Publications
Roberts GK, Stout MD, Sayers B, Fallacara DM, Hejtmancik MR, Waidyanatha S, Hooth MJ.
Toxicology Reports (2016)
DOI: https://doi.org/10.1016/j.toxrep.2016.05.001
PMID: 28042531
National Toxicology Program. 2018. Data Release: Developmental NeuroToxicity Data Integration and Visualization Enabling Resource (DNT-DIVER). Last Updated: December 3, 2018.
DOI:
https://doi.org/10.22427/NTP-DATA-002-00062-0001-0000-1
NOTE: Files in Data Release.zip were replaced on 26 Feb 2020 due to inconsistent data
Benchmark Dose data added on 10 March 2022
Toyoda T1, Cho YM1, Matsushita K1, Tachibana S2, Senuma M2, Akagi JI1, Ogawa K1.
Author information:
1. Division of Pathology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-9501, Japan.
2. Hatano Research Institute, Food and Drug Safety Center, 729-5 Ochiai, Hadano, Kanagawa 257-8523, Japan
PMID:
31402808
PMCID:
PMC6682557
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22687605
DOI:
https://doi.org/10.22427/NTP-DATA-002-01731-0031-0000-8
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DOI:
https://doi.org/10.22427/NTP-DATA-002-03263-0010-0000-7
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DOI:
https://doi.org/10.22427/NTP-DATA-500-012-008-000-6
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https://doi.org/10.22427/NTP-DATA-002-00058-0003-0000-8
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DOI: https://doi.org/10.22427/NTP-DATA-022-00002-0005-000-1
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DOI: https://doi.org/10.22427/NTP-DATA-002-01731-0030-0000-7
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DOI:
https://doi.org/10.22427/NTP-DATA-500-007-003-000-5
Last updated Oct 2024.
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DOI: https://doi.org/10.22427/NTP-DATA-500-007-001-000-3
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DOI:
https://doi.org/10.22427/NTP-DATA-002-00090-0001-0000-2
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https://doi.org/10.1093/nar/gkab981
DOI:
https://doi.org/10.22427/NTP-DATA-002-00094-0001-0000-6
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https://doi.org/10.22427/NTP-DATA-002-00060-0001-0000-9
Dunnick JK, Brix A, Cunny H, Vallant M, Shockley KR.
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Ryan KR, Cesta MF, Herbert R, Brix A, Cora M, Witt K, Kissling G, Morgan DL.
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Behl M, Rice JR, Smith MV, Co CA, Bridge M, Hsieh JH, Freedman JH, Boyd WA.
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DOI: http:/dx.doi.org/10.1093/toxsci/kfw162
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Toxicology and Applied Pharmacology (2020) DOI:
https://doi.org/10.1016/j.taap.2020.115207
DOI:
https://doi.org/10.22427/NTP-DATA-002-03311-0007-0000-7
Keith R Shockley, Michelle C Cora, David E Malarkey, Daven Jackson-Humbles, Molly Vallant, Brad J Collins, Esra Mutlu, Veronica G Robinson, Surayma Waidyanatha, Amy Zmarowski, Nicholas Machesky, Jamie Richey, Sam Harbo, Emily Cheng, Kristin Patton, Barney Sparrow, June K Dunnick
Toxicology Letters (2020) DOI:
https://doi.org/10.1016/j.toxlet.2020.07.016
PMID:
32679240
GEO: GSE153366
K A Shipkowski 1, M C Cora 1, M F Cesta 1, V G Robinson 1, S Waidyanatha 1, K L Witt 1, M K Vallant 1, D M Fallacara 2, M R Hejtmancik 2, S A Masten 1, S D Cooper 3, R A Fernando 3, C R Blystone 1
1Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
2Battelle Memorial Institute, Columbus, OH, USA.
3RTI International, Research Triangle Park, NC, USA.
DOI:
https://doi.org/10.22427/NTP-DATA-002-03276-0000-0000-0
Note: The study data are being disseminated prior to external peer review under applicable information quality guidelines and do not represent and should not be construed to represent any final NTP determination or policy.
Genetox data was added on August 7, 2020
Authors:
Guojing Cong1, Robert Patton1, Frank Chao3, Daniel L. Svoboda4, Warren M. Casey3, Charles P. Schmitt3, Charles Murphy2, Jeremy N. Erickson3, Parker A. Combs3, Scott S. Auerbach3
Corresponding Author:
Scott Auerbach
1Data and AI Section, Oak Ridge National Laboratory, Oak Ridge, TN
2Carnegie Mellon University, Pittsburgh, PA
3Division of Translational Toxicology, National Institute of Environmental Health Sciences, RTP, NC
4Sciome LLC, RTP, NC
DOI:
https://doi.org/10.22427/NTP-DATA-500-010-001-000-7
Auttachoat W, Germolec DR, Smith MJ, White KL Jr, Guo TL.
Food Chem Toxicol (2011)
DOI: https://doi.org/10.1016/j.fct.2011.07.009
PMID: 21777644
Guo TL, Germolec DR, Zhang LX, Auttachoat W, Smith MJ, White KL Jr.
Toxicology (2013)
DOI: https://doi.org/10.1016/j.tox.2013.10.006
PMID: 24172597
Kembra L. Howdeshell, Andrew K. Hotchkiss, L. Earl Gray Jr.
International Journal of Hygiene and Environmental Health (2017)
DOI: https://doi.org/10.1016/j.ijheh.2016.11.007
PMID: 27923611
N. Chernoff, D.J. Hill, I. Chorus, D.L. Diggs, H. Huang, D. King, J.R. Lang, T.-T. Le, J.E. Schmid, G.S. Travlos, E.M. Whitley, R.E. Wilson & C.R. Wood.
