Chloroprene (126-99-8)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID5020316
Study Results
Chronic Bioassay Level of Evidence
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Genetic Toxicology
| Rodent Cytogenetics |
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| CA |
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| Micronucleus - Mice |
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| Drosophila Germ Cell Mutagenicity |
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| Bacterial Mutagenicity |
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Publications
TR-467
Toxicology and Carcinogenesis Studies of Chloroprene (CASRN 126-99-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
Tice, R.R., Boucher, R., Luke, C.A., Paquette, D.F., Melnick, R.L., and Shelby, M.D. Chloroprene and isoprene: Cytogenetic studies in mice. Mutagenesis. Vol. 3 (1988) 141-146
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
Study Data
Toxicity and Carcinogenicity Studies
2-Week Evaluation of the Toxicity (C50522) of Chloroprene (126-99-8) in F344 Rats via Whole Body Respiratory Exposure. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Clinical Chemistry Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
Clinical Chemistry Reports
3-Month Evaluation of the Toxicity (C50522) of Chloroprene (126-99-8) in F344 Rats via Whole Body Respiratory Exposure. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Clinical Chemistry Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Clinical Chemistry Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
2-Week Evaluation of the Toxicity (C50522) of Chloroprene (126-99-8) in B6C3F1 Mice via Whole Body Respiratory Exposure. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Clinical Chemistry Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
Clinical Chemistry Reports
3-Month Evaluation of the Toxicity (C50522) of Chloroprene (126-99-8) in B6C3F1 Mice via Whole Body Respiratory Exposure. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Clinical Chemistry Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Clinical Chemistry Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
26-Week Evaluation of the Toxicity (C50522C) of Chloroprene (126-99-8) in P53(C57BL/6) Mice via Whole Body Respiratory Exposure
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
26-Week Evaluation of the Toxicity (C50522D) of Chloroprene (126-99-8) in Tg.AC Mice via Whole Body Respiratory Exposure
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
3-Month Evaluation of the Toxicity (C50522) of Chloroprene (126-99-8) in F344/N Rats via Whole Body Respiratory Exposure
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C50522) of Chloroprene (126-99-8) in B6C3F1 Mice via Whole Body Respiratory Exposure
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C50522B) of Chloroprene (126-99-8) in F344/N Rats via Whole Body Respiratory Exposure
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C50522B) of Chloroprene (126-99-8) in B6C3F1 Mice via Whole Body Respiratory Exposure
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Chloroprene (126-99-8) in Micronucleus Study A18069 in Tg.AC (FVB/N) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Chloroprene (126-99-8) in Micronucleus Study A73731 in Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Chloroprene (126-99-8) in Micronucleus Study A74378 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Chloroprene (126-99-8) in Micronucleus Study A75483 in Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Chloroprene (126-99-8) in Micronucleus Study A84893 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Chloroprene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 703184
Summary Data
- G06 - Ames Summary Data (141 KB)