Crude MCHM (CRUDEMCHM)
Publications
IMM-01
NTP Technical Report on the Dermal Hypersensitivity and Irritancy Studies of 4-Methylcyclohexanemethanol (CAS No. 34885-03-5) and Crude 4-Methylcyclohexanemethanol Administered Topically to Female BALB/c Mice
Evaluation of 4-methylcyclohexanemethanol (MCHM) in a Combined Irritancy and Local Lymph Node Assay (LLNA) in Mice
Johnson VJ, Auerbach SS, Luster MI, Waidyanatha S, Masten SA, Wolfe MS, Burleson FG, Burleson GR, Germolec DR.
Food and Chemical Toxicology (2017) DOI: https://doi.org/10.1016/j.fct.2017.03.034 PMID: 28343035
Food and Chemical Toxicology (2017) DOI: https://doi.org/10.1016/j.fct.2017.03.034 PMID: 28343035
Study Data
Toxicity and Carcinogenicity Studies
Benchmark Dose Analysis of NTP Elk River, West Virginia Chemical Spill-Associated Samples
Propylene Glycol Phenyl Ether: Benchmark Dose Analysis Results
- Propylene Glycol Phenyl Ether: Individual Gene Benchmark Dose Results in Toxicogenomics Study in Male Harlan Sprague Dawley Rats - June 2016 (12 kB)
- Propylene Glycol Phenyl Ether: Molecular Biological Processes Benchmark Dose Results in Toxicogenomics Study in Male Harlan Sprague Dawley Rats - June 2016 (16 kB)
Documentation
- Chemical Methods - WV Chemical Spill NTP Studies (440 kB)
- Materials and Methods - 5-Day Rat Toxicogenomic Studies (479 kB)
- Readme File for 5-Day Rat Toxicogenomic Studies: Microarray and Benchmark Dose Analysis Components (382 kB)
Crude 4-Methylcyclohexanemethanol: Benchmark Dose Analysis Results
- Crude 4-Methylcyclohexanemethanol: Individual Gene Benchmark Dose Results in Toxicogenomics Study in Male Harlan Sprague Dawley Rats - June 2016 (10 kB)
- Crude 4-Methylcyclohexanemethanol: Molecular Biological Processes Benchmark Dose Results in Toxicogenomics Study in Male Harlan Sprague Dawley Rats - June 2016 (12 kB)
4-Methylcyclohexanemethanol: Benchmark Dose Analysis Results
- 4-Methylcyclohexanemethanol Individual Gene Benchmark Dose Results in Toxicogenomics Study in Male Harlan Sprague Dawley Rats-June 2016 (10 kB)
- 4-Methylcyclohexanemethanol: Molecular Biological Processes Benchmark Dose Results in Toxicogenomics Study in Male Harlan Sprague Dawley Rats - June 2016 (12 kB)
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Crude MCHM (CRUDEMCHM) in Micronucleus Study G14013 in Harlan Sprague-Dawley Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Crude MCHM in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G14013B
Summary Data
- G06 - Ames Summary Data (79 KB)
Other NTP Studies
5-Day Toxicogenomic Evaluation of Crude 4-Methylcyclohexanemethanol (CRUDEMCHM) in Male Harlan Sprague Dawley Rats Exposed via Gavage
Study Tables
- Animal Removal Summary (74 kB)
- Clinical Chemistry Summary (224 kB)
- Clinical Observations Summary (95 kB)
- Gross Pathology Summary (280 kB)
- Growth Curve (78 kB)
- Hematology Summary (123 kB)
- Mean Body Weights and Survival (125 kB)
- Organ Weights Summary (126 kB)
Individual Animal Data
- Individual Animal Body Weights (25 kB)
- Individual Animal Clinical Chemistry (15 kB)
- Individual Animal Clinical Observations (23 kB)
- Individual Animal Gross Pathology (102 kB)
- Individual Animal Hematology (15 kB)
- Individual Animal Organ Weights (16 kB)
- Individual Animal Removal Reasons (12 kB)
Documentation
Immunological Evaluation of Crude and Pure MCHM in a Combined Irritation and Local Lymph Node Assay (LLNA) in Female BALB/c Mice (dermal studies)
MCHM Study Tables
- I01 - Animal Removal Summary (33 kB)
- I04 - Mean Body Weights and Survival (55 kB)
