibody-forming cell response and phenotypic marker expression in F0 and F1 generations of Sprague Dawley rats

White KL Jr, Germolec DR, Booker CD, Hernendez DM, McCay JA, Delclos KB, Newbold RR, Weis C, Guo TL.
Toxicology (2005) DOI: https://doi.org/ 10.1016/j.tox.2004.09.011 PMID: 15596257

Differences in the Rate of in Situ Mammary Gland Development and Other Developmental Endpoints in Three Strains of Female Rat Commonly Used in Mammary Carcinogenesis Studies: Implications for Timing of Carcinogen Exposure

Stanko JP, Kissling GE, Chappell VA, Fenton SE.
Toxicol Pathol (2016), DOI: http:/dx.doi.org/10.1177/0192623316655222 PMID: 27613105

Differential DNA Methylation Profile of Key Genes in Malignant Prostate Epithelial Cells Transformed by Inorganic Arsenic or Cadmium

Katherine E. Pelch, Erik J. Tokar, B. Alex Merrick, Michael P. Waalkes.
Toxicol Appl Pharmacol. (2015) DOI: https://doi.org/10.1016/j.taap.2015.04.011 PMID: 25922126

Differential stimulation of IgE production, STAT activation and cytokine and CD86 expression by 2,4-dinitrochlorobenzene and trimellitic anhydride

Guo TL, Zhang XL, Leffel EK, Peachee VL, Karrow NA, Germolec DR, White KL Jr.
Journal of Immunotoxicology (2018) DOI: https://doi.org/10.1002/jat.876 PMID: 12424743

Disposition and Metabolism of 2',2'''-Dithiobisbenzanilide in Rodents following Intravenous and Gavage Administration and Dermal Application

C. Edwin Garner, Christopher J. Wegerski, Joseph Lucak, Melanie Doyle-Eisele, Jacob D. McDonald, J. Michael Sanders, Benjamin C. Moeller and Suramya Waidyanatha

Radiolabel Description:
Carbon-14 uniformly on the rings; 2',2'''-Dithiobisbenzanilide, [phenyl-¹⁴C(U)]-

Vehicles:
Intravenous, emulphor:ethanol:water (3:5:2) or dimethylacetamide:polyethylene glycol 400:saline (15:55:30); Oral methylcellulose; Dermal, ethanol or acetone

Additional Information:
Two different vehicles were used for the rat 4 mg/kg intravenous treatments. Study C used water:ethanol:alkamuls (3:5:2) vehicle and Study C-2, dimethylacetamide:PEG400:saline (15:40:45).

Disposition and Metabolism of 2,2’-Dimorpholinodiethyl Ether in Harlan Sprague Dawley Rats and B6C3F1/N Mice after Oral, Intravenous Administration, and Dermal Application

Jacob D. McDonald, J. Michael Sanders, C. Edwin Garner, Melanie Doyle-Eisele, Benjamin C. Moeller and Suramya Waidyanatha

https://doi.org/10.22427/NTP-DATA-002-02085-0009-0000-6

Radiolabel Description:
Carbon-14 on the ring carbons adjacent to the nitrogen; 2,2'-Dimorpholinodiethyl ether, [morpholine-2,6-¹⁴C]-

Vehicles:
Intravenous, saline; Oral, purified water; Dermal, ethanol.

Disposition and Metabolism of the Bisphenol Analogue, Bisphenol S, in Harlan Sprague Dawley Rats and B6C3F1/N Mice and In Vitro in Hepatocytes from Rats, Mice, and Humans

Suramya Waidyanatha, Sherry R. Black, Rodney W. Snyder, Yun Lan Yueh, Vicki Sutherland, Purvi R. Patel, Scott L. Watson, and Timothy R. Fennell.
Toxicology and Applied Pharmacology (2018) DOI: https://doi.org/10.1016/j.taap.2018.05.008 PMID: 29753715

Disposition and metabolism of Ethylene glycol 2-ethylhexyl ether in Sprague Dawley rats, B6C3F1/N mice, and in vitro in rat hepatocytes

Atlee T. D. Watson, Benjamin C. Moeller, Melanie Doyle-Eisele, C. Edwin Garner, Chad R. Blystone, Jacob D. McDonald, and Suramya Waidyanatha

Radiolabel Description:
Carbon-14 in 2 positions: Ethylene glycol 2-ethylhexyl ether, [2-ethylhexyl-1-¹⁴C, ethylene glycol-1-¹⁴C]-

Vehicles:
Oral, corn oil; Dermal, ethanol.

DOI: https://doi.org/10.22427/NTP-DATA-002-03310-0005-0000-4

Disposition and metabolism of N-butylbenzenesulfonamide in Sprague Dawley rats and B6C3F1/N mice and in vitro in hepatocytes from rats, mice, and humans

Radiolabel Description:
carbon-14 uniformly in the ring; N-Butylbenzenesulfonamide, [ring-14C(U)]-

Vehicles:
Intravenous, ethanol:Cremophor:water (10:10:80); oral, 0.5% methyl cellulose.

Toxicology Letters (2020): https://pubmed.ncbi.nlm.nih.gov/31760063/
DOI: https://doi.org/10.22427/NTP-DATA-002-03240-0010-0000-2

Disposition and metabolism of antibacterial agent, Triclocarban; a species and route comparison

Suramya Waidyanatha, Sherry R. Black, Purvi R. Patel, Jason Stanko, Scott L. Watson, Rodney W. Snyder, and Timothy R. Fennell

https://doi.org/10.22427/NTP-DATA-002-02949-0005-0000-1

Radiolabel Description:
Carbon-14 in the phenyl ring with one chloride; Triclocarban, [Chlorophenyl ring-¹⁴C(U)]-

Vehicles:
Oral, corn oil; Dermal, acetone.

Disposition and metabolism of sulfolane in Harlan Sprague Dawley rats and B6C3F1/N mice and in vitro in hepatocytes from rats, mice, and humans

Waidyanatha S, Black S, Blystone C, Patel P,Watson S, Snyder R, Fennell T
DOI: https://doi.org/10.22427/NTP-DATA-002-03276-0014-0000-5

Disposition of Tris(4-chlorophenyl)methanol and Tris(4-chlorophenyl)methane in Male and Female Harlan Sprague Dawley Rats and B6C3F1/N Mice Following Oral and Intravenous Administration

Natasha Catlin, Suramya Waidyanatha, Sherry R. Black, James Mathews, Rodney W Snyder, Purvi Patel, Scott Watson, and Timothy R Fennell.
Xenobiotica (2018) DOI: https://doi.org/10.1080/00498254.2018.1463475 PMID: 29659319

Disposition of β-N-methylamino-L-alanine (L-BMAA), a Neurotoxin, in Rodents Following a Single or Repeated Oral Exposure

Suramya Waidyanatha, Kristen Ryan, J. Michael Sanders, Jacob D. McDonald, Christopher J. Wegerski, Melanie Doyle-Eisle, C. Edwin Garner
Toxicology and Applied Pharmacology (2018). DOI: https://doi.org/10.1016/j.taap.2017.12.008 PMID: 29248465

Dose-Response Assessment of the Dermal Toxicity of Virginia Cedarwood Oil in F344/N Rats and B6C3F1/N Mice

Catlin NR, Herbert R, Janardhan K, Hejtmancik MR, Fomby LM, Vallant M, Kissling GE, DeVito MJ.
Food Chem Toxicol. (2016) DOI: http:/dx.doi.org/10.1016/j.fct.2016.10.016 PMID: 27769849

Dose–Response Analysis of RNA-Seq Profiles in Archival Formalin-Fixed Paraffin-Embedded Samples

Susan D. Hester, Virunya Bhat, Brian N. Chorley, Gleta Carswell, Wendell Jones, Leah C. Wehmas, Charles E. Wood
Toxicological Sciences (2016) DOI: https://doi.org/10.1093/toxsci/kfw161 PMID: 27562560

DrugMatrix

DRUGMATRIX is a registered trademark of the U.S. Department of Health and Human Services (HHS)

This page will be updated with more data as it becomes available.

DOI: https://doi.org/10.22427/NTP-DATA-107-022-001-000-3

ERα36, a Variant of Estrogen Receptor α, is Predominantly Localized in Mitochondria of Human Uterine Smooth Muscle and Leiomyoma Cells

Yan Y, Yu L, Castro L, Dixon D.
PLoS One. 2017 DOI: https://doi.org/10.1371/journal.pone.0186078 PMID: 29020039

Effect of Cell Phone Radiofrequency Radiation on Body Temperature in Rodents: Pilot Studies of the National Toxicology Program's Reverberation Chamber Exposure System

Michael E. Wyde, Thomas L. Horn, Myles H. Capstick, John M. Ladbury, Galen Koepke, Perry F. Wilson, Grace E. Kissling, Matthew D. Stout, Niels Kuster, Ronald L. Melnick, James Gauger, John R. Bucher, and David L. McCormick.
Bioelectromagnetics (2018) DOI: https://doi.org/10.1002/bem.22116 PMID: 29537695

Effect of Graded Nrf2 Activation on Phase-I and -II Drug Metabolizing Enzymes and Transporters in Mouse Liver

Kai Connie Wu, Julia Yue Cui, Curtis D. Klaassen
PLoS One (2012) DOI: https://doi.org/10.1371/journal.pone.0039006 PMID: 22808024

Effects of Bisphenol A on Incidence and Severity of Cardiac Lesions in the NCTR-Sprague-Dawley rat: A CLARITY-BPA Study

Robin Gear, Jessica A. Kendziorski, and Scott M. Belcher.
Toxicology Letters (2017) DOI: https://doi.org/10.1016/j.toxlet.2017.05.011 PMID: 28499613

Effects of Continuous Bisphenol A Exposure from Early Gestation on 90 Day Old Rat Testes Function and Sperm Molecular Profiles: A CLARITY-BPA Consortium Study

Edward Dere, Linnea M. Anderson, Susan M. Huse, Daniel J. Spade, Elizabeth McDonnell-Clark, Samantha J. Madnick, Susan J. Hall, Luísa Camacho, Sherry M. Lewis, Michelle M. Vanlandingham, and Kim Boekelheide.
Toxicology and Applied Pharmacology (2018) DOI: https://doi.org/10.1016/j.taap.2018.03.021 PMID: 29596923

Effects of Developmental Exposure to Bisphenol A on Spatial Navigational Learning and Memory in Rats: A CLARITY-BPA Study

Sarah A. Johnson, Angela B. Javurek, Michele S. Painter, Mark R. Ellersieck, Thomas H. Welsh, Jr., Luísa Camacho, Sherry M. Lewis, Michelle M. Vanlandingham, Sherry A. Ferguson, and Cheryl S. Rosenfeld.
Hormones and Behavior (2016) DOI: https://doi.org/10.1016/j.yhbeh.2015.09.005 PMID: 26436835

Effects of Perfluorinated Chemicals on Thyroid Function, Markers of Ovarian Reserve, and Natural Fertility

Natalie M. Crawford, Suzanne E. Fenton, Mark Strynar, Erin P. Hines, David A. Pritchard, and Anne Z. Steiner.
Reproductive Toxicology (2017) DOI: https://doi.org/10.1016/j.reprotox.2017.01.006 PMID: 28111093

