N-Butylbenzenesulfonamide (3622-84-2)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID7027540
Publications
Immunotoxicity of N-Butylbenzenesulfonamide (NBBS): Impacts on Immune Function in Adult Mice and Developmentally Exposed Rats
Victor J. Johnson1, Cynthia V. Rider2, Michael I. Luster1, Amy Brix3, Gary R. Burleson1, Michelle Cora2, Susan A. Elmore2, Rachel P. Frawley2, Franklin R. Lopez4, Esra Mutlu2, Keith R. Shockley2,5, Jessica Pierfelice6, Brian Burback6, Caroll A. Co7, Dori R. Germolec2
1Burleson Research Technologies, Inc., Morrisville, NC, USA
2Division of Translational Toxicology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
3Experimental Pathology Laboratories, Inc., Morrisville, NC, USA
4Charles River Laboratories, Morrisville, NC USA
5Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
6Battelle, Columbus, OH, USA
7Social and Scientific Systems Inc., a DLH Holdings Corp Company, Durham, NC, USA
DOI: https://doi.org/10.22427/NTP-DATA-500-005-003-000-3
1Burleson Research Technologies, Inc., Morrisville, NC, USA
2Division of Translational Toxicology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
3Experimental Pathology Laboratories, Inc., Morrisville, NC, USA
4Charles River Laboratories, Morrisville, NC USA
5Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
6Battelle, Columbus, OH, USA
7Social and Scientific Systems Inc., a DLH Holdings Corp Company, Durham, NC, USA
DOI: https://doi.org/10.22427/NTP-DATA-500-005-003-000-3
Toxicokinetics of the plasticizer, N-butylbenzenesulfonamide, in plasma and brain following oral exposure in rodents: Route, species, and sex comparison
Suramya Waidyanatha, Seth Gibbs, Natalie South, Jeremy P. Smith, Esra Mutlu, Brian Burback, Yu Cao, Cynthia V. Rider
Toxicol Rep (2020): https://pubmed.ncbi.nlm.nih.gov/32551233/
DOI: https://doi.org/10.22427/NTP-DATA-002-03240-0014-0000-6
Toxicol Rep (2020): https://pubmed.ncbi.nlm.nih.gov/32551233/
DOI: https://doi.org/10.22427/NTP-DATA-002-03240-0014-0000-6
Disposition and metabolism of N-butylbenzenesulfonamide in Sprague Dawley rats and B6C3F1/N mice and in vitro in hepatocytes from rats, mice, and humans
Radiolabel Description:
carbon-14 uniformly in the ring; N-Butylbenzenesulfonamide, [ring-14C(U)]-
Vehicles:
Intravenous, ethanol:Cremophor:water (10:10:80); oral, 0.5% methyl cellulose.
Toxicology Letters (2020): https://pubmed.ncbi.nlm.nih.gov/31760063/
DOI: https://doi.org/10.22427/NTP-DATA-002-03240-0010-0000-2
carbon-14 uniformly in the ring; N-Butylbenzenesulfonamide, [ring-14C(U)]-
Vehicles:
Intravenous, ethanol:Cremophor:water (10:10:80); oral, 0.5% methyl cellulose.
