Emodin (518-82-1)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID5025231
Study Results
Chronic Bioassay Level of Evidence
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| Mice | |
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Genetic Toxicology
| Micronucleus - Mice |
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| Micronucleus - Rats |
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| Mammalian Cell Cytogenetics |
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| CA |
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| Bacterial Mutagenicity |
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Publications
TR-493
Toxicology and Carcinogenesis Studies of Emodin (CASRN 518-82-1) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Developmental Toxicity Evaluation of Emodin (CASRN 518-82-1) Administered in the Feed to Sprague Dawley (CD®) Rats on Gestational Days 6 to 20
DEVELOPMENTAL TOXICITY EVALUATION OF EMODIN?(CASRN 518-82-1) ADMINISTERED IN THE FEED TO?SPRAGUE DAWLEY (CD®) RATS ON GESTATIONAL DAYS 6 TO 20
Developmental Toxicity Evaluation of Emodin (CASRN 518-82-1) Administered in the Feed to Swiss (CD-1®) Mice on Gestational Days 6 to 17
DEVELOPMENTAL TOXICITY EVALUATION OF EMODIN?(CASRN 518-82-1) ADMINISTERED IN THE FEED TO?SWISS (CD-1®) MICE ON GESTATIONAL DAYS 6 TO 17
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
Study Data
Toxicity and Carcinogenicity Studies
3-Month Evaluation of the Toxicity (C62408) of Emodin (518-82-1) in F344 Rats Exposed via Dosed Feed. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Clinical Chemistry Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Clinical Chemistry Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
3-Month Evaluation of the Toxicity (C62408) of Emodin (518-82-1) in B6C3F1 Mice Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C62408) of Emodin (518-82-1) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C62408) of Emodin (518-82-1) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C62408) of Emodin (518-82-1) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C62408) of Emodin (518-82-1) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C62408) of Emodin (518-82-1) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Emodin (518-82-1) in Micronucleus Study A43429 in F344 Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Emodin (518-82-1) in Micronucleus Study A58400 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Emodin (518-82-1) in Micronucleus Study A88319 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Emodin in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 278686
Summary Data
- G06 - Ames Summary Data (63 KB)
Genetic Toxicity Evaluation of Emodin in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 399853
Summary Data
- G06 - Ames Summary Data (124 KB)
Other NTP Studies
Prenatal Developmental Toxicity Pilot Study (TRP98003) of Emodin (518-82-1) in Sprague-Dawley Rats Exposed via Dosed Feed
Individual and Summary Data
- Dam Data: Dam Body Weights (21 kB)
- Dam Data: Dam Feed Consumption (19 kB)
- Dam Data: Dam Pregnancy Status (3 kB)
- Dam Data: Dam Water Consumption (19 kB)
- Dam Data: Organ Weights (21 kB)
- Fetal Data: Fetal Body Weights (496 kB)
- Live Litter: All Litter (498 kB)
- Live Litter: Live Litter (500 kB)
Prenatal Developmental Toxicity Pilot Study (TRP99006) of Emodin (518-82-1) in Swiss CD-1 Mice Exposed via Dosed Feed
Individual and Summary Data
- Dam Data: Dam Body Weights (19 kB)
- Dam Data: Dam Feed Consumption (17 kB)
- Dam Data: Dam Pregnancy Status (3 kB)
- Dam Data: Dam Water Consumption (17 kB)
- Dam Data: Organ Weights (21 kB)
- Fetal Data: All Variations (429 kB)
- Fetal Data: Fetal Body Weights (425 kB)
- Live Litter: All Litter (427 kB)
- Live Litter: Live Litter (429 kB)
Prenatal Developmental Toxicity Study (TER98003) of Emodin (518-82-1) in Sprague-Dawley Rats Exposed via Dosed Feed
Individual and Summary Data
- Dam Data: Dam Body Weights (21 kB)
- Dam Data: Dam Feed Consumption (20 kB)
- Dam Data: Dam Pregnancy Status (3 kB)
- Dam Data: Dam Water Consumption (20 kB)
- Dam Data: Organ Weights (23 kB)
- Fetal Data: All Malformations (539 kB)
- Fetal Data: All Variations (539 kB)
- Fetal Data: Fetal Body Weights (535 kB)
- Live Litter: All Litter (537 kB)
- Live Litter: Live Litter (540 kB)
Prenatal Developmental Toxicity Study (TER99003) of Emodin (518-82-1) in Swiss CD-1 Mice Exposed via Dosed Feed
Individual and Summary Data
- Dam Data: Dam Body Weights (20 kB)
- Dam Data: Dam Feed Consumption (18 kB)
- Dam Data: Dam Pregnancy Status (3 kB)
- Dam Data: Dam Water Consumption (18 kB)
- Dam Data: Organ Weights (21 kB)
- Fetal Data: All Malformations (488 kB)
- Fetal Data: All Variations (488 kB)
- Fetal Data: Fetal Body Weights (483 kB)
- Live Litter: All Litter (485 kB)
- Live Litter: Live Litter (488 kB)
Toxicokinetic Evaluation (S0322) of Emodin (DTXSID5025231) in Rat and Mouse
Data
- Annotated Group Parameters (14 kB)
- Annotated Individual Animal Data (94 kB)
- Original Data (42 kB)
- Summary Data - Mouse (115 kB)
- Summary Data - Rat (115 kB)