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CEBS Release Notes

DECEMBER

  1. NTP/DTT Data Collections 2024-Present
  2. Release of 2-Chloro-and 2-Bromopalmitic acids inhibit mitochondrial Function in Airway Epithelial Cells

NOVEMBER 2024 Data Release

  1. November Data Dictionary Update

OCTOBER 2024 Data Release

  1. October Data Dictionary Update
  2. Release of TOX-107 Stachybotrys Chartarum
  3. Release of NIEHS Report 11: NIEHS Report on the Toxicity Studies of Nicotine Bitartrate Dihydrate (CASRN 6019-06-3) Administered in Drinking Water to Sprague Dawley Rats and Swiss Mice
  4. Update to Botanical Safety Consortium Publications Page
  5. Update to Botanical Safety Consortium – Chemical Analysis Page

SEPTEMBER 2024 Data Release

  1. Update of Toxicokinetic Studies
  2. Update of Developmental NeuroToxicity Data Integration and Visualization Enabling Resource (DNT-DIVER)
  3. Update of Fetal Pathology Historical Control
  4. Update of Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes
  5. Update of Botanical Safety Consortium Hepatotoxicity Data

AUGUST 2024 Data Release

  1. Update of Toxicokinetic Studies
  2. August Data Dictionary Update

JULY 2024 Data Release

  1. Update of Publication Page "Botanical Safety Consortium – Chemical Analysis"
  2. Release of Publication Page "Botanical Safety Consortium Hepatotoxicity Data"
  3. Update of Publication Page "DrugMatrix"

JUNE 2024 Data Release

  1. June Data Dictionary Update

MAY 2024 Data Release

  1. Release of TR-604: Triclosan
  2. Release of Publication "Transcriptomic biomarkers of toxicological effect"
  3. Release of Publication Page "Botanical Safety Consortium Publications"
  4. Release of Publication Page "Annotated Toxicokinetic Data"
  5. Release of Publication Page "Chemistry Lists"
  6. Update to Read Me file on Data Dictionary page

APRIL 2024 Data Release

  1. Release of the Publication Page "Lung Anatomy + Particle Deposition (lapd) Mouse Archive for Modeling and Computational Toxicology"
  2. Release of the Publication Page "Completion of the DrugMatrix Toxicogenomics Database using ToxCompl"

MARCH 2024 Data Release

  1. Updates to Study Pages associated with several toxicokinetic studies

FEBRUARY 2024 Data Release

  1. Updates to Study Pages and a Program of Work Page associated with several toxicokinetic studies
  2. Add files to existing study pages for studies associated with the publication "Internal dose of vanadium in rats following repeated exposure to vanadyl sulfate and sodium orthovanadate via drinking water"
  3. February Data Dictionary Updates

JANUARY 2024 Data Release

  1. Updates to Botanical Safety Consortium – Chemical Analysis Page
  2. Updates to Study Pages associated with several toxicokinetic studies
  3. Release of a study page associated with the publication "Exposure to Select PFAS and PFAS Mixtures Alters Response to Platinum-Based Chemotherapy in Endometrial Cancer Cell Lines"
  4. January Data Dictionary Updates

DECEMBER 2023 Data Release

  1. Release of the publication "Exposure to Select PFAS and PFAS Mixtures Alters Response to Platinum-Based Chemotherapy in Endometrial Cancer Cell Lines"
  2. Updates to Study Pages associated with several toxicokinetic studies
  3. Updates to Study Page display for 4 studies associated with Sodium metavanadate and Vanadyl sulfate
  4. Dec Data Dictionary Updates
  5. Release of TR-603: Black Cohosh

NOVEMBER 2023 Data Release

  1. Updates to Study Pages associated with several toxicokinetic studies
  2. Nov Data Dictionary Updates

OCTOBER 2023 Data Release

  1. Release of study pages associated with the publication "Immunotoxicity of N-Butylbenzenesulfonamide (NBBS): Impacts on Immune Function in Adult Mice and Developmentally Exposed Rats"
  2. Update to Benzophenone (119-61-9) Test Article Page
  3. Update to 2-Hydroxy-4-methoxybenzophenone (131-57-7) Test Article Page
  4. Release of "Botanical Safety Consortium – Chemical Analysis" page
  5. Update to publication "Immunotoxicity Studies of Sulfolane Following Developmental Exposure in Hsd:Sprague Dawley SD Rats and Adult Exposure in B6C3F1/N Mice"
  6. Update to publication "Comparison of sulfolane effects in Sprague Dawley rats, B6C3F1/N mice, and Hartley guinea pigs after 28 days of exposure via oral gavage"
  7. Release of study pages associated with the publication "Immunotoxicity Studies of Sulfolane Following Developmental Exposure in Hsd:Sprague Dawley SD Rats and Adult Exposure in B6C3F1/N Mice"
  8. Release of publication "Non-targeted Chemical Analysis of Consumer Botanical Products Labelled as Blue Cohosh (Caulophyllum thalictroides), Goldenseal (Hydrastis canadensis), or Yohimbe Bark (Pausinystalia johimbe) by NMR and MS"
  9. Oct Data Dictionary Updates

