Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

TR-581: Cobalt (7440-48-4)

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Clear Evidence, Female, Rats
  • Clear Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Female, Mice
  • Clear Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to TR-581: Cobalt (7440-48-4).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to TR-581: Cobalt (7440-48-4).
Bacterial Mutagenicity
View
  • Positive

Citation Information

NTP. TR-581: Cobalt (7440-48-4). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-581 Toxicology Studies of Cobalt Metal (CASRN 7440-48-4) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Cobalt Metal in F344/NTac Rats and B6C3F1/N Mice (Inhalation Studies)

Study Data

Protocol

Toxicity and Carcinogenicity Studies

2-Week Evaluation of the Toxicity (C60311) of Cobalt (7440-48-4) in F344/N Rats via Whole Body Respiratory Exposure
Study Tables
Individual Animal Data
2-Week Evaluation of the Toxicity (C60311) of Cobalt (7440-48-4) in B6C3F1 Mice via Whole Body Respiratory Exposure
Study Tables
Individual Animal Data
3-Month Evaluation of the Toxicity (C60311) of Cobalt (7440-48-4) in F344/N Rats via Whole Body Respiratory Exposure
Study Tables
Individual Animal Data
3-Month Evaluation of the Toxicity (C60311) of Cobalt (7440-48-4) in B6C3F1 Mice via Whole Body Respiratory Exposure
Study Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C60311) of Cobalt (7440-48-4) in F344/NTac Rats via Whole Body Respiratory Exposure
Study Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C60311) of Cobalt (7440-48-4) in B6C3F1 Mice via Whole Body Respiratory Exposure
Study Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Cobalt (7440-48-4) in Micronucleus Study A57655 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Cobalt in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A79569
Summary Data