TR-581: Cobalt (7440-48-4)
Publications
TR-581
Toxicology Studies of Cobalt Metal (CASRN 7440-48-4) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Cobalt Metal in F344/NTac Rats and B6C3F1/N Mice (Inhalation Studies)
Study Data
Toxicity and Carcinogenicity Studies
2-Week Evaluation of the Toxicity (C60311) of Cobalt (7440-48-4) in F344/N Rats via Whole Body Respiratory Exposure
Study Tables
- E01 - Animal Removal Summary By Treatment Group (9 kB)
- E03 - Growth Curves (326 kB)
- E04 - Mean Body Weights and Survival Table (12 kB)
- E05 - Clinical Observations Summary (13 kB)
- P02 - Incidence Rates of Neoplasms by Anatomic Site (20 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (21 kB)
- P04 - Neoplasms by Individual Animal (132 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (21 kB)
- P07 - Neoplasms by Individual Animal (Systemic Lesions Abridged) (132 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (147 kB)
- P11 - Statistical Analysis of Survival Data (19 kB)
- P14 - Individual Animal Pathology Data (95 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (132 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (21 kB)
- P40 - Survival Curves (370 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (9 kB)
- Female Individual Animal Clinical Observations (28 kB)
- Female Individual Animal Non Neoplastic Pathology Data (43 kB)
- Female Individual Animal Organ Weight Data (10 kB)
- Female Individual Animal Survival Data (6 kB)
- Male Individual Animal Body Weight Data (9 kB)
- Male Individual Animal Clinical Observations (24 kB)
- Male Individual Animal Non Neoplastic Pathology Data (43 kB)
- Male Individual Animal Organ Weight Data (10 kB)
- Male Individual Animal Survival Data (6 kB)
2-Week Evaluation of the Toxicity (C60311) of Cobalt (7440-48-4) in B6C3F1 Mice via Whole Body Respiratory Exposure
Study Tables
- E01 - Animal Removal Summary By Treatment Group (9 kB)
- E03 - Growth Curves (330 kB)
- E04 - Mean Body Weights and Survival Table (12 kB)
- E05 - Clinical Observations Summary (13 kB)
- P02 - Incidence Rates of Neoplasms by Anatomic Site (20 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (20 kB)
- P04 - Neoplasms by Individual Animal (128 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (20 kB)
- P07 - Neoplasms by Individual Animal (Systemic Lesions Abridged) (127 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (136 kB)
- P11 - Statistical Analysis of Survival Data (19 kB)
- P14 - Individual Animal Pathology Data (93 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (129 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (21 kB)
- P40 - Survival Curves (377 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (9 kB)
- Female Individual Animal Clinical Observations (42 kB)
- Female Individual Animal Non Neoplastic Pathology Data (53 kB)
- Female Individual Animal Organ Weight Data (10 kB)
- Female Individual Animal Survival Data (6 kB)
- Male Individual Animal Body Weight Data (9 kB)
- Male Individual Animal Clinical Observations (31 kB)
- Male Individual Animal Non Neoplastic Pathology Data (54 kB)
- Male Individual Animal Organ Weight Data (10 kB)
- Male Individual Animal Survival Data (6 kB)
3-Month Evaluation of the Toxicity (C60311) of Cobalt (7440-48-4) in F344/N Rats via Whole Body Respiratory Exposure
Study Tables
- E03 - Growth Curves (349 kB)
- E04 - Mean Body Weights and Survival Table (24 kB)
- E05 - Clinical Observations Summary (20 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (32 kB)
- P04 - Neoplasms by Individual Animal (187 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (33 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (196 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (112 kB)
- P14 - Individual Animal Pathology Data (2 mB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (34 kB)
- P40 - Survival Curves (361 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (31 kB)
- Female Individual Animal Non Neoplastic Pathology Data (64 kB)
- Female Individual Animal Organ Weight Data (16 kB)
- Female Individual Animal Survival Data (10 kB)
- Male Individual Animal Body Weight Data (31 kB)
- Male Individual Animal Non Neoplastic Pathology Data (72 kB)
- Male Individual Animal Organ Weight Data (16 kB)
- Male Individual Animal Survival Data (10 kB)
3-Month Evaluation of the Toxicity (C60311) of Cobalt (7440-48-4) in B6C3F1 Mice via Whole Body Respiratory Exposure
Study Tables
