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NTP Data Collections Guided Search

There are numerous datasets from the National Toxicology Program (NTP). They vary in size and content consisting of both small datasets with simple formats and large datasets with complex disparate formats. The NTP Data Collections Guided Search allows public users as well as NTP scientists to access them through new guided search options. The search results are displayed as simple filterable tables and available for download.

Name Group Description
The ICCVAM Acute Systemic Toxicity Reference List NICEATM

The ICCVAM in vitro basal cytotoxicity assays proposed for setting starting doses for in vivo acute oral toxicity studies.

Please download whole dataset from FTP

The NICEATM Estrogen Receptor Uterotrophic Assay Data NICEATM

The dataset provides data on the effects of chemicals on the Estrogen Receptor (ER) from uterotrophic assays.

Please download whole dataset from FTP

The ICCVAM Skin Sensitization (Murine LLNA) Reference List NICEATM

The dataset provides a list of recommended reference substances for validation of In Vitro Murine Local Lymph Node Assay (LLNA) for skin sensitization.

Please download whole dataset from FTP

The ICCVAM Androgen Receptor Agonist Reference List NICEATM

The dataset provides a list of recommended reference substances for evaluation or validation of In Vitro Androgen Receptor (AR) agonism assays.

Please download whole dataset from FTP

Tox21 Phase 2 Purity Tox21

The purity data is for the NTP Tox21 Phase 2 chemicals provided to NCATS for the Tox21 Phase 2 program. These data results from the analysis of neat chemicals, prior to the preparation of the DMSO solutions sent to NCATS and should not be equated with NCATS QC Day 0 or QC Day 4 data.

Key for the purity flags in the MRI 1-page reports

Please download whole dataset from FTP

Bioassay Genetox Conclusion Dataset NTP

Treatment-related findings including bioassay genetox conclusions from chronic bioassay level of evidence, bacterial mutagenicity, micronucleus, Tox21 and comet assay. Note: Large searches may take a long time.

Please download whole dataset from FTP.

Ames Conclusions NTP

Conclusions from Ames studies for each strain, activation condition, etc.

Please download whole dataset from FTP

Toxicity Estimates of the ToxCast Chemicals in C. elegans and Zebrafish NTP

Phase I and II C. elegans and zebrafish toxicity estimates. Developmental Effects of the ToxCast™ Phase I and Phase II Chemicals in Caenorhabditis elegans and Corresponding Responses in Zebrafish, Rats, and Rabbits. Windy A. Boyd , Marjolein V. Smith , Caroll A. Co , Jason R. Pirone , Julie R. Rice , Keith R. Shockley , and Jonathan H. Freedman. Published:01May2016. https://doi.org/10.1289/ehp.1409645.

Please download whole dataset from FTP

Microarray Dataset NTP

Toxicogenomic studies consisting of microarrays to evaluate the biological response to a toxicological challenge at the genome level.

Please download whole dataset from FTP

Drosophila Germ Cell Mutagenicity NTP

Conclusions from Drosophila germ cell mutagenicity studies.

Please download whole dataset from FTP

Mammalian Cell Cytogenetics NTP

Conclusions from mammalian cell cytogenetics studies for CHO-W-B1 hamsters.

Please download whole dataset from FTP

Mammalian Cell Mutagenicity NTP

Conclusions from mammalian cell mutagenics studies for each activation condition.

Please download whole dataset from FTP

Rodent Cytogenetics NTP

Conclusions from rodent cytogenetics studies for B6C3F1 mice.

Please download whole dataset from FTP

In Vivo Micronucleus NTP

Study and trial conclusions from in vivo micronucleus assays for each strain and tissue, etc.

Please download whole dataset from FTP

Benchmark Dose Analysis for Neoplastic and Non-neoplastic Lesions NTP

Benchmark Dose (BMD) analysis for all public neoplastic and non-neoplastic lesion incidence data with best fit models.

Please download whole dataset from FTP

Statistically Analyzed NTP Pathology Lesions (with Incidence) NTP

This dataset contains lesions found in studies where each dose group had two or more of the lesion.  Lesions with a statistically significant difference (p<0.05) in incidence between the exposed and control animals are flagged.

Please download whole dataset from FTP

Comet Assay Conclusions NTP

Conclusions from comet assays for each strain, organ, etc.

Please download whole dataset from FTP

Evaluation of Androgen Receptor Agonists Dataset NTP

Evaluation of androgen assay results using a curated Hershberger database. Kleinstreuer NC, Browne P, Chang X, Judson R, Casey W, Ceger P, Deisenroth C, Baker N, Markey K, Thomas RS. Published: 25 May 2018. https://doi.org/10.1016/j.reprotox.2018.08.017. Performance data from applying the ToxCast/Tox 21 androgen receptor model, based on 11 high throughput assays, to 39 reference chemicals.