- I05 - Clinical Observations Summary (53 kB)
- M01 - Irritancy Assay Summary (33 kB)
- M02 - Hypersensitivity Assay Summary (32 kB)
MCHM Individual Animal Data
- Individual Animal Body Weight Data (6 mB)
- Individual Animal Clinical Observation Data (24 kB)
- Individual Animal Hypersensitivity Data (12 kB)
- Individual Animal Irritancy (16 kB)
- Individual Animal Removal Reasons (10 kB)
Documentation
- Chemical Methods - WV Chemical Spill NTP Studies (440 kB)
- Materials and Methods – Mouse Dermal Irritation and Hypersensitivity Studies (148 kB)
- Readme File – Mouse Dermal Irritation and Hypersensitivity Studies (384 kB)
Crude MCHM Study Tables
- I01 - Animal Removal Summary (32 kB)
- I04 - Mean Body Weights and Survival (69 kB)
- I05 - Clinical Observations Summary (64 kB)
- M01 - Irritancy Assay Summary (36 kB)
- M02 - Hypersensitivity Assay Summary (35 kB)
Crude MCHM Individual Animal Data
Zebrafish Embryo and Larval Photomotor Response for NTP Elk River, West Virginia chemical spill-associated samples
Zebrafish Photomotor Response Study
- PMR-24 Behavior Statistics: Round 1 and Round 2 (68 kB)
- Photomotor Response - Run1 (1 mB)
- Photomotor Response - Run2 (1 mB)
- Table of Main Findings for Zebrafish Photomotor Response (138 kB)
Zebrafish Developmental Toxicity Study
- 2MCHM DevTox Individual Animal Round1 (124 kB)
- 2MCHM DevTox Individual Animal Round2 (125 kB)
- 2MCHM DevTox Summary Table (16 kB)
- 4-Methylcyclohexanecarboxylic acid DevTox Individual Animal Round1 (125 kB)
- 4-Methylcyclohexanecarboxylic acid DevTox Individual Animal Round2 (125 kB)
- 4-Methylcyclohexanecarboxylic acid DevTox Summary Table (16 kB)
- CHDM DevTox Individual Animal Round1 (124 kB)
- CHDM DevTox Individual Animal Round2 (125 kB)
- CHDM DevTox Summary Table (16 kB)
- Crude MCHM DevTox Individual Animal Round1 (125 kB)
- Crude MCHM DevTox Individual Animal Round2 (125 kB)
- Crude MCHM DevTox Summary Table (16 kB)
- Cyclohexanemethanol, 4-[(ethenyloxy)methyl]- DevTox Individual Animal Round1 (125 kB)
- Cyclohexanemethanol, 4-[(ethenyloxy)methyl]- DevTox Individual Animal Round2 (124 kB)
- Cyclohexanemethanol, 4-[(ethenyloxy)methyl]- DevTox Summary Table (16 kB)
- Cyclohexanemethanol, alpha,alpha,4-trimethyl- DevTox Individual Animal Round1 (125 kB)
- Cyclohexanemethanol, alpha,alpha,4-trimethyl- DevTox Individual Animal Round2 (125 kB)
- Cyclohexanemethanol, alpha,alpha,4-trimethyl- DevTox Summary Table (16 kB)
- DMCHDC DevTox Individual Animal Round1 (124 kB)
- DMCHDC DevTox Individual Animal Round2 (124 kB)
- DMCHDC DevTox Summary Table (16 kB)
- DOWANOL™ DiPPh DevTox Summary Table (16 kB)
- DOWANOL™ DiPPh DevTox Individual Animal Round1 (124 kB)
- DOWANOL™ DiPPh DevTox Individual Animal Round2 (125 kB)
- Developmental Toxicity - Lowest Effect Levels (19 kB)
- Developmental Toxicity - Run1 (381 kB)
- Developmental Toxicity - Run2 (392 kB)
- MCHM DevTox Individual Animal Round1 (125 kB)
- MCHM DevTox Individual Animal Round2 (124 kB)
- MCHM DevTox Summary Table (16 kB)
- MMCHC DevTox Individual Animal Round1 (125 kB)
- MMCHC DevTox Individual Animal Round2 (125 kB)
- MMCHC DevTox Summary Table (16 kB)
- MMCHM DevTox Individual Animal Round1 (124 kB)
- MMCHM DevTox Individual Animal Round2 (126 kB)
- MMCHM DevTox Summary Table (16 kB)
- PPH DevTox Individual Animal Round1 (125 kB)
- PPH DevTox Individual Animal Round2 (124 kB)
- PPH DevTox Summary Table (16 kB)
- Phenoxyisopropanol DevTox Individual Animal Round1 (125 kB)
- Phenoxyisopropanol DevTox Individual Animal Round2 (125 kB)
- Phenoxyisopropanol DevTox Summary Table (16 kB)