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TR-251: Toluene diisocyanate (26471-62-5)

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Positive, Male, Rats
View
  • Positive, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
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  • Negative, Male, Mice
View
  • Positive, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to TR-251: Toluene diisocyanate (26471-62-5).
Bacterial Mutagenicity
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  • Positive

Citation Information

NTP. TR-251: Toluene diisocyanate (26471-62-5). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-251 Toxicology and Carcinogenesis Studies of Commercial Grade 2,4 (80)- and 2,6 (20)- Toluene Diisocyanate (CASRN 26471-62-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of 2,4- & 2,6-Toluene Diisocyanate (26471-62-5) in Male F344 Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,4- & 2,6-Toluene Diisocyanate (26471-62-5) in Female F344 Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,4- & 2,6-Toluene Diisocyanate (26471-62-5) in Male B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,4- & 2,6-Toluene Diisocyanate (26471-62-5) in Female B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of 2,4- & 2,6-Toluene Diisocyanate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 654636
Summary Data