Journal of Toxicology and Environmental Health, Part A (2018)
DOI: https://doi.org/10.1080/15287394.2018.1460787
PMID: 29693504
Gao L, Mutlu E, Collins LB, Walker NJ, Hartwell HJ, Olson JR, Sun W, Gold A, Ball LM, Swenberg JA
Chemical Research in Toxicology (2017)
DOI: https://doi.org/10.1021/acs.chemrestox.6b00368
PMID: 28207250
DTT supports FAIR data principles https://www.go-fair.org/fair-principles/. One component of FAIR is to ensure that data are interoperable with applications and workflows, and in particular, that “(Meta)data use vocabularies that follow FAIR principles”.
In support of this aim, DTT is developing the DTT Data Dictionary (DDD), a list of terms, metadata and endpoints used in DTT studies. The DDD is growing as data are consolidated and will be updated or extended approximately monthly. Older versions and change logs will be available. The DDD contains links to external ontologies or other external IDs where available.
We welcome your comments and suggestions. Please contact dttresearchdatacoordinator@mail.nih.gov
DOI: https://doi.org/10.22427/NTP-DATA-002-00092-0002-0000-5
The Division of Translational Toxicology (DTT) has been collecting and reporting histopathology and clinical pathology data since 1976. Over the years, pathology terminologies have evolved. This dictionary includes legacy terms and their current equivalent, and mappings to external ontologies. This dictionary is currently in progress and under review (Version: November 2021)
DOI:
https://doi.org/10.22427/NTP-DATA-002-00092-0001-0000-4
Kleinstreuer NC, Ceger P, Watt ED, Martin M, Houck K, Browne P, Thomas RS, Casey WM, Dix DJ, Allen D, Sakamuru S, Xia M, Huang R, Judson R.
Chemical Research in Toxicology (2017)
DOI: https://doi.org/10.1021/acs.chemrestox.6b00347
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Christina T. Teng, Jui-Hua Hsieh, Jinghua Zhao, Ruili Huang, Menghang Xia, Negin Martin, Xiaohua Gao, Darlene Dixon, Scott S. Auerbach, Kristine L. Witt, B. Alex Merrick.
SLAS Discovery (2017)
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PMID: 28346099
Boyd WA, Smith MV, Co CA, Pirone JR, Rice JR, Shockley KR, Freedman JH.
Environ Health Perspect. (2016)
DOI: http:/dx.doi.org/10.1289/ehp.1409645
PMID: 26496690
DOI: https://doi.org/10.22427/NTP-DATA-002-00901-0003-000-5
Lilah Glazer, Andrew B Hawkey, Corinne N Wells, Meghan Drastal, Kathryn-Ann Odamah, Mamta Behl, and Edward D Levin.
Toxicological Sciences (2018)
DOI: http://dx.doi.org/10.1093/toxsci/kfy173
PMID: 29982741
Lilah Glazer, Corinne N. Wells, Meghan Drastal, Kathryn-Ann Odamah, Richard E. Galat, Mamta Behl, Edward D. Levin.
Neurotoxicology (2017).
DOI: https://doi.org/10.1016/j.neuro.2017.09.007
PMID: 28935585
White KL Jr, Germolec DR, Booker CD, Hernendez DM, McCay JA, Delclos KB, Newbold RR, Weis C, Guo TL.
Toxicology (2005)
DOI: https://doi.org/ 10.1016/j.tox.2004.09.011
PMID: 15596257
Stanko JP, Kissling GE, Chappell VA, Fenton SE.
Toxicol Pathol (2016),
DOI: http:/dx.doi.org/10.1177/0192623316655222
PMID: 27613105
Katherine E. Pelch, Erik J. Tokar, B. Alex Merrick, Michael P. Waalkes.
Toxicol Appl Pharmacol. (2015)
DOI: https://doi.org/10.1016/j.taap.2015.04.011
PMID: 25922126
Guo TL, Zhang XL, Leffel EK, Peachee VL, Karrow NA, Germolec DR, White KL Jr.
Journal of Immunotoxicology (2018)
DOI: https://doi.org/10.1002/jat.876
PMID: 12424743
C. Edwin Garner, Christopher J. Wegerski, Joseph Lucak, Melanie Doyle-Eisele, Jacob D. McDonald, J. Michael Sanders, Benjamin C. Moeller and Suramya Waidyanatha
Radiolabel Description:
Carbon-14 uniformly on the rings; 2',2'''-Dithiobisbenzanilide, [phenyl-14C(U)]-
Vehicles:
Intravenous, emulphor:ethanol:water (3:5:2) or dimethylacetamide:polyethylene glycol 400:saline (15:55:30); Oral methylcellulose; Dermal, ethanol or acetone
Additional Information:
Two different vehicles were used for the rat 4 mg/kg intravenous treatments. Study C used water:ethanol:alkamuls (3:5:2) vehicle and Study C-2, dimethylacetamide:PEG400:saline (15:40:45).
Jacob D. McDonald, J. Michael Sanders, C. Edwin Garner, Melanie Doyle-Eisele, Benjamin C. Moeller and Suramya Waidyanatha
https://doi.org/10.22427/NTP-DATA-002-02085-0009-0000-6
Radiolabel Description:
Carbon-14 on the ring carbons adjacent to the nitrogen; 2,2'-Dimorpholinodiethyl ether, [morpholine-2,6-14C]-
Vehicles:
Intravenous, saline; Oral, purified water; Dermal, ethanol.
Suramya Waidyanatha, Sherry R. Black, Rodney W. Snyder, Yun Lan Yueh, Vicki Sutherland, Purvi R. Patel, Scott L. Watson, and Timothy R. Fennell.
