U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

TR-248: 4,4'-Methylenedianiline dihydrochloride (13552-44-8)

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Positive, Male, Rats
View
  • Positive, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Positive, Male, Mice
View
  • Positive, Female, Mice

Citation Information

NTP. TR-248: 4,4'-Methylenedianiline dihydrochloride (13552-44-8). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-248 Carcinogenesis Studies of 4,4'-Methylenedianiline Dihydrochloride (CASRN 13552-44-8) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of 4,4'-Methylenedianiline Dihydrochloride (13552-44-8) in Male F344 Rats Exposed via Dosed Water
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 4,4'-Methylenedianiline Dihydrochloride (13552-44-8) in Female F344 Rats Exposed via Dosed Water
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 4,4'-Methylenedianiline Dihydrochloride (13552-44-8) in Male B6C3F1 Mice Exposed via Dosed Water
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 4,4'-Methylenedianiline Dihydrochloride (13552-44-8) in Female B6C3F1 Mice Exposed via Dosed Water
Individual Animal Data