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Methapyrilene hydrochloride (135-23-9)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID0020818

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Methapyrilene hydrochloride (135-23-9).
Mammalian Cell Mutagenicity
View
  • Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Methapyrilene hydrochloride (135-23-9).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Methapyrilene hydrochloride (135-23-9).
Bacterial Mutagenicity
View
  • Negative

Citation Information

NTP. Methapyrilene hydrochloride (135-23-9). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

W Lijinsky, MD Reuber, BN Blackwell, Liver Tumors Induced in Rats by Oral Administration of the Antihistaminic Methapyrilene Hydrochloride. Science 209:817-819 (1980)
TOX-46 Hepatoxicity Studies of the Liver Carcinogen Methapyrilene Hydrochloride (CASRN 135-23-9) Administered in Feed to Male F344/N Rats
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of Methapyrilene Hydrochloride (135-23-9) in Male F344 Rats Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Methapyrilene Hydrochloride (135-23-9) in Female F344 Rats Exposed via Dosed Feed
Individual Animal Data
3-Month Evaluation of the Toxicity (C55550E) of Methapyrilene hydrochloride (135-23-9) in F344 Rats Exposed via Dosed Feed. NTP Special Study
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Methapyrilene Hydrochloride (135-23-9) in Male B6C3F1 Mice Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Methapyrilene Hydrochloride (135-23-9) in Female B6C3F1 Mice Exposed via Dosed Feed
Individual Animal Data
3-Month Evaluation of the Toxicity (C55550E) of Methapyrilene Hydrochloride (135-23-9) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Methapyrilene Hydrochloride in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 769480
Summary Data

NTP Data Collections