Toxicology and Applied Pharmacology (2018)
DOI: https://doi.org/10.1016/j.taap.2018.05.008
PMID: 29753715
Atlee T. D. Watson, Benjamin C. Moeller, Melanie Doyle-Eisele, C. Edwin Garner, Chad R. Blystone, Jacob D. McDonald, and Suramya Waidyanatha
Radiolabel Description:
Carbon-14 in 2 positions: Ethylene glycol 2-ethylhexyl ether, [2-ethylhexyl-1-14C, ethylene glycol-1-14C]-
Vehicles:
Oral, corn oil; Dermal, ethanol.
DOI:
https://doi.org/10.22427/NTP-DATA-002-03310-0005-0000-4
Radiolabel Description:
carbon-14 uniformly in the ring; N-Butylbenzenesulfonamide, [ring-14C(U)]-
Vehicles:
Intravenous, ethanol:Cremophor:water (10:10:80); oral, 0.5% methyl cellulose.
Toxicology Letters (2020): https://pubmed.ncbi.nlm.nih.gov/31760063/
DOI:
https://doi.org/10.22427/NTP-DATA-002-03240-0010-0000-2
Suramya Waidyanatha, Sherry R. Black, Purvi R. Patel, Jason Stanko, Scott L. Watson, Rodney W. Snyder, and Timothy R. Fennell
https://doi.org/10.22427/NTP-DATA-002-02949-0005-0000-1
Radiolabel Description:
Carbon-14 in the phenyl ring with one chloride; Triclocarban, [Chlorophenyl ring-14C(U)]-
Vehicles:
Oral, corn oil; Dermal, acetone.
Waidyanatha S, Black S, Blystone C, Patel P,Watson S, Snyder R, Fennell T
DOI:
https://doi.org/10.22427/NTP-DATA-002-03276-0014-0000-5
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DOI: https://doi.org/10.1080/00498254.2018.1463475
PMID: 29659319
Suramya Waidyanatha, Kristen Ryan, J. Michael Sanders, Jacob D. McDonald, Christopher J. Wegerski, Melanie Doyle-Eisle, C. Edwin Garner
Toxicology and Applied Pharmacology (2018).
DOI: https://doi.org/10.1016/j.taap.2017.12.008
PMID: 29248465
Catlin NR, Herbert R, Janardhan K, Hejtmancik MR, Fomby LM, Vallant M, Kissling GE, DeVito MJ.
Food Chem Toxicol. (2016)
DOI: http:/dx.doi.org/10.1016/j.fct.2016.10.016
PMID: 27769849
Susan D. Hester, Virunya Bhat, Brian N. Chorley, Gleta Carswell, Wendell Jones, Leah C. Wehmas, Charles E. Wood
Toxicological Sciences (2016)
DOI: https://doi.org/10.1093/toxsci/kfw161
PMID: 27562560
DRUGMATRIX is a registered trademark of the U.S. Department of Health and Human Services (HHS)
This page will be updated with more data as it becomes available.
DOI:
https://doi.org/10.22427/NTP-DATA-107-022-001-000-3
Yan Y, Yu L, Castro L, Dixon D.
PLoS One. 2017
DOI: https://doi.org/10.1371/journal.pone.0186078
PMID: 29020039
Michael E. Wyde, Thomas L. Horn, Myles H. Capstick, John M. Ladbury, Galen Koepke, Perry F. Wilson, Grace E. Kissling, Matthew D. Stout, Niels Kuster, Ronald L. Melnick, James Gauger, John R. Bucher, and David L. McCormick.
Bioelectromagnetics (2018)
DOI: https://doi.org/10.1002/bem.22116
PMID: 29537695
Kai Connie Wu, Julia Yue Cui, Curtis D. Klaassen
PLoS One (2012)
DOI: https://doi.org/10.1371/journal.pone.0039006
PMID: 22808024
Robin Gear, Jessica A. Kendziorski, and Scott M. Belcher.
Toxicology Letters (2017)
DOI: https://doi.org/10.1016/j.toxlet.2017.05.011
PMID: 28499613
Edward Dere, Linnea M. Anderson, Susan M. Huse, Daniel J. Spade, Elizabeth McDonnell-Clark, Samantha J. Madnick, Susan J. Hall, Luísa Camacho, Sherry M. Lewis, Michelle M. Vanlandingham, and Kim Boekelheide.
Toxicology and Applied Pharmacology (2018)
DOI: https://doi.org/10.1016/j.taap.2018.03.021
PMID: 29596923
Sarah A. Johnson, Angela B. Javurek, Michele S. Painter, Mark R. Ellersieck, Thomas H. Welsh, Jr., Luísa Camacho, Sherry M. Lewis, Michelle M. Vanlandingham, Sherry A. Ferguson, and Cheryl S. Rosenfeld.
Hormones and Behavior (2016)
DOI: https://doi.org/10.1016/j.yhbeh.2015.09.005
PMID: 26436835
Natalie M. Crawford, Suzanne E. Fenton, Mark Strynar, Erin P. Hines, David A. Pritchard, and Anne Z. Steiner.
Reproductive Toxicology (2017)
DOI: https://doi.org/10.1016/j.reprotox.2017.01.006
PMID: 28111093
Sheryl E. Arambula, Joelle Fuchs, Jinyan Cao, and Heather B. Patisaul.
