TR-583: Bromodichloroacetic acid (71133-14-7)

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View Clear Evidence, Female, Rats Clear Evidence, Male, Rats

An overview of chronic evidence from Mice studies.
Mice
View Clear Evidence, Female, Mice Clear Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to TR-583: Bromodichloroacetic acid (71133-14-7).
Micronucleus - Mice
View Male: Negative Female: Negative

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to TR-583: Bromodichloroacetic acid (71133-14-7).
Bacterial Mutagenicity
View Positive
View Weakly Positive

Citation Information

NTP. TR-583: Bromodichloroacetic acid (71133-14-7). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

TR-583 Toxicology Studies of Bromodichloroacetic Acid (CASRN 71133-14-7) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Bromodichloroacetic Acid in F344/NTac Rats and B6C3F1/N Mice (Drinking Water Studies)

Study Data

Protocol

Toxicity and Carcinogenicity Studies

2-Week Evaluation of the Toxicity (C96014) of Water Disinfection Byproducts (Bromodichloroacetic Acid) (71133-14-7) in F344/N Rats Exposed via Dosed Water

2-Week Evaluation of the Toxicity (C96014) of Water Disinfection Byproducts (Bromodichloroacetic Acid) (71133-14-7) in B6C3F1 Mice Exposed via Dosed Water

Data

3-Month Evaluation of the Toxicity (C96014) of Water Disinfection Byproducts (Bromodichloroacetic Acid) (71133-14-7) in F344/N Rats Exposed via Dosed Water

Study Tables

E40 - Mean Body Weights (9 kB)
P02 - Incidence Rates of Neoplasms by Anatomic Site (33 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (48 kB)
P04 - Neoplasms by Individual Animal (254 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (251 kB)
P14 - Individual Animal Pathology Data (176 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (49 kB)
P40 - Survival Curves (8 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (35 kB)
Female Individual Animal Clinical Observations (4 kB)
Female Individual Animal Non Neoplastic Pathology Data (24 kB)
Female Individual Animal Organ Weight Data (20 kB)
Female Individual Animal Survival Data (11 kB)
Male Individual Animal Body Weight Data (35 kB)
Male Individual Animal Clinical Observations (2 kB)
Male Individual Animal Non Neoplastic Pathology Data (25 kB)
Male Individual Animal Organ Weight Data (19 kB)
Male Individual Animal Survival Data (11 kB)

Data

3-Month Evaluation of the Toxicity (C96014) of Water Disinfection Byproducts (Bromodichloroacetic Acid) (71133-14-7) in B6C3F1 Mice Exposed via Dosed Water

Study Tables

E40 - Mean Body Weights (9 kB)
P02 - Incidence Rates of Neoplasms by Anatomic Site (33 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (32 kB)
P04 - Neoplasms by Individual Animal (239 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (250 kB)
P14 - Individual Animal Pathology Data (267 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (33 kB)
P40 - Survival Curves (8 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (36 kB)
Female Individual Animal Non Neoplastic Pathology Data (21 kB)
Female Individual Animal Organ Weight Data (19 kB)
Female Individual Animal Survival Data (11 kB)
Male Individual Animal Body Weight Data (34 kB)
Male Individual Animal Non Neoplastic Pathology Data (32 kB)
Male Individual Animal Organ Weight Data (19 kB)
Male Individual Animal Survival Data (11 kB)

Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C96014B) of Water Disinfection Byproducts (Bromodichloroacetic Acid) (71133-14-7) in F344/NTac Rats Exposed via Dosed Water

Study Tables

E03 - Growth Curves (69 kB)
E04 - Mean Body Weights and Survival Table (19 kB)
E05 - Clinical Observations Summary (22 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (58 kB)
P04 - Neoplasms by Individual Animal (730 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (49 kB)
P08 - Statistical Analysis of Primary Tumors (334 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (833 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (476 kB)
P11 - Statistical Analysis of Survival Data (28 kB)
P14 - Individual Animal Pathology Data (2 mB)
P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (620 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (60 kB)
P40 - Survival Curves (69 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (460 kB)
Female Individual Animal Clinical Observations (532 kB)
Female Individual Animal Neoplastic Pathology Data (217 kB)
Female Individual Animal Non Neoplastic Pathology Data (867 kB)
Female Individual Animal Organ Weight Data (75 kB)
Female Individual Animal Survival Data (44 kB)
Male Individual Animal Body Weight Data (481 kB)
Male Individual Animal Clinical Observations (319 kB)
Male Individual Animal Neoplastic Pathology Data (313 kB)
Male Individual Animal Non Neoplastic Pathology Data (1 mB)
Male Individual Animal Organ Weight Data (75 kB)
Male Individual Animal Survival Data (43 kB)

Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C96014B) of Water Disinfection Byproducts (Bromodichloroacetic Acid) (71133-14-7) in B6C3F1 Mice Exposed via Dosed Water

Study Tables

E03 - Growth Curves (65 kB)
E04 - Mean Body Weights and Survival Table (19 kB)
E05 - Clinical Observations Summary (20 kB)
E08 - Feed and Compound Consumption Table (35 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (58 kB)
P04 - Neoplasms by Individual Animal (1 mB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (52 kB)
P08 - Statistical Analysis of Primary Tumors (228 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (1 mB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (459 kB)
P14 - Individual Animal Pathology Data (1 mB)
P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (882 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (60 kB)
P40 - Survival Curves (67 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (463 kB)
Female Individual Animal Clinical Observations (55 kB)
Female Individual Animal Neoplastic Pathology Data (194 kB)
Female Individual Animal Non Neoplastic Pathology Data (420 kB)
Female Individual Animal Organ Weight Data (75 kB)
Female Individual Animal Survival Data (44 kB)
Male Individual Animal Body Weight Data (496 kB)
Male Individual Animal Clinical Observations (118 kB)
Male Individual Animal Neoplastic Pathology Data (219 kB)
Male Individual Animal Non Neoplastic Pathology Data (433 kB)
Male Individual Animal Organ Weight Data (75 kB)
Male Individual Animal Survival Data (44 kB)

Protocol

Genetic Toxicology Studies

Data

Genetic Toxicity Evaluation of Water Disinfection Byproducts (Bromodichloroacetic Acid) (71133-14-7) in Micronucleus Study A97618 in B6C3F1 Mice

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (72 KB)
Individual Animal In Vivo Micronucleus Data (14 KB)

Data

Genetic Toxicity Evaluation of Water Disinfection Byproducts (Bromodichloroacetic Acid) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A75232

Summary Data

G06 - Ames Summary Data (213 KB)

Data

Genetic Toxicity Evaluation of Water Disinfection Byproducts (Bromodichloroacetic Acid) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G97039

Summary Data

G06 - Ames Summary Data (91 KB)

TR-583: Bromodichloroacetic acid (71133-14-7)

Study Results

Chronic Bioassay Level of Evidence

Genetic Toxicology

Citation Information

Related Links

Publications

Study Data

Toxicity and Carcinogenicity Studies

2-Week Evaluation of the Toxicity (C96014) of Water Disinfection Byproducts (Bromodichloroacetic Acid) (71133-14-7) in F344/N Rats Exposed via Dosed Water

2-Week Evaluation of the Toxicity (C96014) of Water Disinfection Byproducts (Bromodichloroacetic Acid) (71133-14-7) in B6C3F1 Mice Exposed via Dosed Water

3-Month Evaluation of the Toxicity (C96014) of Water Disinfection Byproducts (Bromodichloroacetic Acid) (71133-14-7) in F344/N Rats Exposed via Dosed Water

Study Tables

Individual Animal Data

3-Month Evaluation of the Toxicity (C96014) of Water Disinfection Byproducts (Bromodichloroacetic Acid) (71133-14-7) in B6C3F1 Mice Exposed via Dosed Water

Study Tables

Individual Animal Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C96014B) of Water Disinfection Byproducts (Bromodichloroacetic Acid) (71133-14-7) in F344/NTac Rats Exposed via Dosed Water

Study Tables

Individual Animal Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C96014B) of Water Disinfection Byproducts (Bromodichloroacetic Acid) (71133-14-7) in B6C3F1 Mice Exposed via Dosed Water

Study Tables

Individual Animal Data

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Water Disinfection Byproducts (Bromodichloroacetic Acid) (71133-14-7) in Micronucleus Study A97618 in B6C3F1 Mice

Summary and Individual Animal Data

Genetic Toxicity Evaluation of Water Disinfection Byproducts (Bromodichloroacetic Acid) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A75232

Summary Data

Genetic Toxicity Evaluation of Water Disinfection Byproducts (Bromodichloroacetic Acid) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G97039

Summary Data