TOX-106: Sodium metavanadate (13718-26-8), Vanadyl sulfate (27774-13-6)

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Rats study conclusions related to TOX-106: Sodium metavanadate (13718-26-8), Vanadyl sulfate (27774-13-6).
Micronucleus - Rats
View Male: Negative Female: Negative
View Male: Negative Female: Negative

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to TOX-106: Sodium metavanadate (13718-26-8), Vanadyl sulfate (27774-13-6).
Micronucleus - Mice
View Male: Negative Female: Negative
View Male: Negative Female: Negative

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to TOX-106: Sodium metavanadate (13718-26-8), Vanadyl sulfate (27774-13-6).
Bacterial Mutagenicity
View Negative
View Negative

Citation Information

NTP. TOX-106: Sodium metavanadate (13718-26-8), Vanadyl sulfate (27774-13-6). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

TOX-106 Toxicity Studies of Sodium Metavanadate and Vanadyl Sulfate Administered via Dosed Water to Harlan Sprague-Dawley Rats and B6C3F1 Mice

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Data

3-Month (with Perinatal Exposure) Evaluation of the Toxicity (C08004) of Vanadyl Sulfate (27774-13-6) in Harlan Sprague-Dawley Rats Exposed via Dosed Water

Study Tables

I01 - Animal Removal Summary.pdf (74 kB)
I02 - Animal Removals.pdf (2 mB)
I03 - Growth Curve.pdf (1 mB)
I03C - Growth Curve.pdf (1 mB)
I04 - Mean Body Weight Summary.pdf (327 kB)
I04G - Mean Body Weight Gain.pdf (268 kB)
I05 - Clinical Observations Summary.pdf (217 kB)
I05P - Pup Clinical Observations Summary.pdf (247 kB)
I07 - Mean Water Consumption.pdf (336 kB)
I08 - Mean Test Compound Consumption.pdf (263 kB)
PA02R - Neoplastic Lesion Summary with Percent and Litter Incidence (387 kB)
PA03R - Non-Neoplastic Lesion Summary with Percent and Litter Incidence (401 kB)
PA05R - Incidence Rates of Neoplastic Lesions with Litter Incidence Systemic Lesions Abridged (388 kB)
PA06 - Organ Weight Summary.pdf (141 kB)
PA08R - Statistical Analysis of Neoplastic Lesions with Litter Incidence.pdf (258 kB)
PA10R - Statistical Analysis of Nonneoplastic Lesions with Litter Incidence.pdf (333 kB)
PA14 - Individual Animal Pathology Data (1 mB)
PA18R - Non-Neoplastic Lesion Summary with Mean Severity Grade and Litter Incidence (401 kB)
PA41 - Clinical Chemistry Summary.pdf (251 kB)
PA43 - Hematology Summary.pdf (554 kB)
PA44 - Urinalysis Data Summary.pdf (292 kB)
PA46 - Summary of Gross Pathology.pdf (245 kB)
PA48 - Summary of Tissue Concentration.pdf (53 kB)
R01 - Multigeneration Cross Reference.pdf (2 mB)
R02 - Reproductive Performance Summary.pdf (46 kB)
R03 - Summary of Litter Data.pdf (105 kB)
R06 - Andrology Summary.pdf (60 kB)
R16 - Pubertal Markers Summary.pdf (77 kB)
R19 - Pup Mean Body Weight Summary.pdf (272 kB)
R19C - Pup Growth Curve.pdf (889 kB)
R19G - Pup Mean Body Weight Gain.pdf (206 kB)
Vaginal Cytology Markov Model (179 kB)
Vaginal Cytology Plots (138 kB)
Vaginal Cytology Summary (126 kB)

Individual Animal Data

Individual Animal Andrology Data (10 kB)
Individual Animal Body Weight Data (151 kB)
Individual Animal Clinical Chemistry Data (15 kB)
Individual Animal Clinical Observations Data (237 kB)
Individual Animal Consumption Data (246 kB)
Individual Animal Developmental Markers Data (46 kB)
Individual Animal Gross Pathology Data (246 kB)
Individual Animal Hematology Data (46 kB)
Individual Animal Histopathology Data (81 kB)
Individual Animal Litter Data (138 kB)
Individual Animal Organ Weight Data (21 kB)
Individual Animal Pup Body Weight Data (247 kB)
Individual Animal Pup Clinical Observations Data (762 kB)
Individual Animal Removal Reasons Data (25 kB)
Individual Animal Reproductive Performance Data (8 kB)
Individual Animal Tissue Concentration Data (7 kB)
Individual Animal Urinalysis Data (14 kB)
Individual Animal Whole Litter Weight Data (7 kB)

Data

3-Month (with Perinatal Exposure) Evaluation of the Toxicity (C94043) of Sodium Metavanadate (13718-26-8) in Harlan Sprague-Dawley Rats Exposed via Dosed Water

