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Nickel (II) oxide (1313-99-1)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID7025710


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Some Evidence, Female, Rats
  • Some Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
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  • Equivocal Evidence, Female, Mice
  • No Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Nickel (II) oxide (1313-99-1).
Micronucleus - Mice
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  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Nickel (II) oxide (1313-99-1).
Bacterial Mutagenicity
View
  • Negative

Citation Information


NTP. Nickel (II) oxide (1313-99-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-451 Toxicology and Carcinogenesis Studies of Nickel Oxide (CASRN 1313-99-1) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity (C00862) of Nickel (II) Oxide (1313-99-1) in F344/N Rats via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity (C00862) of Nickel (II) Oxide (1313-99-1) in B6C3F1 Mice via Whole Body Respiratory Exposure

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Nickel (II) Oxide (1313-99-1) in Micronucleus Study A32705 in B6C3F1 Mice
Genetic Toxicity Evaluation of Nickel (II) Oxide in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A66352
Summary Data

Other NTP Studies


ADME/TK Evaluation (K00862) of Nickel (II) Oxide (1313-99-1) in F344/N Rats Exposed via Gavage or Nose-Only Respiratory Exposure