West Virginia Chemical Spill
Study Data
Toxicity and Carcinogenicity Studies
Benchmark Dose Analysis of NTP Elk River, West Virginia Chemical Spill-Associated Samples
Propylene Glycol Phenyl Ether: Benchmark Dose Analysis Results
- Propylene Glycol Phenyl Ether: Individual Gene Benchmark Dose Results in Toxicogenomics Study in Male Harlan Sprague Dawley Rats - June 2016 (12 kB)
- Propylene Glycol Phenyl Ether: Molecular Biological Processes Benchmark Dose Results in Toxicogenomics Study in Male Harlan Sprague Dawley Rats - June 2016 (16 kB)
Documentation
- Chemical Methods - WV Chemical Spill NTP Studies (440 kB)
- Materials and Methods - 5-Day Rat Toxicogenomic Studies (479 kB)
- Readme File for 5-Day Rat Toxicogenomic Studies: Microarray and Benchmark Dose Analysis Components (382 kB)
Crude 4-Methylcyclohexanemethanol: Benchmark Dose Analysis Results
- Crude 4-Methylcyclohexanemethanol: Individual Gene Benchmark Dose Results in Toxicogenomics Study in Male Harlan Sprague Dawley Rats - June 2016 (10 kB)
- Crude 4-Methylcyclohexanemethanol: Molecular Biological Processes Benchmark Dose Results in Toxicogenomics Study in Male Harlan Sprague Dawley Rats - June 2016 (12 kB)
4-Methylcyclohexanemethanol: Benchmark Dose Analysis Results
- 4-Methylcyclohexanemethanol Individual Gene Benchmark Dose Results in Toxicogenomics Study in Male Harlan Sprague Dawley Rats-June 2016 (10 kB)
- 4-Methylcyclohexanemethanol: Molecular Biological Processes Benchmark Dose Results in Toxicogenomics Study in Male Harlan Sprague Dawley Rats - June 2016 (12 kB)
Genetic Toxicology Studies
Genetic Toxicity Evaluation of 1,4-Cyclohexanedimethanol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G14004
Summary Data
- G06 - Ames Summary Data (79 KB)
Genetic Toxicity Evaluation of 2-Methylcyclohexanemethanol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G14027
Summary Data
- G06 - Ames Summary Data (74 KB)
Genetic Toxicity Evaluation of 4-Methoxymethylcyclohexylmethanol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G14002
Summary Data
- G06 - Ames Summary Data (73 KB)
Genetic Toxicity Evaluation of 4-Methylcyclohexanemethanol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G14001B
Summary Data
- G06 - Ames Summary Data (79 KB)
Genetic Toxicity Evaluation of Crude MCHM in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G14013B
Summary Data
- G06 - Ames Summary Data (79 KB)
Genetic Toxicity Evaluation of Dimethyl 1,4-Cyclohexanedicarboxylate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G14005
Summary Data
- G06 - Ames Summary Data (82 KB)
Genetic Toxicity Evaluation of Dipropylene Glycol Phenyl Ether in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G14012
Summary Data
- G06 - Ames Summary Data (78 KB)
Genetic Toxicity Evaluation of Dowanol DiPPh Glycol Ether in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G15004
Summary Data
- G06 - Ames Summary Data (78 KB)
Genetic Toxicity Evaluation of Methyl 4-Methylcyclohexanecarboxylate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G14003
Summary Data
- G06 - Ames Summary Data (86 KB)
Genetic Toxicity Evaluation of Propylene Glycol Phenyl Ether in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G14011B
Summary Data
- G06 - Ames Summary Data (78 KB)
Other NTP Studies
4-Methylcyclohexanemethanol (MCHM): Prenatal Developmental Toxicity Dose Range Finding Study (MCHM; CAS no. 34885-03-5) Administered by Oral Gavage to Harlan Sprague Dawley Rats
Study Tables
- Animal Removal Summary (42 kB)
- Clinical Observations Summary (111 kB)
- Fetal Defect Summary (44 kB)
- Fetal Defects (55 kB)
- Gross Pathology Summary (139 kB)
- Growth Curve (51 kB)
- Mean Body Weight Gain (56 kB)
- Mean Body Weights and Survival (125 kB)
- Mean Feed Consumption (58 kB)
- Organ Weights Summary (38 kB)
- Placental Findings (33 kB)
- Uterine Content Summary (81 kB)
Individual Animal Data
- Individual Animal Body Weights (45 kB)
- Individual Animal Clinical Observations (46 kB)
- Individual Animal Dam Findings (12 kB)
