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N-Butylbenzenesulfonamide (3622-84-2)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID7027540


Study Results


Genetic Toxicology

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to N-Butylbenzenesulfonamide (3622-84-2).
Bacterial Mutagenicity
View
  • Negative

Citation Information


NTP. N-Butylbenzenesulfonamide (3622-84-2). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


Immunotoxicity of N-Butylbenzenesulfonamide (NBBS): Impacts on Immune Function in Adult Mice and Developmentally Exposed Rats Victor J. Johnson1, Cynthia V. Rider2, Michael I. Luster1, Amy Brix3, Gary R. Burleson1, Michelle Cora2, Susan A. Elmore2, Rachel P. Frawley2, Franklin R. Lopez4, Esra Mutlu2, Keith R. Shockley2,5, Jessica Pierfelice6, Brian Burback6, Caroll A. Co7, Dori R. Germolec2

1Burleson Research Technologies, Inc., Morrisville, NC, USA
2Division of Translational Toxicology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
3Experimental Pathology Laboratories, Inc., Morrisville, NC, USA
4Charles River Laboratories, Morrisville, NC USA
5Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
6Battelle, Columbus, OH, USA
7Social and Scientific Systems Inc., a DLH Holdings Corp Company, Durham, NC, USA

DOI: https://doi.org/10.22427/NTP-DATA-500-005-003-000-3
Disposition and metabolism of N-butylbenzenesulfonamide in Sprague Dawley rats and B6C3F1/N mice and in vitro in hepatocytes from rats, mice, and humans Radiolabel Description:
carbon-14 uniformly in the ring; N-Butylbenzenesulfonamide, [ring-14C(U)]-

Vehicles:
Intravenous, ethanol:Cremophor:water (10:10:80); oral, 0.5% methyl cellulose.

Toxicology Letters (2020): https://pubmed.ncbi.nlm.nih.gov/31760063/
DOI: https://doi.org/10.22427/NTP-DATA-002-03240-0010-0000-2

Study Data


Genetic Toxicology Studies


Genetic Toxicity Evaluation of N-Butylbenzenesulfonamide in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G10482
Summary Data

Other NTP Studies


Modified One Generation (MOG) Dose Range Finding Toxicity Study (MOG10482-01) of N-Butylbenzenesulfonamide (3622-84-2) in Sprague-Dawley Rats Exposed via Dosed Feed
13-Week Perinatal Evaluation (I10482B) of N-Butylbenzenesulfonamide (3622-84-2) in Harlan Sprague Dawley rats Exposed via Dosed Feed
Summary Data
Individual Animal Data
28-Day Immunotoxicity Evaluation (I10482) of N-Butylbenzenesulfonamide (3622-84-2) in B6C3F1/N mice Exposed via Dosed Feed
Summary Data
Individual Animal Data
ADME/TK Evaluation (K10482) of N-Butylbenzenesulfonamide (3622-84-2) in Harlan Sprague Dawley Rats and B6C3F1/N Mice Exposed via Gavage Administration or Intravenous Injection
Toxicokinetic Evaluation (K10482B) of N-Butylbenzenesulfonamide (DTXSID7027540) in Rat and Mouse