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Methyleugenol (93-15-2)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Clear Evidence, Female, Rats
  • Clear Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Female, Mice
  • Clear Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Methyleugenol (93-15-2).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Methyleugenol (93-15-2).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Methyleugenol (93-15-2).
Bacterial Mutagenicity
View
  • Negative

Citation Information


NTP. Methyleugenol (93-15-2). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-491 Toxicology and Carcinogenesis Studies of Methyleugenol (CASRN 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
Developmental Toxicity Evaluation for Methyleugenol (CASRN 93-15-2) Administered by Gavage to Sprague-Dawley (CD®) Rats on Gestational Days 6 through 19
DEVELOPMENTAL TOXICITY EVALUATION FOR METHYLEUGENOL (CASRN 93-15-2) ADMINISTERED BY GAVAGE TO SPRAGUE-DAWLEY (CD(r)) RATS ON GESTATIONAL DAYS 6 THROUGH 19 (Laboratory Supplement)
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes William M. Gwinn, Scott S. Auerbach, Fred Parham, Matthew D. Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, B. Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R. Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R. Shah, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Georgia Roberts, Michael J. DeVito


CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005

Study Data


Toxicity and Carcinogenicity Studies


6 - 72-Hour Evaluation of the Toxicity (C60991D) of Methyleugenol (93-15-2) in F344/N Rats Exposed via Gavage. NTP Special Study
150-Day Evaluation of the Toxicity (C20540C) of Methyleugenol (TGMX Rat Liver Evaluation) (93-15-2) in F344/NTac Rats Exposed via Gavage
3-Month Evaluation of the Toxicity (C60991) of Methyleugenol (93-15-2) in F344 Rats Exposed via Gavage. NTP Special Study
3-Month Evaluation of the Toxicity (C60991) of Methyleugenol (93-15-2) in B6C3F1 Mice Exposed via Gavage. NTP Special Study
3-Month Evaluation of the Toxicity (C60991) of Methyleugenol (93-15-2) in F344/N Rats Exposed via Gavage
6 - 48 hour;3 - 6-Month Evaluation of the Toxicity (C60991D) of Methyleugenol (93-15-2) in F344/N Rats Exposed via Gavage. NTP Special Study
3-Month Evaluation of the Toxicity (C60991) of Methyleugenol (93-15-2) in B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C60991B) of Methyleugenol (93-15-2) in F344/N Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C60991B) of Methyleugenol (93-15-2) in B6C3F1 Mice Exposed via Gavage

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Methyleugenol (93-15-2) in Micronucleus Study A29699 in B6C3F1 Mice
Genetic Toxicity Evaluation of Methyleugenol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 690169
Summary Data

Other NTP Studies


Prenatal Developmental Toxicity Pilot Study (TRP97007) of Methyleugenol (93-15-2) in Sprague-Dawley Rats Exposed via Gavage
Prenatal Developmental Toxicity Study (TER97007) of Methyleugenol (93-15-2) in Sprague-Dawley Rats Exposed via Gavage
Toxicokinetic Evaluation (K10265) of Methyleugenol (93-15-2) in F344/N Rats and B6C3F1 Mice Exposed via Intravenous Injection or Gavage
Toxicokinetic Evaluation (S0577) of Methyleugenol (93-15-2) in F344/N Rats and B6C3F1 Mice Exposed via Intravenous Injection or Gavage