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2,2'-Dithiobisbenzanilide (135-57-9)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID7041629

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 2,2'-Dithiobisbenzanilide (135-57-9).
Bacterial Mutagenicity
  • Negative

Citation Information

NTP. 2,2'-Dithiobisbenzanilide (135-57-9). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).


Disposition and Metabolism of 2',2'''-Dithiobisbenzanilide in Rodents following Intravenous and Gavage Administration and Dermal Application C. Edwin Garner, Christopher J. Wegerski, Joseph Lucak, Melanie Doyle-Eisele, Jacob D. McDonald, J. Michael Sanders, Benjamin C. Moeller and Suramya Waidyanatha

Radiolabel Description:
Carbon-14 uniformly on the rings; 2',2'''-Dithiobisbenzanilide, [phenyl-14C(U)]-

Intravenous, emulphor:ethanol:water (3:5:2) or dimethylacetamide:polyethylene glycol 400:saline (15:55:30); Oral methylcellulose; Dermal, ethanol or acetone

Additional Information:
Two different vehicles were used for the rat 4 mg/kg intravenous treatments. Study C used water:ethanol:alkamuls (3:5:2) vehicle and Study C-2, dimethylacetamide:PEG400:saline (15:40:45).

Study Data

Genetic Toxicology Studies

Genetic Toxicity Evaluation of 2',2'''-Dithiobisbenzanilide in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G06048
Summary Data