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Cyclophosphamide (50-18-0)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID5020364

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Cyclophosphamide (50-18-0).
Micronucleus - Mice
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  • Male: Positive
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  • Male: Positive
An overview of Genetic Toxicology Micronucleus Rats study conclusions related to Cyclophosphamide (50-18-0).
Micronucleus - Rats
View
  • Male: Positive
View
  • Male: Not a Valid Test
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Cyclophosphamide (50-18-0).
Mammalian Cell Mutagenicity
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  • Positive
View
  • Positive

Citation Information

NTP. Cyclophosphamide (50-18-0). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutat Res. 2008 Jan 8;649(1-2):101-13. Epub 2007 Aug 11.
Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
The Power of Resolution: Contextualized Understanding of Biological Responses to Liver Injury Chemicals using High Throughput Transcriptomics and Benchmark Concentration Modeling Ramaiahgari SC, Auerbach SS, Saddler TO, Rice JR, Dunlap PE, Sipes NS, DeVito MJ, Shah RR, Bushel PR, Merrick BA, Paules RS, Ferguson SS

Toxicological Sciences (2019) DOI: https://doi.org/10.1093/toxsci/kfz065 PMID: 30850835
CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0001-0000-6
SRA No. SRP166108; BioProject No. PRJNA497448
Gene Expression Alterations in Immune System Pathways in the Thymus Following Exposure to Immunosuppressive Chemicals Rachel Frawley, Kimber White, Jr., Ronnetta Brown, Deborah Musgrove, Nigel Walker, Dori Germolec
Environmental Health Perspectives (2011) DOI: https://doi.org/10.1289/ehp.1002358 PMID: 21041162
DOI: https://doi.org/10.22427/NTP-DATA-002-00086-0001-0000-6

Study Data

Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Cyclophosphamide (50-18-0) in Micronucleus Study A00001 in F344 Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Cyclophosphamide (50-18-0) in Micronucleus Study A78856 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Cyclophosphamide (50-18-0) in Micronucleus Study F21038 in F344 Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Cyclophosphamide (50-18-0) in Micronucleus Study F78856 in B6C3F1 Mice
Summary and Individual Animal Data

Other NTP Studies

2-Week Immunotoxicity Evaluation (IMM83001) of n-Nitrosodimethylamine (62-75-9)) in Female B6C3F1 Mice Exposed via Intraperitoneal Injection
B6CF1 Mice Individual and Summary Data
2-Week Immunotoxicity Evaluation (IMM90011) of Nitrofurazone (59-87-0) in Female B6C3F1 Mice Exposed via Gavage
B6CF1 Mice Individual and Summary Data

DTT Data Collections