Lung Anatomy + Particle Deposition (lapd) Mouse Archive for Modeling and Computational Toxicology
Authors:
Reinhard R. Beichel1, Robb W. Glenny2, Christian Bauer1, Melissa A. Krueger2, Wayne J. E. Lamm2
1 University of Iowa, Dept. of Electrical and Computer Engineering
2 University of Washington, Dept. of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine
Citations:
Bauer C, Krueger M, Lamm WJE, Glenny RW, Beichel RR. lapdMouse: associating lung anatomy with local particle deposition in mice. J Appl Physiol(1985). 2020 Feb 01;128(2):309-323. doi:10.1152/japplphysiol.00615.2019. PMID: 31774357.
RR Beichel, RW Glenny, C Bauer, MA Krueger, and WJ Lamm: “Lung anatomy + particle deposition (lapd) mouse archive.” University of Iowa. 2019. doi:10.25820/9arg-9w56.
DOI: https://doi.org/10.22427/NTP-DATA-501-001-003-000-0
Publication
Abstract
The mouse is the most commonly used animal model for toxicology risk assessments and tobacco smoke exposure. Because it is not possible to study every substance exposure or varying exposure conditions, mathematical models and computer simulations are employed to fill the gap or to extend the range of experimental data. However, computational toxicology is limited in its application to mouse inhalation exposure studies because of the lack of high-resolution accurate airway geometries needed for modeling and site-specific particle deposition data. By combining the unique imaging capabilities of the imaging cryomicrotome at the University of Washington with the expertise in highly-automated airway segmentation algorithms from the University of Iowa, we have developed methods to provide high-resolution 3D geometries of the four most commonly studied mice strains along with site-specific airway particle dosimetry in the same animals. The high-resolution datasets are shared through this website and can be used by other investigators to accelerate investigation of health and diseases related to the respiratory system. This will in turn improve our understanding of site-specific airflows and how they affect drug, environmental, or biological aerosol deposition in health and diseases related to occupational exposures, air pollution and tobacco smoke.