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NIEHS In Vivo Repeat Dose Biological Potency Studies

The National Institute of Environmental Health Sciences (NIEHS) Division of Translational Toxicology (DTT) conducts in vivo repeat dose biological potency studies to estimate a chemical's potency by analyzing transcriptomic changes from short-term animal studies using standardized protocols. Similar to the EPA's Transcriptomic Assessment Product (ETAP), these NIEHS reports use mathematical model-based approaches to identify and report the potency of dose-responsive effects without making subjective interpretations or hazard conclusions. The methodology is based on a peer-reviewed and approved standardized process, where the study design, analysis, and results presentation are consistently applied across different chemicals. This approach is founded on scientific evidence demonstrating that the transcriptomic potency derived from a short-term (e.g., 5-day) in vivo study can serve as a reasonable approximation of the toxicological potency observed in more resource-intensive, long-term guideline assessments.

This page will be updated when new studies are available.
DOI: https://doi.org/10.22427/NTP-DATA-500-200-001-000-8

In Vivo Repeat Dose Biological Potency Study of per- and polyfluoroalkyl substances (PFAS), in Sprague Dawley Rats

NIEHS Report on the In Vivo Repeat Dose Biological Potency Study of 6:1 Fluorotelomer Alcohol (CASRN 375-82-6) in Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats (Gavage Studies)

NIEHS Report 07: https://doi.org/10.22427/NIEHS-07
CEBS Data Page: https://doi.org/10.22427/NIEHS-DATA-NIEHS-07

NIEHS Report on the In Vivo Biological Potency Study of 1,1,2,2-Tetrahydroperfluoro-1-dodecanol (CASRN 865-86-1) in Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats (Gavage Studies)

NIEHS Report 08: https://doi.org/10.22427/NIEHS-08
CEBS Data Page: https://doi.org/10.22427/NIEHS-DATA-NIEHS-08

NIEHS Report on the In Vivo Repeat Dose Biological Potency Study of 2,3-Benzofluorene (CASRN 243-17-4) in Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats (Gavage Studies)

NIEHS Report 09: https://doi.org/10.22427/NIEHS-09
CEBS Data Page: https://doi.org/10.22427/NIEHS-DATA-NIEHS-09

NIEHS Report on the In Vivo Repeat Dose Biological Potency Study of Perfluorohexanesulfonamide (CASRN 41997-13-1) in Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats (Gavage Studies)

NIEHS Report 10: https://doi.org/10.22427/NIEHS-10
CEBS Data Page: https://doi.org/10.22427/NIEHS-DATA-NIEHS-10

In Vivo Repeat Dose Biological Potency Study of Aromatic Phosphates in Sprague Dawley Rats

NIEHS Report on the In Vivo Repeat Dose Biological Potency Study of 2-Ethylhexyl Diphenyl Phosphate (CASRN 1241-94-7) in Male Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats (Gavage Studies)

NIEHS Report 02: https://doi.org/10.22427/NIEHS-02
CEBS Data Page: https://doi.org/10.22427/NIEHS-DATA-NIEHS-02

NIEHS Report on the In Vivo Repeat Dose Biological Potency Study of tert-Butylphenyl Diphenyl Phosphate (CASRN 56803-37-3) in Male Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats (Gavage Studies)

NIEHS Report 03: https://doi.org/10.22427/NIEHS-03
CEBS Data Page: https://doi.org/10.22427/NIEHS-DATA-NIEHS-03

NIEHS Report on the In Vivo Repeat Dose Biological Potency Study of Isodecyl Diphenyl Phosphate (CASRN 29761-21-5) in Male Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats (Gavage Studies)

NIEHS Report 04: https://doi.org/10.22427/NIEHS-04
CEBS Data Page: https://doi.org/10.22427/NIEHS-DATA-NIEHS-04

NIEHS Report on the In Vivo Repeat Dose Biological Potency Study of Isopropylated Phenol Phosphate (CASRN 68937-41-7) in Male Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats (Gavage Studies)

NIEHS Report 05: https://doi.org/10.22427/NIEHS-05
CEBS Data Page: https://doi.org/10.22427/NIEHS-DATA-NIEHS-05

NIEHS Report on the In Vivo Repeat Dose Biological Potency Study of Tricresyl Phosphate (CASRN 1330-78-5) in Male Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats (Gavage Studies)

NIEHS Report 06: https://doi.org/10.22427/NIEHS-06
CEBS Data Page: https://doi.org/10.22427/NIEHS-DATA-NIEHS-06

NTP Research Report on In Vivo Repeat Dose Biological Potency Study of Triphenyl Phosphate (CAS No. 115-86-6) in Male Sprague Dawley Rats (Hsd:Sprague Dawley SD) (Gavage Studies)

NTP Research Report 08: https://doi.org/10.22427/NTP-RR-8
CEBS Data Page: https://doi.org/10.22427/NTP-DATA-RR-8