TOX21 Data

The Toxicology in the 21st Century (Tox21) program utilizes high-throughput screening approaches to rapidly and efficiently evaluate the safety of broad classes of compounds. The Tox21 Consortium is a federal collaboration between the U.S. Environmental Protection Agency (EPA), National Toxicology Program (NTP) headquartered at the National Institute of Environmental Health Sciences (NIEHS), National Center for Advancing Translational Sciences (NCATS), and Food and Drug Administration (FDA).

DOI: https://doi.org/10.22427/NTP-DATA-500-019-000-000-5

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TOX21 Data Access Information

Phase I - initial screening with a compound library to establish proof of principle, assay selection, and data analysis

• Phase I data access details can be found in Table 1 of Improving the Human Hazard Characterization of Chemicals: A Tox21 Update
• Compound purity information is available through the Chemical Effect of Biological System (CEBS) repository

Phase II - expanded, more comprehensive chemical library, focused assays, and data integration

• Phase II data are available through the National Center for Advancing Translational Sciences (NCATS) TOX21 Gateway
• Phase II data are also accessible through the National Library of Medicine (NLM) PubChem Tox21 Bioassays
• Curated Tox21 screening data and EPA ToxCast data are available through the Integrated Chemical Environment (ICE) website