Methacrylonitrile (126-98-7)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID1024176
Study Results
Chronic Bioassay Level of Evidence
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| Mice | |
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Genetic Toxicology
| Micronucleus - Mice |
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| Micronucleus - Rats |
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| Drosophila Germ Cell Mutagenicity |
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| Bacterial Mutagenicity |
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Publications
TR-497
Toxicology and Carcinogenesis Studies of Methacrylonitrile (CASRN 126-98-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
TOX-47
Toxicity Studies of Methacrylonitrile Administered by Gavage to F344/N Rats and B6C3F1Mice (CASRN 126-98-7)
Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
Final Report on the Developmental Toxicity of Methacrylonitrile in New Zealand White Rabbits
Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
Study Data
Toxicity and Carcinogenicity Studies
2-Week Evaluation of the Toxicity (C88050) of Methacrylonitrile (126-98-7) in F344/N Rats Exposed via Dosed Water
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
2-Week Evaluation of the Toxicity (C88050) of Methacrylonitrile (126-98-7) in F344 Rats Exposed via Dosed Water. NTP Special Study
3-Month Evaluation of the Toxicity (C88050) of Methacrylonitrile (126-98-7) in F344 Rats Exposed via Gavage. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Clinical Chemistry Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Clinical Chemistry Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
2-Week Evaluation of the Toxicity (C88050) of Methacrylonitrile (126-98-7) in B6C3F1 Mice Exposed via Dosed Water
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
2-Week Evaluation of the Toxicity (C88050) of Methacrylonitrile (126-98-7) in B6C3F1 Mice Exposed via Dosed Water. NTP Special Study
3-Month Evaluation of the Toxicity (C88050) of Methacrylonitrile (126-98-7) in B6C3F1 Mice Exposed via Gavage. NTP Special Study
3-Month Evaluation of the Toxicity (C88050) of Methacrylonitrile (126-98-7) in F344/N Rats Exposed via Gavage
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C88050) of Methacrylonitrile (126-98-7) in B6C3F1 Mice Exposed via Gavage
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C88050B) of Methacrylonitrile (126-98-7) in F344/N Rats Exposed via Gavage
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C88050B) of Methacrylonitrile (126-98-7) in B6C3F1 Mice Exposed via Gavage
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Methacrylonitrile (126-98-7) in Micronucleus Study A05400 in F344 Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Methacrylonitrile (126-98-7) in Micronucleus Study A38969 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Methacrylonitrile (126-98-7) in Micronucleus Study A63179 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Methacrylonitrile in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 799133
Summary Data
- G06 - Ames Summary Data (145 KB)
Genetic Toxicity Evaluation of Methacrylonitrile in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 926215
Summary Data
- G06 - Ames Summary Data (145 KB)
Other NTP Studies
Prenatal Developmental Toxicity Study (TER92117) of Methacrylonitrile (126-98-7) in Sprague-Dawley Rats Exposed via Gavage
Individual and Summary Data
- Dam Data: Dam Body Weights (24 kB)
- Dam Data: Dam Feed Consumption (22 kB)
- Dam Data: Dam Pregnancy Status (3 kB)
- Dam Data: Dam Water Consumption (23 kB)
- Dam Data: Organ Weights (22 kB)
- Fetal Data: All Malformations (622 kB)
- Fetal Data: All Variations (621 kB)
- Fetal Data: Fetal Body Weights (617 kB)
- Live Litter: All Litter (619 kB)
- Live Litter: Live Litter (622 kB)
Prenatal Developmental Toxicity Study (TER92122) of Methacrylonitrile (126-98-7) in New Zealand White Rabbits Exposed via Gavage
Individual and Summary Data
- Dam Data: Dam Body Weights (23 kB)
- Dam Data: Dam Feed Consumption (23 kB)
- Dam Data: Dam Pregnancy Status (3 kB)
- Dam Data: Organ Weights (22 kB)
- Fetal Data: All Malformations (201 kB)
- Fetal Data: All Variations (201 kB)
- Fetal Data: Fetal Body Weights (196 kB)
- Live Litter: All Litter (198 kB)
- Live Litter: Live Litter (202 kB)