Toxicology Letters (2020): https://pubmed.ncbi.nlm.nih.gov/31760063/
DOI: https://doi.org/10.22427/NTP-DATA-002-03240-0010-0000-2
Study Data
Genetic Toxicology Studies
Genetic Toxicity Evaluation of N-Butylbenzenesulfonamide in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G10482
Other NTP Studies
Modified One Generation (MOG) Dose Range Finding Toxicity Study (MOG10482-01) of N-Butylbenzenesulfonamide (3622-84-2) in Sprague-Dawley Rats Exposed via Dosed Feed
Modified One Generation DRF Study Tables
- I01 - Animal Removal Summary (40 kB)
- I02 - Animal Removals (231 kB)
- I03 - Growth Curve (655 kB)
- I03C - Growth Curve (671 kB)
- I04 - Mean Body Weight Summary (203 kB)
- I04G - Mean Body Weight Gain (113 kB)
- I05 - Clinical Observations Summary (60 kB)
- I05P - Pup Clinical Observations Summary (145 kB)
- I06 - Mean Feed Consumption (156 kB)
- I08 - Mean Test Compound Consumption (124 kB)
- R01 - Multigeneration Cross Reference (795 kB)
- R02 - Reproductive Performance Summary (45 kB)
- R03 - Summary of Litter Data (94 kB)
- R19 - Pup Mean Body Weight Summary (190 kB)
- R19C - Pup Growth Curve (867 kB)
- R19G - Pup Mean Body Weight Gain (159 kB)
- R20 - Pup Necropsy Summary (144 kB)
Modified One Generation DRF Individual Animal Data
- Concentration in plasma, amniotic fluid and fetuses (26 kB)
- Individual Animal Body Weight Data (38 kB)
- Individual Animal Clinical Observations Data (67 kB)
- Individual Animal Consumption Data (38 kB)
- Individual Animal Litter Data (51 kB)
- Individual Animal Pup Body Weight Data (81 kB)
- Individual Animal Pup Clinical Observations Data (393 kB)
- Individual Animal Pup Necropsy Data (7 kB)
- Individual Animal Removal Reasons Data (6 kB)
- Individual Animal Reproductive Performance Data (7 kB)
13-Week Perinatal Evaluation (I10482B) of N-Butylbenzenesulfonamide (3622-84-2) in Harlan Sprague Dawley rats Exposed via Dosed Feed
Summary Data
- I01 - Animal Removal Summary (142 kB)
- I02 - Animal Removals (2 mB)
- I03 - Growth Curve (3 mB)
- I03C - Growth Curve (3 mB)
- I04 - Mean Body Weight Summary (716 kB)
- I04G - Mean Body Weight Gain (496 kB)
- I05 - Clinical Observations Summary (168 kB)
- I05P - Pup Clinical Observations Summary (344 kB)
- I06 - Mean Feed Consumption (650 kB)
- I08 - Mean Test Compound Consumption (458 kB)
- M03 - Peripheral Blood Leukocyte Cell Differential (88 kB)
- M04 - Hematology (71 kB)
- M06 - Spleen_Immunophenotyping (119 kB)
- M07 - TDAR SRBC Spleen AFC (62 kB)
- M08 - Serum IgM Antibody Titers to T - Dependent Antigen Sheep Erythrocytes (39 kB)
- M09 - Serum Antibody Concentrations for the T - Dependent Keyhole Limpet Hemocyanin (KLH) (45 kB)
- M11 - Spleen Cell Proliferative Response to Anti - CD3 Stimulation (51 kB)
- M12 - Cytotoxic T Cell Activity (48 kB)
- M15 - Natural Killer Cell Activity (48 kB)
- M19 - TDAR SRBC ELISpot (51 kB)
- PA06 - Organ Weights Summary (217 kB)
- PA46 - Summary of Gross Pathology (1 mB)
- R01 - Multigeneration Cross Reference (3 mB)
- R02 - Reproductive Performance Summary (38 kB)
- R03 - Summary of Litter Data (80 kB)
- R19 - Pup Mean Body Weight Summary (135 kB)
- R19C - Pup Growth Curve (716 kB)
- R19G - Pup Mean Body Weight Gain (115 kB)
Individual Animal Data
- Individual Animal Anti - SRBC IgM ELISpot Data (11 kB)
- Individual Animal Anti - SRBC Serum IgM Antibody Response Data (9 kB)
- Individual Animal Body Weight Data (265 kB)
- Individual Animal Calculated Endpoints Anti - SRBC ELISpot Data (12 kB)
- Individual Animal Calculated Endpoints CytotoxicTCell Data (13 kB)
- Individual Animal Calculated Endpoints Natural Killer Cell Activity Data (13 kB)
- Individual Animal Calculated Endpoints Spleen Anti - CD3 Proliferation Data (13 kB)
