COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:

Pentabromodiphenyl ether (32534-81-9)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID2024246


Study Results


Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Pentabromodiphenyl ether (32534-81-9).
Micronucleus - Mice
View
  • Male: Negative
View
  • Male: Negative
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Pentabromodiphenyl ether (32534-81-9).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative
View
  • Negative

Citation Information


NTP. Pentabromodiphenyl ether (32534-81-9). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-589 Toxicology Studies of a Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] (CASRN 32534-81-9) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of a Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] in Wistar Han [Crl:WI(Han)] Rats and B6C3F1/N Mice (Gavage Studies)
Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutat Res. 2008 Jan 8;649(1-2):101-13. Epub 2007 Aug 11.
Behl M, Rice JR, Smith MV, Co CA, Bridge MF, Hsieh JH, Freedman JH, Boyd WA. Editor's Highlight: Comparative Toxicity of Organophosphate Flame Retardants and Polybrominated Diphenyl Ethers to Caenorhabditis elegans. Toxicol Sci. 2016 Dec;154(2):241-252. doi: 10.1093/toxsci/kfw162. Epub 2016 Aug 26. PMID: 27566445
Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes William M. Gwinn, Scott S. Auerbach, Fred Parham, Matthew D. Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, B. Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R. Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R. Shah, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Georgia Roberts, Michael J. DeVito


CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005
Carcinogenic Activity of Pentabrominated Diphenyl Ether Mixture (DE-71) in Rats and Mice J.K. Dunnick, A.R. Pandiri, B.A. Merrick, G.E. Kissling, H. Cunny, E. Mutlu, S. Waidyanatha, R. Sills, H.L. Hong, TV. Ton, T. Maynor, L. Recio, S.L. Phillips, M.J. Devito, and A. Brix.
Toxicology Reports (2018) DOI: https://doi.org/10.1016/j.toxrep.2018.05.010 PMID: 29868454

Study Data


Toxicity and Carcinogenicity Studies


5-Day Evaluation of the Toxicity (C20287D) of Pentabromodiphenyl Ether Mixture (DE-71) (32534-81-9) in Harlan Sprague-Dawley Rats Exposed via Gavage
3-Month Evaluation of the Toxicity (C20209) of Pentabromodiphenyl Ether (Technical) (DE 71) (32534-81-9) in F344/N Rats Exposed via Gavage
3-Month Evaluation of the Toxicity (C20209) of Pentabromodiphenyl Ether (Technical) (DE 71) (32534-81-9) in F344/N Rats Exposed via Gavage
3-Month Evaluation of the Toxicity (C20209) of Pentabromodiphenyl Ether (Technical) (DE 71) (32534-81-9) in B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C20209) of Pentabromodiphenyl Ether (Technical) (DE 71) (32534-81-9) in Wistar Han Rats Exposed via Gavage
Study Tables
Interim of Chronic Study at 3-Months
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C20209) of Pentabromodiphenyl Ether (Technical) (DE 71) (32534-81-9) in B6C3F1 Mice Exposed via Gavage
Study Tables
Individual Animal Data

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Pentabromodiphenyl Ether (Technical) (DE 71) (32534-81-9) in Micronucleus Study A27878 in B6C3F1 Mice
Genetic Toxicity Evaluation of Pentabromodiphenyl Ether (Technical) (DE 71) (32534-81-9) in Micronucleus Study A34110 in B6C3F1 Mice
Genetic Toxicity Evaluation of Pentabromodiphenyl Ether (Technical) (DE 71) (32534-81-9) in Micronucleus Study F34110 in B6C3F1 Mice
Genetic Toxicity Evaluation of Pentabromodiphenyl Ether (Technical) (DE 71) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 873255
Summary Data
Genetic Toxicity Evaluation of Pentabromodiphenyl Ether (Technical) (DE 71) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A82572
Summary Data
Genetic Toxicity Evaluation of Pentabromodiphenyl Ether (Technical) (DE 71) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A83261
Summary Data