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Methylene chloride (75-09-2)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID0020868

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Some Evidence, Male, Rats
View
  • Clear Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
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  • Clear Evidence, Male, Mice
View
  • Clear Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Methylene chloride (75-09-2).
Mammalian Cell Mutagenicity
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  • Equivocal
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Methylene chloride (75-09-2).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Methylene chloride (75-09-2).
Bacterial Mutagenicity
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  • Negative
View
  • Positive
View
  • Positive

Citation Information

NTP. Methylene chloride (75-09-2). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-306 Toxicology and Carcinogenesis Studies of Dichloromethane (Methylene Chloride) (CASRN 75-09-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Zeiger, E. Mutagenicity of 42 chemicals in Salmonella Environ. Molec. Mutagen. Vol. 16(Suppl 18) (1990) 32-54
Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of Methylene Chloride (75-09-2) in Male F344 Rats via Whole Body Respiratory Exposure
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Methylene Chloride (75-09-2) in Female F344 Rats via Whole Body Respiratory Exposure
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Methylene Chloride (75-09-2) in Male B6C3F1 Mice via Whole Body Respiratory Exposure
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Methylene Chloride (75-09-2) in Female B6C3F1 Mice via Whole Body Respiratory Exposure
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Methylene Chloride in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 070295
Summary Data
Genetic Toxicity Evaluation of Methylene Chloride in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 413864
Summary Data
Genetic Toxicity Evaluation of Methylene Chloride in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A34199
Summary Data

NTP Data Collections