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Emodin (518-82-1)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID5025231


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Equivocal Evidence, Female, Rats
  • No Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Equivocal Evidence, Male, Mice
  • No Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Emodin (518-82-1).
Micronucleus - Mice
View
  • Male: Negative
    Female: Positive
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Micronucleus Rats study conclusions related to Emodin (518-82-1).
Micronucleus - Rats
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Emodin (518-82-1).
Mammalian Cell Cytogenetics
CA
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Emodin (518-82-1).
Bacterial Mutagenicity
View
  • Positive
View
  • Weakly Positive

Citation Information


NTP. Emodin (518-82-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-493 Toxicology and Carcinogenesis Studies of Emodin (CASRN 518-82-1) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Developmental Toxicity Evaluation of Emodin (CASRN 518-82-1) Administered in the Feed to Sprague Dawley (CD®) Rats on Gestational Days 6 to 20
DEVELOPMENTAL TOXICITY EVALUATION OF EMODIN?(CASRN 518-82-1) ADMINISTERED IN THE FEED TO?SPRAGUE DAWLEY (CD®) RATS ON GESTATIONAL DAYS 6 TO 20
Developmental Toxicity Evaluation of Emodin (CASRN 518-82-1) Administered in the Feed to Swiss (CD-1®) Mice on Gestational Days 6 to 17
DEVELOPMENTAL TOXICITY EVALUATION OF EMODIN?(CASRN 518-82-1) ADMINISTERED IN THE FEED TO?SWISS (CD-1®) MICE ON GESTATIONAL DAYS 6 TO 17
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194

Study Data


Toxicity and Carcinogenicity Studies


3-Month Evaluation of the Toxicity (C62408) of Emodin (518-82-1) in F344 Rats Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C62408) of Emodin (518-82-1) in B6C3F1 Mice Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C62408) of Emodin (518-82-1) in F344/N Rats Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C62408) of Emodin (518-82-1) in B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity (C62408) of Emodin (518-82-1) in F344/N Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity (C62408) of Emodin (518-82-1) in F344/N Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity (C62408) of Emodin (518-82-1) in B6C3F1 Mice Exposed via Dosed Feed

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Emodin (518-82-1) in Micronucleus Study A43429 in F344 Rats
Genetic Toxicity Evaluation of Emodin (518-82-1) in Micronucleus Study A58400 in B6C3F1 Mice
Genetic Toxicity Evaluation of Emodin (518-82-1) in Micronucleus Study A88319 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Emodin in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 278686
Summary Data
Genetic Toxicity Evaluation of Emodin in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 399853
Summary Data

Other NTP Studies


Prenatal Developmental Toxicity Pilot Study (TRP98003) of Emodin (518-82-1) in Sprague-Dawley Rats Exposed via Dosed Feed
Prenatal Developmental Toxicity Pilot Study (TRP99006) of Emodin (518-82-1) in Swiss CD-1 Mice Exposed via Dosed Feed
Prenatal Developmental Toxicity Study (TER98003) of Emodin (518-82-1) in Sprague-Dawley Rats Exposed via Dosed Feed
Prenatal Developmental Toxicity Study (TER99003) of Emodin (518-82-1) in Swiss CD-1 Mice Exposed via Dosed Feed
Toxicokinetic Evaluation (S0322) of Emodin (518-82-1) in F344/N Rats and B6C3F1 Mice Exposed via Gavage or Intravenous Injection
Toxicokinetic Evaluation (S0575) of Emodin (518-82-1) in F344/N Rats and B6C3F1 Mice Exposed via Dosed Feed
Data