Methyleugenol (93-15-2)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID5025607
Study Results
Chronic Bioassay Level of Evidence
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| Mice | |
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Genetic Toxicology
| Micronucleus - Mice |
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| Mammalian Cell Cytogenetics | |
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| CA | SCE |
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| Bacterial Mutagenicity |
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Publications
TR-491
Toxicology and Carcinogenesis Studies of Methyleugenol (CASRN 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
Developmental Toxicity Evaluation for Methyleugenol (CASRN 93-15-2) Administered by Gavage to Sprague-Dawley (CD®) Rats on Gestational Days 6 through 19
DEVELOPMENTAL TOXICITY EVALUATION FOR METHYLEUGENOL (CASRN 93-15-2) ADMINISTERED BY GAVAGE TO SPRAGUE-DAWLEY (CD(r)) RATS ON GESTATIONAL DAYS 6 THROUGH 19 (Laboratory Supplement)
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes
William M. Gwinn, Scott S. Auerbach, Fred Parham, Matthew D. Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, B. Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R. Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R. Shah, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Georgia Roberts, Michael J. DeVito
CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005
CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005
Study Data
Toxicity and Carcinogenicity Studies
6 - 72-Hour Evaluation of the Toxicity (C60991D) of Methyleugenol (93-15-2) in F344/N Rats Exposed via Gavage. NTP Special Study
150-Day Evaluation of the Toxicity (C20540C) of Methyleugenol (TGMX Rat Liver Evaluation) (93-15-2) in F344/NTac Rats Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
5-day study (C10265) of Methyleugenol (93-15-2) delivered via Gavage in HSD Rat
Study Tables
- I01 - Animal Removal Summary (37 kB)
- I03 - Growth Curve (308 kB)
- I03C - Growth Curve (308 kB)
- I04 -Mean Body Weight Summary (65 kB)
- I04G - Mean Body Weight Gain (53 kB)
- I05 - Clinical Observations Summary (110 kB)
- PA06 - Organ Weights Summary (56 kB)
Individual Animal Data
3-Month Evaluation of the Toxicity (C60991) of Methyleugenol (93-15-2) in F344 Rats Exposed via Gavage. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Clinical Chemistry Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Clinical Chemistry Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
3-Month Evaluation of the Toxicity (C60991) of Methyleugenol (93-15-2) in B6C3F1 Mice Exposed via Gavage. NTP Special Study
3-Month Evaluation of the Toxicity (C60991) of Methyleugenol (93-15-2) in F344/N Rats Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
6 - 48 hour;3 - 6-Month Evaluation of the Toxicity (C60991D) of Methyleugenol (93-15-2) in F344/N Rats Exposed via Gavage. NTP Special Study
3-Month Evaluation of the Toxicity (C60991) of Methyleugenol (93-15-2) in B6C3F1 Mice Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C60991B) of Methyleugenol (93-15-2) in F344/N Rats Exposed via Gavage
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C60991B) of Methyleugenol (93-15-2) in B6C3F1 Mice Exposed via Gavage
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Methyleugenol (93-15-2) in Micronucleus Study A29699 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Methyleugenol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 690169
Summary Data
- G06 - Ames Summary Data (136 KB)
Other NTP Studies
Prenatal Developmental Toxicity Pilot Study (TRP97007) of Methyleugenol (93-15-2) in Sprague-Dawley Rats Exposed via Gavage
Individual and Summary Data
- Dam Data: Dam Body Weights (20 kB)
- Dam Data: Dam Feed Consumption (18 kB)
- Dam Data: Dam Pregnancy Status (3 kB)
- Dam Data: Dam Water Consumption (19 kB)
- Dam Data: Organ Weights (20 kB)
- Fetal Data: All Malformations (415 kB)
- Fetal Data: All Variations (415 kB)
- Fetal Data: Fetal Body Weights (412 kB)
- Live Litter: All Litter (414 kB)
- Live Litter: Live Litter (415 kB)
Prenatal Developmental Toxicity Study (TER97007) of Methyleugenol (93-15-2) in Sprague-Dawley Rats Exposed via Gavage
Individual and Summary Data
- Dam Data: Dam Body Weights (20 kB)
- Dam Data: Dam Feed Consumption (19 kB)
- Dam Data: Dam Pregnancy Status (3 kB)
- Dam Data: Dam Water Consumption (19 kB)
- Dam Data: Organ Weights (38 kB)
- Fetal Data: All Malformations (453 kB)
- Fetal Data: All Variations (452 kB)
- Fetal Data: Fetal Body Weights (448 kB)
- Live Litter: All Litter (450 kB)
- Live Litter: Live Litter (453 kB)
Toxicokinetic Evaluation (K10265) of Methyleugenol (93-15-2) in F344/N Rats and B6C3F1 Mice Exposed via Gavage or Intravenous Injection
Toxicokinetic Evaluation (S0577) of Methyleugenol (DTXSID5025607) in Rat and Mouse
Data
- Annotated Group Parameters (18 kB)
- Annotated Individual Animal Data (156 kB)
- Original Data (45 kB)
- Summary Data - Mice (158 kB)
- Summary Data - Rats (116 kB)