2-Ethylhexyl p-methoxycinnamate (5466-77-3)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID1025302
Publications
DART-06
NTP Developmental and Reproductive Toxicity Technical Report on the Modified One-Generation Study of 2-Ethylhexyl p-Methoxycinnamate (CASRN 5466-77-3) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats with Prenatal, Reproductive Performance, and Subchronic Assessments in F1 Offspring
Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
Metabolism and Disposition of 2-ethylhexyl-<i>p</i>-methoxycinnamate following Oral Gavage and Dermal Exposure in Harlan Sprague Dawley Rats and B6C3F1/N Mice and in Hepatocytes <i>in vitro</i>
Timothy R. Fennell, James M. Mathews, Rodney W. Snyder, Yan Hong, Scott L. Watson, Sherry R. Black, Barry S. McIntyre, and Suramya Waidyanatha.
Xenobiotica (2017). DOI: https://doi.org/10.1080/00498254.2017.1400129 PMID: 29111853
Xenobiotica (2017). DOI: https://doi.org/10.1080/00498254.2017.1400129 PMID: 29111853
Study Data
Genetic Toxicology Studies
Genetic Toxicity Evaluation of 2-Ethylhexyl p-Methoxycinnamate (5466-77-3) in Micronucleus Study G20239B in Harlan Sprague-Dawley Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 2-Ethylhexyl p-Methoxycinnamate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 201557
Summary Data
- G06 - Ames Summary Data (131 KB)
Genetic Toxicity Evaluation of 2-Ethylhexyl p-Methoxycinnamate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G20239
Summary Data
- G06 - Ames Summary Data (92 KB)
Other NTP Studies
Modified One Generation (MOG) Dose Range Finding Toxicity Study (MOG003) of 2-Ethylhexyl p-methoxycinnamate (5466-77-3) in Harlan Sprague-Dawley Rats Exposed via Dosed Feed
Study Tables
- I01 - Animal Removal Summary (35 kB)
- I02 - Animal Removals (209 kB)
- I03 - Growth Curve (567 kB)
- I03C - Growth Curve (565 kB)
- I04 - Mean Body Weight Summary (164 kB)
- I04G - Mean Body Weight Gain (94 kB)
- I05 - Clinical Observations Summary (55 kB)
- I05P - Pup Clinical Observations Summary (206 kB)
- I06 - Mean Feed Consumption (108 kB)
- I08 - Mean Test Compound Consumption (78 kB)
- R01 - Multigeneration Cross Reference (936 kB)
- R02 - Reproductive Performance Summary (40 kB)
- R03 - Summary of Litter Data (92 kB)
- R19 - Pup Mean Body Weight Summary (186 kB)
- R19C - Pup Growth Curves (814 kB)
- R19G - Pup Mean Body Weight Gain (144 kB)
- R20 - Pup Necropsy Summary (135 kB)
Individual Animal Data
- Individual Animal Body Weight Data (36 kB)
- Individual Animal Clinical Observations Data (58 kB)
- Individual Animal Consumption Data (33 kB)
- Individual Animal Gross Pathology Data (5 kB)
- Individual Animal Litter Data (43 kB)
- Individual Animal Pup Body Weight Data (80 kB)
- Individual Animal Pup Clinical Observations Data (367 kB)
- Individual Animal Pup Necropsy Data (8 kB)
- Individual Animal Removal Reasons Data (6 kB)
- Individual Animal Reproductive Performance Data (7 kB)
Modified One Generation (MOG) Toxicity Study (MOG003B) of 2-Ethylhexyl p-methoxycinnamate (5466-77-3) in Harlan Sprague-Dawley Rats Exposed via Dosed Feed
Study Tables
- I01 - Animal Removal Summary (200 kB)
- I02 - Animal Removals (6 mB)
- I03 - Growth Curve (2 mB)
- I03C - Growth Curves (2 mB)
- I04 - Mean Body Weight Summary (520 kB)
- I04G - Mean Body Weight Gain (345 kB)
- I05 - Clinical Observations Summary (553 kB)
- I05P - Pup Clinical Observations Summary (403 kB)
- I06 - Mean Feed Consumption (475 kB)
- I08 - Mean Test Compound Consumption (334 kB)
- PA02R - Neoplastic Lesion Summary with Percent and Litter Incidence (936 kB)
- PA03R - Non-Neoplastic Lesion Summary with Percent and Litter Incidence (965 kB)
- PA05R - Incidence Rates of Neoplastic Lesions with Litter Incidence Systemic Lesions Abridged (936 kB)
- PA06R - Organ Weights Summary (233 kB)
- PA08R - Statistical Analysis of Neoplastic Lesions with Litter Incidence (766 kB)
- PA10R - Statistical Analysis of Non-Neoplastic Lesions with Litter Incidence (976 kB)
- PA11 - Statistical Analysis of Survival Data (499 kB)
- PA18R - Non-Neoplastic Lesion Summary with Mean Severity Grade and Litter Incidence (964 kB)
- PA40 - Survival Curve (2 mB)
- PA41 - Clinical Chemistry Summary (145 kB)
- PA43 - Hematology Summary (244 kB)
- PA46R - Summary of Gross Pathology with Litter Incidence (1 mB)
- R01 - Multigeneration Cross Reference (5 mB)
- R02 - Reproductive Performance Summary (75 kB)
- R03 - Summary of Litter Data (153 kB)
- R04 - Anogenital Distance Summary (61 kB)
- R06 - Andrology Summary (49 kB)
- R09 - Uterine Content Summary (82 kB)
- R10 - Fetal Defects (175 kB)
- R11 - Fetal Defect Summary (92 kB)
- R13 - Fetal Defect Cross Reference Summary (126 kB)
- R14 - Developmental Markers Summary (78 kB)
- R14C - Time to Attainment Curves for Testicular Descent (482 kB)
- R16 - Pubertal Markers Summary (67 kB)
- R16C - Time to Attainment Curves for Pubertal Markers (2 mB)
- R19 - Pup Mean Body Weight Summary (417 kB)
- R19C - Pup Growth Curve (2 mB)
- R19G - Pup Mean Body Weight Gain (300 kB)
- R20 - Pup Necropsy Summary (257 kB)
Individual Animal Data
- Individual Animal Andrology Data (17 kB)
- Individual Animal Body Weight Data (638 kB)
- Individual Animal Clinical Chemistry Data (12 kB)
- Individual Animal Clinical Observations Data (2 mB)
- Individual Animal Consumption Data (657 kB)
- Individual Animal Developmental Markers Data (230 kB)
- Individual Animal Gross Pathology Data (347 kB)
- Individual Animal Hematology Data (18 kB)
- Individual Animal Histopathology Data (180 kB)
- Individual Animal Litter Data (298 kB)
- Individual Animal Organ Weight Data (69 kB)
- Individual Animal Pup Body Weight Data (640 kB)
- Individual Animal Pup Clinical Observations Data (2 mB)
- Individual Animal Pup Necropsy Data (23 kB)
- Individual Animal Removal Reasons Data (61 kB)
- Individual Animal Reproductive Performance Data (21 kB)
- Individual Animal Teratology Dam Data (10 kB)
- Individual Animal Teratology Fetal Weight Data (39 kB)
- Individual Animal Teratology Implant Findings Data (186 kB)
- PA14 - Individual Animal Pathology Data (4 mB)
- PA14 - Individual Animal Pathology Data (4 mB)