U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Botanical Safety Consortium Publications

Botanical dietary supplement use is widespread and growing, therefore, ensuring the safety of botanical products is a public health priority. The Botanical Safety Consortium (BSC) is a public-private partnership aimed at enhancing the toolkit for conducting the safety evaluation of botanicals. This partnership is the result of a Memorandum of Understanding between the US FDA, the National Institute of Environmental Health Sciences, and the Health and Environmental Sciences Institute. The BSC serves as a global forum for scientists from government, academia, consumer health groups, industry, and non-profit organizations to work collaboratively on adapting and integrating new approach methodologies (NAMs) into routine botanical safety assessments.

DOI: https://doi.org/10.22427/NTP-DATA-500-007-003-000-5

Publication

Citations

Patel, S., et al. (2023). "Improving the Rigor and Utility of Botanical Toxicity Studies: Recommended Resources." Regulatory Toxicology and Pharmacology. DOI: 10.1016/j.yrtph.2023.105471

Smith, J., et al. (2023). "Potential Pharmacokinetic Interactions with Concurrent Use of Herbal Medicines and a Ritonavir-Boosted COVID-19 Protease Inhibitor in Low and Middle-Income Countries." Frontiers in Pharmacology. DOI: 10.3389/fphar.2023.1210579.

Pearson, A., et al. (2022). "Plant vs. Kidney: Evaluating Nephrotoxicity of Botanicals with the Latest Toxicological Tools." Current Opinion in Toxicology. DOI: 10.1016/j.cotox.2022.100371.

Mitchell, C. A., et al. (2022). "The Botanical Safety Consortium: A public-private partnership to enhance the botanical safety toolkit." Regulatory Toxicology and Pharmacology. DOI: 10.1016/j.yrtph.2021.105090.

Roe, A. L., et al. (2019). "The Botanical Safety Consortium." Applied In Vitro Toxicology, DOI: 10.1089/aivt.2018.29018.rtl

Yitong, L., Lawless., M, Li, M., Fairman, K., Embry, M. R., Mitchell, C.A., (2024). "Prediction of physicochemical and pharmacokinetic properties of botanical constituents by computational models." Journal of Applied Toxicology. DOI: 10.1002/jat.4617.rtl

Waidyanatha, S., Collins, B. J., Cristy, T., Embry, M., Gafner, S., Johnson, H., Kellogg, J., Krzykwa, J., Li, S., Mitchell, C. A., Mutlu, E., Pickett, S., You, H., Breemen, R. V., Baker, T. R., (2024). "Advancing botanical safety: A strategy for selecting, sourcing, and characterizing botanicals for developing toxicological tools." DOI: 10.1016/j.fct.2024.114537.rtl

Zeiger, E., Mitchell, C. A., Pfuhler, S., Liao, y., Witt, K. L., (2024). "Within-laboratory reproducibility of Ames test results: Are repeat tests necessary? Environmental and Molecular Mutagenesis" DOI: 10.1002/em.22597.rtl