Effects of Perinatal Bisphenol A Exposure on the Volume of Sexually-dimorphic Nuclei of Juvenile Rats: A CLARITY-BPA Consortium Study

Sheryl E. Arambula, Joelle Fuchs, Jinyan Cao, and Heather B. Patisaul.
NeuroToxicology (2017) DOI: https://doi.org/10.1016/j.neuro.2017.09.002 PMID: 28890130

Effects of perinatal hydroxyurea treatment and investigation of maternal transfer and age-dependency of toxicokinetics in Sprague Dawley rats

Madelyn Huang, Katie Turner, Molly Vallant, Yi Lu, Catherine Price, Timothy Fennell, Melanie A. Silinski, Suramya Waidyanatha, Kristen Ryan, Sherry R. Black, Reshan Fernando, Barry McIntyre

DOI: https://doi.org/10.22427/NTP-DATA-002-02275-0007-0000-5

Embryo-Fetal Development Studies with The Dietary Supplement Vinpocetine in The Rat and Rabbit

Natasha Catlin, Suramya Waidyanatha, Eve Mylchreest, Lutfiya Miller-Pinsler, Helen Cunny, Paul Foster, Vicki Sutherland, Barry McIntyre
Birth Defects Research (2018) DOI: https://doi.org/10.1002/bdr2.1207 PMID: 29460393

Embryonic Vascular Disruption Adverse Outcomes: Linking High Throughput Signaling Signatures with Functional Consequences

Ellis-Hutchings RG, Settivari RS, McCoy AT, Kleinstreuer N, Franzosa J, Knudsen TB, Carney EW.
Reproductive Toxicology (2017) DOI: https://doi.org/10.1016/j.reprotox.2017.05.005 PMID: 28527947

Evaluation of 4-methylcyclohexanemethanol (MCHM) in a Combined Irritancy and Local Lymph Node Assay (LLNA) in Mice

Johnson VJ, Auerbach SS, Luster MI, Waidyanatha S, Masten SA, Wolfe MS, Burleson FG, Burleson GR, Germolec DR.
Food and Chemical Toxicology (2017) DOI: https://doi.org/10.1016/j.fct.2017.03.034 PMID: 28343035

Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes

William M. Gwinn, Scott S. Auerbach, Fred Parham, Matthew D. Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, B. Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R. Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R. Shah, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Georgia Roberts, Michael J. DeVito

CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005

Evaluation of Immunotoxicity of Sodium Metavanadate Following Drinking Water Exposure in Female B6C3F1/N Mice in a 28-day Study

Rachel Frawley, Victor J. Johnson, Gary R. Burleson, Keith R Shockley, Mark F. Cesta, Greg Travlos, Michelle Cora, Georgia Roberts, Dori Germolec

TOX-106 Vanadium Compounds (Sodium Metavanadate and Vanadyl Sulfate): Abstract for TOX-106
DOI: https://doi.org/10.22427/NTP-DATA-500-001-001-000-7

Evaluation of Maternal, Embryo, and Placental Effects in CD-1 Mice following Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide Dimer Acid (HFPO-DA or GenX)

Bevin E. Blake, Harlie A. Cope, Samantha M. Hall, Robert D. Keys, Beth W. Mahler, James McCord, Brittany Scott, Heather M. Stapleton, Mark J. Strynar, Susan A. Elmore, Suzanne E. Fenton
Environmental Health Perspectives(2020) DOI: https://doi.org/10.1289/EHP6233 PMID: 32074459 PMCID: PMC7064328
DOI: https://doi.org/10.22427/NTP-DATA-021-00006-0001-0000-0

Evaluation of Prenatal Exposure to Bisphenol Analogues on Development and Long-Term Health of the Mammary Gland in Female Mice

Tucker DK, Hayes Bouknight S, Brar SS, Kissling G, Fenton S
Environmental Health Perspectives(2018) DOI: https://doi.org/10.1289/EHP3189 PMID:30102602
DOI: https://doi.org/10.22427/NTP-DATA-021-00004-0001-0000-8

Evaluation of Skin Sensitization Induced by Four Ionic Liquids

Rachel Frawley, Dori Germolec, Victor Johnson, Travis Gulledge, Wimolnut Manheng, Kimber White Jr, Keith R Shockley, Shawn F Harris, Michelle Hooth, Kristen Ryan

Note: Data from this study are available upon request

DOI: https://doi.org/10.22427/NTP-DATA-002-03253-0003-0000-8

Evaluation of the Respiratory Tract Toxicity of ortho-Phthalaldehyde, a Proposed Alternative for the Chemical Disinfectant Glutaraldehyde

Natasha R. Catlin, Cynthia J. Willson, Matthew Stout, Grace E. Kissling, Suramya Waidyanatha, Gregory L. Baker, Barry K. Hayden, Michael Wyde.
Inhalation Toxicology (2017). DOI: https://doi.org/10.1080/08958378.2017.1390015 PMID: 29039228

Evaluation of the herbicide glyphosate, (aminomethyl)phosphonic acid, and glyphosate-based formulations for genotoxic activity using in vitro assays

Stephanie L. Smith-Roe, Carol D. Swartz, Asma Rashid, Nicholas C. Christy, Jamie E. Sly, Xiaoqing Chang, Nisha S. Sipes, Keith R. Shockley, Shawn F. Harris, Sandra J. McBride, Gary J. Larson, Bradley J. Collins, Esra Mutlu, Kristine L. Witt

Environmental and Molecular Mutagenesis: https://onlinelibrary.wiley.com/doi/10.1002/em.22534
DOI: https://doi.org/10.22427/NTP-DATA-002-02220-0014-0000-3

Two data values for one concentration in the 4 h +S9 experimental condition were corrected after a quality assurance audit. This finding did not impact the interpretation of the study.

Evaluation of the immunomodulatory effects of the disinfection by-product, sodium chlorite, in female B6C3F1 mice: a drinking water study

Karrow NA, Guo TL, McCay JA, Johnson GW, Brown RD, Musgrove DL, Germolec DR, Luebke RW, White KL Jr.
Journal of Immunotoxicology (2018) DOI: https://doi.org/10.1081/DCT-100103722 PMID: 11452397

Evaluation of the immunomodulatory effects of the macrolide antibiotic, clarithromycin, in female B6C3F1 mice: a 28-day oral gavage study

Karrow NA, McCay JA, Brown RD, Musgrove DL, Germolec DR, White KL Jr.
Drug Chem Toxicol (2001) DOI: https://doi.org/10.1081/DCT-100103083 PMID: 11307632

Evidence for an Aneugenic Mechanism of Action for Micronucleus Induction by Black Cohosh Extract

Derek T. Bernacki, Steven M. Bryce, Jeffrey C. Bemis, Stephen D. Dertinger, Kristine L. Witt, Stephanie L. Smith-Roe
Environmental and Molecular Mutagenesis, (in press): First Published: 30 September 2019 DOI: https://doi.org/10.1002/em.22334

Experimental studies of the hematologic and immune system toxicity of nucleoside derivatives used against HIV infection

Luster MI, Rosenthal GJ, Cao W, Thompson MB, Munson AE, Prejean JD, Shopp G, Fuchs BA, Germolec DR, Tomaszewski JE.
Toxicol Appl Pharmacol (1989) DOI: https://doi.org/ PMID: 1668555

Exploring Drug Space with ChemMaps.com

Alexandre Borrel, Nicole Kleinstreuer, and Denis Fourches.
Bioinformatics (2018) DOI: https://doi.org/10.1093/bioinformatics/bty412 PMID: 29790904

Exposure to Select PFAS and PFAS Mixtures Alters Response to Platinum-Based Chemotherapy in Endometrial Cancer Cell Lines

Brittany P. Rickard, Marta Overchuk, Justin Tulino, Xianming Tan, Frances S. Ligler, Victoria L. Bae-Jump, Suzanne E. Fenton, and Imran Rizvi

DOI: https://doi.org/10.22427/NTP-DATA-500-009-001-000-5

Expression Studies, Supporting Data

Expression Studies Dataset: DOI: https://doi.org/10.22427/NTP-DATA-022-00004-0003-000-1

DOI: https://doi.org/10.22427/NTP-DATA-002-00094-0003-0000-8

Gene Expression Alterations in Immune System Pathways in the Thymus Following Exposure to Immunosuppressive Chemicals

Rachel Frawley, Kimber White, Jr., Ronnetta Brown, Deborah Musgrove, Nigel Walker, Dori Germolec
Environmental Health Perspectives (2011) DOI: https://doi.org/10.1289/ehp.1002358 PMID: 21041162
DOI: https://doi.org/10.22427/NTP-DATA-002-00086-0001-0000-6

Gene Ontology Mapping as an Unbiased Method for Identifying Molecular Pathways and Processes Affected by Toxicant Exposure: Application to Acute Effects Caused by the Rodent Non-Genotoxic Carcinogen Diethylhexylphthalate

Richard A. Currie, Vincent Bombail, Jason D. Oliver, David J. Moore, Fei Ling Lim, Victoria Gwilliam, Ian Kimber, Kevin Chipman, Jonathan G. Moggs, George Orphanides
Toxicological Sciences (2005) DOI: https://doi.org/10.1093/toxsci/kfi207 PMID: 15901911

Genetic versus Chemoprotective Activation of Nrf2 Signaling: Overlapping yet Distinct Gene Expression Profiles between Keap1 Knockout and Triterpenoid-treated Mice

Melinda S. Yates, Quynh T. Tran, Patrick M. Dolan, William O. Osburn, Soona Shin, Colin C. McCulloch, Jay B. Silkworth, Keiko Taguchi, Masayuki Yamamoto, Charlotte R. Williams, Karen T. Liby, Michael B. Sporn, Thomas R. Sutter, Thomas W. Kensler
Carcinogenesis (2009). DOI: https://doi.org/10.1093/carcin/bgp100 PMID: 19386581

Genistein modulates immune responses and increases host resistance to B16F10 tumor in adult female B6C3F1 mice

Guo TL, McCay JA, Zhang LX, Brown RD, You L, Karrow NA, Germolec DR, White KL Jr.
Journal of Immunotoxicology (2018) DOI: https://doi.org/10.1093/jn/131.12.3251 PMID: 11739876

Genistein modulates splenic natural killer cell activity, antibody-forming cell response, and phenotypic marker expression in F(0) and F(1) generations of Sprague-Dawley rats

Guo TL, White KL Jr, Brown RD, Delclos KB, Newbold RR, Weis C, Germolec DR, McCay JA.
Toxicol Appl Pharmacol (2002) DOI: https://doi.org/10.1006/taap.2002.9418 PMID: 12079431

Genistein protects female nonobese diabetic mice from developing type 1 diabetes when fed a soy- and alfalfa-free diet

Guo TL, Germolec DR, Zheng JF, Kooistra L, Auttachoat W, Smith MJ, White KL, Elmore SA.
Toxicol Pathol (2015) DOI: https://doi.org/10.1177/0192623314526318 PMID: 24713318

Genome-Wide Binding and Transcriptome Analysis of Human Farnesoid X Receptor in Primary Human Hepatocytes