- E03 - Growth Curves (366 kB)
- E04 - Mean Body Weights and Survival Table (191 kB)
- E05 - Clinical Observations Summary (121 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (34 kB)
- P04 - Neoplasms by Individual Animal (227 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (34 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (250 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (156 kB)
- P14 - Individual Animal Pathology Data (2 mB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (35 kB)
- P40 - Survival Curves (389 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (36 kB)
- Female Individual Animal Clinical Observations (10 kB)
- Female Individual Animal Non Neoplastic Pathology Data (124 kB)
- Female Individual Animal Organ Weight Data (19 kB)
- Female Individual Animal Survival Data (11 kB)
- Male Individual Animal Body Weight Data (36 kB)
- Male Individual Animal Clinical Observations (7 kB)
- Male Individual Animal Non Neoplastic Pathology Data (145 kB)
- Male Individual Animal Organ Weight Data (19 kB)
- Male Individual Animal Survival Data (11 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity (C60311) of Cobalt (7440-48-4) in F344/NTac Rats via Whole Body Respiratory Exposure
Study Tables
- E03 - Growth Curves (71 kB)
- E04 - Mean Body Weights and Survival Table (25 kB)
- E05 - Clinical Observations Summary (20 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (60 kB)
- P04 - Neoplasms by Individual Animal (774 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (54 kB)
- P08 - Statistical Analysis of Primary Tumors (307 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (858 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (472 kB)
- P11 - Statistical Analysis of Survival Data (26 kB)
- P14 - Individual Animal Pathology Data (2 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (665 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (62 kB)
- P40 - Survival Curves (68 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (390 kB)
- Female Individual Animal Clinical Observations (290 kB)
- Female Individual Animal Neoplastic Pathology Data (327 kB)
- Female Individual Animal Non Neoplastic Pathology Data (963 kB)
- Female Individual Animal Organ Weight Data (57 kB)
- Female Individual Animal Survival Data (34 kB)
- Male Individual Animal Body Weight Data (405 kB)
- Male Individual Animal Clinical Observations (309 kB)
- Male Individual Animal Neoplastic Pathology Data (396 kB)
- Male Individual Animal Non Neoplastic Pathology Data (1 mB)
- Male Individual Animal Organ Weight Data (57 kB)
- Male Individual Animal Survival Data (34 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity (C60311) of Cobalt (7440-48-4) in B6C3F1 Mice via Whole Body Respiratory Exposure
Study Tables
- E03 - Growth Curves (68 kB)
- E04 - Mean Body Weights and Survival Table (24 kB)
- E05 - Clinical Observations Summary (20 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (51 kB)
- P04 - Neoplasms by Individual Animal (742 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (51 kB)
- P08 - Statistical Analysis of Primary Tumors (184 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (756 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (294 kB)
- P11 - Statistical Analysis of Survival Data (24 kB)
- P14 - Individual Animal Pathology Data (1 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (627 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (54 kB)
- P40 - Survival Curves (66 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (377 kB)
- Female Individual Animal Clinical Observations (86 kB)
- Female Individual Animal Neoplastic Pathology Data (234 kB)
- Female Individual Animal Non Neoplastic Pathology Data (933 kB)
- Female Individual Animal Organ Weight Data (57 kB)
- Female Individual Animal Survival Data (34 kB)
- Male Individual Animal Body Weight Data (367 kB)
- Male Individual Animal Clinical Observations (110 kB)
- Male Individual Animal Neoplastic Pathology Data (188 kB)
- Male Individual Animal Non Neoplastic Pathology Data (883 kB)
- Male Individual Animal Organ Weight Data (57 kB)
- Male Individual Animal Survival Data (34 kB)
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Cobalt (7440-48-4) in Micronucleus Study A57655 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Cobalt in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A79569
Summary Data
- G06 - Ames Summary Data (113 KB)