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Flame Retardants

Citation Information

NTP. Flame Retardants. Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Study Data

Protocol

Toxicity and Carcinogenicity Studies

5-Day Evaluation of the Toxicity (C02047-01) of Tetrabromobisphenol A-bis(2,3-dibromopropyl ether)(21850-44-2) in Sprague Dawley Rats Exposed via Gavage

Study Data

I01 - Animal Removal Summary (29 kB)
I02 - Animal Removals (138 kB)
I03 - Growth Curve (305 kB)
I03C - Growth Curve (321 kB)
I04 - Mean Body Weight Summary (74 kB)
I04G - Mean Body Weight Gain (46 kB)
I05 - Clinical Observations Summary (32 kB)
PA02 - Neoplastic Lesion Summary with Percent Incidence (128 kB)
PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (101 kB)
PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (129 kB)
PA06 - Organ Weights Summary (87 kB)
PA14 - Individual Animal Pathology Data (305 kB)
PA18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grade (102 kB)
PA41 - Clinical Chemistry Summary (146 kB)
PA43 - Hematology Summary (153 kB)
PA46 - Summary of Gross Pathology (226 kB)
PA49 - Summary of Cytochrome Activity (52 kB)
R07 - Hormone Summary (41 kB)

Individual Animal Data

Individual Animal Body Weight Data (11 kB)
Individual Animal Clinical Chemistry Data (9 kB)
Individual Animal Clinical Observations Data (11 kB)
Individual Animal Cytochrome Activity Data (8 kB)
Individual Animal Gross Pathology Data (61 kB)
Individual Animal Hematology Data (10 kB)
Individual Animal Histopathology Data (5 kB)
Individual Animal Hormone Data (6 kB)
Individual Animal Organ Weight Data (8 kB)
Individual Animal Removal Reasons Data (5 kB)

5-Day Evaluation of the Toxicity (C10333-01) of Bis(2-ethylhexyl) tetrabromophthalate (26040-51-7) in Sprague Dawley Rats Exposed via Gavage

Study Tables

I01 - Animal Removal Summary (29 kB)
I02 - Animal Removals (138 kB)
I03 - Growth Curve (324 kB)
I03C - Growth Curve (328 kB)
I04 - Mean Body Weight Summary (75 kB)
I04G - Mean Body Weight Gain (45 kB)
I05 - Clinical Observations Summary (32 kB)
PA02 - Neoplastic Lesion Summary with Percent Incidence (133 kB)
PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (106 kB)
PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (134 kB)
PA06 - Organ Weights Summary (86 kB)
PA14 - Individual Animal Pathology Data (304 kB)
PA18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grade (107 kB)
PA41 - Clinical Chemistry Summary (145 kB)
PA43 - Hematology Summary (153 kB)
PA46 - Summary of Gross Pathology (232 kB)
PA49 - Summary of Cytochrome Activity (51 kB)
R07 - Hormone Summary (41 kB)

Individual Animal Data

Individual Animal Body Weight Data (11 kB)
Individual Animal Clinical Chemistry Data (9 kB)
Individual Animal Clinical Observations Data (11 kB)
Individual Animal Cytochrome Activity Data (8 kB)
Individual Animal Gross Pathology Data (61 kB)
Individual Animal Hematology Data (10 kB)
Individual Animal Histopathology Data (5 kB)
Individual Animal Hormone Data (6 kB)
Individual Animal Organ Weight Data (8 kB)
Individual Animal Removal Reasons Data (5 kB)

5-Day Evaluation of the Toxicity (C10672-01) of Decabromodiphenyl Ether (1163-19-5) in Sprague Dawley Rats Exposed via Gavage

Study Tables

I01 - Animal Removal Summary (29 kB)
I02 - Animal Removals (138 kB)
I03 - Growth Curve (318 kB)
I03C - Growth Curve (320 kB)
I04 - Mean Body Weight Summary (74 kB)
I04G - Mean Body Weight Gain (45 kB)
I05 - Clinical Observations Summary (37 kB)
PA02 - Neoplastic Lesion Summary with Percent Incidence (133 kB)
PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (106 kB)
PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (134 kB)
PA06 - Organ Weights Summary (87 kB)
PA14 - Individual Animal Pathology Data (304 kB)
PA18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grade (2) (106 kB)
PA41 - Clinical Chemistry Summary (146 kB)
PA43 - Hematology Summary (153 kB)
PA46 - Summary of Gross Pathology (238 kB)
PA49 - Summary of Cytochrome Activity (52 kB)
R07 - Hormone Summary (41 kB)

Individual Animal Data

Individual Animal Body Weight Data (11 kB)
Individual Animal Clinical Chemistry Data (9 kB)
Individual Animal Clinical Observations Data (11 kB)
Individual Animal Cytochrome Activity Data (8 kB)
Individual Animal Gross Pathology Data (82 kB)
Individual Animal Hematology Data (9 kB)
Individual Animal Histopathology Data (5 kB)
Individual Animal Hormone Data (6 kB)
Individual Animal Organ Weight Data (8 kB)
Individual Animal Removal Reasons Data (5 kB)