Study Tables

I01 - Animal Removal Summary (79 kB)
I02 - Animal Removals (2 mB)
I03 - Growth Curve (1 mB)
I03C - Growth Curve (1 mB)
I04 - Mean Body Weight Summary (340 kB)
I04G - Mean Body Weight Gain (291 kB)
I05 - Clinical Observations Summary (287 kB)
I05P - Pup Clinical Observations Summary (293 kB)
I07 - Mean Water Consumption (350 kB)
I08 - Mean Test Compound Consumption (273 kB)
PA02R - Neoplastic Lesion Summary with Percent and Litter Incidence (397 kB)
PA03R - Non-Neoplastic Lesion Summary with Percent and Litter Incidence (477 kB)
PA05R - Incidence Rates of Neoplastic Lesions with Litter Incidence Systemic Lesions Abridged (398 kB)
PA06 - Organ Weight Summary (142 kB)
PA10R - Statistical Analysis of Nonneoplastic Lesions with Litter Incidence (433 kB)
PA14 - Individual Animal Pathology Data (2 mB)
PA18R - Non-Neoplastic Lesion Summary with Mean Severity Grade and Litter Incidence (477 kB)
PA41 - Clinical Chemistry Summary (253 kB)
PA43 - Hematology Summary (528 kB)
PA44 - Urinalysis Data Summary (259 kB)
PA46 - Summary of Gross Pathology (235 kB)
PA48 - Summary of Tissue Concentration (48 kB)
R01 - Multigeneration Cross Reference (2 mB)
R02 - Reproductive Performance Summary (46 kB)
R03 - Summary of Litter Data (105 kB)
R06 - Andrology Summary (61 kB)
R16 - Pubertal Markers Summary (72 kB)
R19 - Pup Mean Body Weight Summary (272 kB)
R19C - Pup Growth Curve (942 kB)
R19G - Pup Mean Body Weight Gain (206 kB)
Vaginal Cytology Markov Model (176 kB)
Vaginal Cytology Plots (144 kB)
Vaginal Cytology Summary (126 kB)

Individual Animal Data

Individual Animal Andrology Data (10 kB)
Individual Animal Body Weight Data (155 kB)
Individual Animal Clinical Chemistry Data (16 kB)
Individual Animal Clinical Observations Data (231 kB)
Individual Animal Consumption Data (233 kB)
Individual Animal Developmental Markers Data (37 kB)
Individual Animal Gross Pathology Data (315 kB)
Individual Animal Hematology Data (42 kB)
Individual Animal Histopathology Data (107 kB)
Individual Animal Litter Data (113 kB)
Individual Animal Organ Weight Data (21 kB)
Individual Animal Pup Body Weight Data (193 kB)
Individual Animal Pup Clinical Observations Data (606 kB)
Individual Animal Removal Reasons Data (23 kB)
Individual Animal Reproductive Performance Data (8 kB)
Individual Animal Tissue Concentration Data (7 kB)
Individual Animal Urinalysis Data (13 kB)
Individual Animal Whole Litter Weight Data (6 kB)

Data

3-Month Evaluation of the Toxicity (C08004) of Vanadyl Sulfate (27774-13-6) in B6C3F1 Mice Exposed via Dosed Water

Study Tables

I01 - Animal Removal Summary (39 kB)
I02 - Animal Removals (415 kB)
I03 - Growth Curve (660 kB)
I03C - Growth Curve (658 kB)
I04 - Mean Body Weight Summary (226 kB)
I04G - Mean Body Weight Gain (194 kB)
I05 - Clinical Observations Summary (44 kB)
I07 - Mean Water Consumption (247 kB)
I08 - Mean Test Compound Consumption (195 kB)
PA02 - Neoplastic Lesion Summary with Percent Incidence (378 kB)
PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (365 kB)
PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (379 kB)
PA06 - Organ Weights Summary (139 kB)
PA08 - Statistical Analysis of Neoplastic Lesions (220 kB)
PA10 - Statistical Analysis of Nonneoplastic Lesions (287 kB)
PA14 - Individual Animal Pathology Data (2 mB)
PA18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grade (366 kB)
PA43 - Hematology Summary (283 kB)
PA46 - Summary of Gross Pathology (223 kB)
R06 - Andrology Summary (60 kB)
Vaginal Cytology Markov Model (177 kB)
Vaginal Cytology Plots (138 kB)
Vaginal Cytology Summary (125 kB)

Individual Animal Data

Individual Animal Andrology Data (9 kB)
Individual Animal Body Weight Data (54 kB)
Individual Animal Clinical Observations Data (55 kB)
Individual Animal Consumption Data (96 kB)
Individual Animal Gross Pathology Data (224 kB)
Individual Animal Hematology Data (18 kB)
Individual Animal Histopathology Data (79 kB)
Individual Animal Organ Weight Data (15 kB)
Individual Animal Removal Reasons Data (9 kB)

Data

3-Month Evaluation of the Toxicity (C94043) of Sodium Metavanadate (13718-26-8) in B6C3F1 Mice Exposed via Dosed Water