Le Zhan, Hui-Xin Liu, Yaping Fang, Bo Kong, Yuqi He, Xiao-bo Zhong, Jianwen Fang, Yu-Jui Yvonne Wan, Grace L. Guo
PLoS ONE (2014) DOI: https://doi.org/10.1371/journal.pone.0105930 PMID: 25198545

Genomic Models of Short-Term Exposure Accurately Predict Long-Term Chemical Carcinogenicity and Identify Putative Mechanisms of Action

Daniel Gusenleitner, Scott S. Auerbach, Tisha Melia, Harold F. Gómez, David H. Sherr, Stefano Monti
PLoS ONE (2014) DOI: https://doi.org/10.1371/journal.pone.0102579 PMID: 25058030

Gestational Exposure to Perfluorooctanoic Acid (PFOA): Alterations in Motor Related Behaviors

David R. Goulding, Sally S. White, Sandra J. McBride, Suzanne E. Fenton, and G. Jean Harry.
Neurotoxicology (2017) DOI: https://doi.org/10.1016/j.neuro.2016.11.008 PMID: 27888120

Glycidol modulation of the immune responses in female B6C3F1 mice

Guo TL, McCay JA, Brown RD, Musgrove DL, Butterworth L, Munson AE, Germolec DR, White KL Jr.
Drug Chem Toxicol (2000) DOI: https://doi.org/10.1081/DCT-100100127 PMID: 10959546

Health Consequences of Electric Lighting Practices in The Modern World: A Report on The National Toxicology Program's Workshop on Shift Work At Night, Artificial Light At Night, and Circadian Disruption

Lunn RM, Blask DE, Coogan AN, Figueiro MG, Gorman MR, Hall JE, Hansen J, Nelson RJ, Panda S, Smolensky MH, Stevens RG, Turek FW, Vermeulen R, Carreón T, Caruso CC, Lawson CC, Thayer KA, Twery MJ, Ewens AD, Garner SC, Schwingl PJ, Boyd WA.
The Science of the Total Environment (2017) DOI: https://doi.org/10.1016/j.scitotenv.2017.07.056 PMID: 28724246

Heart Related Biomarker Summaries

DOI: https://doi.org/10.22427/NTP-DATA-500-010-006-000-2

Histology Atlas of the Developing Prenatal and Postnatal Mouse Central Nervous System, with Emphasis on Prenatal Days E7.5 to E18.5

Vivian S. Chen, James P. Morrison, Myra F. Southwell, Julie F. Foley, Brad Bolon, and Susan A. Elmore.
Toxicologic Pathology (2017) DOI: https://doi.org/10.1177/0192623317728134 PMID: 28891434

House Dust Endotoxin and Peripheral Leukocyte Counts: Results from Two Large Epidemiologic Studies

Michael B. Fessler, Megan U. Carnes, Päivi M. Salo, Jesse Wilkerson, Richard D. Cohn, Debra King, Jane A. Hoppin, Dale P. Sandler, Greg Travlos, Stephanie J. London, Peter S. Thorne, and Darryl C. Zeldin.
Environmental Health Perspectives (2017). DOI: https://doi.org/10.1289/EHP661 PMID: 28599265

Identification of Estrogen-Related Receptor Alpha Agonists in the Tox21 Compound Library

Caitlin Lynch, Jinghua Zhao, Ruili Huang, Noriko Kanaya, Lauren Bernal, Jui-Hua Hsieh, Scott S Auerbach, Kristine L Witt, B Alex Merrick, Shiuan Chen, Christina T Teng, and Menghang Xia.
Endocrinology (2018). DOI: https://doi.org/10.1210/en.2017-00658 PMID: 29216352

Identification of Novel NRF2-regulated Genes by ChIP-Seq: Influence on Retinoid X Receptor alpha

Brian N. Chorley, Michelle R. Campbell, Xuting Wang, Mehmet Karaca, Deepa Sambandan, Fatu Bangura, Peng Xue, Jingbo Pi, Steven R. Kleeberger, Douglas A. Bell
Nucleic Acids Research (2012). DOI: https://doi.org/10.1093/nar/gks409 PMID: 22581777

Identification of Vascular Disruptor Compounds by Analysis in Zebrafish Embryos and Mouse Embryonic Endothelial Cells

McCollum CW, Conde-Vancells J, Hans C, Vazquez-Chantada M, Kleinstreuer N, Tal T, Knudsen T, Shah SS, Merchant FA, Finnell RH, Gustafsson JÅ, Cabrera R, Bondesson M.
Reproductive Toxicology (2017) DOI: https://doi.org/10.1016/j.reprotox.2016.11.005 PMID: 27838387

Identification of p53 Activators in a Human Microarray Compendium

Corton JC, KL Witt and CL Yauk
Chemical Research in Toxicology (2019) v. 32 (9): pp. 1748-1759 DOI: https://doi.org/10.1021/acs.chemrestox.9b00052

Identifying Environmental Chemicals as Agonists of the Androgen Receptor by using a Quantitative High-Throughput Screening Platform

Lynch C, Sakamuru S, Huang R, Stavreva DA, Varticovski L, Hager GL, Judson RS, Houck KA, Kleinstreuer NC, Casey W, Paules RS, Simeonov A, Xia M.
Toxicology (2017) DOI: https://doi.org/10.1016/j.tox.2017.05.001 PMID: 28478275

Immunohistochemical Analysis of Rat Renal Tumours Caused by Ochratoxin A

Diana Herman and Peter Mantle.
Toxins (2017). DOI: https://doi.org/10.3390/toxins9120384 PMID: 29182526

Immunohistochemistry in Investigative and Toxicologic Pathology

Kyathanahalli S. Janardhan, Heather Jensen, Natasha P. Clayton, and Ronald A. Herbert
Toxicologic Pathology (2018) DOI: http://dx.doi.org/10.1177/0192623318776907 PMID: 29966501

Immunomodulation in female B₆C₃F₁ mice following treatment with the HIV protease inhibitor saquinavir for 28 days by gavage

Guo TL, Germolec DR, Roesh DM, White KL Jr.
Journal of Immunotoxicology (2010) DOI: https://doi.org/10.3109/1547691X.2010.495097 PMID: 20560775

Immunomodulatory activity of orphan drug Elmiron® in female B6C3F1/N mice

Thakur SA, Nyska A, White KL Jr, Smith MJ, Auttachoat W, Germolec DR.
Food Chem Toxicol. (2014) DOI: https://doi.org/10.1016/j.fct.2014.03.015 PMID: 24657363

Immunotoxic Effects of Sodium Tungstate Dihydrate on Female B6C3F1/N Mice When Administered in Drinking Water

Frawley RP, Smith MJ, White KL Jr, Elmore SA, Herbert R, Moore R, Staska LM, Behl M, Hooth MJ, Kissling GE, Germolec DR.
J Immunotoxicol. (2016). DOI: https://doi.org/10.3109/1547691X.2016.1154118 PMID: 27223060

Immunotoxic and Hepatotoxic Effects of Perfluoro-n-decanoic Acid (PFDA) on Female Harlan Sprague–Dawley Rats and B6C3F1/N Mice when Administered by Oral Gavage for 28 Days

Rachel P. Frawley, Matthew Smith, Mark F. Cesta, Schantel Hayes-Bouknight, Chad Blystone, Grace E. Kissling, Shawn Harris & Dori Germolec.
Journal of Immunotoxicology (2018) DOI: https://doi.org/10.1080/1547691X.2018.1445145 PMID: 29514525

Immunotoxicity Studies of Sulfolane Following Developmental Exposure in Hsd:Sprague Dawley SD Rats and Adult Exposure in B6C3F1/N Mice.

K A Shipkowski ¹, M C Cora ¹, M F Cesta ¹, V G Robinson ¹, S Waidyanatha ¹, K L Witt ¹, M K Vallant ¹, D M Fallacara ², M R Hejtmancik ², S A Masten ¹, S D Cooper ³, R A Fernando ³, C R Blystone ¹

¹Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
²Battelle Memorial Institute, Columbus, OH, USA.
³RTI International, Research Triangle Park, NC, USA.

Note: The PA46 was updated on September 14, 2021 for updates to stats for calculation of % animals with a finding.

Note: M09 was updated for number of spleen cells on September 1, 2021. The new tables contain a correction to a typographical error in the units for the Ig concentrations.

Note: M07 was updated for number of spleen cells on July 22, 2021. The I07 was updated on August 12, 2021 to reflect updated footnotes. The I04G was also updated on August 22, 2021 to reflect updated statistical analysis.

DOI: https://doi.org/10.22427/NTP-DATA-002-03276-0016-0000-7

Immunotoxicity of 180 day exposure to polydimethylsiloxane (silicone) fluid, gel and elastomer and polyurethane disks in female B6C3F1 mice

Bradley SG, White KL Jr, McCay JA, Brown RD, Musgrove DL, Wilson S, Stern M, Luster MI, Munson AE.
Drug Chem Toxicol (1994) DOI: https://doi.org/10.3109/01480549409017861 PMID: 7988384

Immunotoxicity of N-Butylbenzenesulfonamide (NBBS): Impacts on Immune Function in Adult Mice and Developmentally Exposed Rats

Victor J. Johnson¹, Cynthia V. Rider², Michael I. Luster¹, Amy Brix³, Gary R. Burleson¹, Michelle Cora², Susan A. Elmore², Rachel P. Frawley², Franklin R. Lopez⁴, Esra Mutlu², Keith R. Shockley^2,5, Jessica Pierfelice⁶, Brian Burback⁶, Caroll A. Co⁷, Dori R. Germolec²

¹Burleson Research Technologies, Inc., Morrisville, NC, USA
²Division of Translational Toxicology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
³Experimental Pathology Laboratories, Inc., Morrisville, NC, USA
⁴Charles River Laboratories, Morrisville, NC USA
⁵Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
⁶Battelle, Columbus, OH, USA
⁷Social and Scientific Systems Inc., a DLH Holdings Corp Company, Durham, NC, USA

DOI: https://doi.org/10.22427/NTP-DATA-500-005-003-000-3

Immunotoxicity of dibromoacetic acid administered via drinking water to female B₆C₃F₁ mice

Smith MJ, Germolec DR, Luebke RW, Sheth CM, Auttachoat W, Guo TL, White KL Jr.
Journal of Immunotoxicology (2010) DOI: https://doi.org/110.3109/1547691X.2010.519744 PMID: 20958156

Immunotoxicity of sodium bromate in female B6C3F1 mice: a 28-day drinking water study

Guo TL, McCay JA, Karrow NA, Brown RD, Musgrove DL, Luebke RW, Germolec DR, White KL Jr.
Journal of Immunotoxicology (2018) DOI: https://doi.org/10.1081/DCT-100102606 PMID: 11360431

Immunotoxicity studies of trans-resveratrol in male B6C3F1/N mice

Madelyn C. Huang, Kimber L. White Jr., Susan A. Elmore, Tai L. Guo, Dori Germolec

DOI: https://doi.org/10.22427/NTP-DATA-002-02772-0033-0000-6

Immunotoxicological profile of chloramine in female B6C3F1 mice when administered in the drinking water for 28 days

Guo TL, Germolec DR, Collins BJ, Luebke RW, Auttachoat W, Smith MJ, White KL.
Journal of Immunotoxicology (2011) DOI: https://doi.org/10.3109/1547691X.2011.622317 PMID: 22017662