Please download whole dataset from FTP

Update of the 1993 database of Schaper for RD50 and corresponding TLV values* NON_NTP

Inhalation Threshold Limit Values (TLVs) for 103 chemicals originally listed in Schaper, M. (1993), Development of a database for sensory irritants and its use in establishing occupational exposure limits, Am. Ind. Hyg. Assoc. J. 54: 488-544; doi: 10.1080/15298669391355017, were updated in 2015. Data resulting from this update are included in this data table.

Please download whole dataset from FTP

List of Chemicals with Threshold Limit Values Primarily Based on Sensory Irritation* NON_NTP

Inhalation Threshold Limit Values (TLVs) for 112 chemicals listed in the 2015, American Conference of Governmental Industrial Hygienists (ACGIH) booklet entitled "TLVs and BEIs Based on the Documentation of the Threshold Limit Values for Chemical Substances and Physical Agents & Biological Exposure Indices".

Please download whole dataset from FTP

Evaluation of Androgen Receptor Antagonists NTP

Evaluation of androgen assay results using a curated Hershberger database. Kleinstreuer NC, Browne P, Chang X, Judson R, Casey W, Ceger P, Deisenroth C, Baker N, Markey K, Thomas RS. Published: 25 May 2018. https://doi.org/10.1016/j.reprotox.2018.08.017. Performance data from applying the ToxCast/Tox 21 androgen receptor model, based on 11 high throughput assays, to 39 reference chemicals.

Please download whole dataset from FTP

Tox21 Androgen Receptor Assays and Androgen Receptor Pathway Model Dataset NTP

Evaluation of androgen assay results using a curated Hershberger database. Kleinstreuer NC, Browne P, Chang X, Judson R, Casey W, Ceger P, Deisenroth C, Baker N, Markey K, Thomas RS. Published: 25 May 2018. https://doi.org/10.1016/j.reprotox.2018.08.017. Performance data from applying the ToxCast/Tox 21 androgen receptor model, based on 11 high throughput assays, to 39 reference chemicals.

Please download whole dataset from FTP

Hallmark Gene Sets Annotations NTP

Annotation of Hallmark Gene Sets using NextBio platform to identify correlations between Hallmark Gene Sets and gene expression studies focusing on liver, heart and kidney tissue in rodents and humans. Additionally, correlations to gene expression studies in other tissues in rodents are described herein.

Please download whole dataset from FTP

In Vitro Micronucleus NTP

Study and trial conclusions from micronucleus assays for each cell type and activation condition, etc.

Please download whole dataset from FTP

Identification of p53 Activators in a Human Microarray Compendium, Tox21 Positive Results NTP

Biomarkers predictive of molecular and toxicological effects are needed to interpret emerging high-throughput transcriptomic data streams. The TGx-DDI biomarker was compared to microarray data in a compendium derived from human cells using the Running Fisher test, a nonparametric correlation test. In addition, the Tox21 p53 assay examined p53 responses at multiple doses at 16 h and in parallel identified doses that were cytotoxic. This dataset contains 19 biosets that were positive in the Tox21 Assay.

Please download whole dataset from FTP

Identification of p53 Activators in a Human Microarray Compendium with Significant Biomarker Correlation NTP

Biomarkers predictive of molecular and toxicological effects are needed to interpret emerging high-throughput transcriptomic data streams. The TGx-DDI biomarker was compared to microarray data in a compendium derived from human cells using the Running Fisher test, a nonparametric correlation test. This dataset contains 274 biosets with a significant TGx-DDI biomarker correlation.

Please download whole dataset from FTP

Summary of Health Effects Studies of Neonicotinoid Pesticides by Evidence Stream NTP

Data of animal biological systems affected by chemical exposure with relevance to human health effects.

Please download whole dataset from FTP

Chemicals Causing 10% or Greater Body Weight Loss in F344 Strains of Rats NTP

Summary body weight data with ratio of the treatment group body weight mean to the control group body weight mean. 

Please download whole dataset from FTP.

Animal Studies Evaluating Neonicotinoid Exposures and Neurological, Developmental or Congenital Effects NTP

Data of animal neurological and developmental/congenital outcomes from chemical exposure with relevance to human health effects.

Please download whole dataset from FTP

CEBSR: Statistically Analyzed NTP Pathology Lesions (with incidence, BMD, NEL, and LEL) NTP

This dataset contains statistically significant lesions from NTP studies as collated in the CEBSR database, including legacy and recently reported studies. Tissue name and morphology terminology have been harmonized for this dataset. New endpoints for each lesion are available: BMD (benchmark dose), LEL (lowest effect level) and NEL (no effect level).