Study Tables

I01 - Animal Removal Summary (44 kB)
I02 - Animal Removals (415 kB)
I03 - Growth Curve (697 kB)
I03C - Growth Curve (682 kB)
I04 - Mean Body Weight Summary (220 kB)
I04G - Mean Body Weight Gain (190 kB)
I05 - Clinical Observations Summary (59 kB)
I07 - Mean Water Consumption (248 kB)
I08 - Mean Test Compound Consumption (196 kB)
PA02 - Neoplastic Lesion Summary with Percent Incidence (390 kB)
PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (382 kB)
PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (391 kB)
PA06 - Organ Weights Summary (141 kB)
PA08 - Statistical Analysis of Neoplastic Lesions (226 kB)
PA10 - Statistical Analysis of Nonneoplastic Lesions (306 kB)
PA14 - Individual Animal Pathology Data (2 mB)
PA18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grade (382 kB)
PA43 - Hematology Summary (293 kB)
PA46 - Summary of Gross Pathology (227 kB)
R06 - Andrology Summary (60 kB)
Vaginal Cytology Markov Model (175 kB)
Vaginal Cytology Plots (141 kB)
Vaginal Cytology Summary (125 kB)

Individual Animal Data

Individual Animal Andrology Data (9 kB)
Individual Animal Body Weight Data (54 kB)
Individual Animal Clinical Observations Data (55 kB)
Individual Animal Consumption Data (95 kB)
Individual Animal Gross Pathology Data (211 kB)
Individual Animal Hematology Data (18 kB)
Individual Animal Histopathology Data (84 kB)
Individual Animal Organ Weight Data (15 kB)
Individual Animal Removal Reasons Data (9 kB)

Protocol

Genetic Toxicology Studies

Data

Genetic Toxicity Evaluation of Sodium Metavanadate (13718-26-8) in Micronucleus Study G94043B in Male and Female Sprague Dawley Rats

Summary Data

G04 - In Vivo Micronucleus Summary Data (159 kB)
Individual Animal In Vivo Micronucleus Data (22 kB)

Data

Genetic Toxicity Evaluation of Sodium Metavanadate (13718-26-8) in Micronucleus Study G94043C in Male and Female B6C3F1/N Mice

Summary Data

G04 - In Vivo Micronucleus Summary Data (126 kB)
Individual Animal In Vivo Micronucleus Data (22 kB)

Data

Genetic Toxicity Evaluation of Sodium Metavanadate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G94043

Summary Data

G06 - Ames Summary Data (80 kB)

Data

Genetic Toxicity Evaluation of Vanadyl Sulfate (27774-13-6) in Micronucleus Study G08004B in Male and Female Sprague Dawley Rats

Summary Data

G04 - In Vivo Micronucleus Summary Data (124 kB)
Individual Animal In Vivo Micronucleus Data (16 kB)

Data

Genetic Toxicity Evaluation of Vanadyl Sulfate (27774-13-6) in Micronucleus Study G08004C in Male and Female B6C3F1/N Mice

Summary Data

G04 - In Vivo Micronucleus Summary Data (159 kB)
Individual Animal In Vivo Micronucleus Data (16 kB)

Data

Genetic Toxicity Evaluation of Vanadyl Sulfate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G08004

Summary Data

G06 - Ames Summary Data (80 kB)

TOX-106: Sodium metavanadate (13718-26-8), Vanadyl sulfate (27774-13-6)

Study Results

Genetic Toxicology

Citation Information

Related Links

Publications

Study Data

Toxicity and Carcinogenicity Studies

3-Month (with Perinatal Exposure) Evaluation of the Toxicity (C08004) of Vanadyl Sulfate (27774-13-6) in Harlan Sprague-Dawley Rats Exposed via Dosed Water

Study Tables

Individual Animal Data

3-Month (with Perinatal Exposure) Evaluation of the Toxicity (C94043) of Sodium Metavanadate (13718-26-8) in Harlan Sprague-Dawley Rats Exposed via Dosed Water

Study Tables

Individual Animal Data

3-Month Evaluation of the Toxicity (C08004) of Vanadyl Sulfate (27774-13-6) in B6C3F1 Mice Exposed via Dosed Water

Study Tables

Individual Animal Data

3-Month Evaluation of the Toxicity (C94043) of Sodium Metavanadate (13718-26-8) in B6C3F1 Mice Exposed via Dosed Water

Study Tables

Individual Animal Data

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Sodium Metavanadate (13718-26-8) in Micronucleus Study G94043B in Male and Female Sprague Dawley Rats

Summary Data

Genetic Toxicity Evaluation of Sodium Metavanadate (13718-26-8) in Micronucleus Study G94043C in Male and Female B6C3F1/N Mice

Summary Data

Genetic Toxicity Evaluation of Sodium Metavanadate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G94043

Summary Data

Genetic Toxicity Evaluation of Vanadyl Sulfate (27774-13-6) in Micronucleus Study G08004B in Male and Female Sprague Dawley Rats

Summary Data

Genetic Toxicity Evaluation of Vanadyl Sulfate (27774-13-6) in Micronucleus Study G08004C in Male and Female B6C3F1/N Mice

Summary Data

Genetic Toxicity Evaluation of Vanadyl Sulfate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G08004

Summary Data