Formamide (75-12-7)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID8025337
Study Results
Chronic Bioassay Level of Evidence
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| Mice | |
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Genetic Toxicology
| Micronucleus - Mice |
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| Drosophila Germ Cell Mutagenicity |
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| Bacterial Mutagenicity |
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Publications
TR-541
Toxicology and Carcinogenesis Studies of Formamide (CASRN 75-12-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
TER98002
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
Final Report on the Developmental Toxicity of Formamide (CAS# 75-12-7) Administered by Gavage to Sprague-Dawley CD Rats on Gestational Days 6-19
Developmental Toxicity Evaluation of Formamide (CASRN 75-12-7) Administered by Gavage to New Zealand White Rabbits on Gestational Days 6 through 29.
Study Data
Toxicity and Carcinogenicity Studies
2-Week Evaluation of the Toxicity (C88123) of Formamide (75-12-7) in F344/N Rats Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C88123) of Formamide (75-12-7) in F344 Rats Exposed via Gavage. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Clinical Chemistry Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Clinical Chemistry Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
2-Week Evaluation of the Toxicity (C88123) of Formamide (75-12-7) in B6C3F1 Mice Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C88123) of Formamide (75-12-7) in B6C3F1 Mice Exposed via Gavage. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
3-Month Evaluation of the Toxicity (C88123) of Formamide (75-12-7) in F344/N Rats Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P10 - Statistical Analysis Of Non-Neoplastic Lesions
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C88123) of Formamide (75-12-7) in F344/N Rats Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E12 - Animal History
Individual Animal Data
3-Month Evaluation of the Toxicity (C88123) of Formamide (75-12-7) in B6C3F1 Mice Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P10 - Statistical Analysis Of Non-Neoplastic Lesions
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C88123B) of Formamide (75-12-7) in F344/N Rats Exposed via Gavage
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C88123B) of Formamide (75-12-7) in B6C3F1 Mice Exposed via Gavage
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Special Evaluation of the Toxicity (C88123) of Formamide (75-12-7) in F344/N Rats Exposed via Gavage
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Formamide (75-12-7) in Micronucleus Study A14799 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Formamide in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 096297
Summary Data
- G06 - Ames Summary Data (136 KB)
Genetic Toxicity Evaluation of Formamide in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 799767
Summary Data
- G06 - Ames Summary Data (134 KB)
Genetic Toxicity Evaluation of Formamide in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A95988
Summary Data
- G06 - Ames Summary Data (87 KB)
Other NTP Studies
ADME/TK Evaluation (S0533) of Formamide (75-12-7) in F344 Rats and B6C3F1 Mice Exposed via Intravenous Injection or Nose-Only Respiratory Exposure
Prenatal Developmental Toxicity Pilot Study (TRP97008) of Formamide (75-12-7) in Sprague-Dawley Rats Exposed via Gavage
Individual and Summary Data
- Dam Data: Dam Body Weights (22 kB)
- Dam Data: Dam Feed Consumption (20 kB)
- Dam Data: Dam Pregnancy Status (3 kB)
- Dam Data: Dam Water Consumption (20 kB)
- Dam Data: Organ Weights (20 kB)
- Fetal Data: All Malformations (377 kB)
- Fetal Data: Fetal Body Weights (373 kB)
- Live Litter: All Litter (375 kB)
- Live Litter: Live Litter (377 kB)
Prenatal Developmental Toxicity Pilot Study (TRP98002) of Formamide (75-12-7) in New Zealand White Rabbits Exposed via Gavage
Individual and Summary Data
- Dam Data: Dam Body Weights (18 kB)
- Dam Data: Dam Feed Consumption (16 kB)
- Dam Data: Dam Pregnancy Status (3 kB)
- Dam Data: Organ Weights (13 kB)
- Fetal Data: Fetal Body Weights (124 kB)
- Live Litter: All Litter (126 kB)
- Live Litter: Live Litter (127 kB)
Prenatal Developmental Toxicity Study (TER97002) of Formamide (75-12-7) in Sprague-Dawley Rats Exposed via Gavage
Individual and Summary Data
- Dam Data: Dam Body Weights (22 kB)
- Dam Data: Dam Feed Consumption (20 kB)
- Dam Data: Dam Pregnancy Status (3 kB)
- Dam Data: Dam Water Consumption (20 kB)
- Dam Data: Organ Weights (21 kB)
- Fetal Data: All Malformations (501 kB)
- Fetal Data: All Variations (501 kB)
- Fetal Data: Fetal Body Weights (496 kB)
- Live Litter: All Litter (498 kB)
- Live Litter: Live Litter (501 kB)
Prenatal Developmental Toxicity Study (TER98002) of Formamide (75-12-7) in New Zealand White Rabbits Exposed via Gavage
Individual and Summary Data
- Dam Data: Dam Body Weights (28 kB)
- Dam Data: Dam Feed Consumption (24 kB)
- Dam Data: Dam Pregnancy Status (3 kB)
- Dam Data: Organ Weights (21 kB)
- Fetal Data: All Malformations (260 kB)
- Fetal Data: All Variations (260 kB)
- Fetal Data: Fetal Body Weights (255 kB)
- Live Litter: All Litter (257 kB)
- Live Litter: Live Litter (260 kB)
Toxicokinetic Evaluation (S0613) of Formamide (DTXSID8025337) in Rat and Mouse
Data
- Annotated Group Parameters (21 kB)
- Annotated Individual Animal Data (231 kB)
- Data Summary - Mouse (283 kB)
- Data Summary - Rats (153 kB)
- Original Data (91 kB)