Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Disposition and Metabolism of 2',2'''-Dithiobisbenzanilide in Rodents following Intravenous and Gavage Administration and Dermal Application

C. Edwin Garner, Christopher J. Wegerski, Joseph Lucak, Melanie Doyle-Eisele, Jacob D. McDonald, J. Michael Sanders, Benjamin C. Moeller and Suramya Waidyanatha

Radiolabel Description:
Carbon-14 uniformly on the rings; 2',2'''-Dithiobisbenzanilide, [phenyl-14C(U)]-

Vehicles:
Intravenous, emulphor:ethanol:water (3:5:2) or dimethylacetamide:polyethylene glycol 400:saline (15:55:30); Oral methylcellulose; Dermal, ethanol or acetone

Additional Information:
Two different vehicles were used for the rat 4 mg/kg intravenous treatments. Study C used water:ethanol:alkamuls (3:5:2) vehicle and Study C-2, dimethylacetamide:PEG400:saline (15:40:45).


ADME Data


Data Summary - Male Rats

Data Summary - Female Rats

Data Summary - Male Mice

Data Summary - Female Mice