- Individual Animal Food Consumption (18 kB)
- Individual Animal Gross Pathology (48 kB)
- Individual Animal Implant Findings (67 kB)
- Individual Animal Organ Weights (13 kB)
- Individual Animal Removal Reasons (13 kB)
Documentation
4-Methylcyclohexanemethanol (MCHM): Prenatal Developmental Toxicity Study (MCHM; CAS no. 34885-03-5) Administered by Oral Gavage to Harlan Sprague Dawley Rats
Study Tables
- Animal Removal Summary (32 kB)
- Clinical Chemistry Summary (29 kB)
- Clinical Observations Summary (60 kB)
- Dam Pup Cross Reference (449 kB)
- Fetal Defect Cross Reference Summary (213 kB)
- Fetal Defect Summary (115 kB)
- Fetal Defects (366 kB)
- Gross Pathology Summary (152 kB)
- Growth Curve (51 kB)
- Hematology Summary (66 kB)
- Mean Body Weight Gain (58 kB)
- Mean Body Weights and Survival (120 kB)
- Mean Feed Consumption (60 kB)
- Placental Findings (34 kB)
- Uterine Content Summary (84 kB)
Individual Animal Data
- Individual Animal Body Weights (134 kB)
- Individual Animal Clinical Chemistry (35 kB)
- Individual Animal Clinical Observations (117 kB)
- Individual Animal Dam Findings (15 kB)
- Individual Animal Food Consumption (34 kB)
- Individual Animal Gross Pathology (120 kB)
- Individual Animal Hematology (39 kB)
- Individual Animal Implant Findings (394 kB)
- Individual Animal Removal Reasons (15 kB)
Documentation
5-Day Toxicogenomic Evaluation of Crude 4-Methylcyclohexanemethanol (CRUDEMCHM) in Male Harlan Sprague Dawley Rats Exposed via Gavage
Study Tables
- Animal Removal Summary (74 kB)
- Clinical Chemistry Summary (224 kB)
- Clinical Observations Summary (95 kB)
- Gross Pathology Summary (280 kB)
- Growth Curve (78 kB)
- Hematology Summary (123 kB)
- Mean Body Weights and Survival (125 kB)
- Organ Weights Summary (126 kB)
Individual Animal Data
- Individual Animal Body Weights (25 kB)
- Individual Animal Clinical Chemistry (15 kB)
- Individual Animal Clinical Observations (23 kB)
- Individual Animal Gross Pathology (102 kB)
- Individual Animal Hematology (15 kB)
- Individual Animal Organ Weights (16 kB)
- Individual Animal Removal Reasons (12 kB)
Documentation
5-Day Toxicogenomic Evaluation of Propylene Glycol Phenyl Ether (770-35-4) in Male Harlan Sprague Dawley Rats Exposed via Gavage
Study Tables
- Animal Removal Summary (33 kB)
- Clinical Chemistry Summary (33 kB)
- Clinical Observations Summary (80 kB)
- Gross Pathology Summary (215 kB)
- Growth Curve (37 kB)
- Hematology Summary (29 kB)
- Mean Body Weights and Survival (78 kB)
- Organ Weights Summary (74 kB)
Individual Animal Data
- Individual Animal Body Weights (24 kB)
- Individual Animal Clinical Chemistry (14 kB)
- Individual Animal Clinical Observations (25 kB)
- Individual Animal Gross Pathology (87 kB)
- Individual Animal Hematology (14 kB)
- Individual Animal Organ Weights (15 kB)
- Individual Animal Removal Reasons (12 kB)
Documentation
C. Elegans Assessment for NTP Elk River, West Virginia Chemical Spill-Associated Samples
Study Plots
- Feeding Summary Plots (227 kB)
- Growth Summary Plots (225 kB)
- Reproduction Summary Plots (259 kB)
Study Data
- Feeding Data (112 kB)
- Growth Data (114 kB)
- Reproduction Data (64 kB)
Documentation
High Throughput Screening Assessment for NTP Elk River, West Virginia Chemical Spill-Associated Samples
Study Data
- HTS Assays - Conclusions (45 kB)
- HTS Assays - Detailed Data (809 kB)
Documentation
- Readme File - HTS (373 kB)
Immunological Evaluation of Crude MCHM in a Combined Irritation and Local Lymph Node Assay (LLNA) in Female BALB/c Mice (dermal studies)
Documentation
- Chemical Methods - WV Chemical Spill NTP Studies (440 kB)
- Materials and Methods – Mouse Dermal Irritation and Hypersensitivity Studies (148 kB)
Crude MCHM Second Study Tables
- Animal Removal Summary (30 kB)
- Clinical Observations Summary (51 kB)
- Growth Curve (34 kB)
- Hypersensitivity Assay Summary (33 kB)
- Irritancy Assay Summary (41 kB)
- Mean Body Weight Gain (48 kB)
- Mean Body Weights and Survival (55 kB)
Crude MCHM Second Study Individual Animal Data
- Individual Animal Body Weight Data (20 kB)
