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Disposition and Metabolism of 2',2'''-Dithiobisbenzanilide in Rodents following Intravenous and Gavage Administration and Dermal Application

C. Edwin Garner, Christopher J. Wegerski, Joseph Lucak, Melanie Doyle-Eisele, Jacob D. McDonald, J. Michael Sanders, Benjamin C. Moeller and Suramya Waidyanatha

Radiolabel Description:
Carbon-14 uniformly on the rings; 2',2'''-Dithiobisbenzanilide, [phenyl-14C(U)]-

Vehicles:
Intravenous, emulphor:ethanol:water (3:5:2) or dimethylacetamide:polyethylene glycol 400:saline (15:55:30); Oral methylcellulose; Dermal, ethanol or acetone

Additional Information:
Two different vehicles were used for the rat 4 mg/kg intravenous treatments. Study C used water:ethanol:alkamuls (3:5:2) vehicle and Study C-2, dimethylacetamide:PEG400:saline (15:40:45).


ADME Data


Data Summary - Male Rats

Data Summary - Female Rats

Data Summary - Male Mice

Data Summary - Female Mice