SEPTEMBER 2023 Data Release

  1. Release of study pages associated with publication "Phenolic benzotriazoles: a class comparison of toxicokinetics of ultraviolet-light absorbers in male rats"
  2. Update & release of study pages associated with the Test Article Carbon disulfide
  3. Release of study pages associated with several toxicokinetic studies
  4. Release of a Test Article page and associated study pages for Historical Control Studies
  5. Release of a page for DART – Rabbit Historical Control Data (2015-2018)
  6. Sept Data Dictionary Updates

AUGUST 2023 Data Release

  1. July Data Dictionary Updates
  2. Update Publication "Evaluation of the herbicide glyphosate, (aminomethyl)phosphonic acid, and glyphosate-based formulations for genotoxic activity using in vitro assays"
  3. Release of Test Article pages and study pages associated with publication "Evaluation of the herbicide glyphosate, (aminomethyl)phosphonic acid, and glyphosate-based formulations for genotoxic activity using in vitro assays"
  4. Release of the publication "Immunotoxicity of N-Butylbenzenesulfonamide (NBBS): Impacts on Immune Function in Adult Mice and Developmentally Exposed Rats"

JUNE 2023 Data Release

  1. June Data Dictionary Updates
  2. Add data from Manuscript Publications in a Study View format to the following Test Article Pages - Sodium metavanadate (13718-26-8), Thallium (I) sulfate (7446-18-6), N-Butylbenzenesulfonamide (3622-84-2), & alpha-Pinene (80-56-8)
  3. Release of TR-602: TCPP

MAY 2023 Data Release

  1. May Data Dictionary Updates
  2. Updates to Valerian Root Extract Test Article page
  3. Update DrugMatrix Page with an Additional File
  4. Release of publication "Evaluation of Immunotoxicity of Sodium Metavanadate Following Drinking Water Exposure in Female B6C3F1/N Mice in a 28-day Study"
  5. Release of publication "Short-term Toxicity Studies of Thallium (I) Sulfate Administered in Drinking Water to Sprague Dawley Rats and B6C3F1/N Mice"

APRIL 2023 Data Release

  1. April Data Dictionary Updates
  2. Release of DrugMatrix Page
  3. Updates to the publication "Reproductive and developmental toxicity following exposure to organophosphate ester flame retardants and plasticizers, triphenyl phosphate and isopropylated phenyl phosphate, in Sprague Dawley rats"
  4. Updates to NBBS Study K10482B
  5. Update to a file associated with Study G08022 for ASPERGILLUS MICRONUCLEUS

MARCH 2023 Data Release

  1. Release of publication "Evaluation of the herbicide glyphosate, (aminomethyl)phosphonic acid, and glyphosate-based formulations for genotoxic activity using in vitro assays"
  2. March Data Dictionary Updates
  3. Add additional citation link to manuscript publication page for "Evaluation of the herbicide glyphosate, (aminomethyl)phosphonic acid, and glyphosate-based formulations for genotoxic activity using in vitro assays"
  4. Release of TOX-98: Acetoin & 2,3-Pentanedione
  5. Release of the PFAS 5-Day Reports - NIEHS-07, NIEHS-08, NIEHS-09, & NIEHS-10

FEBRUARY 2023 Data Release

  1. Release of TOX-106 Vanadium Compounds
  2. Release of publication "Photodynamic Priming Overcomes Per- and Polyfluoroalkyl Substance (PFAS)-Induced Platinum Resistance in Ovarian Cancer"
  3. Update TR-598 PFOA Page
  4. Release of publication "Repeat 5-day in vivo genomic dose response studies"
  5. Release of "Benchmark Dose Analysis for Neoplastic and Non-neoplastic Lesions" as a publication page

JANUARY 2023 Data Release

  1. January Data Dictionary Updates
  2. Publication Updates
  3. Release of publication "Transcriptional pathways linked to fetal and maternal hepatic dysfunction caused by gestational exposure to perfluorooctanoic acid (PFOA) or hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) in CD-1 mice"

NOVEMBER 2022 Data Release

  1. Gwinn Paper Updates
  2. November Data Dictionary Updates
  3. Correct Typo of Pentabromodiphenyl Oxide to Pentabromodiphenyl Ether
  4. PFAS PCR data labeling File Update
  5. New Dataset Compiling Data on Flame Retardants

OCTOBER 2022 Data Release

  1. TOX-104/105 Release
  2. NIEHS-02, NIEHS-03, NIEHS-04, NIEHS-05, NIEHS-06 (aromatic phosphate 5-day reports) release
  3. Genetox File Update for Sulfolane (G11054C)
  4. Di(n-hexyl)phthalate K10996 ADME File Update
  5. Apply updates to Flame Retardants page on CEBS

SEPTEMBER 2022 Data Release

  1. DART-08 Release

AUGUST 2022 Data Release

  1. Data Dictionary (August Updates)
  2. Data were incorrectly placed on a test article page with incorrect CAS number. This has been rectified and data are now shown on the correct page.

