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Diphenhydramine hydrochloride (147-24-0)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID4020537

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Equivocal Evidence, Male, Rats
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  • Equivocal Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
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  • No Evidence, Male, Mice
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  • No Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Diphenhydramine hydrochloride (147-24-0).
Mammalian Cell Mutagenicity
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  • Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Diphenhydramine hydrochloride (147-24-0).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Diphenhydramine hydrochloride (147-24-0).
Bacterial Mutagenicity
View
  • Negative

Citation Information

NTP. Diphenhydramine hydrochloride (147-24-0). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-355 Toxicology and Carcinogenesis Studies of Diphenhydramine Hydrochloride (CASRN 147-24-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
Teratologic Evaluation of Diphenhydramine Hydrochloride Administered to CD-1 Mice on Gestational Days 11 through 14
Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of Diphenhydramine Hydrochloride (147-24-0) in Male B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Diphenhydramine Hydrochloride (147-24-0) in Female B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Diphenhydramine Hydrochloride (147-24-0) in Male F344 Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Diphenhydramine Hydrochloride (147-24-0) in Female F344 Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Diphenhydramine Hydrochloride in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 637175
Summary Data

Other NTP Studies

Prenatal Developmental Toxicity Study (TER82068) of Diphenhydramine Hydrochloride (147-24-0) in Swiss CD-1 Mice Exposed via Gavage
Individual and Summary Data

NTP Data Collections