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Organ Weight Summary Data

This dataset contains a subset of the organ weight summary data collected over the past 30 years (1987 – 2016) by the Division of Translational Toxicology (DTT) from dose-response studies. The selection criteria were studies with a single test article, route of exposure, species, and strain.

Individual animal data (IAD) from different dose and/or treatment groups are summarized, and statistical test results are presented. Results from analyses of both absolute organ weight and relative organ weight are summarized. The absolute weight is the weight recorded at the time of organ removal. Relative organ weight is the ratio of absolute organ weight divided by terminal body weight. 

The assay names and units have been standardized. The original assay names and data are shown in the IAD Collection. The level of significance (1, 2, or blank) is displayed in “Mult Comp Signif” and “Trend Signif” for pairwise and trend tests, respectively. A brief description of the content in these two fields, including blanks, is given in “Mult Comp Signif Description” and “Trend Signif Description”.

Datasets with one treatment dose and a vehicle control were analyzed by the Welch Two Sample t-test. The Jonckheere's trend test, followed by the Dunn or Shirley pairwise test, was applied to datasets with more than two dose groups. 

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Chemical DTXSID Standard Assay Name Standard Unit Species Strain Sex Dose Dose Unit Treatment Group Type Endpoint Name Mean SEM N Mult Comp Test Mult Comp Signif Mult Comp Signif Description Trend Test Trend Direction Trend Pvalue Trend Signif Trend Signif Description Comparator Reference Route Vehicle Time In Study Time In Study Unit Start Year DTT Publication Number Study Title Standard Study Type Standard Study Domain Data Domain CASRN Study UID Depositor Study Number Assay UID Standard Tissue Name