Immunotoxicological profile of chloroform in female B6C3F1 mice when administered in drinking water

Auttachoat W, Germolec DR, Collins BJ, Luebke RW, White KL Jr, Guo TL.
Journal of Immunotoxicology (2018) DOI: https://doi.org/10.1080/1547691X.2018.1445145 PMID: https://doi.org/10.1080/1547691X.2018.1445145 PMID: 19514942

Immunotoxicology: a Brief History, Current Status and Strategies for Future Immunotoxicity Assessment

Dori Germolec, Robert Luebke, Andrew Rooney, Kelly Shipkowski, Rob Vandebriel, Henk van Loveren.
Current Opinion in Toxicology (2017). DOI: https://doi.org/10.1016/j.cotox.2017.08.002 PMID: 28989989

Impact of Low Dose Oral Exposure to Bisphenol A (BPA) on the Neonatal Rat Hypothalamic and Hippocampal Transcriptome: A CLARITY-BPA Consortium Study

Sheryl E. Arambula, Scott M. Belcher, Antonio Planchart, Stephen D. Turner, and Heather B. Patisaul.
Endocrinology (2016). DOI: https://doi.org/10.1210/en.2016-1339 PMID: 27571134

Impact of Low-Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: A CLARITY-BPA Consortium Study

Meghan E. Rebuli, Luísa Camacho, Maria E. Adonay, David M. Reif, David L. Aylor, and Heather B. Patisaul.
Toxicological Sciences (2015) DOI: https://doi.org/10.1093/toxsci/kfv163 PMID: 26209558

In Silico Prediction of Physicochemical Properties of Environmental Chemicals Using Molecular Fingerprints and Machine Learning

Zang Q, Mansouri K, Williams AJ, Judson RS, Allen DG, Casey WM, Kleinstreuer NC.
Journal of Chemical Information and Modeling (2017) DOI: https://doi.org/10.1021/acs.jcim.6b00625 PMID: 28006899

In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making

Shannon M. Bell, Xiaoqing Chang, John F. Wambaugh, David G. Allen, Mike Bartels, Kim L.R. Brouwer, Warren M. Casey, Neepa Choksi, Stephen S. Ferguson, Grazyna Fraczkiewicz, Annie M. Jarabek, Alice Ke, Annie Lumen, Scott G. Lynn, Alicia Paini, Paul S. Price, Caroline Ring, Ted W. Simon, Nisha S. Sipes, Catherine S. Sprankle, Judy Strickland, John Troutman, Barbara A. Wetmore, Nicole C. Kleinstreuer.
Toxicology in Vitro (2018). DOI: https://doi.org/10.1016/j.tiv.2017.11.016 PMID: 29203341

In utero Exposure to DDT and Incidence of Diarrhea Among Boys from Tropical Mexico

Lea A. Cupul-Uicab, Efraín A. Terrazas-Medina, Mauricio Hernández-Ávila, Matthew P. Longnecker.
Environmental Research (2017). DOI: https://doi.org/10.1016/j.envres.2017.08.027 PMID: 28841520

In vitro Cardiotoxicity Assessment of Environmental Chemicals Using an Organotypic Human Induced Pluripotent Stem Cell-Derived Model

Oksana Sirenko, Fabian A. Grimm, Kristen R. Ryan, Yasuhiro Iwata, Weihsueh A. Chiu, Frederick Parham, Jessica A. Wignall, Blake Anson, Evan F. Cromwell, Mamta Behl, Ivan Rusyn, and Raymond R. Tice.
Toxicology and Applied Pharmacology (2017) DOI: https://doi.org/10.1016/j.taap.2017.02.020 PMID: 28259702

Incidences of Mast Cell Tumor and Histiocytic Sarcoma in Rats in NTP Studies

DOI: https://doi.org/10.22427/NTP-DATA-002-00070-0001-0000-0

Influence of Study Design on Developmental and Reproductive Toxicology Study Outcomes

Paul M. D. Foster
Toxicologic Pathology (2017) DOI: https://doi.org/10.1177/0192623316671608 PMID: 27708197

Insecticide Use and Breast Cancer Risk among Farmers’ Wives in the Agricultural Health Study

Lawrence S. Engel, Emily Werder, Jaya Satagopan, Aaron Blair, Jane A. Hoppin, Stella Koutros, Catherine C. Lerro, Dale P. Sandler, Michael C. Alavanja, and Laura E. Beane Freeman
Environmental Health Perspectives (2017) DOI: https://doi.org/10.1289/EHP1295 PMID: 28934092

Integrating Drug's Mode of Action into Quantitative Structure-Activity Relationships for Improved Prediction of Drug-Induced Liver Injury

Leihong Wu, Zhichao Liu, Scott Auerbach, Ruili Huang, Minjun Chen, Kristin McEuen, Joshua Xu, Hong Fang, and Weida Tong.
Journal of Chemical Information and Modeling (2017) DOI: https://doi.org/10.1021/acs.jcim.6b00719 PMID: 28350954

Internal dose of vanadium in rats following repeated exposure to vanadyl sulfate and sodium orthovanadate via drinking water

James M. Harrington, Laura G. Haines, Keith E. Levine, Chamindu Liyanapatirana, Amal S. Essader, Reshan A. Fernando, Veronica G. Robinson, Georgia K. Roberts, Matthew D. Stout, Michelle J. Hooth and Suramya Waidyanatha

Toxicology and Applied Pharmacology (2020)
DOI: https://doi.org/10.1016/j.taap.2021.1153955 PMID: 33421504

Corrigendum to “Internal dose of vanadium in rats following repeated exposure to vanadyl sulfate and sodium orthovanadate via drinking water” Toxicology and Applied Pharmacology 412 (2021) Authors: James M. Harrington, Laura G. Haines, Keith E. Levine, Chamindu Liyanapatirana, Amal S. Essader, Reshan A. Fernando, Veronica G. Robinson, Georgia K. Roberts, Matthew D. Stout, Michelle J. Hooth and Suramya Waidyanatha PMID: 33905758

DOI: https://doi.org/10.22427/NTP-DATA-002-02993-0008-0000-3

Intestine Related Biomarker Summaries

DOI: https://doi.org/10.22427/NTP-DATA-500-010-007-000-3

Investigating the Generalizability of the MultiFlow® DNA Damage Assay and Several Companion Machine Learning Models with a Set of 103 Diverse Test Chemicals

Steven M Bryce, Derek T Bernacki, Stephanie L Smith-Roe, Kristine L Witt, Jeffrey C Bemis, and Stephen D Dertinger.
Toxicological Sciences (2017). DOI: https://doi.org/10.1093/toxsci/kfx235 PMID: 29106658

Is It Adverse, Nonadverse, Adaptive, or Artifact?

Pandiri AR, Kerlin RL, Mann PC, Everds NE, Sharma AK, Myers LP, Steinbach TJ.
Toxicol Pathol. (2016) DOI: http://dx.doi.org/10.1177/0192623316672352 PMID: 27770107

Kidney Related Biomarker Summaries

DOI: https://doi.org/10.22427/NTP-DATA-500-010-008-000-4

Latent, sex-specific metabolic health effects in CD-1 mouse offspring exposed to PFOA or HFPO-DA (GenX) during gestation

Harlie A. Cope, Bevin E. Blake, Charlotte Love, James McCord, Susan A. Elmore, Janice B. Harvey, Vesna A. Chappell, Suzanne E. Fenton
Science Direct (2021) https://doi.org/10.1016/j.emcon.2021.10.004 PMID: 35097227
DOI: https://doi.org/10.22427/NTP-DATA-002-02657-0013-0000-6

Liver Related Biomarker Summaries

DOI: https://doi.org/10.22427/NTP-DATA-500-010-009-000-5

Low Dose Assessment of the Carcinogenicity of Furan in Male F344/N Nctr Rats in a 2-Year Gavage Study

Von Tungeln LS, Walker NJ, Olson GR, Mendoza MC, Felton RP, Thorn BT, Marques MM, Pogribny IP, Doerge DR, Beland FA.
Food Chem Toxicol. (2016), DOI: http://dx.doi.org/10.1016/j.fct.2016.11.015 PMID: 27871980

Lung Anatomy + Particle Deposition (lapd) Mouse Archive for Modeling and Computational Toxicology

Authors:
Reinhard R. Beichel¹, Robb W. Glenny², Christian Bauer¹, Melissa A. Krueger², Wayne J. E. Lamm²
¹ University of Iowa, Dept. of Electrical and Computer Engineering
² University of Washington, Dept. of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine

Citations:
Bauer C, Krueger M, Lamm WJE, Glenny RW, Beichel RR. lapdMouse: associating lung anatomy with local particle deposition in mice. J Appl Physiol(1985). 2020 Feb 01;128(2):309-323. doi:10.1152/japplphysiol.00615.2019. PMID: 31774357.

RR Beichel, RW Glenny, C Bauer, MA Krueger, and WJ Lamm: “Lung anatomy + particle deposition (lapd) mouse archive.” University of Iowa. 2019. doi:10.25820/9arg-9w56.

DOI: https://doi.org/10.22427/NTP-DATA-501-001-003-000-0

Lung Deposition and Clearance of Microparticle and Nanoparticle C₆₀ Fullerene Aggregates in B6C3F1 Mice and Wistar Han Rats Following Nose-Only Inhalation for 13 Weeks

Sayers BC, Walker NJ, Roycroft JH, Germolec DR, Baker GL, Clark ML, Hayden BK, DeFord H, Dill JA, Gupta A, Stout MD.
Toxicology (2016). DOI: https://doi.org/10.1016/j.tox.2015.11.003 PMID: 26612504

Lung Related Biomarker Summaries

DOI: https://doi.org/10.22427/NTP-DATA-500-010-010-000-7

Mammary Gland Evaluation in Juvenile Toxicity Studies: Temporal Developmental Patterns in the Male and Female Harlan Sprague-Dawley Rat

Filgo AJ, Foley JF, Puvanesarajah S, Borde AR, Midkiff BR, Reed CE, Chappell VA, Alexander LB, Borde PR, Troester MA, Hayes Bouknight SA, Fenton SE.
Toxicol Pathol (2016), DOI: https://doi.org/10.1177/0192623316663864 PMID: 27613106

Metabolic Disruption Early in Life is Associated With Latent Carcinogenic Activity of Dichloroacetic Acid in Mice

Leah C. Wehmas, Anthony B. DeAngelo, Susan D. Hester, Brian N. Chorley, Gleta Carswell, Greg R. Olson, Michael H. George, Julia H. Carter, Sandra R. Eldridge, Anna Fisher, Beena Vallanat, Charles E. Wood
Toxicological Sciences (2017) DOI: https://doi.org/10.1093/toxsci/kfx146 PMID: 28962523

Metabolism and Disposition of 2-ethylhexyl-p-methoxycinnamate following Oral Gavage and Dermal Exposure in Harlan Sprague Dawley Rats and B6C3F1/N Mice and in Hepatocytes in vitro