5-Day Evaluation of the Toxicity (C11297-01) of the Toxicity of 1,3,5,7,9,11-Hexabromocyclododecane (25637-99-4) in Sprague Dawley Rats Exposed via Gavage

Study Tables

I01 - Animal Removal Summary (29 kB)
I02 - Animal Removals (138 kB)
I03 - Growth Curve (317 kB)
I03C - Growth Curve (311 kB)
I04 - Mean Body Weight Summary (74 kB)
I04G - Mean Body Weight Gain (45 kB)
I05 - Clinical Observations Summary (32 kB)
PA02 - Neoplastic Lesion Summary with Percent Incidence (128 kB)
PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (105 kB)
PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (129 kB)
PA06 - Organ Weights Summary (87 kB)
PA14 - Individual Animal Pathology Data (321 kB)
PA18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grade (105 kB)
PA41 - Clinical Chemistry Summary (146 kB)
PA43 - Hematology Summary (153 kB)
PA46 - Summary of Gross Pathology (226 kB)
PA49 - Summary of Cytochrome Activity (52 kB)
R07 - Hormone Summary (41 kB)

Individual Animal Data

Individual Animal Body Weight Data (11 kB)
Individual Animal Clinical Chemistry Data (9 kB)
Individual Animal Clinical Observations Data (11 kB)
Individual Animal Cytochrome Activity Data (8 kB)
Individual Animal Gross Pathology Data (61 kB)
Individual Animal Hematology Data (10 kB)
Individual Animal Histopathology Data (6 kB)
Individual Animal Hormone Data (6 kB)
Individual Animal Organ Weight Data (8 kB)
Individual Animal Removal Reasons Data (5 kB)

5-Day Evaluation of the Toxicity (C13063-01) of 2-ethylhexyl-2,3,4,5-Tetrabromobenzoate (TBB) (183658-27-7) in Sprague Dawley Rats Exposed via Gavage

Study Tables

I01 - Animal Removal Summary (31 kB)
I02 - Animal Removals (138 kB)
I03 - Growth Curve (315 kB)
I03C - Growth Curve (307 kB)
I04 - Mean Body Weight Summary (74 kB)
I04G - Mean Body Weight Gain (45 kB)
I05 - Clinical Observations Summary (37 kB)
PA02 - Neoplastic Lesion Summary with Percent Incidence (135 kB)
PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (108 kB)
PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (136 kB)
PA06 - Organ Weight Summary (87 kB)
PA14 - Individual Animal Pathology Data (305 kB)
PA18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grade (108 kB)
PA41 - Clinical Chemistry Summary (146 kB)
PA43 - Hematology Summary (154 kB)
PA46 - Summary of Gross Pathology (127 kB)
PA49 - Summary of Cytochrome Activity (52 kB)
R07 - Hormone Summary (41 kB)

Individual Animal Data

Individual Animal Body Weight Data (11 kB)
Individual Animal Clinical Chemistry Data (9 kB)
Individual Animal Clinical Observations Data (11 kB)
Individual Animal Cytochrome Activity Data (8 kB)
Individual Animal Gross Pathology Data (76 kB)
Individual Animal Hematology Data (9 kB)
Individual Animal Histopathology Data (5 kB)
Individual Animal Hormone Data (6 kB)
Individual Animal Organ Weight Data (8 kB)
Individual Animal Removal Reasons Data (5 kB)

5-Day Evaluation of the Toxicity (C15002-01) of 1,2-bis(pentabromophenyl)ethane (84852-53-9) in Sprague Dawley Rats Exposed via Gavage

Study Tables

I01 - Animal Removal Summary (29 kB)
I02 - Animal Removals (138 kB)
I03 - Growth Curve (294 kB)
I03C - Growth Curve (302 kB)
I04 - Mean Body Weight Summary (74 kB)
I04G - Mean Body Weight Gain (45 kB)
I05 - Clinical Observations Summary (37 kB)
PA02 - Neoplastic Lesion Summary with Percent Incidence (133 kB)
PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (106 kB)
PA05 - Incidence Rates of Neoplastic Lesions with systemic Lesions Abridged (134 kB)
PA06 - Organ Weights Summary (87 kB)
PA14 - Individual Animal Pathology Data (306 kB)
PA18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grade (107 kB)
PA41 - Clinical Chemistry Summary (145 kB)
PA43 - Hematology Summary (156 kB)
PA46 - Summary of Gross Pathology (128 kB)
PA49 - Summary of Cytochrome Activity (51 kB)
R07 - Hormone Summary (41 kB)

Individual Animal Data

Individual Animal Body Weight Data (11 kB)
Individual Animal Clinical Chemistry Data (9 kB)
Individual Animal Clinical Observations Data (11 kB)
Individual Animal Cytochrome Activity Data (8 kB)
Individual Animal Gross Pathology Data (76 kB)
Individual Animal Hematology Data (10 kB)
Individual Animal Histopathology Data (5 kB)
Individual Animal Hormone Data (6 kB)
Individual Animal Organ Weight Data (8 kB)
Individual Animal Removal Reasons Data (5 kB)

