TR-580: beta-Picoline (108-99-6)
Study Results
Chronic Bioassay Level of Evidence
| Rats | |
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| Mice | |
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Genetic Toxicology
| Micronucleus - Mice |
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| Bacterial Mutagenicity |
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Publications
TR-580
Toxicology and Carcinogenesis Studies of ?-Picoline (CASRN 108-99-6) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
Study Data
Toxicity and Carcinogenicity Studies
3-Month Evaluation of the Toxicity (C20009) of beta-Picoline (108-99-6) in F344/N Rats Exposed via Dosed Water
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P10 - Statistical Analysis Of Non-Neoplastic Lesions
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C20009) of beta-Picoline (108-99-6) in B6C3F1 Mice Exposed via Dosed Water
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P10 - Statistical Analysis Of Non-Neoplastic Lesions
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C20009) of beta-Picoline (108-99-6) in F344/N Rats Exposed via Dosed Water
Study Tables
- E03 - Growth Curves (80 kB)
- E04 - Mean Body Weights and Survival Table (24 kB)
- E05 - Clinical Observations Summary (22 kB)
- E08 - Feed and Compound Consumption Table (36 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (58 kB)
- P04 - Neoplasms by Individual Animal (734 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (51 kB)
- P08 - Statistical Analysis of Primary Tumors (249 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (806 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (398 kB)
- P11 - Statistical Analysis of Survival Data (24 kB)
- P14 - Individual Animal Pathology Data (1 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (605 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (59 kB)
- P40 - Survival Curves (80 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (357 kB)
- Female Individual Animal Clinical Observations (313 kB)
- Female Individual Animal Neoplastic Pathology Data (250 kB)
- Female Individual Animal Non Neoplastic Pathology Data (533 kB)
- Female Individual Animal Organ Weight Data (57 kB)
- Female Individual Animal Survival Data (34 kB)
- Male Individual Animal Body Weight Data (362 kB)
- Male Individual Animal Clinical Observations (188 kB)
- Male Individual Animal Neoplastic Pathology Data (332 kB)
- Male Individual Animal Non Neoplastic Pathology Data (679 kB)
- Male Individual Animal Organ Weight Data (57 kB)
- Male Individual Animal Survival Data (34 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity (C20009) of beta-Picoline (108-99-6) in B6C3F1 Mice Exposed via Dosed Water
Study Tables
- E03 - Growth Curves (71 kB)
- E04 - Mean Body Weights and Survival Table (25 kB)
- E05 - Clinical Observations Summary (21 kB)
- E08 - Feed and Compound Consumption Table (39 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (46 kB)
- P04 - Neoplasms by Individual Animal (708 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (52 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (698 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (275 kB)
- P11 - Statistical Analysis of Survival Data (24 kB)
- P14 - Individual Animal Pathology Data (1 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (635 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (48 kB)
- P40 - Survival Curves (67 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (350 kB)
- Female Individual Animal Clinical Observations (38 kB)
- Female Individual Animal Neoplastic Pathology Data (263 kB)
- Female Individual Animal Non Neoplastic Pathology Data (237 kB)
- Female Individual Animal Organ Weight Data (57 kB)
- Female Individual Animal Survival Data (34 kB)
- Male Individual Animal Body Weight Data (407 kB)
- Male Individual Animal Clinical Observations (52 kB)
- Male Individual Animal Neoplastic Pathology Data (186 kB)
- Male Individual Animal Non Neoplastic Pathology Data (363 kB)
- Male Individual Animal Organ Weight Data (57 kB)
- Male Individual Animal Survival Data (34 kB)
Genetic Toxicology Studies
Genetic Toxicity Evaluation of beta-Picoline (108-99-6) in Micronucleus Study A31463 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of beta-Picoline in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 421607
Summary Data
- G06 - Ames Summary Data (128 KB)
Genetic Toxicity Evaluation of beta-Picoline in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A73702
Summary Data
- G06 - Ames Summary Data (147 KB)
Genetic Toxicity Evaluation of beta-Picoline in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A80302
Summary Data
- G06 - Ames Summary Data (68 KB)