- Individual Animal Calculated Endpoints Spleen Antibody Forming Cell Response Data (12 kB)
- Individual Animal Calculated Endpoints Spleen Immunophenotyping Data (36 kB)
- Individual Animal Clinical Observations Data (1 mB)
- Individual Animal Consumption Data (283 kB)
- Individual Animal Cytotoxic T Cell Activity Data (21 kB)
- Individual Animal Gross Pathology Data (56 kB)
- Individual Animal Hematology Data (22 kB)
- Individual Animal KLH TDAR Data (14 kB)
- Individual Animal Litter Data (176 kB)
- Individual Animal Natural Killer Cell Activity Data (21 kB)
- Individual Animal Organ Weight Data (39 kB)
- Individual Animal Pup Body Weight Data (236 kB)
- Individual Animal Pup Clinical Observations Data (1 mB)
- Individual Animal Removal Reasons Data (30 kB)
- Individual Animal Reproductive Performance Data (9 kB)
- Individual Animal Spleen Anti - CD3 Proliferation Data (17 kB)
- Individual Animal Spleen Antibody Forming Cell Response Data (12 kB)
- Individual Animal Spleen Immunophenotyping Data (18 kB)
28-Day Immunotoxicity Evaluation (I10482) of N-Butylbenzenesulfonamide (3622-84-2) in B6C3F1/N mice Exposed via Dosed Feed
Summary Data
- I01 - Animal Removal Summary (78 kB)
- I02 - Animal Removals (947 kB)
- I03 - Growth Curve (2 mB)
- I03C - Growth Curve (2 mB)
- I04 - Mean Body Weight Summary (294 kB)
- I04G - Mean Body Weight Gain (275 kB)
- I05 - Clinical Observations Summary (110 kB)
- I06 - Mean Feed Consumption (303 kB)
- I08 - Mean Test Compound Consumption (242 kB)
- M03 - Peripheral Blood Leukocyte Cell Differential (63 kB)
- M04 - Hematology (60 kB)
- M06 - Spleen Immunophenotyping (84 kB)
- M07 - TDAR SRBC Spleen AFC (45 kB)
- M08 - Serum IgM Antibody Titers to T - Dependent Antigen Sheep Erythrocytes (33 kB)
- M09 - Serum Antibody Concentrations for the T - Dependent Keyhole Limpet Hemocyanin (KLH) (37 kB)
- M11 - Spleen Cell Proliferative Response to Anti - CD3 Stimulation (41 kB)
- M12 - Cytotoxic T Cell Activity (39 kB)
- M15 - Natural Killer Cell Activity (39 kB)
- M19 - TDAR SRBC ELISpot (35 kB)
- PA06 - Organ Weights Summary (163 kB)
- PA46 - Summary of Gross Pathology (633 kB)
Individual Animal Data
- Individual Animal KLH TDAR Data (9 kB)
- Individual Animal Anti - SRBC IgM ELISpot Data (8 kB)
- Individual Animal Anti - SRBC Serum IgM Antibody Response Data (7 kB)
- Individual Animal Body Weight Data (47 kB)
- Individual Animal Clinical Observations Data (257 kB)
- Individual Animal Consumption Data (65 kB)
- Individual Animal Cytotoxic T Cell Activity Data (12 kB)
- Individual Animal Gross Pathology Data (44 kB)
- Individual Animal Hematology Data (13 kB)
- Individual Animal Natural Killer Cell Activity Data (13 kB)
- Individual Animal Organ Weight Data (18 kB)
- Individual Animal Removal Reasons Data (12 kB)
- Individual Animal Spleen Antibody Forming Cell Response Data (8 kB)
- Individual Animal Spleen Immunophenotyping Data (12 kB)
ADME/TK Evaluation (K10482) of N-Butylbenzenesulfonamide (3622-84-2) in Harlan Sprague Dawley Rats and B6C3F1/N Mice Exposed via Gavage Administration or Intravenous Injection
Data Summary - Male Rats
- Gavage Single Dose (2 mg/kg, Study Duration 72 hours) (113 kB)
- Gavage Single Dose (20 mg/kg, Study Duration 24 hours) (78 kB)
- Gavage Single Dose (20 mg/kg, Study Duration 72 hours) (123 kB)
- Gavage Single Dose (200 mg/kg, Study Duration 72 hours) (118 kB)
- IV Single Dose (20 mg/kg, Study Duration 72 hours) (118 kB)
Data Summary - Male Mice
- Gavage Single Dose (20 mg/kg, Study Duration 72 hours) (115 kB)
- IV Single Dose (20 mg/kg, Study Duration 72 hours) (126 kB)
Data Summary - Female Rats
- Gavage Single Dose (20 mg/kg, Study Duration 72 hours) (127 kB)
- IV Single Dose (20 mg/kg, Study Duration 72 hours) (117 kB)