Timothy R. Fennell, James M. Mathews, Rodney W. Snyder, Yan Hong, Scott L. Watson, Sherry R. Black, Barry S. McIntyre, and Suramya Waidyanatha.
Xenobiotica (2017). DOI: https://doi.org/10.1080/00498254.2017.1400129 PMID: 29111853

Modulation of immune response following dietary genistein exposure in F0 and F1 generations of C57BL/6 mice: evidence of thymic regulation

Guo TL, Chi RP, Zhang XL, Musgrove DL, Weis C, Germolec DR, White KL Jr.
Food Chem Toxicol (2005) DOI: https://doi.org/10.1016/j.fct.2005.08.001 PMID: 16162389

Molecular Effects of 1-Naphthyl-Methylcarbamate and Solar Radiation Exposures on Human Melanocytes

Bianca Ferrucio, Manoela Tiago, Richard D. Fannin, Liwen Liu, Kevin Gerrish, Silvya Stuchi Maria-Engler, Richard S. Paules, and Silvia Berlanga de Moraes Barros.
Toxicology in Vitro (2017) DOI: https://doi.org/10.1016/j.tiv.2016.11.005 PMID: 27829164

Mouse Population-Based Evaluation of Urinary Protein and miRna Biomarker Performance Associated with Cisplatin Renal Injury

Alison H Harrill, Haixia Lin, Julia Tobacyk, John C Seely
Experimental Biology and Medicine (2017). DOI: https://doi.org/10.1177/1535370217740854 PMID: 29110506

Multigenerational reproductive assessment of 4-methylimidazole administered in the diet to Hsd:Sprague Dawley SD rats

Mamta Behl, Cynthia J Willson, Helen Cunny, Paul M D Foster, Barry McIntyre, Cynthia Shackelford, Keith R Shockley, Sandra McBride, Katie Turner, Suramya Waidyanatha, Chad R Blystone

Reproductive Toxicology (2020) DOI: https://doi.org/10.1016/j.reprotox.2020.03.005 PMID: 32229253
DOI: https://doi.org/10.22427/NTP-DATA-002-01511-0000-0000-0

Multivariate Models for Prediction of Human Skin Sensitization Hazard

Judy Strickland, Qingda Zang, Michael Paris, David M. Lehmann, David Allen, Neepa Choksi, Joanna Matheson, Abigail Jacobs, Warren Casey, Nicole Kleinstreuer.
Journal of Applied Toxicology (2017) DOI: https://doi.org/10.1002/jat.3366 PMID: 27480324

NIEHS/FDA CLARITY-BPA research program update

Heindel JJ, Newbold RR, Bucher JR, Camacho L, Delclos KB, Lewis SM, Vanlandingham M, Churchwell MI, Twaddle NC, McLellen M, Chidambaram M, Bryant M, Woodling K, Gamboa da Costa G, Ferguson SA, Flaws J, Howard PC, Walker NJ, Zoeller RT, Fostel J, Favaro C, Schug TT.
Reprod Toxicol. (2015) DOI: https://doi.org/10.1016/j.reprotox.2015.07.075 PMID: 26232693

NTP Provantis Glossaries

NOTE:The NTP Fetal Observation Classification Glossary, NTP Clinical Observation Symptom Glossary and NTP Measurements and Endpoints Glossary are now searchable excel files

NTP short-term reproductive and developmental toxicity studies on triphenyl phosphate (TPHP) and isopropylated phenyl phosphate (IPP)

Shannah Witchey, Brad Collins, Georgia Roberts, Keith Shockley, Molly Vallant, Eve Mylchreest, Barney Sparrow, Robert Moyer, Tomas Guilarte, Helen Cunny, Jeffrey Krause, Mamta Behl

DOI: https://doi.org/10.22427/NTP-DATA-002-00600-0003-000-1

SOT Poster: https://ntp.niehs.nih.gov/ntp/results/pubs/posters/witchey_sot20210312.pdf

The I03/I03C, I04/I04G, R19/R19G/R19C were updated on November 8, 2021 due to updates in the statistics.

NTP/DTT Data Collections 2024-Present

DTT supports FAIR data principles . Two components of FAIR are Findability and Accessibility of curated data sets. Findability refers to the ability of users to locate and clearly identify compilations of data. Accessibility refers to the ability of users to access and integrate requested data easily and efficiently into workflows or processes.

In support of this aim, DTT is developing the NTP/DTT Data Collections, a selection of curated data sets that are available via a searchable User Interface (DTT Data Collections Guided Search) as well as via complete downloadable spreadsheets. These curated data sets are aligned with standard terminology from the DTT Data Dictionary while also maintaining pertinent legacy terms and will be updated approximately every month. Updates will include 1) the addition of new data to existing Data Collections, 2) modifications of existing Data Collections, 3) and addition of new Data Collections. Previous versions of each featured Data Collection on this page will be available for download by the user.

We welcome your comments on these Data Collections, as well as suggestions of topics for future Data Collections. Please contact dttresearchdatacoordinator@mail.nih.gov

DOI: https://doi.org/10.22427/NTP-DATA-110-021-001-000-6

Neurite Outgrowth in Human Induced Pluripotent Stem Cell-Derived Neurons as A High-Throughput Screen for Developmental Neurotoxicity or Neurotoxicity

Ryan KR, Sirenko O, Parham F, Hsieh JH, Cromwell EF, Tice RR, Behl M.
Neurotoxicology. 2016 DOI: https://doi.org/10.1016/j.neuro.2016.02.003 PMID: 26854185

New Rodent Population Models May Inform Human Health Risk Assessment and Identification of Genetic Susceptibility to Environmental Exposures

Alison H. Harrill and Kimberly A. McAllister
Environmental Health Perspectives (2017). DOI: https://doi.org/10.1289/EHP1274 PMID: 28886592

Non-Animal Methods to Predict Skin Sensitization (I): The Cosmetics Europe Database

Sebastian Hoffmann, Nicole Kleinstreuer, Nathalie Alépée, David Allen, Anne Marie Api, Takao Ashikaga, Elodie Clouet, Magalie Cluzel, Bertrand Desprez, Nichola Gellatly, Carsten Goebel, Petra S. Kern, Martina Klaric, Jochen Kühnl, Jon F. Lalko, Silvia Martinozzi-Teissier, Karsten Mewes, Masaaki Miyazawa, Rahul Parakhia, Erwin van Vliet, Qingda Zang, Dirk Petersohn
Critical Reviews in Toxicology (2018) DOI: https://doi.org/10.1080/10408444.2018.1429385 PMID: 29474128

Non-Animal Methods to Predict Skin Sensitization (II): An Assessment of Defined Approaches

Nicole C. Kleinstreuer, Sebastian Hoffmann, Nathalie Alépée, David Allen, Takao Ashikaga, Warren Casey, Elodie Clouet, Magalie Cluzel, Bertrand Desprez, Nichola Gellatly, Carsten Göbel, Petra S. Kern, Martina Klaric, Jochen Kühnl, Silvia Martinozzi-Teissier, Karsten Mewes, Masaaki Miyazawa, Judy Strickland, Erwin van Vliet, Qingda Zang, Dirk Petersohn.
Critical Reviews in Toxicology (2018) DOI: https://doi.org/10.1080/10408444.2018.1429386 PMID: 29474122

Non-targeted Chemical Analysis of Consumer Botanical Products Labelled as Blue Cohosh (Caulophyllum thalictroides), Goldenseal (Hydrastis canadensis), or Yohimbe Bark (Pausinystalia johimbe) by NMR and MS

Giovanni O. Quiroz-Delfi¹²³, Cynthia V. Rider³, Stephen Ferguson ³, Scott A. Gabel¹, Alan K. Jarmusch², Geoffrey A. Mueller¹

1 Genome Integrity and Structural Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
2 Immunity, Inflammation, and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
3 Division of Translational Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA

DOI: https://doi.org/10.22427/NTP-DATA-500-006-001-000-2

Nonylphenol alters the activity of splenic NK cells and the numbers of leukocyte subpopulations in Sprague-Dawley rats: a two-generation feeding study

Karrow NA, Guo TL, Delclos KB, Newbold RR, Weis C, Germolec DR, White KL Jr, McCay JA.
Toxicology (2004) DOI: https://doi.org/10.1016/j.tox.2003.11.009 PMID: 15036750

ORIO (Online Resource for Integrative Omics): A Web-Based Platform for Rapid Integration of Next Generation Sequencing Data

Lavender CA, Shapiro AJ, Burkholder AB, Bennett BD, Adelman K, Fargo DC.
Nucleic Acids Research (2017) DOI: https://doi.org/10.1093/nar/gkx270 PMID: 27933809

Optimized Method for Robust Transcriptome Profiling of Minute Tissues Using Laser Capture Microdissection and Low-Input RNA-Seq

Shannon Farris, Yu Wang, James M. Ward, Serena M. Dudek.
Frontiers in Molecular Neuroscience (2017) DOI: https://doi.org/10.3389/fnmol.2017.00185 PMID: 28659759

Oral Deoxynivalenol Toxicity in Sprague Dawley Rat dams and their offspring

Madelyn C. Huang, Johnathan R. Furr, Veronica G. Robinson, Laura Betz, Keith Shockley, Helen Cunny ,Kristine Witt, Suramya Waidyanatha, Dori Germolec

DOI: https://doi.org/10.22427/NTP-DATA-002-03342-0004-0000-8

Oral exposure to atrazine modulates cell-mediated immune function and decreases host resistance to the B16F10 tumor model in female B6C3F1 mice

Karrow NA, McCay JA, Brown RD, Musgrove DL, Guo TL, Germolec DR, White KL Jr.
Toxicology (2005) DOI: https://doi.org/10.1016/j.tox.2004.12.002 PMID: 15725510

Pathology of Diacetyl and 2,3-Pentanedione Airway Lesions in A Rat Model of Obliterative Bronchiolitis

Gordon P. Flake, and Daniel L.Morgan.
Toxicology (2017) DOI: https://doi.org/10.1016/j.tox.2016.10.013 PMID: 27984136

Performance of the BG1Luc ER TA Method in a qHTS Format

Ceger P, Allen D, Huang RL, Xia MH, Casey W.
ALTEX (2016) DOI: https://doi.org/10.14573/altex.1505121 PMID: 26117232

Phenolic benzotriazoles: a class comparison of toxicokinetics of ultraviolet-light absorbers in male rats

Suramya Waidyanatha, Esra Mutlu, Seth Gibbs, Jessica Pierfelice, Jeremy P. Smith, Brian Burback, and Chad T. Blystone

PMID: 33952035

DOI: https://doi.org/10.22427/NTP-DATA-002-03291-0028-0000-7

Photodynamic Priming Overcomes Per- and Polyfluoroalkyl Substance (PFAS)-Induced Platinum Resistance in Ovarian Cancer

Brittany P Rickard, Xianming Tan, Suzanne E Fenton, Imran Rizvi

Plasma concentrations of tris(1-chloro-2-propyl) phosphate and a metabolite bis(2-chloroisopropyl) 1-carboxyethyl phosphate in Sprague-Dawley rats and B6C3F1/N mice from a chronic study of tris(chloropropyl) phosphate via feed

BJ Collins, D Slade, K Aillon, M Stout, L Betz, S Waidyanatha, K Ryan
Toxicology Reports (2022) DOI: https://doi.org/10.1016/j.toxrep.2022.03.025

