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Isopropylated Phenol Phosphate (68937-41-7)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID4028880

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Isopropylated Phenol Phosphate (68937-41-7).
Bacterial Mutagenicity
  • Negative

Citation Information

NTP. Isopropylated Phenol Phosphate (68937-41-7). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).


NIEHS-05 NIEHS Report on the In Vivo Repeat Dose Biological Potency Study of Isopropylated Phenol Phosphate (CASRN 68937-41-7) in Male Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats (Gavage Studies)
Behl M, Rice JR, Smith MV, Co CA, Bridge MF, Hsieh JH, Freedman JH, Boyd WA. Editor's Highlight: Comparative Toxicity of Organophosphate Flame Retardants and Polybrominated Diphenyl Ethers to Caenorhabditis elegans. Toxicol Sci. 2016 Dec;154(2):241-252. doi: 10.1093/toxsci/kfw162. Epub 2016 Aug 26. PMID: 27566445
Sirenko O, Grimm FA, Ryan KR, Iwata Y, Chiu WA, Parham F, Wignall JA, Anson B, Cromwell EF, Behl M, Rusyn I, Tice RR. In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model. Toxicol Appl Pharmacol. 2017 May 1;322:60-74. doi: 10.1016/j.taap.2017.02.020. Epub 2017 Mar 1. PMID: 28259702
Glazer L, Hawkey AB, Wells CN, Drastal M, Odamah KA, Behl M, Levin ED. Developmental Exposure to Low Concentrations of Organophosphate Flame Retardants Causes Life-Long Behavioral Alterations in Zebrafish. Toxicol Sci. 2018 Oct 1;165(2):487-498. doi: 10.1093/toxsci/kfy173. PMID: 29982741
Alzualde A, Behl M, Sipes NS, Hsieh JH, Alday A, Tice RR, Paules RS, Muriana A, Quevedo C. Toxicity profiling of flame retardants in zebrafish embryos using a battery of assays for developmental toxicity, neurotoxicity, cardiotoxicity and hepatotoxicity toward human relevance. Neurotoxicol Teratol. 2018 Nov-Dec;70:40-50. doi: 10.1016/j.ntt.2018.10.002. Epub 2018 Oct 9. PMID: 30312655
Zhang S, Ireland D, Sipes NS, Behl M, Collins ES. Screening for neurotoxic potential of 15 flame retardants using freshwater planarians. Neurotoxicol Teratol. 2019 May-Jun;73:54-66. doi: 10.1016/j.ntt.2019.03.003. Epub 2019 Mar 31. PMID: 30943442
Hogberg HT, de Cássia da Silveira E Sá R, Kleensang A, Bouhifd M, Cemiloglu Ulker O, Smirnova L, Behl M, Maertens A, Zhao L, Hartung T. Organophosphorus flame retardants are developmental neurotoxicants in a rat primary brainsphere in vitro model. Arch Toxicol. 2021 Jan;95(1):207-228. doi: 10.1007/s00204-020-02903-2. Epub 2020 Oct 19. PMID: 33078273
Klose J, Pahl M, Bartmann K, Bendt F, Blum J, Dolde X, Förster N, Holzer AK, Hübenthal U, Keßel HE, Koch K, Masjosthusmann S, Schneider S, Stürzl LC, Woeste S, Rossi A, Covaci A, Behl M, Leist M, Tigges J, Fritsche E. Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery. Cell Biol Toxicol. 2022 Oct;38(5):781-807. doi: 10.1007/s10565-021-09603-2. Epub 2021 May 10. PMID: 33969458
Emond C, DeVito MJ, Birnbaum LS. A PBPK model describing the pharmacokinetics of γ-HBCD exposure in mice. Toxicol Appl Pharmacol. 2021 Oct 1;428:115678. doi: 10.1016/j.taap.2021.115678. Epub 2021 Aug 11. PMID: 34390738
Jarema KA, Hunter DL, Shaffer RM, Behl M, Padilla S. Acute and developmental behavioral effects of flame retardants and related chemicals in zebrafish. Neurotoxicol Teratol. 2015 Nov-Dec;52(Pt B):194-209. doi: 10.1016/j.ntt.2015.08.010. Epub 2015 Sep 5. PMID: 26348672
Behl M, Hsieh JH, Shafer TJ, Mundy WR, Rice JR, Boyd WA, Freedman JH, Hunter ES 3rd, Jarema KA, Padilla S, Tice RR. Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. Neurotoxicol Teratol. 2015 Nov-Dec;52(Pt B):181-93. doi: 10.1016/j.ntt.2015.09.003. Epub 2015 Sep 18. PMID: 26386178
NTP short-term reproductive and developmental toxicity studies on triphenyl phosphate (TPHP) and isopropylated phenyl phosphate (IPP) Shannah Witchey, Brad Collins, Georgia Roberts, Keith Shockley, Molly Vallant, Eve Mylchreest, Barney Sparrow, Robert Moyer, Tomas Guilarte, Helen Cunny, Jeffrey Krause, Mamta Behl

DOI: https://doi.org/10.22427/NTP-DATA-002-00600-0003-000-1

SOT Poster: https://ntp.niehs.nih.gov/ntp/results/pubs/posters/witchey_sot20210312.pdf

The I03/I03C, I04/I04G, R19/R19G/R19C were updated on November 8, 2021 due to updates in the statistics.
Reproductive and developmental toxicity following exposure to organophosphate ester flame retardants and plasticizers, triphenyl phosphate and isopropylated phenyl phosphate, in Sprague Dawley rats Shannah K. Witchey, Vicki Sutherland, Brad Collins, Georgia Roberts, Keith R. Shockley, Molly Vallant, Jeff Krause, Helen Cunny, Suramya Waidyanatha, Eve Mylchreest, Barney Sparrow, Robert Moyer and Mamta Behl

DOI: https://doi.org/10.22427/NTP-DATA-002-02974-0007-0000-1

Study Data

Toxicity and Carcinogenicity Studies

5-Day Evaluation of the Toxicity (C10866B) of Isopropylated Phenyl Phosphate (IPP) (68937-41-7) on Harlan Sprague-Dawley Rats Exposed via Gavage

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Isopropylated Phenol Phosphate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G10866
Summary Data

Other NTP Studies

Modified One Generation (MOG) Dose Range Finding Toxicity Study (MOG10866) of Isopropylated Phenyl Phosphate (68937-41-7) in Sprague-Dawley Rats Exposed via Dosed Feed
Screen for Developmental Toxicity in Zebrafish- Study 1