- Individual Animal Clinical Observation Data (56 kB)
- Individual Animal Hypersensitivity (13 kB)
- Individual Animal Irritancy (21 kB)
- Individual Animal Removal Reasons (103 kB)
Immunological Evaluation of Crude and Pure MCHM in a Combined Irritation and Local Lymph Node Assay (LLNA) in Female BALB/c Mice (dermal studies)
MCHM Study Tables
- I01 - Animal Removal Summary (33 kB)
- I04 - Mean Body Weights and Survival (55 kB)
- I05 - Clinical Observations Summary (53 kB)
- M01 - Irritancy Assay Summary (33 kB)
- M02 - Hypersensitivity Assay Summary (32 kB)
MCHM Individual Animal Data
- Individual Animal Body Weight Data (6 mB)
- Individual Animal Clinical Observation Data (24 kB)
- Individual Animal Hypersensitivity Data (12 kB)
- Individual Animal Irritancy (16 kB)
- Individual Animal Removal Reasons (10 kB)
Documentation
- Chemical Methods - WV Chemical Spill NTP Studies (440 kB)
- Materials and Methods – Mouse Dermal Irritation and Hypersensitivity Studies (148 kB)
- Readme File – Mouse Dermal Irritation and Hypersensitivity Studies (384 kB)
Crude MCHM Study Tables
- I01 - Animal Removal Summary (32 kB)
- I04 - Mean Body Weights and Survival (69 kB)
- I05 - Clinical Observations Summary (64 kB)
- M01 - Irritancy Assay Summary (36 kB)
- M02 - Hypersensitivity Assay Summary (35 kB)
Crude MCHM Individual Animal Data
Zebrafish Embryo and Larval Photomotor Response for NTP Elk River, West Virginia chemical spill-associated samples
Zebrafish Photomotor Response Study
- PMR-24 Behavior Statistics: Round 1 and Round 2 (68 kB)
- Photomotor Response - Run1 (1 mB)
- Photomotor Response - Run2 (1 mB)
- Table of Main Findings for Zebrafish Photomotor Response (138 kB)
Zebrafish Developmental Toxicity Study
- 2MCHM DevTox Individual Animal Round1 (124 kB)
- 2MCHM DevTox Individual Animal Round2 (125 kB)
- 2MCHM DevTox Summary Table (16 kB)
- 4-Methylcyclohexanecarboxylic acid DevTox Individual Animal Round1 (125 kB)
- 4-Methylcyclohexanecarboxylic acid DevTox Individual Animal Round2 (125 kB)
- 4-Methylcyclohexanecarboxylic acid DevTox Summary Table (16 kB)
- CHDM DevTox Individual Animal Round1 (124 kB)
- CHDM DevTox Individual Animal Round2 (125 kB)
- CHDM DevTox Summary Table (16 kB)
- Crude MCHM DevTox Individual Animal Round1 (125 kB)
- Crude MCHM DevTox Individual Animal Round2 (125 kB)
- Crude MCHM DevTox Summary Table (16 kB)
- Cyclohexanemethanol, 4-[(ethenyloxy)methyl]- DevTox Individual Animal Round1 (125 kB)
- Cyclohexanemethanol, 4-[(ethenyloxy)methyl]- DevTox Individual Animal Round2 (124 kB)
- Cyclohexanemethanol, 4-[(ethenyloxy)methyl]- DevTox Summary Table (16 kB)
- Cyclohexanemethanol, alpha,alpha,4-trimethyl- DevTox Individual Animal Round1 (125 kB)
- Cyclohexanemethanol, alpha,alpha,4-trimethyl- DevTox Individual Animal Round2 (125 kB)
- Cyclohexanemethanol, alpha,alpha,4-trimethyl- DevTox Summary Table (16 kB)
- DMCHDC DevTox Individual Animal Round1 (124 kB)
- DMCHDC DevTox Individual Animal Round2 (124 kB)
- DMCHDC DevTox Summary Table (16 kB)
- DOWANOL™ DiPPh DevTox Summary Table (16 kB)
- DOWANOL™ DiPPh DevTox Individual Animal Round1 (124 kB)
- DOWANOL™ DiPPh DevTox Individual Animal Round2 (125 kB)
- Developmental Toxicity - Lowest Effect Levels (19 kB)
- Developmental Toxicity - Run1 (381 kB)
- Developmental Toxicity - Run2 (392 kB)
- MCHM DevTox Individual Animal Round1 (125 kB)
- MCHM DevTox Individual Animal Round2 (124 kB)
- MCHM DevTox Summary Table (16 kB)
- MMCHC DevTox Individual Animal Round1 (125 kB)
- MMCHC DevTox Individual Animal Round2 (125 kB)
- MMCHC DevTox Summary Table (16 kB)
- MMCHM DevTox Individual Animal Round1 (124 kB)
- MMCHM DevTox Individual Animal Round2 (126 kB)
- MMCHM DevTox Summary Table (16 kB)
- PPH DevTox Individual Animal Round1 (125 kB)
- PPH DevTox Individual Animal Round2 (124 kB)
- PPH DevTox Summary Table (16 kB)
- Phenoxyisopropanol DevTox Individual Animal Round1 (125 kB)
- Phenoxyisopropanol DevTox Individual Animal Round2 (125 kB)
- Phenoxyisopropanol DevTox Summary Table (16 kB)