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tris(1,3-Dichloro-2-propyl) phosphate (13674-87-8)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID9026261

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to tris(1,3-Dichloro-2-propyl) phosphate (13674-87-8).
Bacterial Mutagenicity
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  • Positive
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  • Positive
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  • Positive
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  • Positive
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  • Positive
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  • Positive
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  • Positive
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  • Positive
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  • Positive

Citation Information

NTP. tris(1,3-Dichloro-2-propyl) phosphate (13674-87-8). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
Behl M, Rice JR, Smith MV, Co CA, Bridge MF, Hsieh JH, Freedman JH, Boyd WA. Editor's Highlight: Comparative Toxicity of Organophosphate Flame Retardants and Polybrominated Diphenyl Ethers to Caenorhabditis elegans. Toxicol Sci. 2016 Dec;154(2):241-252. doi: 10.1093/toxsci/kfw162. Epub 2016 Aug 26. PMID: 27566445
Alzualde A, Behl M, Sipes NS, Hsieh JH, Alday A, Tice RR, Paules RS, Muriana A, Quevedo C. Toxicity profiling of flame retardants in zebrafish embryos using a battery of assays for developmental toxicity, neurotoxicity, cardiotoxicity and hepatotoxicity toward human relevance. Neurotoxicol Teratol. 2018 Nov-Dec;70:40-50. doi: 10.1016/j.ntt.2018.10.002. Epub 2018 Oct 9. PMID: 30312655
Klose J, Pahl M, Bartmann K, Bendt F, Blum J, Dolde X, Förster N, Holzer AK, Hübenthal U, Keßel HE, Koch K, Masjosthusmann S, Schneider S, Stürzl LC, Woeste S, Rossi A, Covaci A, Behl M, Leist M, Tigges J, Fritsche E. Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery. Cell Biol Toxicol. 2022 Oct;38(5):781-807. doi: 10.1007/s10565-021-09603-2. Epub 2021 May 10. PMID: 33969458
Emond C, DeVito MJ, Birnbaum LS. A PBPK model describing the pharmacokinetics of γ-HBCD exposure in mice. Toxicol Appl Pharmacol. 2021 Oct 1;428:115678. doi: 10.1016/j.taap.2021.115678. Epub 2021 Aug 11. PMID: 34390738
Jarema KA, Hunter DL, Shaffer RM, Behl M, Padilla S. Acute and developmental behavioral effects of flame retardants and related chemicals in zebrafish. Neurotoxicol Teratol. 2015 Nov-Dec;52(Pt B):194-209. doi: 10.1016/j.ntt.2015.08.010. Epub 2015 Sep 5. PMID: 26348672
Behl M, Hsieh JH, Shafer TJ, Mundy WR, Rice JR, Boyd WA, Freedman JH, Hunter ES 3rd, Jarema KA, Padilla S, Tice RR. Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. Neurotoxicol Teratol. 2015 Nov-Dec;52(Pt B):181-93. doi: 10.1016/j.ntt.2015.09.003. Epub 2015 Sep 18. PMID: 26386178
Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT): Interlaboratory Study Dose Range Finding (DRF) data DOI: https://doi.org/10.22427/NTP-DATA-002-00102-0001-000-6

Study Data

Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of tris(1,3-Dichloro-2-propyl) Phosphate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 055416
Summary Data
Genetic Toxicity Evaluation of tris(1,3-Dichloro-2-propyl) Phosphate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 268593
Summary Data
Genetic Toxicity Evaluation of tris(1,3-Dichloro-2-propyl) Phosphate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 422335
Summary Data
Genetic Toxicity Evaluation of tris(1,3-Dichloro-2-propyl) Phosphate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 673999
Summary Data
Genetic Toxicity Evaluation of tris(1,3-Dichloro-2-propyl) Phosphate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 685038
Summary Data
Genetic Toxicity Evaluation of tris(1,3-Dichloro-2-propyl) Phosphate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 719875
Summary Data
Genetic Toxicity Evaluation of tris(1,3-Dichloro-2-propyl) Phosphate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 764028
Summary Data
Genetic Toxicity Evaluation of tris(1,3-Dichloro-2-propyl) Phosphate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 891478
Summary Data
Genetic Toxicity Evaluation of tris(1,3-Dichloro-2-propyl) Phosphate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 970291
Summary Data

Other NTP Studies

ADME/TK Evaluation (S0440) of tris(1,3-Dichloro-2-propyl) phosphate (13674-87-8) in F344 Rats Exposed via Intravenous Injection Administration
Data Summary

DTT Data Collections