Codeine (76-57-3)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID2020341
Publications
TR-455
Toxicology and Carcinogenesis Studies of Codeine (CASRN 76-57-3) in F344 Rats and B6C3F1 Mice (Feed Studies)
Teratologic Evaluation of Codeine Administered to LVG Hamsters on Gestational Days 5 through 13
Teratologic Evaluation of Codeine Administered to CD-1 Mice on Gestation Days 6 through 15
Study Data
Toxicity and Carcinogenicity Studies
3-Month Evaluation of the Toxicity (C61541A) of Codeine (76-57-3) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C61541A) of Codeine (76-57-3) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C61541B) of Codeine (76-57-3) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C61541B) of Codeine (76-57-3) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C61541C) of Codeine (76-57-3) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C61541B) of Codeine (76-57-3) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C61541B) of Codeine (76-57-3) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C61541C) of Codeine (76-57-3) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Other NTP Studies
Prenatal Developmental Toxicity Study (TER90057) of Codeine (76-57-3) in Swiss CD-1 Mice Exposed via Gavage
Individual and Summary Data
- Dam Data: Dam Body Weights (25 kB)
- Dam Data: Dam Pregnancy Status (3 kB)
- Dam Data: Organ Weights (42 kB)
- Fetal Data: All Malformations (674 kB)
- Fetal Data: All Variations (674 kB)
- Fetal Data: Fetal Body Weights (668 kB)
- Live Litter: All Litter (671 kB)
- Live Litter: Live Litter (675 kB)
Prenatal Developmental Toxicity Study (TER90058) of Codeine (76-57-3) in Syrian Golden Hamsters Exposed via Gavage
Individual and Summary Data
- Dam Data: Dam Body Weights (17 kB)
- Dam Data: Dam Pregnancy Status (3 kB)
- Dam Data: Organ Weights (21 kB)
- Fetal Data: All Malformations (486 kB)
- Fetal Data: All Variations (486 kB)
- Fetal Data: Fetal Body Weights (480 kB)
- Live Litter: All Litter (483 kB)
- Live Litter: Live Litter (486 kB)
Toxicokinetic Evaluation (K61541B) of Codeine (DTXSID2020341) in Rat
Codeine + Codeine Phosphate
- Annotated Group Parameters (23 kB)
- Summary Data (236 kB)
Codeine
- Annotated Individual Animal Data (230 kB)
Toxicokinetic Evaluation (K61541C) of Codeine (DTXSID2020341) in Rat
Data
- Annotated Group Parameters (29 kB)
- Annotated Individual Animal Data (351 kB)
- Original Data (123 kB)
- Summary Data (317 kB)
Toxicokinetic Evaluation (K61541D) of Codeine (DTXSID2020341) in Rat
Toxicokinetic Evaluation (K61541E) of Codeine (DTXSID2020341) in Mice
Data
- Annotated Group Parameters (22 kB)
- Annotated Individual Animal Data (232 kB)
- Original Data (86 kB)
- Summary Data (203 kB)