JULY 2022 Data Release

  1. Re-Release of TOX-96 and TOX-97
  2. Data Dictionary (July Updates)
  3. Update DART-05 and DART-06 abstract links
  4. Fluorotelomer alcohol 8+2 (678-39-7) Page Update
  5. Release Tox21 Purity
  6. Genetic Toxicity Evaluation of tris(Chloropropyl)phosphate (13674-84-5) in Micronucleus Study G20263B in B6C3F1 Mice to Equivocal for Male Mice
  7. Linked Expression Studies, Additional studies added to the Expression Studies Dataset

JUNE 2022 Data Release

  1. Release of NTP Publication TOX-103 (Ionic Liquids)
  2. Release of NTP Publication DART-05 (2-Hydroxy-4-methoxybenzophenone)
  3. Release of NTP Publication DART-06 (2-Ethylhexyl p-Methoxycinnamate)
  4. Release of NTP Publication NIEHS-01 NIEHS Report on Evaluating Features and Application of Neurodevelopmental Tests in Epidemiological Studies
  5. Release of publication "Whole-body inhalation exposure to 2-ethyltoluene for two weeks produced nasal lesions in rats and mice"
  6. Updates to DNTP Data Dictionary for Modifiers and Locators

MAY 2022 Data Release

  1. Update data on DNTP Data Dictionary
  2. Added page for past terminology for DNTP Data Dictionary
  3. Release of publication " The common indoor air pollutant α-pinene is metabolized to a genotoxic metabolite α-pinene oxide"
  4. Updated name of Expression Study Catalog to Expression Studies, Supporting Data
  5. Linked Expression Studies, Supporting Data to the Expression Studies Dataset
  6. Release Data for "Genetic Toxicity Evaluation of N-Ethyl-N-nitrosourea (759-73-9) in Micronucleus Study G11185 in Male Harlan Sprague Dawley Rats"
  7. Updated result of Gentox study G07018B. Changed result for Female Mice to Negative to match the report
  8. Updated Organ Sites with Neoplasia search results to include the "Organ Site Call", as well as the Level of Evidence for the Overall Category of carcinogenicity, for the TR, Species, Strain, and Sex.
  9. Updated the Bioassay Genetox Conclusion Dataset to include data from newly released Genetox studies mentioned above
  10. Updated the In Vivo Micronucleus Dataset to include data from newly released Genetox studies mentioned above
  11. Release of publication "Select Per- and Polyfluoroalkyl Substances (PFAS) Induce Resistance to Carboplatin in Ovarian Cancer Cell Lines"

APRIL 2022 Data Release

  1. DNTP Data Dictionary
  2. Expression Study Catalog
  3. Publication A high-throughput toxicity screen of 42 per- and polyfluoroalkyl substances (PFAS) and functional assessment of migration and gene expression in human placental trophoblast cells by Bevin Blake, Brittany P. Rickard, and Suzanne E. Fenton

MARCH 2022 Data Release

  1. Added Benchmark Response (BMR) Table to publication Developmental NeuroToxicity Data Integration and Visualization Enabling Resource (DNT-DIVER).

FEBRUARY 2022 Data Release

  1. Data for the following publications:
    • TR-599
    • TR-600
    • TR-601
    • TOX-14
    • TOX-54
    • TOX-59
    • TOX-71
    • TOX-73
    • TOX-79
    • TOX-102
    • DART-07

  2. Re-release of Artificial Butter Flavorings and related pages

  3. Searchable and Filterable Excel files added to NTP Provantis Glossaries for Clinical observations, Fetal Pathology and Measurements and Endpoints

  4. The following updates were made to Genetox Conclusion Dataset

    • "Multiple LOE Conclusion" column is used to show chemically-related neoplastic effects in studies showing multiple chemical related neoplastic effect
    • DTXSID (DSSTox substance identifier) was added
    • Dataset was updated with conclusions from recent NTP Technical Reports (e.g. TR-599, TR-600, TR-601)
    • Not a Valid Test, or No Call were removed from legacy genetox conclusions
    • Nonstandard Protocol note was removed from older genetox conclusions
    • Conclusions for bioassay fish studies were removed
    • Conclusions of Tox21 studies were removed

  5. Release of data for publication titled "Latent, sex-specific metabolic health effects in CD-1 mouse offspring exposed to PFOA or HFPO-DA (GenX) during gestation"

  6. Updated abstract link for publication "Final Report on the Developmental Toxicity of 1,4-Butanediol in Swiss (CD-1) Mice"