DOI: https://doi.org/10.22427/NTP-DATA-002-03220-0026-0000-7

Pred-Skin: A Fast and Reliable Web Application to Assess Skin Sensitization Effect of Chemicals

Rodolpho C. Braga, Vinicius M. Alves, Eugene N. Muratov, Judy Strickland∥, Nicole Kleinstreuer, Alexander Trospsha, and Carolina Horta Andrade.
Journal of Chemical Information and Modeling (2017) DOI: https://doi.org/10.1021/acs.jcim.7b00194 PMID: 28459556

Prediction of Skin Sensitization Potency Using Machine Learning Approaches

Zang Q, Paris M, Lehmann DM, Bell S, Kleinstreuer N, Allen D, Matheson J, Jacobs A, Casey W, Strickland J.
Journal of Applied Toxicology (2017) DOI: https://doi.org/10.1002/jat.3424 PMID: 28074598

Prenatal Arsenic Exposure and the Epigenome: Altered microRNAs Associated With Innate and Adaptive Immune Signaling in Newborn Cord Blood

Julia E. Rager, Kathryn A. Bailey, Lisa Smeester, Sloane K. Miller, Joel S. Parker, Jessica E. Laine, Zuzana Drobná, Jenna Currier, Christelle Douillet, Andrew F. Olshan, Marisela Rubio-Andrade, Miroslav Stýblo, Gonzalo García-Vargas, Rebecca C. Fry
Environmental and Molecular Mutagenesis (2014) DOI: https://doi.org/10.1002/em.21842 PMID: 24327377

Prenatal Bisphenol A (BPA) Exposure Alters the Transcriptome of the Neonate Rat Amygdala in a Sex-specific Manner: a CLARITY-BPA Consortium Study

Sheryl E. Arambula, Dereje Jima, and Heather B. Patisaul.
NeuroToxicology (2018) DOI: https://doi.org/10.1016/j.neuro.2017.10.005 PMID: 29097150

Proteomic Analysis of Primary Human Airway Epithelial Cells Exposed to the Respiratory Toxicant Diacetyl

Foster MW, Gwinn WM, Kelly FL, Brass DM, Valente AM, Moseley MA, Thompson JW, Morgan DL, Palmer SM.
Journal of Proteome Research (2017) DOI: https://doi.org/10.1021/acs.jproteome.6b00672 PMID: 27966365

QSAR Models of Human Data can Enrich or Replace LLNA Testing for Human Skin Sensitization

Vinicius M. Alves, Stephen J. Capuzzi, Eugene N. Muratov, Rodolpho C. Braga, Thomas E. Thornton, Denis Fourches, Judy Strickland, Nicole Kleinstreuer, Carolina H. Andrade and Alexander Tropsha.
Green Chemistry (2016) DOI: https://doi.org/10.1039/c6gc01836j PMID: 28630595

Quantifying Branching Density in Rat Mammary Gland Whole-mounts Using the Sholl Analysis Method

Stanko JP, Fenton SE.
Jove-Journal of Visualized Experiments (2017) DOI: https://doi.org/10.3791/55789 PMID: 28745626

RNA-Seq Profiling Reveals Novel Hepatic Gene Expression Pattern in Aflatoxin B1 Treated Rats

Merrick BA, Phadke DP, Auerbach SS, Mav D, Stiegelmeyer SM, Shah RR, Tice RR.
PLoS One (2013) DOI: https://doi.org/10.1371/journal.pone.0061768 PMID: 23630614

Real-time Cell Toxicity Profiling of Tox21 10K Compounds Reveals Cytotoxicity Dependent Toxicity Pathway Linkage

Hsieh JH, Huang R, Lin JA, Sedykh A, Zhao J, Tice RR, Paules RS, Xia M, Auerbach SS.
PLoS One (2017) DOI: https://doi.org/10.1371/journal.pone.0177902 PMID: 28531190

Reduced Disc Shedding and Phagocytosis of Photoreceptor Outer Segment Contributes to Kava Kava Extract-induced Retinal Degeneration in F344/N Rats

Haruhiro Yamashita, Mark J. Hoenerhoff, Keith R. Shockley, Shyamal D. Peddada, Kevin E. Gerrish, Deloris Sutton, Connie A. Cummings, Yu Wang, Julie F. Foley, Mamta Behl, Suramya Waidyanatha, Robert C. Sills, and Arun R. Pandiri.
Toxicologic Pathology (2018) DOI: https://doi.org/10.1177/0192623318778796 PMID: 29806545

Relative potency for altered humoral immunity induced by polybrominated and polychlorinated dioxins/furans in female B6C3F1/N mice

Frawley R, DeVito M, Walker NJ, Birnbaum L, White K Jr, Smith M, Maynor T, Recio L, Germolec D
Toxicol Sci (2014) DOI: https://doi.org/10.1093/toxsci/kfu041 PMID: 24713691

Repeat 5-day in vivo genomic dose response studies

Fred Parham, Michele R Balik-Meisner, William M Gwinn, Matthew D Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, Bruce Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R Shah, Deepak Mav, Dhiral P Phadke, Georgia Roberts, Michael J DeVito, Scott S Auerbach

DOI: https://doi.org/10.22427/NTP-DATA-002-00099-0001-000-1

BioProject ID: PRJNA926950

Reproductive and Developmental Toxicity Assessment of Butyl Paraben in Hsd: Sprague Dawley SD rats following Feed Exposure

https://doi.org/10.22427/NTP-DATA-NTP-DATA-RACB-BP

Note: The study data are being disseminated prior to external peer review under applicable information quality guidelines and do not represent and should not be construed to represent any final NTP determination or policy.

Reproductive and Developmental Toxicity Assessment of Diisobutyl Phthalate in Sprague Dawley rats following Feed Exposure

https://doi.org/10.22427/NTP-DATA-002-02047-0004-0000-9

Note: The study data are being disseminated prior to external peer review under applicable information quality guidelines and do not represent and should not be construed to represent any final NTP determination or policy.

Reproductive and developmental toxicity following exposure to organophosphate ester flame retardants and plasticizers, triphenyl phosphate and isopropylated phenyl phosphate, in Sprague Dawley rats

Shannah K. Witchey, Vicki Sutherland, Brad Collins, Georgia Roberts, Keith R. Shockley, Molly Vallant, Jeff Krause, Helen Cunny, Suramya Waidyanatha, Eve Mylchreest, Barney Sparrow, Robert Moyer and Mamta Behl

DOI: https://doi.org/10.22427/NTP-DATA-002-02974-0007-0000-1

Respiratory toxicity and immunotoxicity evaluations of microparticle and nanoparticle C60 fullerene aggregates in mice and rats following nose-only inhalation for 13 weeks

Sayers BC, Germolec DR, Walker NJ, Shipkowski KA, Stout MD, Cesta MF, Roycroft JH, White KL, Baker GL, Dill JA, Smith MJ
Nanotoxicology (2016) DOI: https://doi.org/10.1080/17435390.2016.1235737 PMID: 27618498

Respiratory, Dermal, and Eye Irritation Symptoms Associated with Corexit™ EC9527A/EC9500A following the Deepwater Horizon Oil Spill: Findings from the GuLF STUDY

Craig J. McGowan, Richard K. Kwok, Lawrence S. Engel, Mark R. Stenzel, Patricia A. Stewart, and Dale P. Sandler
Environmental Health Perspectives (2017). DOI: https://doi.org/10.1289/EHP1677 PMID: 28934097

Screening a Mouse Liver Gene Expression Compendium Identifies Modulators of the Aryl hydrocarbon Receptor (AhR)

Keiyu Oshida, Naresh Vasani, Russell S. Thomas, Dawn Applegate, Frank J. Gonzalez, Lauren M. Aleksunes, Curtis D. Klaassen and J. Christopher Corton
Toxicology (2015) DOI: https://doi.org/10.1016/j.tox.2015.07.005 PMID: 26215100

Screening for Angiogenic Inhibitors in Zebrafish to Evaluate A Predictive Model for Developmental Vascular Toxicity

Tamara Tal, Claire Kilty, Andrew Smith, Carlie LaLone, Brendán Kennedy, AlanTennant, Catherine W. McCollum, Maria Bondesson, Thomas Knudsen, Stephanie Padilla, and Nicole Kleinstreuer.
Reproductive Toxicology (2017) DOI: https://doi.org/10.1016/j.reprotox.2016.12.004 PMID: 28007540

Select Per- and Polyfluoroalkyl Substances (PFAS) Induce Resistance to Carboplatin in Ovarian Cancer Cell Lines

Brittany P. Rickard, Xianming Tan, Suzanne E. Fenton, and Imran Rizvi
International Journal of Molecular Sciences (2022), 23(9), 5176; DOI: https://doi.org/10.3390/ijms23095176

DOI: https://doi.org/10.22427/NTP-DATA-025-00001-0002-000-0

Serum Metabolomic Profiles in Neonatal Mice following Oral Brominated Flame Retardant Exposures to Hexabromocyclododecane (HBCD) Alpha, Gamma, and Commercial Mixture

Szabo DT, Pathmasiri W, Sumner S, Birnbaum LS.
Environmental Health Perspectives (2017) DOI: https://doi.org/10.1289/ehp242 PMID: 27814246

Shifts in the Gut Microbiota Composition Due to Depleted Bone Marrow Beta Adrenergic Signaling Are Associated with Suppressed Inflammatory Transcriptional Networks in the Mouse Colon

Tao Yang, Niousha Ahmari, Jordan T. Schmidt, Ty Redler, Rebeca Arocha, Kevin Pacholec, Kacy L. Magee, Wendi Malphurs, Jennifer L. Owen, Gregory A. Krane, Eric Li, Gary P. Wang, Thomas W. Vickroy, Mohan K. Raizada, Christopher J. Martyniuk, and Jasenka Zubcevic.
Frontiers in Physiology (2017) DOI: https://doi.org/10.3389/fphys.2017.00220 PMID: 28446880

Short-term Toxicity Studies of Thallium (I) Sulfate Administered in Drinking Water to Sprague Dawley Rats and B6C3F1/N Mice

Kelly A. Shipkowski, Troy D. Hubbard, Kristen Ryan, Suramya Waidyanatha, Helen Cunny, Keith R. Shockley, Joshua L. Allen, Heather Toy, Keith Levine, James Harrington, Laura Betz, Barney Sparrow, Georgia K. Roberts

DOI: https://doi.org/10.22427/NTP-DATA-500-003-001-000-9

Simultaneous Quantitation of 2-Hydroxy-4-Methoxybenzophenone, a Sunscreen Ingredient, and its Metabolites in Harlan Sprague Dawley Rat Plasma Following Perinatal Dietary Exposure

Mutlu E, Pierfelice J, McIntyre BS, Cunny HC, Kissling GE, Burback B, Waidyanatha S.
Journal of Analytical Toxicology (2017) DOI: https://doi.org/10.1093/jat/bkx070 PMID: 28977387

