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Nickel (II) oxide (1313-99-1)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID7025710

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Some Evidence, Female, Rats
  • Some Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Equivocal Evidence, Female, Mice
  • No Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Nickel (II) oxide (1313-99-1).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Nickel (II) oxide (1313-99-1).
Bacterial Mutagenicity
View
  • Negative

Citation Information

NTP. Nickel (II) oxide (1313-99-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-451 Toxicology and Carcinogenesis Studies of Nickel Oxide (CASRN 1313-99-1) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity (C00862) of Nickel (II) Oxide (1313-99-1) in F344/N Rats via Whole Body Respiratory Exposure
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C00862) of Nickel (II) Oxide (1313-99-1) in B6C3F1 Mice via Whole Body Respiratory Exposure
Pathology Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Nickel (II) Oxide (1313-99-1) in Micronucleus Study A32705 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Nickel (II) Oxide in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A66352
Summary Data

Other NTP Studies

ADME/TK Evaluation (K00862) of Nickel (II) Oxide (1313-99-1) in F344/N Rats Exposed via Gavage or Nose-Only Respiratory Exposure
Data Summary

DTT Data Collections