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Caffeine (58-08-2)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID0020232

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Caffeine (58-08-2).
Bacterial Mutagenicity
  • Negative

Citation Information

NTP. Caffeine (58-08-2). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).


Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
The Power of Resolution: Contextualized Understanding of Biological Responses to Liver Injury Chemicals using High Throughput Transcriptomics and Benchmark Concentration Modeling Ramaiahgari SC, Auerbach SS, Saddler TO, Rice JR, Dunlap PE, Sipes NS, DeVito MJ, Shah RR, Bushel PR, Merrick BA, Paules RS, Ferguson SS

Toxicological Sciences (2019) DOI: https://doi.org/10.1093/toxsci/kfz065 PMID: 30850835
CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0001-0000-6
SRA No. SRP166108; BioProject No. PRJNA497448

Study Data

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Caffeine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 075951
Summary Data

Other NTP Studies

Toxicokinetic Evaluation (S0976) of Ephedrine (299-42-3) and Ma Huang (EPHEDRA), Alone or in Combination with Caffeine (58-08-2), in F344/N Rats Exposed via Intravenous Injection or Gavage
Data - Ma Huang + Caffeine
Data - Ma Huang
Data - L-Ephedrine
Data - Ephedrine + Caffeine, L-Ephedrine, Ma Huang, and Ma Huang + Caffeine
Data - Ephedrine + Caffeine