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Hexabromocyclododecane (25637-99-4)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID8025383

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Hexabromocyclododecane (25637-99-4).
Bacterial Mutagenicity
View
  • Negative

Citation Information

NTP. Hexabromocyclododecane (25637-99-4). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
Szabo DT, Pathmasiri W, Sumner S, Birnbaum LS. Serum Metabolomic Profiles in Neonatal Mice following Oral Brominated Flame Retardant Exposures to Hexabromocyclododecane (HBCD) Alpha, Gamma, and Commercial Mixture. Environmental Health Perspectives. (2017) DOI: https://doi.org/10.1289/ehp242. PMID: 27814246
Shockley KR, Cora MC, Malarkey DE, Jackson-Humbles D, Vallant M, Collins BJ, Mutlu E, Robinson VG, Waidyanatha S, Zmarowski A, Machesky N, Richey J, Harbo S, Cheng E, Patton K, Sparrow B, Dunnick JK. Transcriptomic data from the rat liver after five days of exposure to legacy or emerging brominated flame retardants. Data Brief. 2020 Aug 5;32:106136. doi: 10.1016/j.dib.2020.106136. eCollection 2020 Oct. PMID: 32904430
Emond C, DeVito MJ, Birnbaum LS. A PBPK model describing the pharmacokinetics of γ-HBCD exposure in mice. Toxicol Appl Pharmacol. 2021 Oct 1;428:115678. doi: 10.1016/j.taap.2021.115678. Epub 2021 Aug 11. PMID: 34390738
Comparative toxicity and liver transcriptomics of legacy and emerging brominated flame retardants following 5-day exposure in the rat Keith R Shockley, Michelle C Cora, David E Malarkey, Daven Jackson-Humbles, Molly Vallant, Brad J Collins, Esra Mutlu, Veronica G Robinson, Surayma Waidyanatha, Amy Zmarowski, Nicholas Machesky, Jamie Richey, Sam Harbo, Emily Cheng, Kristin Patton, Barney Sparrow, June K Dunnick

Toxicology Letters (2020) DOI: https://doi.org/10.1016/j.toxlet.2020.07.016 PMID: 32679240

GEO: GSE153366

Study Data

Protocol

Toxicity and Carcinogenicity Studies

5-Day Evaluation of the Toxicity (C11297-01) of the Toxicity of 1,3,5,7,9,11-Hexabromocyclododecane (25637-99-4) in Sprague Dawley Rats Exposed via Gavage
Study Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Hexabromocyclododecane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 045544
Summary Data

DTT Data Collections