NeuroToxicology (2017)
DOI: https://doi.org/10.1016/j.neuro.2017.09.002
PMID: 28890130
Madelyn Huang, Katie Turner, Molly Vallant, Yi Lu, Catherine Price, Timothy Fennell, Melanie A. Silinski, Suramya Waidyanatha, Kristen Ryan, Sherry R. Black, Reshan Fernando, Barry McIntyre
DOI: https://doi.org/10.22427/NTP-DATA-002-02275-0007-0000-5
Natasha Catlin, Suramya Waidyanatha, Eve Mylchreest, Lutfiya Miller-Pinsler, Helen Cunny, Paul Foster, Vicki Sutherland, Barry McIntyre
Birth Defects Research (2018)
DOI: https://doi.org/10.1002/bdr2.1207
PMID: 29460393
Ellis-Hutchings RG, Settivari RS, McCoy AT, Kleinstreuer N, Franzosa J, Knudsen TB, Carney EW.
Reproductive Toxicology (2017)
DOI: https://doi.org/10.1016/j.reprotox.2017.05.005
PMID: 28527947
Johnson VJ, Auerbach SS, Luster MI, Waidyanatha S, Masten SA, Wolfe MS, Burleson FG, Burleson GR, Germolec DR.
Food and Chemical Toxicology (2017)
DOI:
https://doi.org/10.1016/j.fct.2017.03.034
PMID: 28343035
William M. Gwinn, Scott S. Auerbach, Fred Parham, Matthew D. Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, B. Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R. Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R. Shah, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Georgia Roberts, Michael J. DeVito
CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005
Rachel Frawley, Victor J. Johnson, Gary R. Burleson, Keith R Shockley, Mark F. Cesta, Greg Travlos, Michelle Cora, Georgia Roberts, Dori Germolec
TOX-106 Vanadium Compounds (Sodium Metavanadate and Vanadyl Sulfate):
Abstract for TOX-106
DOI:
https://doi.org/10.22427/NTP-DATA-500-001-001-000-7
Bevin E. Blake, Harlie A. Cope, Samantha M. Hall, Robert D. Keys, Beth W. Mahler, James McCord, Brittany Scott, Heather M. Stapleton, Mark J. Strynar, Susan A. Elmore, Suzanne E. Fenton
Environmental Health Perspectives(2020)
DOI:
https://doi.org/10.1289/EHP6233
PMID:
32074459
PMCID:
PMC7064328
DOI:
https://doi.org/10.22427/NTP-DATA-021-00006-0001-0000-0
Tucker DK, Hayes Bouknight S, Brar SS, Kissling G, Fenton S
Environmental Health Perspectives(2018)
DOI: https://doi.org/10.1289/EHP3189
PMID:30102602
DOI:
https://doi.org/10.22427/NTP-DATA-021-00004-0001-0000-8
Rachel Frawley, Dori Germolec, Victor Johnson, Travis Gulledge, Wimolnut Manheng, Kimber White Jr, Keith R Shockley, Shawn F Harris, Michelle Hooth, Kristen Ryan
Note: Data from this study are available upon request
DOI:
https://doi.org/10.22427/NTP-DATA-002-03253-0003-0000-8
Natasha R. Catlin, Cynthia J. Willson, Matthew Stout, Grace E. Kissling, Suramya Waidyanatha, Gregory L. Baker, Barry K. Hayden, Michael Wyde.
Inhalation Toxicology (2017).
DOI: https://doi.org/10.1080/08958378.2017.1390015
PMID: 29039228
Stephanie L. Smith-Roe, Carol D. Swartz, Asma Rashid, Nicholas C. Christy, Jamie E. Sly, Xiaoqing Chang, Nisha S. Sipes, Keith R. Shockley, Shawn F. Harris, Sandra J. McBride, Gary J. Larson, Bradley J. Collins, Esra Mutlu, Kristine L. Witt
Environmental and Molecular Mutagenesis:
https://onlinelibrary.wiley.com/doi/10.1002/em.22534
DOI:
https://doi.org/10.22427/NTP-DATA-002-02220-0014-0000-3
Two data values for one concentration in the 4 h +S9 experimental condition were corrected after a quality assurance audit. This finding did not impact the interpretation of the study.
Karrow NA, Guo TL, McCay JA, Johnson GW, Brown RD, Musgrove DL, Germolec DR, Luebke RW, White KL Jr.
Journal of Immunotoxicology (2018)
DOI: https://doi.org/10.1081/DCT-100103722
PMID: 11452397
Karrow NA, McCay JA, Brown RD, Musgrove DL, Germolec DR, White KL Jr.
Drug Chem Toxicol (2001)
DOI: https://doi.org/10.1081/DCT-100103083
PMID: 11307632
Derek T. Bernacki, Steven M. Bryce, Jeffrey C. Bemis, Stephen D. Dertinger, Kristine L. Witt, Stephanie L. Smith-Roe
Environmental and Molecular Mutagenesis, (in press): First Published: 30 September 2019
DOI:
https://doi.org/10.1002/em.22334
Luster MI, Rosenthal GJ, Cao W, Thompson MB, Munson AE, Prejean JD, Shopp G, Fuchs BA, Germolec DR, Tomaszewski JE.
Toxicol Appl Pharmacol (1989)
DOI: https://doi.org/
PMID: 1668555
Alexandre Borrel, Nicole Kleinstreuer, and Denis Fourches.
