TR-594: p-Chloro-a,a,a-trifluorotoluene (98-56-6)

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Rats study conclusions related to TR-594: p-Chloro-a,a,a-trifluorotoluene (98-56-6).
Micronucleus - Rats
View Male: Equivocal Female: Negative

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to TR-594: p-Chloro-a,a,a-trifluorotoluene (98-56-6).
Micronucleus - Mice
View Male: Positive Female: Equivocal

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to TR-594: p-Chloro-a,a,a-trifluorotoluene (98-56-6).
Bacterial Mutagenicity
View Negative
View Negative

Citation Information

NTP. TR-594: p-Chloro-a,a,a-trifluorotoluene (98-56-6). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

TR-594 Toxicology and Carcinogenesis Studies of p-Chloro-α,α,α-trifluorotoluene (CAS No. 98-56-6) in Sprague Dawley Rats (Hsd: Sprague Dawley SD) and B6C3F1/N Mice (Inhalation Studies)

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Data

3-Month Evaluation of the Toxicity (C10472) of p-Chloro-a,a,a-trifluorotoluene (98-56-6) in Harlan Sprague-Dawley Rats via Whole Body Respiratory Exposure

Study Tables

E03 - Growth Curves (478 kB)
E04 - Mean Body Weights and Survival Table (18 kB)
E05 - Clinical Observations Summary (14 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (37 kB)
P04 - Neoplasms by Individual Animal (219 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (35 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (247 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (211 kB)
P14 - Individual Animal Pathology Data (289 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (37 kB)
P40 - Survival Curves (437 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (35 kB)
Female Individual Animal Clinical Observations (3 kB)
Female Individual Animal Non Neoplastic Pathology Data (62 kB)
Female Individual Animal Organ Weight Data (19 kB)
Female Individual Animal Survival Data (11 kB)
Male Individual Animal Body Weight Data (35 kB)
Male Individual Animal Non Neoplastic Pathology Data (104 kB)
Male Individual Animal Organ Weight Data (19 kB)
Male Individual Animal Survival Data (11 kB)

Data

3-Month Evaluation of the Toxicity (C10472) of p-Chloro-a,a,a-trifluorotoluene (98-56-6) in B6C3F1 Mice via Whole Body Respiratory Exposure

Study Tables

E03 - Growth Curves (460 kB)
E04 - Mean Body Weights and Survival Table (18 kB)
E05 - Clinical Observations Summary (18 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (34 kB)
P04 - Neoplasms by Individual Animal (220 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (34 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (228 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (86 kB)
P14 - Individual Animal Pathology Data (288 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (35 kB)
P40 - Survival Curves (438 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (34 kB)
Female Individual Animal Clinical Observations (6 kB)
Female Individual Animal Non Neoplastic Pathology Data (61 kB)
Female Individual Animal Organ Weight Data (19 kB)
Female Individual Animal Survival Data (11 kB)
Male Individual Animal Body Weight Data (34 kB)
Male Individual Animal Clinical Observations (7 kB)
Male Individual Animal Non Neoplastic Pathology Data (62 kB)
Male Individual Animal Organ Weight Data (19 kB)
Male Individual Animal Survival Data (11 kB)

Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C10472B) of p-Chloro-a,a,a-trifluorotoluene (98-56-6 ) in Harlan Sprague-Dawley Rats Exposed via Whole Body Respiratory Exposure

Study Tables

E03 - Growth Curves (467 kB)
E04 - Mean Body Weights and Survival Table (25 kB)
E05 - Clinical Observations Summary (21 kB)
E12 - Animal History (1 mB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (64 kB)
P04 - Neoplasms by Individual Animal (716 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (52 kB)
P08 - Statistical Analysis of Primary Tumors (271 kB)
P08 - Statistical Analysis of Primary Tumors Combining Adenomas and Adenocarcinomas (4 mB)
P09 - Non-Neoplastic Lesions by Individual Animal (895 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (460 kB)
P11 - Statistical Analysis of Survival Data (27 kB)
P14 - Individual Animal Pathology Data (2 mB)
P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (640 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (66 kB)
P40 - Survival Curves (464 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (366 kB)
Female Individual Animal Clinical Observations (207 kB)
Female Individual Animal Neoplastic Pathology Data (128 kB)
Female Individual Animal Non Neoplastic Pathology Data (815 kB)
Female Individual Animal Organ Weight Data (57 kB)
Female Individual Animal Survival Data (34 kB)
Male Individual Animal Body Weight Data (440 kB)
Male Individual Animal Clinical Observations (217 kB)
Male Individual Animal Neoplastic Pathology Data (109 kB)
Male Individual Animal Non Neoplastic Pathology Data (904 kB)
Male Individual Animal Organ Weight Data (57 kB)
Male Individual Animal Survival Data (33 kB)

Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C10472B) of p-Chloro-a,a,a-trifluorotoluene (98-56-6 ) in B6C3F1 Mice Exposed via Whole Body Respiratory Exposure

Study Tables

E03 - Growth Curves (463 kB)
E04 - Mean Body Weights and Survival Table (24 kB)
E05 - Clinical Observations Summary (20 kB)
E12 - Animal History (1 mB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (53 kB)
P04 - Neoplasms by Individual Animal (761 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (54 kB)
P08 - Statistical Analysis of Primary Tumors (188 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (807 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (434 kB)
P11 - Statistical Analysis of Survival Data (24 kB)
P14 - Individual Animal Pathology Data (1 mB)
P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (640 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (55 kB)
P40 - Survival Curves (450 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (376 kB)
Female Individual Animal Clinical Observations (47 kB)
Female Individual Animal Neoplastic Pathology Data (190 kB)
Female Individual Animal Non Neoplastic Pathology Data (566 kB)
Female Individual Animal Organ Weight Data (57 kB)
Female Individual Animal Survival Data (34 kB)
Male Individual Animal Body Weight Data (366 kB)
Male Individual Animal Clinical Observations (77 kB)
Male Individual Animal Neoplastic Pathology Data (173 kB)
Male Individual Animal Non Neoplastic Pathology Data (568 kB)
Male Individual Animal Organ Weight Data (57 kB)
Male Individual Animal Survival Data (33 kB)

Protocol

Genetic Toxicology Studies

Data

Genetic Toxicity Evaluation of p-Chloro-a,a,a-trifluorotoluene (98-56-6) in Micronucleus Study G10472 in Harlan Sprague-Dawley Rats

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (79 kB)
Individual Animal In Vivo Micronucleus Data (10 kB)

Data

Genetic Toxicity Evaluation of p-Chloro-a,a,a-trifluorotoluene (98-56-6) in Micronucleus Study G10472B in B6C3F1 Mice

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (77 KB)
Individual Animal In Vivo Micronucleus Data (10 KB)

Data

Genetic Toxicity Evaluation of p-Chloro-a,a,a-trifluorotoluene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 176994

Summary Data

G06 - Ames Summary Data (136 kB)

Data

Genetic Toxicity Evaluation of p-Chloro-a,a,a-trifluorotoluene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G10472C

Summary Data

G06 - Ames Summary Data (85 kB)

TR-594: p-Chloro-a,a,a-trifluorotoluene (98-56-6)

Study Results

Genetic Toxicology

Citation Information

Related Links

Publications

Study Data

Toxicity and Carcinogenicity Studies

3-Month Evaluation of the Toxicity (C10472) of p-Chloro-a,a,a-trifluorotoluene (98-56-6) in Harlan Sprague-Dawley Rats via Whole Body Respiratory Exposure

Study Tables

Individual Animal Data

3-Month Evaluation of the Toxicity (C10472) of p-Chloro-a,a,a-trifluorotoluene (98-56-6) in B6C3F1 Mice via Whole Body Respiratory Exposure

Study Tables

Individual Animal Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C10472B) of p-Chloro-a,a,a-trifluorotoluene (98-56-6 ) in Harlan Sprague-Dawley Rats Exposed via Whole Body Respiratory Exposure

Study Tables

Individual Animal Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C10472B) of p-Chloro-a,a,a-trifluorotoluene (98-56-6 ) in B6C3F1 Mice Exposed via Whole Body Respiratory Exposure

Study Tables

Individual Animal Data

Genetic Toxicology Studies

Genetic Toxicity Evaluation of p-Chloro-a,a,a-trifluorotoluene (98-56-6) in Micronucleus Study G10472 in Harlan Sprague-Dawley Rats

Summary and Individual Animal Data

Genetic Toxicity Evaluation of p-Chloro-a,a,a-trifluorotoluene (98-56-6) in Micronucleus Study G10472B in B6C3F1 Mice

Summary and Individual Animal Data

Genetic Toxicity Evaluation of p-Chloro-a,a,a-trifluorotoluene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 176994

Summary Data

Genetic Toxicity Evaluation of p-Chloro-a,a,a-trifluorotoluene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G10472C

Summary Data