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Methacrylonitrile (126-98-7)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • No Evidence, Female, Rats
  • No Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • No Evidence, Female, Mice
  • No Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Methacrylonitrile (126-98-7).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
View
  • Male: Negative
An overview of Genetic Toxicology Micronucleus Rats study conclusions related to Methacrylonitrile (126-98-7).
Micronucleus - Rats
View
  • Male: Negative
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Methacrylonitrile (126-98-7).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Methacrylonitrile (126-98-7).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative

Citation Information


NTP. Methacrylonitrile (126-98-7). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-497 Toxicology and Carcinogenesis Studies of Methacrylonitrile (CASRN 126-98-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
TOX-47 Toxicity Studies of Methacrylonitrile Administered by Gavage to F344/N Rats and B6C3F1Mice (CASRN 126-98-7)
Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
Final Report on the Developmental Toxicity of Methacrylonitrile in Sprague-Dawley Rats
Final Report on the Developmental Toxicity of Methacrylonitrile in New Zealand White Rabbits
Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252

Study Data


Toxicity and Carcinogenicity Studies


2-Week Evaluation of the Toxicity (C88050) of Methacrylonitrile (126-98-7) in F344/N Rats Exposed via Dosed Water
2-Week Evaluation of the Toxicity (C88050) of Methacrylonitrile (126-98-7) in F344 Rats Exposed via Dosed Water. NTP Special Study
3-Month Evaluation of the Toxicity (C88050) of Methacrylonitrile (126-98-7) in F344 Rats Exposed via Gavage. NTP Special Study
2-Week Evaluation of the Toxicity (C88050) of Methacrylonitrile (126-98-7) in B6C3F1 Mice Exposed via Dosed Water
2-Week Evaluation of the Toxicity (C88050) of Methacrylonitrile (126-98-7) in B6C3F1 Mice Exposed via Dosed Water. NTP Special Study
3-Month Evaluation of the Toxicity (C88050) of Methacrylonitrile (126-98-7) in B6C3F1 Mice Exposed via Gavage. NTP Special Study
3-Month Evaluation of the Toxicity (C88050) of Methacrylonitrile (126-98-7) in F344/N Rats Exposed via Gavage
3-Month Evaluation of the Toxicity (C88050) of Methacrylonitrile (126-98-7) in B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C88050B) of Methacrylonitrile (126-98-7) in F344/N Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C88050B) of Methacrylonitrile (126-98-7) in B6C3F1 Mice Exposed via Gavage

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Methacrylonitrile (126-98-7) in Micronucleus Study A05400 in F344 Rats
Genetic Toxicity Evaluation of Methacrylonitrile (126-98-7) in Micronucleus Study A38969 in B6C3F1 Mice
Genetic Toxicity Evaluation of Methacrylonitrile (126-98-7) in Micronucleus Study A63179 in B6C3F1 Mice
Genetic Toxicity Evaluation of Methacrylonitrile in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 799133
Summary Data
Genetic Toxicity Evaluation of Methacrylonitrile in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 926215
Summary Data

Other NTP Studies


Prenatal Developmental Toxicity Study (TER92117) of Methacrylonitrile (126-98-7) in Sprague-Dawley Rats Exposed via Gavage
Prenatal Developmental Toxicity Study (TER92122) of Methacrylonitrile (126-98-7) in New Zealand White Rabbits Exposed via Gavage