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TOX-101: Trimethylsilyldiazomethane (18107-18-1)

Citation Information

NTP. TOX-101: Trimethylsilyldiazomethane (18107-18-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

TOX-101 NTP Technical Report on the Toxicity Studies of Trimethylsilyldiazomethane (CASRN 18107-18-1) Administered by Nose-only Inhalation to Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats and B6C3F1/N Mice

Study Data

Protocol

Toxicity and Carcinogenicity Studies

One-Day and Five-Day Evaluation of the Toxicity (C11049-01) of Trimethylsilyldiazomethane (18107-18-1) in Harlan Sprague Dawley Rats Exposed via Nose-Only Respiratory Exposure

Study Tables

Growth Curves (146 kB)
I01 - Animal Removal Summary (57 kB)
I02 - Animal Removals (503 kB)
I04 – Mean Body Weight Summary (204 kB)
I04G – Mean Body Weight Gain (108 kB)
I05 - Clinical Observations Summary (88 kB)
PA02 - Neoplastic Lesion Summary with Percent Incidence (436 kB)
PA03 - Non-Neoplastic Lesion Summary with Percent Incidence 6- (424 kB)
PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (437 kB)
PA08 - Statistical Analysis of Neoplastic Lesions (358 kB)
PA10 - Statistical Analysis of Non-Neoplastic Lesions (439 kB)
PA14 - Individual Animal Pathology Data (2 mB)
PA18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grade (424 kB)

Individual Animal Data

Individual Animal Body Weight Data (37 kB)
Individual Animal Clinical Observations Data (41 kB)
Individual Animal Gross Pathology Data (279 kB)
Individual Animal Histopathology Data (64 kB)
Individual Animal Organ Weight Data (19 kB)
Individual Animal Removal Reasons Data (8 kB)

One-Day and Five-Day Evaluation (C11049-02) of the Toxicity of Trimethylsilyldiazomethane (18107-18-1) in B6C3F1/N Mice via Nose-Only Respiratory Exposure

Study Tables

Growth Curves (139 kB)
I01 - Animal Removal Summary (69 kB)
I02 - Animal Removals (503 kB)
I04 – Mean Body Weight Summary (202 kB)
I04G – Mean Body Weight Gain (108 kB)
I05 - Clinical Observations Summary (108 kB)
PA02 - Neoplastic Lesion Summary with Percent Incidence (437 kB)
PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (418 kB)
PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (438 kB)
PA08 - Statistical Analysis of Neoplastic Lesions (356 kB)
PA10 - Statistical Analysis of Non-Neoplastic Lesions (431 kB)
PA14 - Individual Animal Pathology Data (2 mB)
PA18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grad (419 kB)

Individual Animal Data

Individual_Animal_Body_Weight_Data.xlsx (33 kB)
Individual_Animal_Clinical_Observations_Data.xlsx (80 kB)
Individual_Animal_Gross_Pathology_Data.xlsx (267 kB)
Individual_Animal_Histopathology_Data.xlsx (65 kB)
Individual_Animal_Organ_Weight_Data.xlsx (16 kB)
Individual_Animal_Removal_Reasons_Data.xlsx (8 kB)