TR-589: Pentabromodiphenyl ether (32534-81-9)
Publications
TR-589
Toxicology Studies of a Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] (CASRN 32534-81-9) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of a Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] in Wistar Han [Crl:WI(Han)] Rats and B6C3F1/N Mice (Gavage Studies)
Study Data
Toxicity and Carcinogenicity Studies
3-Month Evaluation of the Toxicity (C20209) of Pentabromodiphenyl Ether (Technical) (DE 71) (32534-81-9) in F344/N Rats Exposed via Gavage
Study Tables
- E03 - Growth Curves (374 kB)
- E04 - Mean Body Weights and Survival Table (61 kB)
- E05 - Clinical Observations Summary (59 kB)
- P02 - Incidence Rates of Neoplasms by Anatomic Site (102 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (39 kB)
- P04 - Neoplasms by Individual Animal (223 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (39 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (235 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (164 kB)
- P14 - Individual Animal Pathology Data (204 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (40 kB)
- P40 - Survival Curves (387 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (37 kB)
- Female Individual Animal Clinical Observations (11 kB)
- Female Individual Animal Non Neoplastic Pathology Data (42 kB)
- Female Individual Animal Organ Weight Data (19 kB)
- Female Individual Animal Survival Data (11 kB)
- Male Individual Animal Body Weight Data (37 kB)
- Male Individual Animal Clinical Observations (3 kB)
- Male Individual Animal Non Neoplastic Pathology Data (43 kB)
- Male Individual Animal Organ Weight Data (19 kB)
- Male Individual Animal Survival Data (11 kB)
3-Month Evaluation of the Toxicity (C20209) of Pentabromodiphenyl Ether (Technical) (DE 71) (32534-81-9) in F344/N Rats Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C20209) of Pentabromodiphenyl Ether (Technical) (DE 71) (32534-81-9) in B6C3F1 Mice Exposed via Gavage
Study Tables
- E03 - Growth Curves (362 kB)
- E04 - Mean Body Weights and Survival Table (195 kB)
- E05 - Clinical Observations Summary (44 kB)
- P02 - Incidence Rates of Neoplasms by Anatomic Site (121 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (108 kB)
- P04 - Neoplasms by Individual Animal (2 mB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (133 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (2 mB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (400 kB)
- P14 - Individual Animal Pathology Data (410 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (157 kB)
- P40 - Survival Curves (381 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (35 kB)
- Female Individual Animal Clinical Observations (6 kB)
- Female Individual Animal Non Neoplastic Pathology Data (26 kB)
- Female Individual Animal Organ Weight Data (19 kB)
- Female Individual Animal Survival Data (11 kB)
- Male Individual Animal Body Weight Data (36 kB)
- Male Individual Animal Clinical Observations (3 kB)
- Male Individual Animal Non Neoplastic Pathology Data (34 kB)
- Male Individual Animal Organ Weight Data (18 kB)
- Male Individual Animal Survival Data (11 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity (C20209) of Pentabromodiphenyl Ether (Technical) (DE 71) (32534-81-9) in Wistar Han Rats Exposed via Gavage
Study Tables
- E03 - Growth Curves (79 kB)
- E04 - Mean Body Weights and Survival Table (24 kB)
- E05 - Clinical Observations Summary (22 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (75 kB)
- P04 - Neoplasms by Individual Animal (656 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (51 kB)
- P08 - Statistical Analysis of Additional Grouping of Primary Liver Tumors (22 kB)
- P08 - Statistical Analysis of Primary Tumors (278 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (952 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (560 kB)
- P11 - Statistical Analysis of Survival Data (24 kB)
- P14 - Individual Animal Pathology Data (2 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (608 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (78 kB)
- P40 - Survival Curves (64 kB)
Interim of Chronic Study at 3-Months
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (31 kB)
- P04 - Neoplasms by Individual Animal (117 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (32 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (125 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (114 kB)
- P14 - Individual Animal Pathology Data (89 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (32 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (424 kB)
- Female Individual Animal Clinical Observations (96 kB)
- Female Individual Animal Neoplastic Pathology Data (115 kB)
- Female Individual Animal Non Neoplastic Pathology Data (913 kB)
- Female Individual Animal Organ Weight Data (62 kB)
- Female Individual Animal Survival Data (37 kB)
- Male Individual Animal Body Weight Data (435 kB)
- Male Individual Animal Clinical Observations (93 kB)
- Male Individual Animal Neoplastic Pathology Data (107 kB)
- Male Individual Animal Non Neoplastic Pathology Data (900 kB)
- Male Individual Animal Organ Weight Data (62 kB)
- Male Individual Animal Survival Data (37 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity (C20209) of Pentabromodiphenyl Ether (Technical) (DE 71) (32534-81-9) in B6C3F1 Mice Exposed via Gavage
Study Tables
- E03 - Growth Curves (70 kB)
- E04 - Mean Body Weights and Survival Table (29 kB)
- E05 - Clinical Observations Summary (29 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (80 kB)
- P04 - Neoplasms by Individual Animal (699 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (51 kB)
- P08 - Statistical Analysis of Primary Tumors (182 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (1 mB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (716 kB)
- P11 - Statistical Analysis of Survival Data (32 kB)
- P14 - Individual Animal Pathology Data (2 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (593 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (83 kB)
- P40 - Survival Curves (69 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (374 kB)
- Female Individual Animal Clinical Observations (380 kB)
- Female Individual Animal Neoplastic Pathology Data (137 kB)
- Female Individual Animal Non Neoplastic Pathology Data (1 mB)
- Female Individual Animal Survival Data (34 kB)
- Female Individual Animal Terminal Body Weight Data (57 kB)
- Male Individual Animal Body Weight Data (404 kB)
- Male Individual Animal Clinical Observations (295 kB)
- Male Individual Animal Neoplastic Pathology Data (146 kB)
- Male Individual Animal Non Neoplastic Pathology Data (1 mB)
- Male Individual Animal Survival Data (34 kB)
- Male Individual Animal Terminal Body Weight Data (57 kB)
Genetic Toxicology Studies
Genetic Toxicity Evaluation of 2,2',4,4',5,5'-Hexabromodiphenyl Ether (PBDE 153) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A07760
Summary Data
- G06 - Ames Summary Data (57 KB)
Genetic Toxicity Evaluation of 2,2',4,4',5-Pentabromodiphenyl Ether in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A93319
Summary Data
- G06 - Ames Summary Data (61 KB)
Genetic Toxicity Evaluation of 2,2',4,4'-Tetrabromodiphenyl Ether (BDE-47) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A90466
Summary Data
- G06 - Ames Summary Data (61 KB)