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Chloroprene (126-99-8)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID5020316


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Clear Evidence, Female, Rats
  • Clear Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Female, Mice
  • Clear Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to Chloroprene (126-99-8).
Rodent Cytogenetics
CA
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Chloroprene (126-99-8).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
View
  • Female: Negative
View
  • Male: Negative (Nonstandard Protocol)
View
  • Female: Negative
View
  • Female: Negative
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Chloroprene (126-99-8).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Chloroprene (126-99-8).
Bacterial Mutagenicity
View
  • Negative

Citation Information


NTP. Chloroprene (126-99-8). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-467 Toxicology and Carcinogenesis Studies of Chloroprene (CASRN 126-99-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
Tice, R.R., Boucher, R., Luke, C.A., Paquette, D.F., Melnick, R.L., and Shelby, M.D. Chloroprene and isoprene: Cytogenetic studies in mice. Mutagenesis. Vol. 3 (1988) 141-146
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227

Study Data


Toxicity and Carcinogenicity Studies


2-Week Evaluation of the Toxicity (C50522) of Chloroprene (126-99-8) in F344 Rats via Whole Body Respiratory Exposure. NTP Special Study
3-Month Evaluation of the Toxicity (C50522) of Chloroprene (126-99-8) in F344 Rats via Whole Body Respiratory Exposure. NTP Special Study
2-Week Evaluation of the Toxicity (C50522) of Chloroprene (126-99-8) in B6C3F1 Mice via Whole Body Respiratory Exposure. NTP Special Study
3-Month Evaluation of the Toxicity (C50522) of Chloroprene (126-99-8) in B6C3F1 Mice via Whole Body Respiratory Exposure. NTP Special Study
26-Week Evaluation of the Toxicity (C50522C) of Chloroprene (126-99-8) in P53(C57BL/6) Mice via Whole Body Respiratory Exposure
26-Week Evaluation of the Toxicity (C50522D) of Chloroprene (126-99-8) in Tg.AC Mice via Whole Body Respiratory Exposure
3-Month Evaluation of the Toxicity (C50522) of Chloroprene (126-99-8) in F344/N Rats via Whole Body Respiratory Exposure
3-Month Evaluation of the Toxicity (C50522) of Chloroprene (126-99-8) in B6C3F1 Mice via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity (C50522B) of Chloroprene (126-99-8) in F344/N Rats via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity (C50522B) of Chloroprene (126-99-8) in B6C3F1 Mice via Whole Body Respiratory Exposure

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Chloroprene (126-99-8) in Micronucleus Study A18069 in Tg.AC (FVB/N) Mice
Genetic Toxicity Evaluation of Chloroprene (126-99-8) in Micronucleus Study A73731 in Mice
Genetic Toxicity Evaluation of Chloroprene (126-99-8) in Micronucleus Study A74378 in B6C3F1 Mice
Genetic Toxicity Evaluation of Chloroprene (126-99-8) in Micronucleus Study A75483 in Mice
Genetic Toxicity Evaluation of Chloroprene (126-99-8) in Micronucleus Study A84893 in B6C3F1 Mice
Genetic Toxicity Evaluation of Chloroprene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 703184
Summary Data