Bioinformatics (2018)
DOI: https://doi.org/10.1093/bioinformatics/bty412
PMID: 29790904
Brittany P. Rickard, Marta Overchuk, Justin Tulino, Xianming Tan, Frances S. Ligler, Victoria L. Bae-Jump, Suzanne E. Fenton, and Imran Rizvi
DOI:
https://doi.org/10.22427/NTP-DATA-500-009-001-000-5
Expression Studies Dataset:
DOI:
https://doi.org/10.22427/NTP-DATA-022-00004-0003-000-1
DOI:
https://doi.org/10.22427/NTP-DATA-002-00094-0003-0000-8
Rachel Frawley, Kimber White, Jr., Ronnetta Brown, Deborah Musgrove, Nigel Walker, Dori Germolec
Environmental Health Perspectives (2011) DOI:
https://doi.org/10.1289/ehp.1002358 PMID: 21041162
DOI:
https://doi.org/10.22427/NTP-DATA-002-00086-0001-0000-6
Richard A. Currie, Vincent Bombail, Jason D. Oliver, David J. Moore, Fei Ling Lim, Victoria Gwilliam, Ian Kimber, Kevin Chipman, Jonathan G. Moggs, George Orphanides
Toxicological Sciences (2005)
DOI: https://doi.org/10.1093/toxsci/kfi207
PMID: 15901911
Melinda S. Yates, Quynh T. Tran, Patrick M. Dolan, William O. Osburn, Soona Shin, Colin C. McCulloch, Jay B. Silkworth, Keiko Taguchi, Masayuki Yamamoto, Charlotte R. Williams, Karen T. Liby, Michael B. Sporn, Thomas R. Sutter, Thomas W. Kensler
Carcinogenesis (2009).
DOI: https://doi.org/10.1093/carcin/bgp100
PMID: 19386581
Guo TL, McCay JA, Zhang LX, Brown RD, You L, Karrow NA, Germolec DR, White KL Jr.
Journal of Immunotoxicology (2018)
DOI: https://doi.org/10.1093/jn/131.12.3251
PMID: 11739876
Guo TL, White KL Jr, Brown RD, Delclos KB, Newbold RR, Weis C, Germolec DR, McCay JA.
Toxicol Appl Pharmacol (2002)
DOI: https://doi.org/10.1006/taap.2002.9418
PMID: 12079431
Guo TL, Germolec DR, Zheng JF, Kooistra L, Auttachoat W, Smith MJ, White KL,
Elmore SA.
Toxicol Pathol (2015)
DOI: https://doi.org/10.1177/0192623314526318
PMID: 24713318
Le Zhan, Hui-Xin Liu, Yaping Fang, Bo Kong, Yuqi He, Xiao-bo Zhong, Jianwen Fang, Yu-Jui Yvonne Wan, Grace L. Guo
PLoS ONE (2014)
DOI: https://doi.org/10.1371/journal.pone.0105930
PMID: 25198545
Daniel Gusenleitner, Scott S. Auerbach, Tisha Melia, Harold F. Gómez, David H. Sherr, Stefano Monti
PLoS ONE (2014)
DOI: https://doi.org/10.1371/journal.pone.0102579
PMID: 25058030
David R. Goulding, Sally S. White, Sandra J. McBride, Suzanne E. Fenton, and G. Jean Harry.
Neurotoxicology (2017)
DOI: https://doi.org/10.1016/j.neuro.2016.11.008
PMID: 27888120
Guo TL, McCay JA, Brown RD, Musgrove DL, Butterworth L, Munson AE, Germolec DR, White KL Jr.
Drug Chem Toxicol (2000)
DOI: https://doi.org/10.1081/DCT-100100127
PMID: 10959546
Lunn RM, Blask DE, Coogan AN, Figueiro MG, Gorman MR, Hall JE, Hansen J, Nelson RJ, Panda S, Smolensky MH, Stevens RG, Turek FW, Vermeulen R, Carreón T, Caruso CC, Lawson CC, Thayer KA, Twery MJ, Ewens AD, Garner SC, Schwingl PJ, Boyd WA.
The Science of the Total Environment (2017)
DOI: https://doi.org/10.1016/j.scitotenv.2017.07.056
PMID: 28724246
Vivian S. Chen, James P. Morrison, Myra F. Southwell, Julie F. Foley, Brad Bolon, and Susan A. Elmore.
Toxicologic Pathology (2017)
DOI: https://doi.org/10.1177/0192623317728134
PMID: 28891434
Michael B. Fessler, Megan U. Carnes, Päivi M. Salo, Jesse Wilkerson, Richard D. Cohn, Debra King, Jane A. Hoppin, Dale P. Sandler, Greg Travlos, Stephanie J. London, Peter S. Thorne, and Darryl C. Zeldin.
Environmental Health Perspectives (2017).
DOI: https://doi.org/10.1289/EHP661
PMID: 28599265
Caitlin Lynch, Jinghua Zhao, Ruili Huang, Noriko Kanaya, Lauren Bernal, Jui-Hua Hsieh, Scott S Auerbach, Kristine L Witt, B Alex Merrick, Shiuan Chen, Christina T Teng, and Menghang Xia.
Endocrinology (2018).
DOI: https://doi.org/10.1210/en.2017-00658
PMID: 29216352
Brian N. Chorley, Michelle R. Campbell, Xuting Wang, Mehmet Karaca, Deepa Sambandan, Fatu Bangura, Peng Xue, Jingbo Pi, Steven R. Kleeberger, Douglas A. Bell
Nucleic Acids Research (2012).
DOI: https://doi.org/10.1093/nar/gks409
PMID: 22581777
McCollum CW, Conde-Vancells J, Hans C, Vazquez-Chantada M, Kleinstreuer N, Tal T, Knudsen T, Shah SS, Merchant FA, Finnell RH, Gustafsson JÅ, Cabrera R, Bondesson M.
Reproductive Toxicology (2017)
DOI: https://doi.org/10.1016/j.reprotox.2016.11.005
PMID: 27838387
Corton JC, KL Witt and CL Yauk
Chemical Research in Toxicology (2019) v. 32 (9): pp. 1748-1759
DOI:
https://doi.org/10.1021/acs.chemrestox.9b00052
Lynch C, Sakamuru S, Huang R, Stavreva DA, Varticovski L, Hager GL, Judson RS, Houck KA, Kleinstreuer NC, Casey W, Paules RS, Simeonov A, Xia M.
