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Diphenhydramine hydrochloride (147-24-0)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID4020537


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Equivocal Evidence, Male, Rats
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  • Equivocal Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
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  • No Evidence, Male, Mice
View
  • No Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Diphenhydramine hydrochloride (147-24-0).
Mammalian Cell Mutagenicity
View
  • Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Diphenhydramine hydrochloride (147-24-0).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Diphenhydramine hydrochloride (147-24-0).
Bacterial Mutagenicity
View
  • Negative

Citation Information


NTP. Diphenhydramine hydrochloride (147-24-0). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-355 Toxicology and Carcinogenesis Studies of Diphenhydramine Hydrochloride (CASRN 147-24-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
Teratologic Evaluation of Diphenhydramine Hydrochloride Administered to CD-1 Mice on Gestational Days 11 through 14
Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity of Diphenhydramine Hydrochloride (147-24-0) in Male B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of Diphenhydramine Hydrochloride (147-24-0) in Female B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of Diphenhydramine Hydrochloride (147-24-0) in Male F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of Diphenhydramine Hydrochloride (147-24-0) in Female F344 Rats Exposed via Dosed Feed

Other NTP Studies


Prenatal Developmental Toxicity Study (TER82068) of Diphenhydramine Hydrochloride (147-24-0) in Swiss CD-1 Mice Exposed via Gavage