Skeletal Muscle Related Biomarker Summaries

DOI: https://doi.org/10.22427/NTP-DATA-500-010-011-000-8

Skin Related Biomarker Summaries

DOI: https://doi.org/10.22427/NTP-DATA-500-010-012-000-9

Sodium metasilicate hypersensitivity in BALB/c mice

Karrow NA, Guo TL, Leffel EK, Zhang LX, McCay JA, Germolec DR, White KL Jr.
Am J Contact Dermat (2002) DOI: PMID: 12165932

Splenic cell targets in gallium arsenide-induced suppression of the primary antibody response

Sikorski EE, Burns LA, Stern ML, Luster MI, Munson AE
Toxicol Appl Pharmacol (1991) DOI: https://doi.org/ PMID: 1871769

Standardisation of Defined Approaches for Skin Sensitisation Testing to Support Regulatory Use and International Adoption: Position of the International Cooperation on Alternative Test Methods

Casati S, Aschberger K, Barroso J, Casey W, Delgado I, Kim TS, Kleinstreuer N, Kojima H, Lee JK, Lowit A, Park HK, Régimbald-Krnel MJ, Strickland J, Whelan M, Yang Y, Zuang V.
Archives of Toxicology (2017). DOI: https://doi.org/10.1007/s00204-017-2097-4 PMID: 29127450

Statistical Guidance for Reviewers of Toxicologic Pathology

Keith R. Shockley and Grace E. Kissling
Toxicologic Pathology (2018) DOI: http://dx.doi.org/10.1177/0192623318785097 PMID: 29966505

Stimulation of the immune response in B6C3F1 mice by genistein is affected by exposure duration, gender, and litter order

Guo TL, Chi RP, Germolec DR, White KL Jr.
J Nutr (2005) DOI: https://doi.org/10.1093/jn/135.10.24495 PMID: 16177211

Subchronic 10 day immunotoxicity of polydimethylsiloxane (silicone) fluid, gel and elastomer and polyurethane disks in female B6C3F1 mice

Bradley SG, Munson AE, McCay JA, Brown RD, Musgrove DL, Wilson S, Stern M, Luster MI, White KL Jr.
Drug Chem Toxicol. (1994) DOI: https://doi.org/10.3109/01480549409017860 PMID: 7988383

Supplemental Material for NTP Research Report on Biological Activity of Bisphenol A (BPA) Structural Analogues and Functional Alternatives.

Pelch KE, Wignall JA, Goldstone AE, Ross PK, Blain RB, Shapiro AJ, Holmgren SD, Hsieh J-H, Svoboda D, Auerbach SS, Parham FM, Masten SA, Thayer KA.
2017 NTP Research Report on Biological Activity of Bisphenol A (BPA) Structural Analogues and Functional Alternatives. NTP RR 4. Research Triangle Park, NC: National Toxicology Program. (4): 1-78. https://doi.org/10.22427/NTP-RR-4

Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT): Interlaboratory Study Dose Range Finding (DRF) data

DOI: https://doi.org/10.22427/NTP-DATA-002-00102-0001-000-6

Systematic Review of Community Health Impacts of Mountaintop Removal Mining

Boyles AL, Blain RB, Rochester JR, Avanasi R, Goldhaber SB, McComb S, Holmgren SD, Masten SA, Thayer KA.
Environment International (2017) DOI: https://doi.org/10.1016/j.envint.2017.07.002 PMID: 28738262

Systemic Exposure of Vinpocetine in Pregnant Sprague Dawley Rats Following Repeated Oral Exposure: An Investigation of Fetal Transfer

Suramya Waidyanatha, Heather Toy, Natalie South, Seth Gibbs, Esra Mutlu, Brian Burback, Barry S.McIntyre, and Natasha Catlin.
Toxicology and Applied Pharmacology (2018) DOI: https://doi.org/10.1016/j.taap.2017.11.011 PMID: 29155086

Systemic exposure and urinary excretion of vanadium following perinatal subchronic exposure to vanadyl sulfate and sodium metavanadate via drinking water

Suramya Waidyanatha, Frank X. Weber, James M. Harrington, Dawn M. Fallacara, Keith Levine, Veronica G. Robinson, Barney R. Sparrow, Matthew D. Stout, Reshan Fernando, Michelle J. Hooth, Guanhua Xie, Chamindu Liyanapatirana, Georgia K. Roberts
Toxciology Letters(2022) DOI: https://doi.org/10.1016/j.toxlet.2022.03.004

DOI: https://doi.org/10.22427/NTP-DATA-002-00048-0001-000-5

Systems Biology for Organotypic Cell Cultures

Grego S, Dougherty ER, Alexander FJ, Auerbach SS, Berridge BR, Bittner ML, Casey W, Cooley PC, Dash A, Ferguson SS, Fennell TR, Hawkins BT, Hickey AJ, Kleensang A, Liebman MNJ, Martin F, Maull EA, Paragas J, Qiao GG, Ramaiahgari S, Sumner SJ, Yoon M.
ALTEX (2017) DOI: https://doi.org/10.14573/altex.1608221 PMID: 27846345

TDMSE Glossaries

Temporarily Unavailable Data Collections

Tetrabromobisphenol A Activates the Hepatic Interferon Pathway in Rats

Dunnick JK, Morgan DL, Elmore SA, Gerrish K, Pandiri A, Ton TV, Shockley KR, Merrick BA.
Toxicology Letters (2017) DOI: https://doi.org/10.1016/j.toxlet.2016.11.019 PMID: 27914987

Tetrabromobisphenol-A Promotes Early Adipogenesis and Lipogenesis in 3T3-L1 Cells

Chappell VA, Janesick A, Blumberg B, Fenton S
Toxicological Sciences (2018) DOI: https://doi.org/10.1093/toxsci/kfy209 PMID: 30496566
DOI: https://doi.org/10.22427/NTP-DATA-021-00003-0001-0000-7

Thalidomide enhances both primary and secondary host resistances to Listeria monocytogenes infection by a neutrophil-related mechanism in female B6C3F1 mice

Guo TL, Chi RP, Karrow NA, Zhang LX, Pruett SB, Germolec DR, White KL Jr.
Toxicol Appl Pharmacol (2005) DOI: https://doi.org/10.1016/j.taap.2005.04.014 PMID: 15921716

Thalidomide modulation of the immune response in female B6C3F1 mice: a host resistance study

Karrow NA, Guo TL, Zhang LX, McCay JA, Musgrove DL, Peachee VL, Germolec DR, White KL Jr.
Int Immunopharmacol (2003) DOI: https://doi.org/10.1016/S1567-5769(03)00143-7 PMID: 12946441

Thalidomide stimulates splenic IgM antibody response and cytotoxic T lymphocyte activity and alters leukocyte subpopulation numbers in female B6C3F1 mice

Karrow NA, McCay JA, Brown RD, Musgrove DL, Pettit DA, Munson AE, Germolec DR, White KL Jr.
Toxicol Appl Pharmacol (2000) DOI: https://doi.org/10.1006/taap.2000.8939 PMID: 10873712

The Association of Arsenic Exposure and Metabolism With Type 1 and Type 2 Diabetes in Youth: The SEARCH Case-Control Study

Grau-Perez M, Kuo CC, Spratlen M, Thayer KA, Mendez MA, Hamman RF, Dabelea D, Adgate JL, Knowler WC, Bell RA, Miller FW, Liese AD, Zhang C, Douillet C, Drobná Z, Mayer-Davis EJ, Styblo M, Navas-Acien A.
Diabetes Care (2017) DOI: https://doi.org/10.2337/dc16-0810 PMID: 27810988

The B lymphocyte is the immune cell target for 2',3'-dideoxyadenosine

Sikorski EE, Fuchs BA, Stern ML, Luster MI, Munson AE.
Toxicol Appl Pharmacol (1990) DOI: https://doi.org/ PMID: 2237921

The Concordance between RNA-seq and Microarray Data Depends on Chemical Treatment And Transcript Abundance

Charles Wang, Binsheng Gong, Pierre R Bushel, Jean Thierry-Mieg, Danielle Thierry-Mieg, Joshua Xu, Hong Fang, Huixiao Hong, Jie Shen, Zhenqiang Su, Joe Meehan, Xiaojin Li, Lu Yang, Haiqing Li, Paweł P Łabaj, David P Kreil, Dalila Megherbi, Stan Gaj, Florian Caiment, Joost van Delft, Jos Kleinjans, Andreas Scherer, Viswanath Devanarayan, Jian Wang, Yong Yang, Hui-Rong Qian, Lee J Lancashire, Marina Bessarabova, Yuri Nikolsky, Cesare Furlanello, Marco Chierici, Davide Albanese, Giuseppe Jurman, Samantha Riccadonna, Michele Filosi, Roberto Visintainer, Ke K Zhang, Jianying Li, Jui-Hua Hsieh, Daniel L Svoboda, James C Fuscoe, Youping Deng, Leming Shi, Richard S Paules, Scott S Auerbach, and Weida Tong.
Nature Biotechnology (2014) DOI: https://doi.org/10.1038/nbt.3001 PMID: 25150839

The Diacetyl-Exposed Human Airway Epithelial Secretome: New Insights into Flavoring-Induced Airways Disease

Brass DM, Gwinn WM, Valente AM, Kelly FL, Brinkley CD, Nagler AE, Moseley MA, Morgan DL, Palmer SM, Foster MW.
American Journal of Respiratory Cell and Molecular Biology (2017) DOI: https://doi.org/10.1165/rcmb.2016-0372OC PMID: 28248570

The Genomic Analysis of the Impact of Steroid Receptor Coactivators Ablation on Hepatic Metabolism

Jae-Wook Jeong, Inseok Kwak, Kevin Y. Lee, Lisa D. White, Xiao-Ping Wang, F. C. Brunicardi, Bert W. O’Malley, Francesco J. DeMayo
Molecular Endocrinology (2006) DOI: https://doi.org/10.1210/me.2005-0407 PMID: 16423883

The Mammary Gland is a Sensitive Pubertal Target in CD-1 and C57Bl/6 Mice Following Perinatal Perfluorooctanoic Acid (PFOA) Exposure

Tucker DK, Macon MB, Strynar MJ, Dagnino S, Andersen E, Fenton SE.
Reprod Toxicol (2015) DOI: https://doi.org/10.1016/j.reprotox.2014.12.002 PMID:30496566

The Power of Resolution: Contextualized Understanding of Biological Responses to Liver Injury Chemicals using High Throughput Transcriptomics and Benchmark Concentration Modeling

Ramaiahgari SC, Auerbach SS, Saddler TO, Rice JR, Dunlap PE, Sipes NS, DeVito MJ, Shah RR, Bushel PR, Merrick BA, Paules RS, Ferguson SS

Toxicological Sciences (2019) DOI: https://doi.org/10.1093/toxsci/kfz065 PMID: 30850835
CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0001-0000-6
SRA No. SRP166108; BioProject No. PRJNA497448

The TGx-28.65 Biomarker Online Application for Analysis of Transcriptomics Data to Identify DNA Damage-inducing Chemicals in Human Cell Cultures

Jackson MA, Yang L, Lea IA, Rashid A, Kuo B, Williams A, Yauk CL, Fostel J.
Environ Mol Mutagen. (2017) DOI: https://doi.org/10.1002/em.22114 PMID: 28766826

The common indoor air pollutant α-pinene is metabolized to a genotoxic metabolite α-pinene oxide