Please download whole dataset from FTP.

CEBSR: NTP Clinical Pathology Data NTP

This dataset contains clinical pathology summary data from the CEBSR database, including legacy and recently reported studies. The test names and units have been harmonized for this dataset.  Documentation including test name descriptions and study exclusion are available here: https://cebs.niehs.nih.gov/cebs/paper/14893.

Regarding statistical analyses and interpretation of clinical pathology data: statistical analyses are a starting point in the interpretation of clinical pathology data and should not be used as a primary tool to identify test article-related effects.  Statistical significance testing of clinical pathology data should not replace critical scientific interpretation of data (ideally by an experienced veterinary toxicologic clinical pathologist) and consideration of clinical and biological relevance of any observed changes.  Clinical pathology data should be evaluated in context with all other available study data including in-life data (e.g., food consumption, body weight) and histopathology.  For more information about statistical significance testing for clinical pathology in toxicology studies, please refer to the below listed references.  

Aulbach A, Vitsky A, Arndt T, et al. Overview and considerations for the reporting of clinical pathology interpretations in nonclinical toxicology studies. Vet Clin Pathol. 2019;48:389–399. https://doi.org/10.1111/vcp.12772

Hall RL. Practical Considerations in Clinical Pathology Data Interpretation and Description: The Use of Statistics, Reference Intervals, and Severity Descriptors. Toxiol Path. 2017;45:362-365.  https://doi.org/10.1177/0192623316669824

Siska W, Gupta A, Tomlinson L, Tripathi N, von Beust B. Recommendations for clinical pathology data generation, interpretation, and reporting in target animal safety studies for veterinary drug development. Int J Toxicol. 2017;36:293-302.  https://doi.org/10.1177/1091581817711876

Please download whole dataset from FTP.

CEBSR: NTP Clinical Pathology Control Data NTP

This dataset contains control group clinical pathology summary data from the CEBSR database, including legacy and recently reported studies. The test names and units have been harmonized for this dataset.  Documentation including test name descriptions and study exclusion are available here: https://cebs.niehs.nih.gov/cebs/paper/14893.

Regarding statistical analyses and interpretation of clinical pathology data: statistical analyses are a starting point in the interpretation of clinical pathology data and should not be used as a primary tool to identify test article-related effects.  Statistical significance testing of clinical pathology data should not replace critical scientific interpretation of data (ideally by an experienced veterinary toxicologic clinical pathologist) and consideration of clinical and biological relevance of any observed changes.  Clinical pathology data should be evaluated in context with all other available study data including in-life data (e.g., food consumption, body weight) and histopathology.  For more information about statistical significance testing for clinical pathology in toxicology studies, please refer to the below listed references.  

Aulbach A, Vitsky A, Arndt T, et al. Overview and considerations for the reporting of clinical pathology interpretations in nonclinical toxicology studies. Vet Clin Pathol. 2019;48:389–399. https://doi.org/10.1111/vcp.12772

Hall RL. Practical Considerations in Clinical Pathology Data Interpretation and Description: The Use of Statistics, Reference Intervals, and Severity Descriptors. Toxiol Path. 2017;45:362-365.  https://doi.org/10.1177/0192623316669824

Siska W, Gupta A, Tomlinson L, Tripathi N, von Beust B. Recommendations for clinical pathology data generation, interpretation, and reporting in target animal safety studies for veterinary drug development. Int J Toxicol. 2017;36:293-302.  https://doi.org/10.1177/1091581817711876

Please download whole dataset from FTP

CEBSR: Statistically Analyzed Control NTP Pathology Lesions (with incidence, BMD, NEL, and LEL) NTP

This dataset contains lesions from control groups in NTP studies as collated in the CEBSR database, including legacy and recently reported studies. Tissue name and morphology terminology have been harmonized for this dataset. New endpoints for each lesion are available: BMD (benchmark dose), LEL (lowest effect level) and NEL (no effect level).

Please download whole dataset from FTP

NTP Individual Animal Pathology Lesions NTP

This dataset contains individual animal lesions from the Division of the National Toxicology Program (DNTP) studies including legacy and recently reported data.  Tissue name, locator, morphology, and modifier terminologies have been harmonized for this dataset.  

This is a large dataset containing over 3.8 million rows. The full dataset can be downloaded from the FTP site with options to download a .zip file containing the data divided into 4 Excel files or a single .tsv file containing all data. 

Note: DNTP Standardized Histopathology Glossary is available at https://doi.org/10.22427/NTP-DATA-002-00092-0001-0000-4. Glossary is under review.