5-Day Evaluation of the Toxicity (C15003-01) of Hexachlorocyclopentadienyl-dibromocyclooctane (HCDBCO) (51936-55-1) in Sprague Dawley Rats Exposed via Gavage

Study Tables

I01 - Animal Removal Summary (29 kB)
I02 - Animal Removals (138 kB)
I03 - Growth Curve (321 kB)
I03C - Growth Curve (327 kB)
I04 - Mean Body Weight Summary (74 kB)
I04G - Mean Body Weight Gain (45 kB)
I05 - Clinical Observations Summary (32 kB)
PA02 - Neoplastic Lesion Summary with Percent Incidence (133 kB)
PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (108 kB)
PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (134 kB)
PA06 - Organ Weights Summary (87 kB)
PA14 - Individual Animal Pathology Data (337 kB)
PA18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grade (109 kB)
PA41 - Clinical Chemistry Summary (146 kB)
PA43 - Hematology Summary (156 kB)
PA46 - Summary of Gross Pathology (230 kB)
PA49 - Summary of Cytochrome Activity (52 kB)
R07 - Hormone Summary (41 kB)

Individual Animal Data

Individual Animal Body Weight Data (11 kB)
Individual Animal Clinical Chemistry Data (9 kB)
Individual Animal Clinical Observations Data (11 kB)
Individual Animal Cytochrome Activity Data (8 kB)
Individual Animal Gross Pathology Data (61 kB)
Individual Animal Hematology Data (10 kB)
Individual Animal Histopathology Data (6 kB)
Individual Animal Hormone Data (6 kB)
Individual Animal Organ Weight Data (8 kB)
Individual Animal Removal Reasons Data (5 kB)

5-Day Evaluation of the Toxicity (C20292-01) of Firemaster 680 (37853-59-1) in Sprague Dawley Rats Exposed via Gavage

Study Tables

I01 - Animal Removal Summary (29 kB)
I02 - Animal Removals (138 kB)
I03 - Growth Curve (301 kB)
I03C - Growth Curve (315 kB)
I04 - Mean Body Weight Summary (74 kB)
I05 - Clinical Observations Summary (32 kB)
PA02 - Neoplastic Lesion Summary with Percent Incidence (133 kB)
PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (110 kB)
PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (134 kB)
PA06 - Organ Weights Summary (87 kB)
PA14 - Individual Animal Pathology Data (310 kB)
PA18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grade (110 kB)
PA41 - Clinical Chemistry Summary (145 kB)
PA43 - Hematology Summary (156 kB)
PA46 - Summary of Gross Pathology (230 kB)
PA49 - Summary of Cytochrome Activity (52 kB)
R07 - Hormone Summary (41 kB)

Individual Animal Data

Individual Animal Body Weight Data (11 kB)
Individual Animal Clinical Chemistry Data (9 kB)
Individual Animal Clinical Observations Data (11 kB)
Individual Animal Cytochrome Activity Data (8 kB)
Individual Animal Gross Pathology Data (68 kB)
Individual Animal Hematology Data (10 kB)
Individual Animal Histopathology Data (5 kB)
Individual Animal Hormone Data (6 kB)
Individual Animal Organ Weight Data (8 kB)
Individual Animal Removal Reasons Data (5 kB)

5-Day Evaluation of the Toxicity (C98090C-01) of 2,2',4,4'-Tetrabromodiphenyl Ether (BDE-47) (5436-43-1) in Sprague Dawley Rats Exposed via Gavage

Study Tables

I01 - Animal Removal Summary (29 kB)
I02 - Animal Removals (138 kB)
I03 - Growth Curve (317 kB)
I03C - Growth Curve (327 kB)
I04 - Mean Body Weight Summary (74 kB)
I04G - Mean Body Weight Gain (45 kB)
I05 - Clinical Observations Summary (32 kB)
PA02 - Neoplastic Lesion Summary with Percent Incidence (133 kB)
PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (110 kB)
PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (134 kB)
PA06 - Organ Weights Summary (87 kB)
PA14 - Individual Animal PAthology Data (342 kB)
PA18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grade (110 kB)
PA41 - Clinical Chemistry Summary (146 kB)
PA43 - Hematology Summary (156 kB)
PA46 - Summary of Gross PAthology (232 kB)
PA49 - Summary of Cytochrome Activity (52 kB)
R07 - Hormone Summary (41 kB)

Individual Animal Data

Individual Animal Body Weight Data (11 kB)
Individual Animal Clinical Chemistry Data (9 kB)
Individual Animal Clinical Observations Data (11 kB)
Individual Animal Cytochrome Activity Data (8 kB)
Individual Animal Gross PAthology Data (61 kB)
Individual Animal Hematology Data (9 kB)
Individual Animal HistoPAthology Data (6 kB)
Individual Animal Hormone Data (6 kB)
Individual Animal Organ Weight Data (8 kB)
Individual Animal Removal Reasons Data (5 kB)