Disposition and metabolism of antibacterial agent, Triclocarban; a species and route comparison
Suramya Waidyanatha, Sherry R. Black, Purvi R. Patel, Jason Stanko, Scott L. Watson, Rodney W. Snyder, and Timothy R. Fennell
https://doi.org/10.22427/NTP-DATA-002-02949-0005-0000-1
Radiolabel Description:
Carbon-14 in the phenyl ring with one chloride; Triclocarban, [Chlorophenyl ring-14C(U)]-
Vehicles:
Oral, corn oil; Dermal, acetone.
ADME Data
Data Summary - Male Rats
- Dermal Single Dose Group 9 (3 %, 15 mg/kg, Covered, Study Duration 72 hours) (67 KB)
- Dermal Single Dose Group 10 (1.5%, 7.5 mg/kg,Covered, Study Duration 72 hours) (61 KB)
- Dermal Single Dose Group 14 (3 %, 15 mg/kg, Study Duration 72 hours) (67 KB)
- Gavage Single Dose Group 1 (500 mg/kg, Study Duration 72 hours) (68 KB)
- Gavage Single Dose Group 2 (150 mg/kg, Study Duration 72 hours) (65 KB)
- Gavage Single Dose Group 3 (50 mg/kg, Study Duration 72 hours) (80 KB)
- Gavage Single Dose Group 4 (50 mg/kg, Study Duration 24 hours) (55 KB)
- Gavage Single Dose Group 5 (50 mg/kg, Study Duration 48 hours) (50 KB)
Data Summary - Female Rats
- Dermal Single Dose Group 11 (1.5%, 7.5 mg/kg, Covered, Study Duration 72 hours (60 KB)
- Gavage Single Dose Group 6 (50 mg/kg, Study Duration 72 hours) (71 KB)
Data Summary - Male Mice
- Dermal Single Dose Group 12 (1.5%, 18.75 mg/kg, Covered, Study Duration 72 hours) (76 KB)
- Gavage Single Dose Group 7 (50 mg/kg, Study Duration 72 hours) (86 KB)