Suramya Waidyanatha, Sherry R. Black, Kristine L. Witt, Timothy R. Fennell, Carol Swartz, Leslie Recio, Scott L. Watson, Purvi R. Patel, Reshan A. Fernando, and Cynthia V. Rider

Taylor & Francis Online (2022) DOI: https://doi.org/10.1080/00498254.2022.2070047 PMID: 35473450
DOI: https://doi.org/10.22427/NTP-DATA-002-03031-0019-0000-9

Three-Dimensional (3D) HepaRG Spheroid Model with Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening

Sreenivasa C. Ramaiahgari, Suramya Waidyanatha, Darlene Dixon, Michael J. DeVito, Richard S. Paules, Stephen S. Ferguson.
Toxicological Sciences (2017) DOI: https://doi.org/10.1093/toxsci/kfx122 PMID: 28633424

Thyroid Related Biomarker Summaries

DOI: https://doi.org/10.22427/NTP-DATA-500-010-013-000-0

Tox21 Enricher: Web-based Chemical/Biological Functional Annotation Analysis Tool Based on Tox21 Toxicity Screening Platform

Junguk Hur, Larson Danes, Jui‐Hua Hsieh, Brett McGregor, Dakota Krout, Scott Auerbach.
Molecular Informatics (2017) DOI: https://doi.org/10.1002/minf.201700129 PMID: 29377626

Toxicogenomics Profiling of Bone Marrow from Rats Treated with Topotecan in Combination with Oxaliplatin: a Mechanistic Strategy to Inform Combination Toxicity

Myrtle Davis, Jianying Li, Elaine Knight, Sandy R. Eldridge, Kellye K. Daniels and Pierre R. Bushel
Frontiers in Genetics (2015) DOI: https://doi.org/10.3389/fgene.2015.00014 PMID: 25729387

Toxicogenomics of the Flame Retardant tris(2-butoxyethyl)Phosphate in HepG2 Cells using RNA-seq

Boris V. Krivoshiev, Gerrit T.S. Beemster, Katrien Sprangers, Bart Cuypers, Kris Laukens, Ronny Blust and Steven J. Husson.
Toxicology in Vitro (2018) DOI: https://doi.org/10.1016/j.tiv.2017.10.011 PMID: 29024780

Toxicokinetic Evaluation (K01090C) of Resveratrol (501-36-0) in Harlan Sprague Dawley Rats and B6C3F1/N Mice Exposed via Intravenous Injection or Gavage

Esra Mutlu, Seth T. Gibbs, Natalie South, Jessica Pierfelice, Brian Burback, Dori Germolec, Suramya Waidyanatha
Toxciology and Applied Pharmacology(2020) DOI: https://doi.org/10.1016/j.taap.2020.114962 PMID: 32205187

DOI: https://doi.org/10.22427/NTP-DATA-002-02772-0032-0000-5

Toxicokinetic Evaluation (K08002D) of Bisphenol AF (1478-61-1) in Harlan Sprague Dawley Rats and B6C3F1/N Mice Exposed via Dosed Feed

DOI: https://doi.org/10.22427/NTP-DATA-002-03263-0011-0000-8

Toxicokinetic Evaluation (K94150C) of Bisphenol S (80-09-1) in Harlan Sprague Dawley Rats and B6C3F1/N Mice Exposed via Dosed Feed

DOI: https://doi.org/10.22427/NTP-DATA-002-03311-0008-0000-8

Toxicokinetic evaluation of the common indoor air pollutant, α-pinene, and its potential reactive metabolite, α-pinene oxide, following inhalation exposure in rodents

Suramya Waidyanatha, Michael Hackett, Sherry R. Black, Timothy R. Fennell, Mathew D. Stout, Melanie R. Silinski, Scott L. Watson, Joseph Licause, Veronica G. Robinson, Barney Sparrow, Reshan A. Fernando, Stephen Cooper and Cynthia V. Rider

DOI: https://doi.org/10.22427/NTP-DATA-002-03031-0014-0000-4

Toxicokinetics and bioavailability of sulfolane, a ground water contaminant, following oral and intravenous administration in rodents: A dose, species, and sex comparison

Suramya Waidyanatha, Sherry R. Black, Timothy R. Fennell, Scott L. Watson, Purvi R.Patel, Stephen D. Cooper, James Blake, Veronica Godfrey Robinson, Reshan A.Fernando, Chad R. Blystone DOI: https://doi.org/10.1016/j.taap.2019.114690

Toxicokinetics of 8:2 Fluorotelomer Alcohol (8:2-FTOH) in Male and Female Hsd:Sprague Dawley SD Rats after Intravenous and Gavage Administration

Huang M.C, Robinson V.G., Waidyanatha S., Dzierlenga A.L, DeVito M.J, Eifrid M.A, Gibbs S.T, Blystone CR

DOI: https://doi.org/10.22427/NTP-DATA-002-02182-0003-0000-8

Toxicokinetics of Perfluorobutane Sulfonate (PFBS), Perfluorohexane-1-Sulphonic Acid (PFHxS), and Perfluorooctane Sulfonic Acid (PFOS) in Male and Female Hsd:Sprague Dawley SD Rats after Intravenous and Gavage Administration

Huang M.C., Dzierlenga A., Robinson V.G, Waidyanatha S, DeVito M.J, Eifrid M.A, Granville C.A., Gibbs S.T, Blystone C.R
DOI: https://doi.org/10.22427/NTP-DATA-002-00037-0001-000-3

Toxicokinetics of Perfluorohexanoic acid (PFHxA), Perfluorooctanoic acid (PFOA), and Perfluorodecanoic Acid (PFDA) in Male and Female Hsd:Sprague Dawley SD Rats following Intravenous or Gavage Administration

Dzierlenga A.L, Robinson V.G, Waidyanatha S, DeVito M.J, Eifrid M.A, Gibbs S.T, Granville C.A, *Blystone C.R

DOI: https://doi.org/10.22427/NTP-DATA-002-00037-0002-000-4

Toxicokinetics of the plasticizer, N-butylbenzenesulfonamide, in plasma and brain following oral exposure in rodents: Route, species, and sex comparison

Suramya Waidyanatha, Seth Gibbs, Natalie South, Jeremy P. Smith, Esra Mutlu, Brian Burback, Yu Cao, Cynthia V. Rider

Toxicol Rep (2020): https://pubmed.ncbi.nlm.nih.gov/32551233/
DOI: https://doi.org/10.22427/NTP-DATA-002-03240-0014-0000-6

Transcriptional pathways linked to fetal and maternal hepatic dysfunction caused by gestational exposure to perfluorooctanoic acid (PFOA) or hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) in CD-1 mice

Bevin E. Blake, Colette N. Miller, Helen Nguyen, Vesna A. Chappell, Trina P. Phan, Dhiral P. Phadke, Michele R. Balik-Meisner, Deepak Mav, Ruchir R. Shah, Suzanne E. Fenton

Transcriptomic Profiling of Rat Liver Samples in A Comprehensive Study Design by RNA-Seq

Binsheng Gong, Charles Wang, Zhenqiang Su, Huixiao Hong, Jean Thierry-Mieg, Danielle Thierry-Mieg, Leming Shi, Scott S. Auerbach, Weida Tong, and Joshua Xu
Scientific Data (2014) DOI: https://doi.org/10.1038/sdata.2014.21 PMID: 25977778

Transcriptomic biomarkers of toxicological effect

Oleg Stroganov¹, Bing Zhou¹, Tyler Myers¹, Nicole Kleinstreuer², Warren Casey², Kelly Shipkowski^2,3, Scott Auerbach⁴
1: Rancho Biosciences, San Diego, CA 92025
2: National Institute of Environmental Health Sciences, Division of Translational Toxicology, Research Triangle Park, NC 27709
3: Contract Office Representative
4: Project Lead
DOI: https://doi.org/10.22427/NTP-DATA-500-010-002-000-8
Dataset: /datasets/search/biomarker-data-collection

Urinary miRNA biomarkers of drug-induced kidney injury and their site specificity within the nephron

Brian Chorley, Heidrun Ellinger-Ziegelbauer, Michael Tackett, Frank J. Simutis, Alison H. Harrill, James McDuffie, Elnaz Atabakhsh, Rounak Nassirpour, Laurence O. Whiteley, Jean-François Léonard, Ernie Harpur, Connie L. Chen, Jean-Charles Gautier

Toxicological Sciences (2020) DOI: https://doi.org/10.1093/toxsci/kfaa181
DOI: https://doi.org/10.22427/NTP-DATA-002-00085-0001-0000-6

Using Tox21 High Throughput Screening Assays for the Evaluation of Botanical and Dietary Supplements

DOI: https://doi.org/10.22427/NTP-DATA-023-00001-0001-000-7
PubMed: 30944845

Uterine Paramesonephric Cysts in Sprague-Dawley Rats from National Toxicology Program Studies

Daven N. Jackson-Humbles, John Curtis Seely, Ronald A. Herbert, David E. Malarkey, Barry S. McIntyre, Paul M. Foster, and Darlene Dixon
Toxicologic Pathology (2018). DOI: https://doi.org/10.1177/0192623318772487 PMID: 29706125

Vinclozolin modulates splenic natural killer cell activity, antibody-forming cell response and phenotypic marker expression in sprague dawley rats: a two-generation feeding study

White KL Jr, Germolec DR, Musgrove DL, Delclos KB, Newbold RR, Weis C, Guo TL.
Journal of Immunotoxicology (2004) DOI: https://doi.org/10.1080/15476910490518893 PMID: 18958644

Whole-body inhalation exposure to 1-bromopropane suppresses the IgM response to sheep red blood cells in female B6C3F1 mice and Fisher 344/N rats

Anderson SE, Munson AE, Butterworth LF, Germolec D, Morgan DL, Roycroft JA, Dill J, Meade BJ.
Journal of Immunotoxicology (2018) DOI: https://doi.org/10.3109/08958370902953910 PMID: 20041805

Whole-body inhalation exposure to 2-ethyltoluene for two weeks produced nasal lesions in rats and mice

Madelyn C. Huang, Cynthia J. Willson, Sridhar Jaligama, Gregory L. Baker, Alan W. Singer, Yu Cao, Jessica Pierfelice, Esra Mutlu, Brian Burback, Guanhua Xie, David E. Malarkey, Barney Sparrow, Kristen Ryan, Matthew Stout, and Georgia K. Roberts
Inhalation Toxicology (2021) DOI: https://doi.org/10.1080/08958378.2021.2002480
DOI: https://doi.org/10.22427/NTP-DATA-002-03356-0005-0000-4

Zileuton Liver Toxicity Study in DO Mice

Dahea You, Lascelles E. Lyn-Cook Jr., Daniel M. Gatti, Natalie Bell,, Philip R. Mayeux, Laura P. James, William B. Mattes, Alison H. Harrill.
DOI: https://doi.org/10.22427/NTP-DATA-002-00076-0001-0000-6

httk: R Package for High-Throughput Toxicokinetics

Robert G. Pearce, R. Woodrow Setzer, Cory L. Strope, Nisha S. Sipes, John F. Wambaugh.
Journal of Statistical Software (2017) DOI: https://doi.org/10.18637/jss.v079.i04 PMID: Not available