Toxicology (2017)
DOI: https://doi.org/10.1016/j.tox.2017.05.001
PMID: 28478275
Diana Herman and Peter Mantle.
Toxins (2017).
DOI: https://doi.org/10.3390/toxins9120384
PMID: 29182526
Kyathanahalli S. Janardhan, Heather Jensen, Natasha P. Clayton, and Ronald A. Herbert
Toxicologic Pathology (2018)
DOI: http://dx.doi.org/10.1177/0192623318776907
PMID: 29966501
Guo TL, Germolec DR, Roesh DM, White KL Jr.
Journal of Immunotoxicology (2010)
DOI: https://doi.org/10.3109/1547691X.2010.495097
PMID: 20560775
Thakur SA, Nyska A, White KL Jr, Smith MJ, Auttachoat W, Germolec DR.
Food Chem Toxicol. (2014)
DOI: https://doi.org/10.1016/j.fct.2014.03.015
PMID: 24657363
Frawley RP, Smith MJ, White KL Jr, Elmore SA, Herbert R, Moore R, Staska LM, Behl M, Hooth MJ, Kissling GE, Germolec DR.
J Immunotoxicol. (2016).
DOI: https://doi.org/10.3109/1547691X.2016.1154118
PMID: 27223060
Rachel P. Frawley, Matthew Smith, Mark F. Cesta, Schantel Hayes-Bouknight, Chad Blystone, Grace E. Kissling, Shawn Harris & Dori Germolec.
Journal of Immunotoxicology (2018)
DOI: https://doi.org/10.1080/1547691X.2018.1445145
PMID: 29514525
K A Shipkowski 1, M C Cora 1, M F Cesta 1, V G Robinson 1, S Waidyanatha 1, K L Witt 1, M K Vallant 1, D M Fallacara 2, M R Hejtmancik 2, S A Masten 1, S D Cooper 3, R A Fernando 3, C R Blystone 1
1Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
2Battelle Memorial Institute, Columbus, OH, USA.
3RTI International, Research Triangle Park, NC, USA.
Note: The PA46 was updated on September 14, 2021 for updates to stats for calculation of % animals with a finding.
Note: M09 was updated for number of spleen cells on September 1, 2021. The new tables contain a correction to a typographical error in the units for the Ig concentrations.
Note: M07 was updated for number of spleen cells on July 22, 2021. The I07 was updated on August 12, 2021 to reflect updated footnotes. The I04G was also updated on August 22, 2021 to reflect updated statistical analysis.
DOI:
https://doi.org/10.22427/NTP-DATA-002-03276-0016-0000-7
Bradley SG, White KL Jr, McCay JA, Brown RD, Musgrove DL, Wilson S, Stern M, Luster MI, Munson AE.
Drug Chem Toxicol (1994)
DOI: https://doi.org/10.3109/01480549409017861
PMID: 7988384
Victor J. Johnson1, Cynthia V. Rider2, Michael I. Luster1, Amy Brix3, Gary R. Burleson1, Michelle Cora2, Susan A. Elmore2, Rachel P. Frawley2, Franklin R. Lopez4, Esra Mutlu2, Keith R. Shockley2,5, Jessica Pierfelice6, Brian Burback6, Caroll A. Co7, Dori R. Germolec2
1Burleson Research Technologies, Inc., Morrisville, NC, USA
2Division of Translational Toxicology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
3Experimental Pathology Laboratories, Inc., Morrisville, NC, USA
4Charles River Laboratories, Morrisville, NC USA
5Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
6Battelle, Columbus, OH, USA
7Social and Scientific Systems Inc., a DLH Holdings Corp Company, Durham, NC, USA
DOI:
https://doi.org/10.22427/NTP-DATA-500-005-003-000-3
Smith MJ, Germolec DR, Luebke RW, Sheth CM, Auttachoat W, Guo TL, White KL Jr.
Journal of Immunotoxicology (2010)
DOI: https://doi.org/110.3109/1547691X.2010.519744
PMID: 20958156
Guo TL, McCay JA, Karrow NA, Brown RD, Musgrove DL, Luebke RW, Germolec DR, White KL Jr.
Journal of Immunotoxicology (2018)
DOI: https://doi.org/10.1081/DCT-100102606
PMID: 11360431
Madelyn C. Huang, Kimber L. White Jr., Susan A. Elmore, Tai L. Guo, Dori Germolec
DOI:
https://doi.org/10.22427/NTP-DATA-002-02772-0033-0000-6
Guo TL, Germolec DR, Collins BJ, Luebke RW, Auttachoat W, Smith MJ, White KL.
Journal of Immunotoxicology (2011)
DOI: https://doi.org/10.3109/1547691X.2011.622317
PMID: 22017662
Auttachoat W, Germolec DR, Collins BJ, Luebke RW, White KL Jr, Guo TL.
Journal of Immunotoxicology (2018)
DOI: https://doi.org/10.1080/1547691X.2018.1445145
PMID: https://doi.org/10.1080/1547691X.2018.1445145
PMID: 19514942
Dori Germolec, Robert Luebke, Andrew Rooney, Kelly Shipkowski, Rob Vandebriel, Henk van Loveren.
Current Opinion in Toxicology (2017).
DOI: https://doi.org/10.1016/j.cotox.2017.08.002
PMID: 28989989
Sheryl E. Arambula, Scott M. Belcher, Antonio Planchart, Stephen D. Turner, and Heather B. Patisaul.
