GMM-11: Dichloroacetic acid (79-43-6)
Publications
GMM-11
Toxicology Studies of Dichloroacetic Acid (CASRN 79-43-6) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Dichloroacetic Acid in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water Studies)
Study Data
Toxicity and Carcinogenicity Studies
2-Week Evaluation of the Toxicity (C97013D) of Water Disinfection Model (Dichloroacetic Acid) (79-43-6) in FVB/N Mice Exposed via Topical Application
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
2-Week Evaluation of the Toxicity (C97013D) of Water Disinfection Model (Dichloroacetic Acid) (79-43-6) in FVB/N Mice Exposed via Topical Application
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
26-39 Week Evaluation of the Toxicity (C97013I) of Water Disinfection Model (Dichloroacetic Acid) (79-43-6) in P53(C57BL/6) Mice Exposed via Dosed Water
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
26-Week Evaluation of the Toxicity (C97013C) of Water Disinfection Model (Dichloroacetic Acid) (79-43-6) in P53(C57BL/6) Mice Exposed via Dosed Water
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
26-39 Week Evaluation of the Toxicity (C97013D) of Water Disinfection Model (Dichloroacetic Acid) (79-43-6) in Tg.AC Mice Exposed via Topical Application
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
26-39 Week Evaluation of the Toxicity (C97013I) of Water Disinfection Model (Dichloroacetic Acid) (79-43-6) in Tg.AC Mice Exposed via Dosed Water
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
26-Week Evaluation of the Toxicity (C97013C) of Water Disinfection Model (Dichloroacetic Acid) (79-43-6) in Tg.AC Mice Exposed via Dosed Water
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
26-Week Evaluation of the Toxicity (C97013D) of Water Disinfection Model (Dichloroacetic Acid) (79-43-6) in Tg.AC Mice Exposed via Topical Application
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Water Disinfection Byproducts (Dichloroacetic Acid) (79-43-6) in Micronucleus Study A15985 in Tg.AC (FVB/N) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Water Disinfection Byproducts (Dichloroacetic Acid) (79-43-6) in Micronucleus Study A67778 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Water Disinfection Byproducts (Dichloroacetic Acid) (79-43-6) in Micronucleus Study A72842 in Tg.AC (FVB/N) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Water Disinfection Byproducts (Dichloroacetic Acid) (79-43-6) in Micronucleus Study A91472 in P53 +/- (C57BL/6) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Water Disinfection Byproducts (Dichloroacetic Acid) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 024933
Summary Data
- G06 - Ames Summary Data (74 KB)
Genetic Toxicity Evaluation of Water Disinfection Byproducts (Dichloroacetic Acid) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A67820
Summary Data
- G06 - Ames Summary Data (55 KB)