Endocrinology (2016).
DOI: https://doi.org/10.1210/en.2016-1339
PMID: 27571134
Meghan E. Rebuli, Luísa Camacho, Maria E. Adonay, David M. Reif, David L. Aylor, and Heather B. Patisaul.
Toxicological Sciences (2015)
DOI: https://doi.org/10.1093/toxsci/kfv163
PMID: 26209558
Zang Q, Mansouri K, Williams AJ, Judson RS, Allen DG, Casey WM, Kleinstreuer NC.
Journal of Chemical Information and Modeling (2017)
DOI: https://doi.org/10.1021/acs.jcim.6b00625
PMID: 28006899
Shannon M. Bell, Xiaoqing Chang, John F. Wambaugh, David G. Allen, Mike Bartels, Kim L.R. Brouwer, Warren M. Casey, Neepa Choksi, Stephen S. Ferguson, Grazyna Fraczkiewicz, Annie M. Jarabek, Alice Ke, Annie Lumen, Scott G. Lynn, Alicia Paini, Paul S. Price, Caroline Ring, Ted W. Simon, Nisha S. Sipes, Catherine S. Sprankle, Judy Strickland, John Troutman, Barbara A. Wetmore, Nicole C. Kleinstreuer.
Toxicology in Vitro (2018).
DOI: https://doi.org/10.1016/j.tiv.2017.11.016
PMID: 29203341
Lea A. Cupul-Uicab, Efraín A. Terrazas-Medina, Mauricio Hernández-Ávila, Matthew P. Longnecker.
Environmental Research (2017).
DOI: https://doi.org/10.1016/j.envres.2017.08.027
PMID: 28841520
Oksana Sirenko, Fabian A. Grimm, Kristen R. Ryan, Yasuhiro Iwata, Weihsueh A. Chiu, Frederick Parham, Jessica A. Wignall, Blake Anson, Evan F. Cromwell, Mamta Behl, Ivan Rusyn, and Raymond R. Tice.
Toxicology and Applied Pharmacology (2017)
DOI: https://doi.org/10.1016/j.taap.2017.02.020
PMID: 28259702
DOI: https://doi.org/10.22427/NTP-DATA-002-00070-0001-0000-0
Paul M. D. Foster
Toxicologic Pathology (2017)
DOI: https://doi.org/10.1177/0192623316671608
PMID: 27708197
Lawrence S. Engel, Emily Werder, Jaya Satagopan, Aaron Blair, Jane A. Hoppin, Stella Koutros, Catherine C. Lerro, Dale P. Sandler, Michael C. Alavanja, and Laura E. Beane Freeman
Environmental Health Perspectives (2017)
DOI: https://doi.org/10.1289/EHP1295
PMID: 28934092
Leihong Wu, Zhichao Liu, Scott Auerbach, Ruili Huang, Minjun Chen, Kristin McEuen, Joshua Xu, Hong Fang, and Weida Tong.
Journal of Chemical Information and Modeling (2017)
DOI: https://doi.org/10.1021/acs.jcim.6b00719
PMID: 28350954
James M. Harrington, Laura G. Haines, Keith E. Levine, Chamindu Liyanapatirana, Amal S. Essader, Reshan A. Fernando, Veronica G. Robinson, Georgia K. Roberts, Matthew D. Stout, Michelle J. Hooth and Suramya Waidyanatha
Toxicology and Applied Pharmacology (2020)
DOI:
https://doi.org/10.1016/j.taap.2021.1153955
PMID: 33421504
Corrigendum to “Internal dose of vanadium in rats following repeated exposure to vanadyl sulfate and sodium orthovanadate via drinking water” Toxicology and Applied Pharmacology 412 (2021) Authors: James M. Harrington, Laura G. Haines, Keith E. Levine, Chamindu Liyanapatirana, Amal S. Essader, Reshan A. Fernando, Veronica G. Robinson, Georgia K. Roberts, Matthew D. Stout, Michelle J. Hooth and Suramya Waidyanatha PMID: 33905758
DOI:
https://doi.org/10.22427/NTP-DATA-002-02993-0008-0000-3
Steven M Bryce, Derek T Bernacki, Stephanie L Smith-Roe, Kristine L Witt, Jeffrey C Bemis, and Stephen D Dertinger.
Toxicological Sciences (2017).
DOI: https://doi.org/10.1093/toxsci/kfx235
PMID: 29106658
Pandiri AR, Kerlin RL, Mann PC, Everds NE, Sharma AK, Myers LP, Steinbach TJ.
Toxicol Pathol. (2016)
DOI: http://dx.doi.org/10.1177/0192623316672352
PMID: 27770107
Harlie A. Cope, Bevin E. Blake, Charlotte Love, James McCord, Susan A. Elmore, Janice B. Harvey, Vesna A. Chappell, Suzanne E. Fenton
Science Direct (2021)
https://doi.org/10.1016/j.emcon.2021.10.004
PMID:
35097227
DOI:
https://doi.org/10.22427/NTP-DATA-002-02657-0013-0000-6
Von Tungeln LS, Walker NJ, Olson GR, Mendoza MC, Felton RP, Thorn BT, Marques MM, Pogribny IP, Doerge DR, Beland FA.
Food Chem Toxicol. (2016), DOI: http://dx.doi.org/10.1016/j.fct.2016.11.015 PMID: 27871980
Authors:
Reinhard R. Beichel1, Robb W. Glenny2, Christian Bauer1, Melissa A. Krueger2, Wayne J. E. Lamm2
1 University of Iowa, Dept. of Electrical and Computer Engineering
2 University of Washington, Dept. of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine
Citations:
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RR Beichel, RW Glenny, C Bauer, MA Krueger, and WJ Lamm: “Lung anatomy + particle deposition (lapd) mouse archive.” University of Iowa. 2019. doi:10.25820/9arg-9w56.
DOI: https://doi.org/10.22427/NTP-DATA-501-001-003-000-0
Sayers BC, Walker NJ, Roycroft JH, Germolec DR, Baker GL, Clark ML, Hayden BK, DeFord H, Dill JA, Gupta A, Stout MD.
Toxicology (2016).
DOI: https://doi.org/10.1016/j.tox.2015.11.003
PMID: 26612504
Filgo AJ, Foley JF, Puvanesarajah S, Borde AR, Midkiff BR, Reed CE, Chappell VA, Alexander LB, Borde PR, Troester MA, Hayes Bouknight SA, Fenton SE.
Toxicol Pathol (2016),
DOI: https://doi.org/10.1177/0192623316663864
PMID: 27613106
Leah C. Wehmas, Anthony B. DeAngelo, Susan D. Hester, Brian N. Chorley, Gleta Carswell, Greg R. Olson, Michael H. George, Julia H. Carter, Sandra R. Eldridge, Anna Fisher, Beena Vallanat, Charles E. Wood
Toxicological Sciences (2017)
DOI: https://doi.org/10.1093/toxsci/kfx146
PMID: 28962523
Timothy R. Fennell, James M. Mathews, Rodney W. Snyder, Yan Hong, Scott L. Watson, Sherry R. Black, Barry S. McIntyre, and Suramya Waidyanatha.
Xenobiotica (2017).
DOI: https://doi.org/10.1080/00498254.2017.1400129
PMID: 29111853
Guo TL, Chi RP, Zhang XL, Musgrove DL, Weis C, Germolec DR, White KL Jr.
Food Chem Toxicol (2005)
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Reproductive Toxicology (2020)
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32229253
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NOTE:The NTP Fetal Observation Classification Glossary, NTP Clinical Observation Symptom Glossary and NTP Measurements and Endpoints Glossary are now searchable excel files
Shannah Witchey, Brad Collins, Georgia Roberts, Keith Shockley, Molly Vallant, Eve Mylchreest, Barney Sparrow, Robert Moyer, Tomas Guilarte, Helen Cunny, Jeffrey Krause, Mamta Behl
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Giovanni O. Quiroz-Delfi123, Cynthia V. Rider3, Stephen Ferguson
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1 Genome Integrity and Structural Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
2 Immunity, Inflammation, and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
3 Division of Translational Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
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https://doi.org/10.22427/NTP-DATA-002-02047-0004-0000-9
Note: The study data are being disseminated prior to external peer review under applicable information quality guidelines and do not represent and should not be construed to represent any final NTP determination or policy.
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1: Rancho Biosciences, San Diego, CA 92025
2: National Institute of Environmental Health Sciences, Division of Translational Toxicology, Research Triangle Park, NC 27709
3: Contract Office Representative
4: Project Lead
DOI:
https://doi.org/10.22427/NTP-DATA-500-010-002-000-8
Dataset: /datasets/search/biomarker-data-collection
Brian Chorley, Heidrun Ellinger-Ziegelbauer, Michael Tackett, Frank J. Simutis, Alison H. Harrill, James McDuffie, Elnaz Atabakhsh, Rounak Nassirpour, Laurence O. Whiteley, Jean-François Léonard, Ernie Harpur, Connie L. Chen, Jean-Charles Gautier
Toxicological Sciences (2020)
DOI:
https://doi.org/10.1093/toxsci/kfaa181
DOI:
https://doi.org/10.22427/NTP-DATA-002-00085-0001-0000-6
DOI:
https://doi.org/10.22427/NTP-DATA-023-00001-0001-000-7
PubMed:
30944845
Daven N. Jackson-Humbles, John Curtis Seely, Ronald A. Herbert, David E. Malarkey, Barry S. McIntyre, Paul M. Foster, and Darlene Dixon
Toxicologic Pathology (2018).
DOI: https://doi.org/10.1177/0192623318772487
PMID: 29706125
White KL Jr, Germolec DR, Musgrove DL, Delclos KB, Newbold RR, Weis C, Guo TL.
Journal of Immunotoxicology (2004)
DOI: https://doi.org/10.1080/15476910490518893
PMID: 18958644
Anderson SE, Munson AE, Butterworth LF, Germolec D, Morgan DL, Roycroft JA, Dill J, Meade BJ.
Journal of Immunotoxicology (2018)
DOI: https://doi.org/10.3109/08958370902953910
PMID: 20041805
Madelyn C. Huang, Cynthia J. Willson, Sridhar Jaligama, Gregory L. Baker, Alan W. Singer, Yu Cao, Jessica Pierfelice, Esra Mutlu, Brian Burback, Guanhua Xie, David E. Malarkey, Barney Sparrow, Kristen Ryan, Matthew Stout, and Georgia K. Roberts
Inhalation Toxicology (2021) DOI:
https://doi.org/10.1080/08958378.2021.2002480
DOI:
https://doi.org/10.22427/NTP-DATA-002-03356-0005-0000-4
Dahea You, Lascelles E. Lyn-Cook Jr., Daniel M. Gatti, Natalie Bell,, Philip R. Mayeux, Laura P. James, William B. Mattes, Alison H. Harrill.
DOI:
https://doi.org/10.22427/NTP-DATA-002-00076-0001-0000-6
Robert G. Pearce, R. Woodrow Setzer, Cory L. Strope, Nisha S. Sipes, John F. Wambaugh.
Journal of Statistical Software (2017)
DOI: https://doi.org/10.18637/jss.v079.i04
PMID: Not available